LeishMANIAdb
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PKD_channel domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
PKD_channel domain-containing protein
Gene product:
LEM3 (ligand-effect modulator 3) family / CDC50 family, putative
Species:
Leishmania braziliensis
UniProt:
A4H5T1_LEIBR
TriTrypDb:
LbrM.09.1080 , LBRM2903_090017200 *
Length:
613

Annotations

LeishMANIAdb annotations

Homologous to animal CDC50 family phospholipid flippase (ATPase) proteins.. This family has expanded in kinetoplastids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0016020 membrane 2 16
GO:0110165 cellular anatomical entity 1 16
GO:0005783 endoplasmic reticulum 5 2
GO:0005794 Golgi apparatus 5 2
GO:0005886 plasma membrane 3 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1

Expansion

Sequence features

A4H5T1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5T1

Function

Biological processes
Term Name Level Count
GO:0033036 macromolecule localization 2 16
GO:0051179 localization 1 16
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 290 294 PF00656 0.306
CLV_C14_Caspase3-7 54 58 PF00656 0.686
CLV_C14_Caspase3-7 71 75 PF00656 0.812
CLV_NRD_NRD_1 326 328 PF00675 0.462
CLV_NRD_NRD_1 451 453 PF00675 0.501
CLV_NRD_NRD_1 482 484 PF00675 0.490
CLV_NRD_NRD_1 562 564 PF00675 0.386
CLV_NRD_NRD_1 573 575 PF00675 0.361
CLV_NRD_NRD_1 80 82 PF00675 0.494
CLV_PCSK_FUR_1 108 112 PF00082 0.380
CLV_PCSK_FUR_1 560 564 PF00082 0.397
CLV_PCSK_KEX2_1 110 112 PF00082 0.464
CLV_PCSK_KEX2_1 540 542 PF00082 0.433
CLV_PCSK_KEX2_1 562 564 PF00082 0.360
CLV_PCSK_KEX2_1 80 82 PF00082 0.494
CLV_PCSK_PC1ET2_1 110 112 PF00082 0.381
CLV_PCSK_PC1ET2_1 540 542 PF00082 0.433
CLV_PCSK_SKI1_1 111 115 PF00082 0.375
CLV_PCSK_SKI1_1 229 233 PF00082 0.480
CLV_PCSK_SKI1_1 26 30 PF00082 0.408
CLV_PCSK_SKI1_1 297 301 PF00082 0.499
CLV_PCSK_SKI1_1 304 308 PF00082 0.555
CLV_PCSK_SKI1_1 327 331 PF00082 0.528
CLV_PCSK_SKI1_1 6 10 PF00082 0.406
DEG_APCC_DBOX_1 228 236 PF00400 0.171
DEG_Nend_UBRbox_1 1 4 PF02207 0.613
DEG_ODPH_VHL_1 313 325 PF01847 0.290
DEG_SPOP_SBC_1 45 49 PF00917 0.743
DEG_SPOP_SBC_1 56 60 PF00917 0.722
DEG_SPOP_SBC_1 66 70 PF00917 0.792
DOC_CDC14_PxL_1 339 347 PF14671 0.227
DOC_CYCLIN_yClb3_PxF_3 547 553 PF00134 0.538
DOC_CYCLIN_yCln2_LP_2 159 165 PF00134 0.375
DOC_MAPK_DCC_7 229 237 PF00069 0.171
DOC_MAPK_FxFP_2 144 147 PF00069 0.622
DOC_MAPK_gen_1 281 291 PF00069 0.224
DOC_MAPK_gen_1 391 400 PF00069 0.322
DOC_MAPK_gen_1 452 462 PF00069 0.267
DOC_MAPK_gen_1 481 488 PF00069 0.291
DOC_MAPK_MEF2A_6 220 227 PF00069 0.275
DOC_PP1_RVXF_1 389 396 PF00149 0.304
DOC_PP2B_LxvP_1 159 162 PF13499 0.375
DOC_PP4_FxxP_1 144 147 PF00568 0.622
DOC_USP7_MATH_1 20 24 PF00917 0.616
DOC_USP7_MATH_1 427 431 PF00917 0.257
DOC_USP7_MATH_1 432 436 PF00917 0.273
DOC_USP7_MATH_1 539 543 PF00917 0.634
DOC_USP7_MATH_1 56 60 PF00917 0.673
DOC_USP7_MATH_1 61 65 PF00917 0.662
DOC_USP7_MATH_1 66 70 PF00917 0.815
DOC_USP7_MATH_1 95 99 PF00917 0.724
DOC_USP7_UBL2_3 110 114 PF12436 0.577
DOC_WW_Pin1_4 145 150 PF00397 0.592
DOC_WW_Pin1_4 27 32 PF00397 0.642
DOC_WW_Pin1_4 284 289 PF00397 0.328
DOC_WW_Pin1_4 327 332 PF00397 0.367
DOC_WW_Pin1_4 35 40 PF00397 0.665
DOC_WW_Pin1_4 350 355 PF00397 0.338
DOC_WW_Pin1_4 41 46 PF00397 0.649
DOC_WW_Pin1_4 62 67 PF00397 0.616
LIG_14-3-3_CanoR_1 261 270 PF00244 0.348
LIG_14-3-3_CanoR_1 304 309 PF00244 0.358
LIG_14-3-3_CanoR_1 444 454 PF00244 0.296
LIG_14-3-3_CanoR_1 481 487 PF00244 0.295
LIG_Actin_WH2_2 558 576 PF00022 0.646
LIG_AP2alpha_1 319 323 PF02296 0.276
LIG_BIR_III_2 42 46 PF00653 0.600
LIG_BIR_III_4 293 297 PF00653 0.213
LIG_CSL_BTD_1 36 39 PF09270 0.598
LIG_EH1_1 518 526 PF00400 0.404
LIG_eIF4E_1 463 469 PF01652 0.206
LIG_FHA_1 320 326 PF00498 0.276
LIG_FHA_1 350 356 PF00498 0.361
LIG_FHA_1 464 470 PF00498 0.347
LIG_FHA_1 489 495 PF00498 0.316
LIG_FHA_1 516 522 PF00498 0.339
LIG_FHA_1 587 593 PF00498 0.543
LIG_FHA_2 219 225 PF00498 0.386
LIG_FHA_2 288 294 PF00498 0.333
LIG_FHA_2 328 334 PF00498 0.330
LIG_FHA_2 351 357 PF00498 0.280
LIG_FHA_2 397 403 PF00498 0.262
LIG_FHA_2 411 417 PF00498 0.328
LIG_FHA_2 46 52 PF00498 0.608
LIG_LIR_Apic_2 406 412 PF02991 0.290
LIG_LIR_Apic_2 542 547 PF02991 0.573
LIG_LIR_Gen_1 148 158 PF02991 0.437
LIG_LIR_Gen_1 181 192 PF02991 0.277
LIG_LIR_Gen_1 219 227 PF02991 0.328
LIG_LIR_Gen_1 472 480 PF02991 0.328
LIG_LIR_Nem_3 148 153 PF02991 0.432
LIG_LIR_Nem_3 181 187 PF02991 0.264
LIG_LIR_Nem_3 219 225 PF02991 0.328
LIG_LIR_Nem_3 276 280 PF02991 0.262
LIG_LIR_Nem_3 321 326 PF02991 0.270
LIG_LIR_Nem_3 402 408 PF02991 0.267
LIG_LIR_Nem_3 448 454 PF02991 0.266
LIG_LIR_Nem_3 472 478 PF02991 0.234
LIG_LIR_Nem_3 542 546 PF02991 0.616
LIG_LIR_Nem_3 550 556 PF02991 0.547
LIG_LYPXL_L_2 462 471 PF13949 0.206
LIG_Pex14_1 404 408 PF04695 0.236
LIG_Pex14_2 319 323 PF04695 0.276
LIG_Pex14_2 447 451 PF04695 0.244
LIG_PTB_Apo_2 417 424 PF02174 0.234
LIG_PTB_Phospho_1 417 423 PF10480 0.234
LIG_SH2_CRK 190 194 PF00017 0.247
LIG_SH2_CRK 275 279 PF00017 0.328
LIG_SH2_CRK 326 330 PF00017 0.273
LIG_SH2_CRK 475 479 PF00017 0.328
LIG_SH2_NCK_1 475 479 PF00017 0.328
LIG_SH2_PTP2 544 547 PF00017 0.543
LIG_SH2_SRC 190 193 PF00017 0.267
LIG_SH2_STAP1 437 441 PF00017 0.247
LIG_SH2_STAT3 270 273 PF00017 0.206
LIG_SH2_STAT3 437 440 PF00017 0.189
LIG_SH2_STAT5 157 160 PF00017 0.370
LIG_SH2_STAT5 192 195 PF00017 0.247
LIG_SH2_STAT5 270 273 PF00017 0.328
LIG_SH2_STAT5 275 278 PF00017 0.247
LIG_SH2_STAT5 305 308 PF00017 0.348
LIG_SH2_STAT5 417 420 PF00017 0.268
LIG_SH2_STAT5 423 426 PF00017 0.261
LIG_SH2_STAT5 467 470 PF00017 0.280
LIG_SH2_STAT5 544 547 PF00017 0.549
LIG_SH3_2 36 41 PF14604 0.602
LIG_SH3_3 25 31 PF00018 0.725
LIG_SH3_3 296 302 PF00018 0.364
LIG_SH3_3 33 39 PF00018 0.653
LIG_SH3_3 458 464 PF00018 0.389
LIG_SH3_3 542 548 PF00018 0.658
LIG_SH3_3 8 14 PF00018 0.607
LIG_SUMO_SIM_anti_2 352 359 PF11976 0.313
LIG_SUMO_SIM_par_1 286 293 PF11976 0.262
LIG_SUMO_SIM_par_1 466 473 PF11976 0.276
LIG_TRFH_1 150 154 PF08558 0.402
LIG_TYR_ITIM 324 329 PF00017 0.290
LIG_WRC_WIRS_1 477 482 PF05994 0.265
MOD_CDC14_SPxK_1 38 41 PF00782 0.659
MOD_CDK_SPK_2 62 67 PF00069 0.597
MOD_CDK_SPxK_1 35 41 PF00069 0.658
MOD_CK1_1 136 142 PF00069 0.641
MOD_CK1_1 195 201 PF00069 0.255
MOD_CK1_1 44 50 PF00069 0.692
MOD_CK1_1 446 452 PF00069 0.253
MOD_CK1_1 55 61 PF00069 0.757
MOD_CK1_1 65 71 PF00069 0.800
MOD_CK2_1 218 224 PF00069 0.386
MOD_CK2_1 327 333 PF00069 0.327
MOD_CK2_1 350 356 PF00069 0.171
MOD_CK2_1 396 402 PF00069 0.266
MOD_CK2_1 410 416 PF00069 0.328
MOD_CK2_1 45 51 PF00069 0.731
MOD_CK2_1 57 63 PF00069 0.688
MOD_CK2_1 596 602 PF00069 0.702
MOD_CK2_1 72 78 PF00069 0.812
MOD_Cter_Amidation 481 484 PF01082 0.490
MOD_GlcNHglycan 105 108 PF01048 0.444
MOD_GlcNHglycan 21 25 PF01048 0.548
MOD_GlcNHglycan 339 342 PF01048 0.495
MOD_GlcNHglycan 54 57 PF01048 0.568
MOD_GlcNHglycan 59 62 PF01048 0.580
MOD_GlcNHglycan 602 606 PF01048 0.386
MOD_GlcNHglycan 97 100 PF01048 0.519
MOD_GSK3_1 2 9 PF00069 0.764
MOD_GSK3_1 262 269 PF00069 0.271
MOD_GSK3_1 27 34 PF00069 0.758
MOD_GSK3_1 41 48 PF00069 0.770
MOD_GSK3_1 51 58 PF00069 0.713
MOD_GSK3_1 586 593 PF00069 0.666
MOD_GSK3_1 594 601 PF00069 0.628
MOD_GSK3_1 61 68 PF00069 0.810
MOD_GSK3_1 95 102 PF00069 0.702
MOD_N-GLC_1 195 200 PF02516 0.585
MOD_N-GLC_1 225 230 PF02516 0.519
MOD_N-GLC_1 319 324 PF02516 0.476
MOD_N-GLC_1 359 364 PF02516 0.486
MOD_N-GLC_1 396 401 PF02516 0.528
MOD_N-GLC_2 378 380 PF02516 0.434
MOD_NEK2_1 319 324 PF00069 0.276
MOD_NEK2_1 335 340 PF00069 0.276
MOD_NEK2_1 371 376 PF00069 0.234
MOD_NEK2_1 383 388 PF00069 0.234
MOD_NEK2_1 443 448 PF00069 0.275
MOD_NEK2_1 488 493 PF00069 0.265
MOD_NEK2_1 515 520 PF00069 0.369
MOD_NEK2_2 125 130 PF00069 0.648
MOD_PIKK_1 133 139 PF00454 0.640
MOD_PIKK_1 255 261 PF00454 0.262
MOD_PIKK_1 590 596 PF00454 0.667
MOD_PKA_2 378 384 PF00069 0.261
MOD_PKA_2 443 449 PF00069 0.281
MOD_PKA_2 482 488 PF00069 0.269
MOD_PKA_2 66 72 PF00069 0.693
MOD_PKB_1 253 261 PF00069 0.171
MOD_Plk_1 182 188 PF00069 0.349
MOD_Plk_1 195 201 PF00069 0.333
MOD_Plk_1 266 272 PF00069 0.376
MOD_Plk_1 319 325 PF00069 0.290
MOD_Plk_1 396 402 PF00069 0.328
MOD_Plk_4 319 325 PF00069 0.235
MOD_Plk_4 463 469 PF00069 0.356
MOD_Plk_4 482 488 PF00069 0.311
MOD_Plk_4 509 515 PF00069 0.351
MOD_Plk_4 552 558 PF00069 0.605
MOD_ProDKin_1 145 151 PF00069 0.590
MOD_ProDKin_1 27 33 PF00069 0.642
MOD_ProDKin_1 284 290 PF00069 0.328
MOD_ProDKin_1 327 333 PF00069 0.367
MOD_ProDKin_1 35 41 PF00069 0.666
MOD_ProDKin_1 350 356 PF00069 0.338
MOD_ProDKin_1 62 68 PF00069 0.616
MOD_SUMO_for_1 366 369 PF00179 0.171
MOD_SUMO_rev_2 534 542 PF00179 0.558
TRG_ENDOCYTIC_2 157 160 PF00928 0.421
TRG_ENDOCYTIC_2 184 187 PF00928 0.229
TRG_ENDOCYTIC_2 190 193 PF00928 0.214
TRG_ENDOCYTIC_2 238 241 PF00928 0.276
TRG_ENDOCYTIC_2 277 280 PF00928 0.262
TRG_ENDOCYTIC_2 326 329 PF00928 0.290
TRG_ENDOCYTIC_2 455 458 PF00928 0.328
TRG_ENDOCYTIC_2 475 478 PF00928 0.307
TRG_ENDOCYTIC_2 533 536 PF00928 0.663
TRG_ENDOCYTIC_2 556 559 PF00928 0.563
TRG_ER_diArg_1 1 4 PF00400 0.613
TRG_ER_diArg_1 480 483 PF00400 0.282
TRG_ER_diArg_1 559 562 PF00400 0.594
TRG_ER_diArg_1 80 82 PF00400 0.641
TRG_NES_CRM1_1 569 582 PF08389 0.474

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0U8 Leptomonas seymouri 65% 98%
A0A0S4JQR9 Bodo saltans 37% 100%
A0A1X0NHQ5 Trypanosomatidae 45% 100%
A0A3Q8IBY5 Leishmania donovani 79% 100%
A0A3R7LIN7 Trypanosoma rangeli 45% 100%
A0A3S7X9N4 Leishmania donovani 33% 100%
A4HN07 Leishmania braziliensis 35% 100%
A4HU24 Leishmania infantum 80% 100%
A4IBN0 Leishmania infantum 33% 100%
D0A9K3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9AFG4 Leishmania major 33% 100%
E9AMV4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 100%
E9B6L9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
P42838 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
Q4QHS2 Leishmania major 80% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS