MSP domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MSP (Major sperm protein) domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H5T4_LEIBR

TriTrypDb:

LbrM.09.1110 , LBRM2903_090017600

Length:

250

Annotations

LeishMANIAdb annotations

As the MSP domain is involved in providing cell motility, this protein is likely involved in the same function.. Has a number of plant (E1ZCB1_CHLVA), fungal (G8B4Z0_CANPC) and animal orthologs.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	10
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0005886	plasma membrane	3	1
GO:0020016	ciliary pocket	2	1

Expansion

Sequence features

A4H5T4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5T4

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022406	membrane docking	2	1
GO:0051179	localization	1	1
GO:0051640	organelle localization	2	1
GO:0051643	endoplasmic reticulum localization	3	1
GO:0061024	membrane organization	4	1
GO:0061817	endoplasmic reticulum-plasma membrane tethering	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090158	endoplasmic reticulum membrane organization	5	1
GO:0140056	organelle localization by membrane tethering	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.615
CLV_NRD_NRD_1	201	203	PF00675	0.503
CLV_PCSK_KEX2_1	183	185	PF00082	0.516
CLV_PCSK_KEX2_1	199	201	PF00082	0.497
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.539
CLV_PCSK_SKI1_1	133	137	PF00082	0.493
CLV_PCSK_SKI1_1	184	188	PF00082	0.599
DEG_Nend_UBRbox_2	1	3	PF02207	0.768
DOC_MAPK_RevD_3	186	200	PF00069	0.646
DOC_USP7_MATH_1	154	158	PF00917	0.642
DOC_USP7_MATH_1	160	164	PF00917	0.669
DOC_USP7_UBL2_3	55	59	PF12436	0.499
LIG_14-3-3_CanoR_1	183	189	PF00244	0.829
LIG_14-3-3_CanoR_1	201	210	PF00244	0.771
LIG_14-3-3_CanoR_1	213	223	PF00244	0.674
LIG_14-3-3_CanoR_1	40	46	PF00244	0.523
LIG_BIR_III_4	165	169	PF00653	0.723
LIG_FHA_1	215	221	PF00498	0.619
LIG_FHA_1	24	30	PF00498	0.572
LIG_FHA_1	42	48	PF00498	0.428
LIG_FHA_1	65	71	PF00498	0.523
LIG_FHA_1	87	93	PF00498	0.582
LIG_FHA_2	193	199	PF00498	0.715
LIG_FHA_2	72	78	PF00498	0.557
LIG_LIR_Gen_1	13	21	PF02991	0.542
LIG_LIR_Gen_1	217	227	PF02991	0.441
LIG_LIR_Nem_3	13	18	PF02991	0.517
LIG_LIR_Nem_3	206	212	PF02991	0.642
LIG_LIR_Nem_3	217	222	PF02991	0.421
LIG_PTB_Apo_2	28	35	PF02174	0.499
LIG_PTB_Phospho_1	28	34	PF10480	0.582
LIG_SH2_STAP1	34	38	PF00017	0.582
LIG_SH2_STAT5	129	132	PF00017	0.726
LIG_SH2_STAT5	50	53	PF00017	0.519
LIG_SH2_STAT5	85	88	PF00017	0.554
LIG_Sin3_3	226	233	PF02671	0.332
LIG_TYR_ITIM	32	37	PF00017	0.582
MOD_CK1_1	182	188	PF00069	0.666
MOD_CK1_1	203	209	PF00069	0.645
MOD_CK2_1	192	198	PF00069	0.723
MOD_CK2_1	71	77	PF00069	0.585
MOD_GlcNHglycan	156	159	PF01048	0.485
MOD_GlcNHglycan	162	165	PF01048	0.476
MOD_GlcNHglycan	205	208	PF01048	0.564
MOD_GlcNHglycan	62	65	PF01048	0.382
MOD_GSK3_1	178	185	PF00069	0.743
MOD_GSK3_1	23	30	PF00069	0.585
MOD_GSK3_1	60	67	PF00069	0.510
MOD_N-GLC_1	177	182	PF02516	0.516
MOD_N-GLC_1	203	208	PF02516	0.553
MOD_N-GLC_1	214	219	PF02516	0.428
MOD_N-GLC_1	60	65	PF02516	0.299
MOD_NEK2_1	27	32	PF00069	0.526
MOD_NEK2_1	51	56	PF00069	0.552
MOD_NEK2_2	64	69	PF00069	0.549
MOD_PKA_1	200	206	PF00069	0.634
MOD_PKA_2	182	188	PF00069	0.813
MOD_PKA_2	200	206	PF00069	0.634
MOD_PKA_2	41	47	PF00069	0.560
MOD_PKA_2	83	89	PF00069	0.580
MOD_PKB_1	200	208	PF00069	0.753
MOD_Plk_1	214	220	PF00069	0.599
MOD_Plk_1	23	29	PF00069	0.518
MOD_Plk_2-3	192	198	PF00069	0.723
MOD_Plk_2-3	23	29	PF00069	0.582
MOD_Plk_4	109	115	PF00069	0.679
MOD_Plk_4	121	127	PF00069	0.684
MOD_Plk_4	205	211	PF00069	0.661
MOD_Plk_4	215	221	PF00069	0.579
TRG_DiLeu_BaEn_1	13	18	PF01217	0.557
TRG_ENDOCYTIC_2	34	37	PF00928	0.582
TRG_ER_diArg_1	200	202	PF00400	0.765
TRG_ER_diArg_1	39	42	PF00400	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9W8	Leptomonas seymouri	65%	100%
A0A1X0NI22	Trypanosomatidae	29%	91%
A0A3S7WQS6	Leishmania donovani	81%	100%
A0A422MXK0	Trypanosoma rangeli	30%	100%
A4HU27	Leishmania infantum	81%	100%
E9AMV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QHR9	Leishmania major	76%	98%
V5BI56	Trypanosoma cruzi	32%	100%