Putative phospholipid:diacylglycerol acyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phospholipid:diacylglycerol acyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4H5T3_LEIBR

TriTrypDb:

LbrM.09.1100 , LBRM2903_090017500

Length:

718

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4H5T3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5T3

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008080	N-acetyltransferase activity	6	7
GO:0008374	O-acyltransferase activity	5	12
GO:0016407	acetyltransferase activity	5	7
GO:0016410	N-acyltransferase activity	5	7
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	12
GO:0046027	phospholipid:diacylglycerol acyltransferase activity	7	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.561
CLV_C14_Caspase3-7	64	68	PF00656	0.719
CLV_NRD_NRD_1	103	105	PF00675	0.431
CLV_NRD_NRD_1	178	180	PF00675	0.332
CLV_NRD_NRD_1	234	236	PF00675	0.480
CLV_NRD_NRD_1	24	26	PF00675	0.390
CLV_NRD_NRD_1	32	34	PF00675	0.432
CLV_NRD_NRD_1	374	376	PF00675	0.533
CLV_NRD_NRD_1	447	449	PF00675	0.509
CLV_NRD_NRD_1	689	691	PF00675	0.609
CLV_NRD_NRD_1	70	72	PF00675	0.560
CLV_NRD_NRD_1	708	710	PF00675	0.456
CLV_NRD_NRD_1	711	713	PF00675	0.574
CLV_NRD_NRD_1	88	90	PF00675	0.527
CLV_PCSK_KEX2_1	118	120	PF00082	0.441
CLV_PCSK_KEX2_1	180	182	PF00082	0.396
CLV_PCSK_KEX2_1	234	236	PF00082	0.481
CLV_PCSK_KEX2_1	31	33	PF00082	0.433
CLV_PCSK_KEX2_1	609	611	PF00082	0.430
CLV_PCSK_KEX2_1	689	691	PF00082	0.609
CLV_PCSK_KEX2_1	70	72	PF00082	0.476
CLV_PCSK_KEX2_1	708	710	PF00082	0.456
CLV_PCSK_KEX2_1	88	90	PF00082	0.569
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.324
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.306
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.382
CLV_PCSK_PC7_1	704	710	PF00082	0.414
CLV_PCSK_SKI1_1	105	109	PF00082	0.462
CLV_PCSK_SKI1_1	262	266	PF00082	0.629
CLV_PCSK_SKI1_1	448	452	PF00082	0.406
CLV_PCSK_SKI1_1	614	618	PF00082	0.406
DEG_APCC_DBOX_1	366	374	PF00400	0.231
DEG_Nend_UBRbox_1	1	4	PF02207	0.602
DEG_SCF_TRCP1_1	309	314	PF00400	0.309
DEG_SPOP_SBC_1	18	22	PF00917	0.572
DEG_SPOP_SBC_1	44	48	PF00917	0.569
DOC_CDC14_PxL_1	526	534	PF14671	0.231
DOC_CYCLIN_yClb1_LxF_4	367	373	PF00134	0.309
DOC_CYCLIN_yCln2_LP_2	441	447	PF00134	0.146
DOC_MAPK_FxFP_2	317	320	PF00069	0.146
DOC_MAPK_gen_1	118	125	PF00069	0.601
DOC_MAPK_gen_1	179	188	PF00069	0.430
DOC_MAPK_gen_1	234	240	PF00069	0.243
DOC_MAPK_gen_1	257	267	PF00069	0.228
DOC_MAPK_gen_1	375	384	PF00069	0.275
DOC_MAPK_gen_1	70	77	PF00069	0.582
DOC_MAPK_HePTP_8	177	189	PF00069	0.495
DOC_MAPK_MEF2A_6	180	189	PF00069	0.416
DOC_MAPK_MEF2A_6	260	267	PF00069	0.368
DOC_MAPK_MEF2A_6	70	77	PF00069	0.582
DOC_PP1_RVXF_1	178	185	PF00149	0.498
DOC_PP2B_LxvP_1	160	163	PF13499	0.553
DOC_PP2B_LxvP_1	441	444	PF13499	0.162
DOC_PP4_FxxP_1	317	320	PF00568	0.175
DOC_USP7_MATH_1	10	14	PF00917	0.605
DOC_USP7_MATH_1	161	165	PF00917	0.566
DOC_USP7_MATH_1	24	28	PF00917	0.630
DOC_USP7_MATH_1	56	60	PF00917	0.689
DOC_USP7_MATH_1	82	86	PF00917	0.712
DOC_USP7_MATH_1	90	94	PF00917	0.703
DOC_USP7_UBL2_3	636	640	PF12436	0.256
DOC_WW_Pin1_4	136	141	PF00397	0.636
DOC_WW_Pin1_4	20	25	PF00397	0.596
DOC_WW_Pin1_4	349	354	PF00397	0.249
DOC_WW_Pin1_4	564	569	PF00397	0.275
DOC_WW_Pin1_4	75	80	PF00397	0.694
LIG_14-3-3_CanoR_1	119	124	PF00244	0.632
LIG_14-3-3_CanoR_1	152	160	PF00244	0.631
LIG_14-3-3_CanoR_1	216	222	PF00244	0.356
LIG_14-3-3_CanoR_1	227	232	PF00244	0.405
LIG_14-3-3_CanoR_1	31	37	PF00244	0.582
LIG_14-3-3_CanoR_1	43	51	PF00244	0.579
LIG_14-3-3_CanoR_1	465	474	PF00244	0.230
LIG_14-3-3_CanoR_1	585	593	PF00244	0.328
LIG_14-3-3_CanoR_1	694	703	PF00244	0.269
LIG_Actin_RPEL_3	174	193	PF02755	0.382
LIG_Actin_WH2_2	617	635	PF00022	0.256
LIG_APCC_Cbox_2	409	415	PF00515	0.309
LIG_BIR_III_2	214	218	PF00653	0.301
LIG_BIR_III_2	480	484	PF00653	0.146
LIG_BRCT_BRCA1_1	313	317	PF00533	0.155
LIG_BRCT_BRCA1_1	572	576	PF00533	0.256
LIG_Clathr_ClatBox_1	290	294	PF01394	0.164
LIG_EH1_1	182	190	PF00400	0.332
LIG_FHA_1	152	158	PF00498	0.493
LIG_FHA_1	206	212	PF00498	0.262
LIG_FHA_1	244	250	PF00498	0.298
LIG_FHA_1	389	395	PF00498	0.233
LIG_FHA_1	438	444	PF00498	0.274
LIG_FHA_1	46	52	PF00498	0.567
LIG_FHA_1	497	503	PF00498	0.318
LIG_FHA_1	565	571	PF00498	0.305
LIG_FHA_1	590	596	PF00498	0.221
LIG_FHA_1	625	631	PF00498	0.146
LIG_FHA_1	682	688	PF00498	0.475
LIG_FHA_2	208	214	PF00498	0.361
LIG_FHA_2	295	301	PF00498	0.206
LIG_FHA_2	311	317	PF00498	0.206
LIG_FHA_2	32	38	PF00498	0.681
LIG_FHA_2	523	529	PF00498	0.321
LIG_FHA_2	62	68	PF00498	0.655
LIG_FHA_2	673	679	PF00498	0.403
LIG_GBD_Chelix_1	185	193	PF00786	0.337
LIG_LIR_Apic_2	314	320	PF02991	0.288
LIG_LIR_Gen_1	128	138	PF02991	0.666
LIG_LIR_Gen_1	169	177	PF02991	0.443
LIG_LIR_Gen_1	309	320	PF02991	0.281
LIG_LIR_Gen_1	464	475	PF02991	0.272
LIG_LIR_Gen_1	693	703	PF02991	0.272
LIG_LIR_Nem_3	115	120	PF02991	0.664
LIG_LIR_Nem_3	128	133	PF02991	0.718
LIG_LIR_Nem_3	169	174	PF02991	0.443
LIG_LIR_Nem_3	220	225	PF02991	0.375
LIG_LIR_Nem_3	309	315	PF02991	0.281
LIG_LIR_Nem_3	316	322	PF02991	0.263
LIG_LIR_Nem_3	360	366	PF02991	0.206
LIG_LIR_Nem_3	464	470	PF02991	0.247
LIG_LIR_Nem_3	479	485	PF02991	0.317
LIG_LIR_Nem_3	693	699	PF02991	0.276
LIG_OCRL_FandH_1	406	418	PF00620	0.309
LIG_PCNA_TLS_4	448	455	PF02747	0.240
LIG_Pex14_1	287	291	PF04695	0.309
LIG_Pex14_2	319	323	PF04695	0.146
LIG_REV1ctd_RIR_1	219	228	PF16727	0.383
LIG_REV1ctd_RIR_1	394	402	PF16727	0.309
LIG_SH2_NCK_1	696	700	PF00017	0.210
LIG_SH2_PTP2	415	418	PF00017	0.309
LIG_SH2_STAP1	347	351	PF00017	0.206
LIG_SH2_STAT3	337	340	PF00017	0.249
LIG_SH2_STAT5	231	234	PF00017	0.414
LIG_SH2_STAT5	278	281	PF00017	0.297
LIG_SH2_STAT5	415	418	PF00017	0.241
LIG_SH2_STAT5	555	558	PF00017	0.209
LIG_SH2_STAT5	569	572	PF00017	0.329
LIG_SH2_STAT5	676	679	PF00017	0.413
LIG_SH3_2	140	145	PF14604	0.587
LIG_SH3_3	137	143	PF00018	0.707
LIG_SH3_3	192	198	PF00018	0.447
LIG_SH3_3	527	533	PF00018	0.240
LIG_SH3_3	543	549	PF00018	0.228
LIG_SH3_3	663	669	PF00018	0.427
LIG_SH3_3	73	79	PF00018	0.710
LIG_SUMO_SIM_par_1	73	78	PF11976	0.745
LIG_UBA3_1	290	296	PF00899	0.231
LIG_UBA3_1	650	656	PF00899	0.261
LIG_WRC_WIRS_1	519	524	PF05994	0.366
MOD_CDC14_SPxK_1	23	26	PF00782	0.593
MOD_CDC14_SPxK_1	352	355	PF00782	0.231
MOD_CDK_SPK_2	20	25	PF00069	0.596
MOD_CDK_SPxK_1	20	26	PF00069	0.597
MOD_CDK_SPxK_1	349	355	PF00069	0.231
MOD_CK1_1	310	316	PF00069	0.182
MOD_CK1_1	387	393	PF00069	0.148
MOD_CK1_1	493	499	PF00069	0.298
MOD_CK1_1	61	67	PF00069	0.640
MOD_CK2_1	207	213	PF00069	0.363
MOD_CK2_1	507	513	PF00069	0.314
MOD_CK2_1	518	524	PF00069	0.316
MOD_CK2_1	672	678	PF00069	0.309
MOD_CK2_1	90	96	PF00069	0.649
MOD_GlcNHglycan	309	312	PF01048	0.473
MOD_GlcNHglycan	404	407	PF01048	0.487
MOD_GlcNHglycan	429	432	PF01048	0.440
MOD_GlcNHglycan	509	512	PF01048	0.479
MOD_GlcNHglycan	63	67	PF01048	0.397
MOD_GlcNHglycan	637	640	PF01048	0.390
MOD_GlcNHglycan	658	661	PF01048	0.502
MOD_GlcNHglycan	84	87	PF01048	0.535
MOD_GSK3_1	10	17	PF00069	0.695
MOD_GSK3_1	146	153	PF00069	0.650
MOD_GSK3_1	20	27	PF00069	0.645
MOD_GSK3_1	307	314	PF00069	0.273
MOD_GSK3_1	384	391	PF00069	0.274
MOD_GSK3_1	461	468	PF00069	0.309
MOD_GSK3_1	489	496	PF00069	0.327
MOD_GSK3_1	518	525	PF00069	0.329
MOD_GSK3_1	58	65	PF00069	0.619
MOD_GSK3_1	620	627	PF00069	0.317
MOD_GSK3_1	672	679	PF00069	0.407
MOD_LATS_1	692	698	PF00433	0.340
MOD_N-GLC_1	18	23	PF02516	0.372
MOD_N-GLC_1	301	306	PF02516	0.455
MOD_N-GLC_1	461	466	PF02516	0.399
MOD_N-GLC_1	489	494	PF02516	0.523
MOD_N-GLC_1	536	541	PF02516	0.391
MOD_N-GLC_1	571	576	PF02516	0.476
MOD_N-GLC_1	577	582	PF02516	0.485
MOD_N-GLC_1	620	625	PF02516	0.521
MOD_NEK2_1	463	468	PF00069	0.298
MOD_NEK2_1	620	625	PF00069	0.256
MOD_NEK2_1	650	655	PF00069	0.222
MOD_NEK2_2	217	222	PF00069	0.358
MOD_NEK2_2	252	257	PF00069	0.335
MOD_NEK2_2	571	576	PF00069	0.281
MOD_PIKK_1	10	16	PF00454	0.572
MOD_PIKK_1	146	152	PF00454	0.675
MOD_PIKK_1	24	30	PF00454	0.569
MOD_PIKK_1	453	459	PF00454	0.309
MOD_PKA_1	118	124	PF00069	0.515
MOD_PKA_1	31	37	PF00069	0.569
MOD_PKA_2	118	124	PF00069	0.621
MOD_PKA_2	151	157	PF00069	0.626
MOD_PKA_2	226	232	PF00069	0.237
MOD_PKA_2	24	30	PF00069	0.675
MOD_PKA_2	31	37	PF00069	0.685
MOD_PKA_2	402	408	PF00069	0.231
MOD_PKA_2	437	443	PF00069	0.290
MOD_PKA_2	44	50	PF00069	0.685
MOD_PKA_2	496	502	PF00069	0.342
MOD_PKA_2	584	590	PF00069	0.309
MOD_PKB_1	43	51	PF00069	0.570
MOD_Plk_1	252	258	PF00069	0.366
MOD_Plk_1	517	523	PF00069	0.354
MOD_Plk_1	536	542	PF00069	0.173
MOD_Plk_1	571	577	PF00069	0.279
MOD_Plk_1	578	584	PF00069	0.287
MOD_Plk_1	589	595	PF00069	0.309
MOD_Plk_1	620	626	PF00069	0.285
MOD_Plk_1	672	678	PF00069	0.390
MOD_Plk_1	682	688	PF00069	0.375
MOD_Plk_2-3	289	295	PF00069	0.220
MOD_Plk_2-3	518	524	PF00069	0.271
MOD_Plk_2-3	672	678	PF00069	0.324
MOD_Plk_4	112	118	PF00069	0.599
MOD_Plk_4	119	125	PF00069	0.569
MOD_Plk_4	161	167	PF00069	0.632
MOD_Plk_4	217	223	PF00069	0.328
MOD_Plk_4	227	233	PF00069	0.391
MOD_Plk_4	469	475	PF00069	0.363
MOD_Plk_4	483	489	PF00069	0.344
MOD_Plk_4	518	524	PF00069	0.334
MOD_Plk_4	571	577	PF00069	0.312
MOD_Plk_4	650	656	PF00069	0.243
MOD_ProDKin_1	136	142	PF00069	0.634
MOD_ProDKin_1	20	26	PF00069	0.597
MOD_ProDKin_1	349	355	PF00069	0.249
MOD_ProDKin_1	564	570	PF00069	0.275
MOD_ProDKin_1	75	81	PF00069	0.695
MOD_SUMO_rev_2	289	297	PF00179	0.280
MOD_SUMO_rev_2	300	306	PF00179	0.334
TRG_DiLeu_BaEn_2	517	523	PF01217	0.194
TRG_DiLeu_BaEn_4	128	134	PF01217	0.556
TRG_DiLeu_BaLyEn_6	591	596	PF01217	0.182
TRG_ENDOCYTIC_2	278	281	PF00928	0.286
TRG_ENDOCYTIC_2	415	418	PF00928	0.279
TRG_ENDOCYTIC_2	554	557	PF00928	0.343
TRG_ENDOCYTIC_2	648	651	PF00928	0.302
TRG_ENDOCYTIC_2	696	699	PF00928	0.268
TRG_ER_diArg_1	179	182	PF00400	0.538
TRG_ER_diArg_1	233	235	PF00400	0.309
TRG_ER_diArg_1	267	270	PF00400	0.283
TRG_ER_diArg_1	30	33	PF00400	0.640
TRG_ER_diArg_1	42	45	PF00400	0.585
TRG_ER_diArg_1	689	691	PF00400	0.409
TRG_ER_diArg_1	69	71	PF00400	0.586
TRG_ER_diArg_1	707	709	PF00400	0.287
TRG_ER_diArg_1	88	90	PF00400	0.660
TRG_ER_diLys_1	714	718	PF00400	0.261
TRG_NES_CRM1_1	199	214	PF08389	0.298
TRG_NLS_MonoExtC_3	711	716	PF00514	0.400
TRG_NLS_MonoExtN_4	709	716	PF00514	0.387
TRG_Pf-PMV_PEXEL_1	448	452	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU70	Leptomonas seymouri	63%	94%
A0A0S4J6G5	Bodo saltans	35%	100%
A0A1X0NHY0	Trypanosomatidae	46%	90%
A0A3R7KCW2	Trypanosoma rangeli	45%	100%
A0A3S7WQS8	Leishmania donovani	85%	100%
A4HU26	Leishmania infantum	85%	100%
D0A9K5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AMV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
O94680	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
P40345	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q4QHS0	Leishmania major	85%	100%
V5BDI6	Trypanosoma cruzi	43%	100%