PITH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5U2_LEIBR

TriTrypDb:

LbrM.09.1190 , LBRM2903_090018400

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0030992	intraciliary transport particle B	2	7
GO:0032991	protein-containing complex	1	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1

Expansion

Sequence features

A4H5U2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5U2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0007017	microtubule-based process	2	7
GO:0007018	microtubule-based movement	3	7
GO:0009987	cellular process	1	7
GO:0010970	transport along microtubule	4	7
GO:0030705	cytoskeleton-dependent intracellular transport	4	7
GO:0031503	protein-containing complex localization	2	7
GO:0042073	intraciliary transport	3	7
GO:0046907	intracellular transport	3	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0051641	cellular localization	2	7
GO:0051649	establishment of localization in cell	3	7
GO:0099111	microtubule-based transport	4	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.362
CLV_PCSK_SKI1_1	137	141	PF00082	0.469
CLV_PCSK_SKI1_1	75	79	PF00082	0.407
DEG_Nend_Nbox_1	1	3	PF02207	0.490
DOC_MAPK_gen_1	125	133	PF00069	0.467
DOC_MAPK_gen_1	198	207	PF00069	0.461
DOC_MAPK_MEF2A_6	125	133	PF00069	0.467
DOC_MAPK_MEF2A_6	198	207	PF00069	0.461
DOC_MAPK_MEF2A_6	4	13	PF00069	0.441
DOC_PP1_RVXF_1	196	203	PF00149	0.460
DOC_PP1_RVXF_1	73	79	PF00149	0.595
DOC_USP7_MATH_1	161	165	PF00917	0.650
DOC_USP7_MATH_1	71	75	PF00917	0.623
DOC_USP7_UBL2_3	64	68	PF12436	0.484
DOC_WW_Pin1_4	145	150	PF00397	0.505
DOC_WW_Pin1_4	31	36	PF00397	0.521
DOC_WW_Pin1_4	37	42	PF00397	0.490
LIG_14-3-3_CanoR_1	120	129	PF00244	0.425
LIG_BIR_III_4	221	225	PF00653	0.468
LIG_BRCT_BRCA1_1	33	37	PF00533	0.453
LIG_BRCT_BRCA1_1	73	77	PF00533	0.469
LIG_FHA_1	100	106	PF00498	0.544
LIG_FHA_1	186	192	PF00498	0.531
LIG_FHA_2	130	136	PF00498	0.364
LIG_FHA_2	148	154	PF00498	0.616
LIG_FHA_2	170	176	PF00498	0.624
LIG_LIR_Gen_1	150	160	PF02991	0.614
LIG_LIR_Gen_1	199	207	PF02991	0.455
LIG_LIR_Gen_1	209	218	PF02991	0.466
LIG_LIR_Gen_1	23	32	PF02991	0.456
LIG_LIR_Gen_1	79	90	PF02991	0.499
LIG_LIR_Nem_3	150	155	PF02991	0.362
LIG_LIR_Nem_3	199	205	PF02991	0.461
LIG_LIR_Nem_3	209	214	PF02991	0.480
LIG_LIR_Nem_3	23	27	PF02991	0.460
LIG_LIR_Nem_3	50	56	PF02991	0.495
LIG_LIR_Nem_3	74	80	PF02991	0.496
LIG_Pex14_2	78	82	PF04695	0.581
LIG_SH2_CRK	24	28	PF00017	0.463
LIG_SH2_STAP1	218	222	PF00017	0.460
LIG_SH2_STAT5	211	214	PF00017	0.345
LIG_SH3_3	178	184	PF00018	0.674
LIG_SH3_3	29	35	PF00018	0.557
LIG_SH3_3	95	101	PF00018	0.613
LIG_TRFH_1	189	193	PF08558	0.641
LIG_TRFH_1	37	41	PF08558	0.471
LIG_WRC_WIRS_1	82	87	PF05994	0.482
MOD_CK1_1	127	133	PF00069	0.454
MOD_CK1_1	168	174	PF00069	0.719
MOD_CK1_1	25	31	PF00069	0.543
MOD_CK2_1	147	153	PF00069	0.579
MOD_CK2_1	169	175	PF00069	0.646
MOD_CK2_1	233	239	PF00069	0.629
MOD_GlcNHglycan	122	125	PF01048	0.479
MOD_GlcNHglycan	163	166	PF01048	0.633
MOD_GlcNHglycan	208	211	PF01048	0.406
MOD_GSK3_1	100	107	PF00069	0.607
MOD_GSK3_1	116	123	PF00069	0.514
MOD_GSK3_1	161	168	PF00069	0.570
MOD_GSK3_1	22	29	PF00069	0.678
MOD_GSK3_1	31	38	PF00069	0.708
MOD_N-GLC_1	168	173	PF02516	0.608
MOD_NEK2_1	104	109	PF00069	0.513
MOD_NEK2_1	129	134	PF00069	0.385
MOD_NEK2_1	14	19	PF00069	0.611
MOD_NEK2_1	69	74	PF00069	0.709
MOD_PIKK_1	224	230	PF00454	0.549
MOD_PKA_2	119	125	PF00069	0.363
MOD_PKA_2	161	167	PF00069	0.681
MOD_PKA_2	203	209	PF00069	0.446
MOD_Plk_1	156	162	PF00069	0.514
MOD_Plk_4	100	106	PF00069	0.544
MOD_Plk_4	26	32	PF00069	0.409
MOD_Plk_4	9	15	PF00069	0.446
MOD_ProDKin_1	145	151	PF00069	0.506
MOD_ProDKin_1	31	37	PF00069	0.523
MOD_SUMO_rev_2	130	139	PF00179	0.459
MOD_SUMO_rev_2	60	70	PF00179	0.487
TRG_ENDOCYTIC_2	2	5	PF00928	0.453
TRG_ENDOCYTIC_2	211	214	PF00928	0.495
TRG_ENDOCYTIC_2	24	27	PF00928	0.464
TRG_ENDOCYTIC_2	53	56	PF00928	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A8	Leptomonas seymouri	76%	100%
A0A3S5H6E4	Leishmania donovani	85%	100%
A4HU36	Leishmania infantum	85%	100%
E9AMW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QHR1	Leishmania major	73%	100%