Mitochondrial RNA binding protein 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding protein 2

Species:

Leishmania braziliensis

UniProt:

A4H5U0_LEIBR

TriTrypDb:

LbrM.09.1170 , LBRM2903_090018200

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 7
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5U0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5U0

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	12
GO:0009889	regulation of biosynthetic process	4	12
GO:0010468	regulation of gene expression	5	12
GO:0010556	regulation of macromolecule biosynthetic process	5	12
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031326	regulation of cellular biosynthetic process	5	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051252	regulation of RNA metabolic process	5	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0080090	regulation of primary metabolic process	4	12
GO:1903506	regulation of nucleic acid-templated transcription	7	12
GO:2001141	regulation of RNA biosynthetic process	6	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	46	50	PF00656	0.599
CLV_NRD_NRD_1	239	241	PF00675	0.679
CLV_NRD_NRD_1	3	5	PF00675	0.606
CLV_NRD_NRD_1	74	76	PF00675	0.441
CLV_PCSK_FUR_1	72	76	PF00082	0.415
CLV_PCSK_KEX2_1	3	5	PF00082	0.606
CLV_PCSK_KEX2_1	74	76	PF00082	0.441
CLV_PCSK_SKI1_1	115	119	PF00082	0.409
CLV_PCSK_SKI1_1	136	140	PF00082	0.489
CLV_PCSK_SKI1_1	226	230	PF00082	0.413
DEG_Nend_Nbox_1	1	3	PF02207	0.626
DOC_MAPK_gen_1	133	142	PF00069	0.398
DOC_MAPK_MEF2A_6	133	142	PF00069	0.394
DOC_USP7_MATH_1	218	222	PF00917	0.463
DOC_USP7_MATH_1	28	32	PF00917	0.607
DOC_WW_Pin1_4	51	56	PF00397	0.736
LIG_14-3-3_CanoR_1	113	121	PF00244	0.505
LIG_14-3-3_CanoR_1	136	141	PF00244	0.394
LIG_14-3-3_CanoR_1	226	234	PF00244	0.378
LIG_14-3-3_CanoR_1	44	53	PF00244	0.809
LIG_14-3-3_CanoR_1	64	69	PF00244	0.438
LIG_deltaCOP1_diTrp_1	211	216	PF00928	0.413
LIG_FHA_1	116	122	PF00498	0.527
LIG_FHA_1	137	143	PF00498	0.468
LIG_FHA_1	17	23	PF00498	0.648
LIG_FHA_1	192	198	PF00498	0.477
LIG_FHA_1	227	233	PF00498	0.452
LIG_FHA_1	52	58	PF00498	0.559
LIG_FHA_2	44	50	PF00498	0.620
LIG_LIR_Gen_1	104	111	PF02991	0.413
LIG_LIR_Nem_3	104	109	PF02991	0.413
LIG_MAD2	136	144	PF02301	0.499
LIG_MYND_1	38	42	PF01753	0.532
LIG_Pex14_1	212	216	PF04695	0.413
LIG_SH2_STAP1	146	150	PF00017	0.291
LIG_SH2_STAT3	111	114	PF00017	0.378
LIG_SH2_STAT5	183	186	PF00017	0.491
LIG_SH3_2	55	60	PF14604	0.560
LIG_SH3_3	137	143	PF00018	0.368
LIG_SH3_3	52	58	PF00018	0.559
LIG_SUMO_SIM_par_1	135	141	PF11976	0.499
LIG_WW_1	143	146	PF00397	0.499
MOD_CK1_1	116	122	PF00069	0.273
MOD_CK1_1	165	171	PF00069	0.372
MOD_CK1_1	63	69	PF00069	0.470
MOD_CK2_1	156	162	PF00069	0.503
MOD_Cter_Amidation	72	75	PF01082	0.525
MOD_GlcNHglycan	115	118	PF01048	0.273
MOD_GlcNHglycan	26	29	PF01048	0.697
MOD_GlcNHglycan	30	33	PF01048	0.667
MOD_GSK3_1	181	188	PF00069	0.442
MOD_GSK3_1	206	213	PF00069	0.415
MOD_GSK3_1	24	31	PF00069	0.684
MOD_GSK3_1	60	67	PF00069	0.459
MOD_N-GLC_1	90	95	PF02516	0.273
MOD_NEK2_1	185	190	PF00069	0.380
MOD_PIKK_1	226	232	PF00454	0.378
MOD_PK_1	64	70	PF00069	0.273
MOD_PKA_2	156	162	PF00069	0.435
MOD_PKA_2	165	171	PF00069	0.319
MOD_PKA_2	43	49	PF00069	0.774
MOD_PKA_2	63	69	PF00069	0.425
MOD_PKB_1	113	121	PF00069	0.525
MOD_Plk_1	206	212	PF00069	0.421
MOD_Plk_4	168	174	PF00069	0.411
MOD_Plk_4	218	224	PF00069	0.378
MOD_ProDKin_1	51	57	PF00069	0.734
TRG_AP2beta_CARGO_1	104	113	PF09066	0.413
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.535
TRG_ER_diArg_1	2	4	PF00400	0.623
TRG_ER_diArg_1	72	75	PF00400	0.438
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2W9	Leptomonas seymouri	65%	100%
A0A0S4JSM9	Bodo saltans	38%	100%
A0A1X0NIK6	Trypanosomatidae	57%	100%
A0A3R7KW77	Trypanosoma rangeli	56%	100%
A0A3S7WQT7	Leishmania donovani	81%	100%
A4HU34	Leishmania infantum	81%	100%
D0A9L2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AMW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QHR3	Leishmania major	81%	100%
V5AY48	Trypanosoma cruzi	56%	100%