Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5T2_LEIBR

TriTrypDb:

LbrM.09.1090 , LBRM2903_090017300 , LBRM2903_090017400

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5T2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5T2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	332	336	PF00656	0.478
CLV_C14_Caspase3-7	91	95	PF00656	0.537
CLV_NRD_NRD_1	208	210	PF00675	0.535
CLV_NRD_NRD_1	286	288	PF00675	0.541
CLV_NRD_NRD_1	308	310	PF00675	0.599
CLV_NRD_NRD_1	322	324	PF00675	0.557
CLV_NRD_NRD_1	406	408	PF00675	0.583
CLV_NRD_NRD_1	79	81	PF00675	0.586
CLV_PCSK_FUR_1	306	310	PF00082	0.585
CLV_PCSK_KEX2_1	208	210	PF00082	0.535
CLV_PCSK_KEX2_1	220	222	PF00082	0.425
CLV_PCSK_KEX2_1	286	288	PF00082	0.548
CLV_PCSK_KEX2_1	308	310	PF00082	0.599
CLV_PCSK_KEX2_1	322	324	PF00082	0.557
CLV_PCSK_KEX2_1	79	81	PF00082	0.586
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.389
CLV_PCSK_SKI1_1	208	212	PF00082	0.622
CLV_PCSK_SKI1_1	226	230	PF00082	0.384
CLV_PCSK_SKI1_1	308	312	PF00082	0.626
CLV_PCSK_SKI1_1	338	342	PF00082	0.534
CLV_PCSK_SKI1_1	379	383	PF00082	0.378
DEG_APCC_DBOX_1	363	371	PF00400	0.379
DEG_Nend_Nbox_1	1	3	PF02207	0.566
DEG_SPOP_SBC_1	174	178	PF00917	0.554
DEG_SPOP_SBC_1	210	214	PF00917	0.386
DEG_SPOP_SBC_1	315	319	PF00917	0.636
DOC_CKS1_1	27	32	PF01111	0.563
DOC_MAPK_gen_1	219	227	PF00069	0.385
DOC_MAPK_gen_1	294	302	PF00069	0.521
DOC_MAPK_MEF2A_6	220	229	PF00069	0.390
DOC_MAPK_MEF2A_6	364	371	PF00069	0.379
DOC_MAPK_NFAT4_5	364	372	PF00069	0.378
DOC_USP7_MATH_1	117	121	PF00917	0.709
DOC_USP7_MATH_1	15	19	PF00917	0.700
DOC_USP7_MATH_1	159	163	PF00917	0.488
DOC_USP7_MATH_1	174	178	PF00917	0.554
DOC_USP7_MATH_1	314	318	PF00917	0.749
DOC_USP7_MATH_1	49	53	PF00917	0.620
DOC_WW_Pin1_4	126	131	PF00397	0.515
DOC_WW_Pin1_4	147	152	PF00397	0.810
DOC_WW_Pin1_4	259	264	PF00397	0.654
DOC_WW_Pin1_4	26	31	PF00397	0.558
DOC_WW_Pin1_4	36	41	PF00397	0.538
DOC_WW_Pin1_4	47	52	PF00397	0.547
DOC_WW_Pin1_4	62	67	PF00397	0.542
DOC_WW_Pin1_4	83	88	PF00397	0.552
LIG_14-3-3_CanoR_1	144	151	PF00244	0.663
LIG_14-3-3_CanoR_1	157	165	PF00244	0.461
LIG_14-3-3_CanoR_1	308	316	PF00244	0.619
LIG_14-3-3_CanoR_1	338	343	PF00244	0.477
LIG_14-3-3_CanoR_1	352	356	PF00244	0.378
LIG_14-3-3_CanoR_1	387	393	PF00244	0.504
LIG_BRCT_BRCA1_1	338	342	PF00533	0.549
LIG_FHA_1	143	149	PF00498	0.520
LIG_FHA_1	210	216	PF00498	0.423
LIG_FHA_1	401	407	PF00498	0.505
LIG_FHA_1	65	71	PF00498	0.568
LIG_FHA_1	91	97	PF00498	0.521
LIG_FHA_2	17	23	PF00498	0.572
LIG_FHA_2	211	217	PF00498	0.532
LIG_FHA_2	37	43	PF00498	0.526
LIG_IBAR_NPY_1	158	160	PF08397	0.629
LIG_IRF3_LxIS_1	58	63	PF10401	0.553
LIG_SH2_SRC	170	173	PF00017	0.510
LIG_SH2_STAP1	194	198	PF00017	0.514
LIG_SH3_1	24	30	PF00018	0.560
LIG_SH3_2	27	32	PF14604	0.563
LIG_SH3_3	109	115	PF00018	0.742
LIG_SH3_3	233	239	PF00018	0.641
LIG_SH3_3	24	30	PF00018	0.572
LIG_SH3_3	251	257	PF00018	0.688
LIG_SH3_3	389	395	PF00018	0.466
LIG_SH3_3	48	54	PF00018	0.567
LIG_SH3_3	63	69	PF00018	0.555
LIG_SUMO_SIM_anti_2	366	371	PF11976	0.379
LIG_TRAF2_1	19	22	PF00917	0.568
MOD_CDK_SPK_2	259	264	PF00069	0.654
MOD_CDK_SPxK_1	126	132	PF00069	0.519
MOD_CDK_SPxK_1	26	32	PF00069	0.561
MOD_CK1_1	126	132	PF00069	0.583
MOD_CK1_1	134	140	PF00069	0.585
MOD_CK1_1	259	265	PF00069	0.502
MOD_CK1_1	317	323	PF00069	0.691
MOD_CK1_1	333	339	PF00069	0.474
MOD_CK1_1	400	406	PF00069	0.639
MOD_CK1_1	44	50	PF00069	0.699
MOD_CK2_1	15	21	PF00069	0.566
MOD_CK2_1	210	216	PF00069	0.387
MOD_CK2_1	36	42	PF00069	0.600
MOD_GlcNHglycan	13	16	PF01048	0.589
MOD_GlcNHglycan	136	139	PF01048	0.618
MOD_GlcNHglycan	258	261	PF01048	0.535
MOD_GlcNHglycan	324	327	PF01048	0.695
MOD_GlcNHglycan	338	341	PF01048	0.457
MOD_GlcNHglycan	399	402	PF01048	0.637
MOD_GlcNHglycan	42	46	PF01048	0.644
MOD_GSK3_1	11	18	PF00069	0.607
MOD_GSK3_1	122	129	PF00069	0.529
MOD_GSK3_1	143	150	PF00069	0.520
MOD_GSK3_1	211	218	PF00069	0.525
MOD_GSK3_1	314	321	PF00069	0.755
MOD_GSK3_1	330	337	PF00069	0.477
MOD_GSK3_1	397	404	PF00069	0.642
MOD_GSK3_1	41	48	PF00069	0.670
MOD_GSK3_1	56	63	PF00069	0.559
MOD_GSK3_1	90	97	PF00069	0.523
MOD_N-GLC_1	126	131	PF02516	0.515
MOD_N-GLC_1	397	402	PF02516	0.642
MOD_NEK2_1	215	220	PF00069	0.650
MOD_NEK2_1	60	65	PF00069	0.575
MOD_NEK2_2	388	393	PF00069	0.449
MOD_PIKK_1	131	137	PF00454	0.534
MOD_PIKK_1	262	268	PF00454	0.476
MOD_PKA_1	322	328	PF00069	0.649
MOD_PKA_2	117	123	PF00069	0.594
MOD_PKA_2	131	137	PF00069	0.605
MOD_PKA_2	143	149	PF00069	0.523
MOD_PKA_2	322	328	PF00069	0.643
MOD_PKA_2	333	339	PF00069	0.496
MOD_PKA_2	351	357	PF00069	0.389
MOD_Plk_2-3	345	351	PF00069	0.426
MOD_Plk_4	56	62	PF00069	0.553
MOD_ProDKin_1	126	132	PF00069	0.519
MOD_ProDKin_1	147	153	PF00069	0.808
MOD_ProDKin_1	259	265	PF00069	0.646
MOD_ProDKin_1	26	32	PF00069	0.561
MOD_ProDKin_1	36	42	PF00069	0.542
MOD_ProDKin_1	47	53	PF00069	0.544
MOD_ProDKin_1	62	68	PF00069	0.540
MOD_ProDKin_1	83	89	PF00069	0.551
TRG_ENDOCYTIC_2	289	292	PF00928	0.611
TRG_ER_diArg_1	200	203	PF00400	0.513
TRG_ER_diArg_1	208	210	PF00400	0.408
TRG_ER_diArg_1	285	287	PF00400	0.547
TRG_ER_diArg_1	306	309	PF00400	0.580
TRG_ER_diArg_1	322	324	PF00400	0.539
TRG_ER_diArg_1	375	378	PF00400	0.498
TRG_ER_diArg_1	79	81	PF00400	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQV2	Leishmania donovani	66%	100%
A4HU25	Leishmania infantum	65%	100%
E9AMV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
Q4QHS1	Leishmania major	63%	98%