Dilute domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5T8_LEIBR

TriTrypDb:

LbrM.09.1150 , LBRM2903_090018000

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5T8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5T8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	195	197	PF00675	0.534
CLV_PCSK_KEX2_1	137	139	PF00082	0.440
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.410
CLV_PCSK_SKI1_1	108	112	PF00082	0.545
DEG_APCC_KENBOX_2	45	49	PF00400	0.486
DEG_SPOP_SBC_1	97	101	PF00917	0.485
DOC_PP2B_LxvP_1	167	170	PF13499	0.462
DOC_USP7_MATH_1	11	15	PF00917	0.576
DOC_USP7_MATH_1	214	218	PF00917	0.534
DOC_USP7_MATH_1	75	79	PF00917	0.500
DOC_WW_Pin1_4	23	28	PF00397	0.785
LIG_14-3-3_CanoR_1	151	160	PF00244	0.454
LIG_14-3-3_CanoR_1	76	80	PF00244	0.498
LIG_Actin_WH2_2	174	192	PF00022	0.516
LIG_BIR_II_1	1	5	PF00653	0.642
LIG_FHA_1	162	168	PF00498	0.548
LIG_FHA_1	39	45	PF00498	0.560
LIG_FHA_1	92	98	PF00498	0.537
LIG_FHA_1	99	105	PF00498	0.491
LIG_FHA_2	134	140	PF00498	0.490
LIG_LIR_Gen_1	109	118	PF02991	0.446
LIG_LIR_Gen_1	158	167	PF02991	0.426
LIG_LIR_Nem_3	109	114	PF02991	0.471
LIG_LIR_Nem_3	158	163	PF02991	0.436
LIG_MYND_1	187	191	PF01753	0.572
LIG_SH2_CRK	238	242	PF00017	0.420
LIG_SH3_3	226	232	PF00018	0.516
LIG_SUMO_SIM_anti_2	38	47	PF11976	0.508
MOD_CK1_1	125	131	PF00069	0.504
MOD_CK1_1	95	101	PF00069	0.487
MOD_CK2_1	133	139	PF00069	0.489
MOD_GlcNHglycan	13	16	PF01048	0.575
MOD_GlcNHglycan	215	219	PF01048	0.537
MOD_GlcNHglycan	27	30	PF01048	0.604
MOD_GSK3_1	169	176	PF00069	0.500
MOD_GSK3_1	23	30	PF00069	0.532
MOD_GSK3_1	239	246	PF00069	0.549
MOD_GSK3_1	91	98	PF00069	0.457
MOD_N-GLC_1	144	149	PF02516	0.503
MOD_NEK2_1	173	178	PF00069	0.405
MOD_NEK2_1	37	42	PF00069	0.559
MOD_PIKK_1	85	91	PF00454	0.534
MOD_PKA_1	122	128	PF00069	0.508
MOD_PKA_2	75	81	PF00069	0.530
MOD_Plk_1	37	43	PF00069	0.522
MOD_Plk_4	169	175	PF00069	0.417
MOD_Plk_4	239	245	PF00069	0.543
MOD_ProDKin_1	23	29	PF00069	0.783
MOD_SUMO_for_1	248	251	PF00179	0.463
TRG_DiLeu_BaEn_1	158	163	PF01217	0.475
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.397
TRG_ENDOCYTIC_2	238	241	PF00928	0.422
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA21	Leptomonas seymouri	66%	92%
A0A3S7WQT3	Leishmania donovani	84%	100%
A0A422MTH2	Trypanosoma rangeli	29%	83%
A4HU32	Leishmania infantum	84%	100%
E9AMW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QHR5	Leishmania major	82%	100%