Putative DNA-directed RNA polymerase III subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA-directed RNA polymerase III subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4H5T5_LEIBR

TriTrypDb:

LbrM.09.1120 , LBRM2903_090017700

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	10
GO:0030880	RNA polymerase complex	3	10
GO:0032991	protein-containing complex	1	10
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	10
GO:0140535	intracellular protein-containing complex	2	10
GO:1902494	catalytic complex	2	10
GO:1990234	transferase complex	3	10
GO:0005666	RNA polymerase III complex	4	1
GO:0016020	membrane	2	1
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4H5T5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5T5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006352	DNA-templated transcription initiation	6	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009059	macromolecule biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0018130	heterocycle biosynthetic process	4	10
GO:0019438	aromatic compound biosynthetic process	4	10
GO:0032774	RNA biosynthetic process	5	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034654	nucleobase-containing compound biosynthetic process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901362	organic cyclic compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10
GO:0006384	transcription initiation at RNA polymerase III promoter	7	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0034062	5'-3' RNA polymerase activity	5	1
GO:0097747	RNA polymerase activity	4	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	258	262	PF00656	0.358
CLV_C14_Caspase3-7	290	294	PF00656	0.429
CLV_PCSK_SKI1_1	65	69	PF00082	0.447
DEG_Nend_Nbox_1	1	3	PF02207	0.458
DOC_CDC14_PxL_1	146	154	PF14671	0.336
DOC_PP4_FxxP_1	151	154	PF00568	0.274
DOC_PP4_FxxP_1	219	222	PF00568	0.200
DOC_USP7_MATH_1	104	108	PF00917	0.389
DOC_USP7_MATH_1	154	158	PF00917	0.200
DOC_USP7_MATH_1	213	217	PF00917	0.468
DOC_USP7_MATH_1	49	53	PF00917	0.582
DOC_WW_Pin1_4	119	124	PF00397	0.270
DOC_WW_Pin1_4	218	223	PF00397	0.200
LIG_14-3-3_CanoR_1	71	77	PF00244	0.356
LIG_BIR_III_4	281	285	PF00653	0.391
LIG_BRCT_BRCA1_1	215	219	PF00533	0.211
LIG_eIF4E_1	140	146	PF01652	0.336
LIG_FHA_1	111	117	PF00498	0.427
LIG_FHA_1	140	146	PF00498	0.473
LIG_FHA_1	266	272	PF00498	0.200
LIG_FHA_1	8	14	PF00498	0.432
LIG_FHA_2	61	67	PF00498	0.366
LIG_LIR_Apic_2	216	222	PF02991	0.200
LIG_LIR_Gen_1	144	154	PF02991	0.288
LIG_LIR_Nem_3	144	149	PF02991	0.291
LIG_LIR_Nem_3	3	8	PF02991	0.341
LIG_MYND_1	150	154	PF01753	0.391
LIG_PDZ_Class_3	290	295	PF00595	0.643
LIG_Pex14_2	18	22	PF04695	0.538
LIG_SH2_CRK	8	12	PF00017	0.332
LIG_SH2_NCK_1	8	12	PF00017	0.432
LIG_SH2_STAP1	60	64	PF00017	0.516
LIG_SH2_STAP1	8	12	PF00017	0.332
LIG_SH2_STAT5	140	143	PF00017	0.381
LIG_SH2_STAT5	17	20	PF00017	0.393
LIG_SH2_STAT5	172	175	PF00017	0.391
LIG_SH2_STAT5	5	8	PF00017	0.326
LIG_SH2_STAT5	76	79	PF00017	0.362
LIG_SH3_3	115	121	PF00018	0.399
LIG_SH3_3	13	19	PF00018	0.413
LIG_SH3_3	144	150	PF00018	0.391
LIG_SUMO_SIM_par_1	9	14	PF11976	0.309
LIG_TRAF2_1	256	259	PF00917	0.310
LIG_TYR_ITIM	6	11	PF00017	0.333
MOD_CDK_SPxxK_3	119	126	PF00069	0.273
MOD_CK1_1	162	168	PF00069	0.336
MOD_CK1_1	217	223	PF00069	0.496
MOD_CK1_1	43	49	PF00069	0.561
MOD_CK1_1	97	103	PF00069	0.458
MOD_CK2_1	252	258	PF00069	0.370
MOD_CK2_1	284	290	PF00069	0.336
MOD_CK2_1	49	55	PF00069	0.435
MOD_GlcNHglycan	106	109	PF01048	0.381
MOD_GlcNHglycan	164	167	PF01048	0.448
MOD_GlcNHglycan	201	204	PF01048	0.483
MOD_GlcNHglycan	210	213	PF01048	0.232
MOD_GlcNHglycan	254	257	PF01048	0.470
MOD_GlcNHglycan	29	32	PF01048	0.573
MOD_GlcNHglycan	42	45	PF01048	0.482
MOD_GlcNHglycan	95	99	PF01048	0.426
MOD_GSK3_1	104	111	PF00069	0.399
MOD_GSK3_1	20	27	PF00069	0.468
MOD_GSK3_1	213	220	PF00069	0.435
MOD_GSK3_1	34	41	PF00069	0.571
MOD_GSK3_1	45	52	PF00069	0.538
MOD_N-GLC_2	24	26	PF02516	0.529
MOD_NEK2_1	1	6	PF00069	0.396
MOD_NEK2_1	110	115	PF00069	0.378
MOD_NEK2_1	214	219	PF00069	0.336
MOD_NEK2_1	274	279	PF00069	0.317
MOD_NEK2_1	34	39	PF00069	0.516
MOD_NEK2_1	7	12	PF00069	0.370
MOD_NEK2_1	94	99	PF00069	0.440
MOD_NEK2_2	265	270	PF00069	0.200
MOD_NEK2_2	60	65	PF00069	0.450
MOD_PKA_2	274	280	PF00069	0.328
MOD_PKA_2	70	76	PF00069	0.351
MOD_Plk_4	1	7	PF00069	0.333
MOD_Plk_4	154	160	PF00069	0.236
MOD_Plk_4	214	220	PF00069	0.200
MOD_Plk_4	274	280	PF00069	0.283
MOD_Plk_4	284	290	PF00069	0.321
MOD_ProDKin_1	119	125	PF00069	0.268
MOD_ProDKin_1	218	224	PF00069	0.200
MOD_SUMO_for_1	241	244	PF00179	0.206
TRG_ENDOCYTIC_2	140	143	PF00928	0.333
TRG_ENDOCYTIC_2	172	175	PF00928	0.391
TRG_ENDOCYTIC_2	8	11	PF00928	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P336	Leptomonas seymouri	52%	89%
A0A1X0NIF1	Trypanosomatidae	35%	96%
A0A3Q8I7I6	Leishmania donovani	82%	99%
A0A422MXM4	Trypanosoma rangeli	33%	100%
A4HU28	Leishmania infantum	81%	99%
E9AMV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
Q4QHR8	Leishmania major	82%	100%
V5BI52	Trypanosoma cruzi	33%	100%