Mitochondrial import inner membrane translocase subunit TIM22

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial import inner membrane translocase subunit TIM17, putative

Species:

Leishmania braziliensis

UniProt:

A4H5U1_LEIBR

TriTrypDb:

LbrM.09.1180 , LBRM2903_090018300

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0032991	protein-containing complex	1	2
GO:0042721	TIM22 mitochondrial import inner membrane insertion complex	4	2
GO:0098796	membrane protein complex	2	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0098800	inner mitochondrial membrane protein complex	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H5U1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5U1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006839	mitochondrial transport	4	2
GO:0006886	intracellular protein transport	4	2
GO:0006996	organelle organization	4	2
GO:0007005	mitochondrion organization	5	2
GO:0007006	mitochondrial membrane organization	5	2
GO:0007007	inner mitochondrial membrane organization	6	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	2
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0045039	protein insertion into mitochondrial inner membrane	6	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051204	protein insertion into mitochondrial membrane	5	2
GO:0051205	protein insertion into membrane	5	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0061024	membrane organization	4	2
GO:0070585	protein localization to mitochondrion	6	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0072594	establishment of protein localization to organelle	4	2
GO:0072655	establishment of protein localization to mitochondrion	5	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:0090151	establishment of protein localization to mitochondrial membrane	4	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0008320	protein transmembrane transporter activity	3	2
GO:0022857	transmembrane transporter activity	2	2
GO:0022884	macromolecule transmembrane transporter activity	3	2
GO:0140318	protein transporter activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	177	179	PF00675	0.449
CLV_NRD_NRD_1	4	6	PF00675	0.647
CLV_NRD_NRD_1	47	49	PF00675	0.833
CLV_NRD_NRD_1	70	72	PF00675	0.650
CLV_PCSK_KEX2_1	176	178	PF00082	0.449
CLV_PCSK_KEX2_1	4	6	PF00082	0.647
CLV_PCSK_KEX2_1	47	49	PF00082	0.833
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.449
DEG_ODPH_VHL_1	12	24	PF01847	0.549
DEG_SPOP_SBC_1	133	137	PF00917	0.449
DOC_CYCLIN_RxL_1	20	28	PF00134	0.549
DOC_USP7_MATH_1	102	106	PF00917	0.738
DOC_USP7_MATH_1	133	137	PF00917	0.449
DOC_WW_Pin1_4	5	10	PF00397	0.825
LIG_14-3-3_CanoR_1	147	151	PF00244	0.449
LIG_14-3-3_CanoR_1	34	40	PF00244	0.645
LIG_14-3-3_CanoR_1	47	52	PF00244	0.468
LIG_14-3-3_CanoR_1	58	66	PF00244	0.357
LIG_14-3-3_CanoR_1	7	13	PF00244	0.804
LIG_BIR_III_4	226	230	PF00653	0.538
LIG_BRCT_BRCA1_1	158	162	PF00533	0.549
LIG_BRCT_BRCA1_1	16	20	PF00533	0.549
LIG_BRCT_BRCA1_1	217	221	PF00533	0.549
LIG_BRCT_BRCA1_2	217	223	PF00533	0.549
LIG_FHA_1	107	113	PF00498	0.549
LIG_FHA_1	60	66	PF00498	0.549
LIG_FHA_1	81	87	PF00498	0.843
LIG_LIR_Apic_2	201	205	PF02991	0.650
LIG_LIR_Gen_1	159	167	PF02991	0.549
LIG_LIR_Gen_1	218	228	PF02991	0.631
LIG_LIR_Nem_3	159	165	PF02991	0.549
LIG_LIR_Nem_3	201	207	PF02991	0.650
LIG_LYPXL_yS_3	204	207	PF13949	0.650
LIG_Pex14_2	16	20	PF04695	0.549
LIG_Pex14_2	163	167	PF04695	0.549
LIG_Pex14_2	217	221	PF04695	0.549
LIG_REV1ctd_RIR_1	143	151	PF16727	0.449
LIG_REV1ctd_RIR_1	18	27	PF16727	0.549
LIG_SH2_CRK	202	206	PF00017	0.650
LIG_SH2_STAT5	118	121	PF00017	0.549
LIG_SH3_3	85	91	PF00018	0.819
LIG_WW_3	76	80	PF00397	0.840
MOD_CK1_1	129	135	PF00069	0.549
MOD_CK1_1	149	155	PF00069	0.199
MOD_CK1_1	38	44	PF00069	0.646
MOD_CK1_1	64	70	PF00069	0.549
MOD_CK1_1	8	14	PF00069	0.795
MOD_Cter_Amidation	178	181	PF01082	0.449
MOD_Cter_Amidation	69	72	PF01082	0.825
MOD_DYRK1A_RPxSP_1	5	9	PF00069	0.830
MOD_GlcNHglycan	131	134	PF01048	0.549
MOD_GlcNHglycan	151	154	PF01048	0.400
MOD_GSK3_1	102	109	PF00069	0.730
MOD_GSK3_1	122	129	PF00069	0.199
MOD_GSK3_1	57	64	PF00069	0.549
MOD_GSK3_1	77	84	PF00069	0.595
MOD_NEK2_1	122	127	PF00069	0.549
MOD_NEK2_1	146	151	PF00069	0.449
MOD_NEK2_1	156	161	PF00069	0.375
MOD_NEK2_1	25	30	PF00069	0.549
MOD_OFUCOSY	49	54	PF10250	0.828
MOD_PIKK_1	134	140	PF00454	0.449
MOD_PK_1	61	67	PF00069	0.549
MOD_PKA_1	47	53	PF00069	0.629
MOD_PKA_2	146	152	PF00069	0.449
MOD_PKA_2	47	53	PF00069	0.629
MOD_PKA_2	57	63	PF00069	0.375
MOD_PKB_1	5	13	PF00069	0.813
MOD_Plk_1	103	109	PF00069	0.729
MOD_Plk_1	80	86	PF00069	0.846
MOD_Plk_2-3	81	87	PF00069	0.843
MOD_Plk_4	126	132	PF00069	0.549
MOD_Plk_4	35	41	PF00069	0.647
MOD_Plk_4	61	67	PF00069	0.549
MOD_Plk_4	81	87	PF00069	0.593
MOD_ProDKin_1	5	11	PF00069	0.821
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.549
TRG_ENDOCYTIC_2	204	207	PF00928	0.650
TRG_ER_diArg_1	177	180	PF00400	0.650
TRG_ER_diArg_1	4	7	PF00400	0.845
TRG_NES_CRM1_1	90	104	PF08389	0.772

Homologs


Protein	Taxonomy	Sequence identity	Coverage
Q5U4U5	XENLA	30%	100%