ZU5 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 10

Species:

Leishmania braziliensis

UniProt:

A4H5S9_LEIBR

TriTrypDb:

LbrM.09.1060

Length:

614

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0005929	cilium	4	1
GO:0016020	membrane	2	2
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031514	motile cilium	5	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4H5S9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5S9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.462
CLV_NRD_NRD_1	244	246	PF00675	0.474
CLV_NRD_NRD_1	382	384	PF00675	0.540
CLV_NRD_NRD_1	593	595	PF00675	0.449
CLV_PCSK_SKI1_1	136	140	PF00082	0.621
CLV_PCSK_SKI1_1	150	154	PF00082	0.463
CLV_PCSK_SKI1_1	256	260	PF00082	0.379
CLV_PCSK_SKI1_1	300	304	PF00082	0.393
CLV_PCSK_SKI1_1	404	408	PF00082	0.374
CLV_PCSK_SKI1_1	432	436	PF00082	0.416
CLV_PCSK_SKI1_1	52	56	PF00082	0.454
CLV_PCSK_SKI1_1	79	83	PF00082	0.668
DEG_APCC_DBOX_1	168	176	PF00400	0.700
DEG_SCF_FBW7_1	310	317	PF00400	0.669
DOC_CKS1_1	311	316	PF01111	0.675
DOC_MAPK_gen_1	150	158	PF00069	0.614
DOC_MAPK_gen_1	363	369	PF00069	0.570
DOC_MAPK_gen_1	383	393	PF00069	0.472
DOC_MAPK_gen_1	543	552	PF00069	0.497
DOC_MAPK_MEF2A_6	151	160	PF00069	0.600
DOC_PP4_FxxP_1	40	43	PF00568	0.794
DOC_PP4_FxxP_1	55	58	PF00568	0.781
DOC_USP7_MATH_1	314	318	PF00917	0.674
DOC_USP7_MATH_1	43	47	PF00917	0.845
DOC_USP7_MATH_1	433	437	PF00917	0.684
DOC_USP7_MATH_1	463	467	PF00917	0.588
DOC_USP7_MATH_1	64	68	PF00917	0.838
DOC_USP7_UBL2_3	132	136	PF12436	0.817
DOC_USP7_UBL2_3	221	225	PF12436	0.585
DOC_WW_Pin1_4	170	175	PF00397	0.617
DOC_WW_Pin1_4	310	315	PF00397	0.661
DOC_WW_Pin1_4	492	497	PF00397	0.778
DOC_WW_Pin1_4	558	563	PF00397	0.749
LIG_14-3-3_CanoR_1	432	438	PF00244	0.672
LIG_14-3-3_CanoR_1	577	586	PF00244	0.603
LIG_APCC_ABBA_1	265	270	PF00400	0.619
LIG_BIR_III_4	125	129	PF00653	0.654
LIG_BIR_III_4	462	466	PF00653	0.500
LIG_BRCT_BRCA1_1	318	322	PF00533	0.666
LIG_BRCT_BRCA1_1	605	609	PF00533	0.580
LIG_deltaCOP1_diTrp_1	335	340	PF00928	0.602
LIG_eIF4E_1	408	414	PF01652	0.601
LIG_FHA_1	129	135	PF00498	0.845
LIG_FHA_1	137	143	PF00498	0.630
LIG_FHA_1	20	26	PF00498	0.460
LIG_FHA_1	234	240	PF00498	0.703
LIG_FHA_1	325	331	PF00498	0.577
LIG_FHA_1	348	354	PF00498	0.625
LIG_FHA_1	500	506	PF00498	0.626
LIG_FHA_1	578	584	PF00498	0.578
LIG_FHA_1	67	73	PF00498	0.816
LIG_FHA_1	8	14	PF00498	0.482
LIG_FHA_2	101	107	PF00498	0.752
LIG_FHA_2	247	253	PF00498	0.607
LIG_FHA_2	31	37	PF00498	0.756
LIG_FHA_2	311	317	PF00498	0.661
LIG_FHA_2	366	372	PF00498	0.621
LIG_FHA_2	510	516	PF00498	0.672
LIG_IRF3_LxIS_1	152	159	PF10401	0.509
LIG_LIR_Apic_2	337	343	PF02991	0.586
LIG_LIR_Apic_2	37	43	PF02991	0.794
LIG_LIR_Gen_1	187	196	PF02991	0.718
LIG_LIR_Gen_1	460	469	PF02991	0.683
LIG_LIR_Gen_1	605	614	PF02991	0.680
LIG_LIR_Nem_3	187	191	PF02991	0.679
LIG_LIR_Nem_3	252	258	PF02991	0.662
LIG_LIR_Nem_3	319	325	PF02991	0.643
LIG_LIR_Nem_3	405	411	PF02991	0.606
LIG_LIR_Nem_3	460	464	PF02991	0.680
LIG_LIR_Nem_3	590	596	PF02991	0.646
LIG_LIR_Nem_3	605	610	PF02991	0.570
LIG_PDZ_Class_3	609	614	PF00595	0.705
LIG_Pex14_1	184	188	PF04695	0.683
LIG_Pex14_1	338	342	PF04695	0.596
LIG_Pex14_2	603	607	PF04695	0.611
LIG_PTB_Apo_2	182	189	PF02174	0.681
LIG_REV1ctd_RIR_1	320	328	PF16727	0.670
LIG_SH2_CRK	299	303	PF00017	0.646
LIG_SH2_CRK	411	415	PF00017	0.578
LIG_SH2_STAP1	261	265	PF00017	0.568
LIG_SH2_STAP1	459	463	PF00017	0.664
LIG_SH2_STAP1	596	600	PF00017	0.671
LIG_SH2_STAT3	285	288	PF00017	0.552
LIG_SH2_STAT3	481	484	PF00017	0.656
LIG_SH2_STAT5	285	288	PF00017	0.563
LIG_SH2_STAT5	352	355	PF00017	0.474
LIG_SH2_STAT5	411	414	PF00017	0.584
LIG_SH2_STAT5	424	427	PF00017	0.570
LIG_SH2_STAT5	459	462	PF00017	0.628
LIG_SH3_2	487	492	PF14604	0.759
LIG_SH3_3	101	107	PF00018	0.682
LIG_SH3_3	118	124	PF00018	0.806
LIG_SH3_3	131	137	PF00018	0.804
LIG_SH3_3	180	186	PF00018	0.639
LIG_SH3_3	236	242	PF00018	0.681
LIG_SH3_3	308	314	PF00018	0.661
LIG_SH3_3	411	417	PF00018	0.570
LIG_SH3_3	477	483	PF00018	0.627
LIG_SH3_3	484	490	PF00018	0.703
LIG_SH3_3	58	64	PF00018	0.815
LIG_SH3_3	80	86	PF00018	0.682
LIG_Sin3_3	108	115	PF02671	0.602
LIG_SUMO_SIM_anti_2	22	28	PF11976	0.744
LIG_SUMO_SIM_anti_2	270	275	PF11976	0.612
LIG_SUMO_SIM_anti_2	564	570	PF11976	0.698
LIG_SUMO_SIM_par_1	100	106	PF11976	0.633
LIG_SUMO_SIM_par_1	200	206	PF11976	0.584
LIG_TRAF2_1	249	252	PF00917	0.664
LIG_TRAF2_1	495	498	PF00917	0.741
LIG_TRAF2_1	519	522	PF00917	0.653
LIG_WRC_WIRS_1	604	609	PF05994	0.618
MOD_CDK_SPK_2	558	563	PF00069	0.749
MOD_CDK_SPxxK_3	558	565	PF00069	0.747
MOD_CK1_1	423	429	PF00069	0.702
MOD_CK1_1	45	51	PF00069	0.838
MOD_CK1_1	488	494	PF00069	0.763
MOD_CK1_1	62	68	PF00069	0.756
MOD_CK2_1	246	252	PF00069	0.655
MOD_CK2_1	365	371	PF00069	0.599
MOD_CK2_1	492	498	PF00069	0.769
MOD_CK2_1	516	522	PF00069	0.621
MOD_CK2_1	558	564	PF00069	0.720
MOD_CK2_1	65	71	PF00069	0.860
MOD_GlcNHglycan	15	18	PF01048	0.442
MOD_GlcNHglycan	394	397	PF01048	0.434
MOD_GlcNHglycan	40	43	PF01048	0.533
MOD_GlcNHglycan	55	58	PF01048	0.557
MOD_GlcNHglycan	587	590	PF01048	0.449
MOD_GlcNHglycan	92	96	PF01048	0.613
MOD_GSK3_1	128	135	PF00069	0.750
MOD_GSK3_1	137	144	PF00069	0.729
MOD_GSK3_1	221	228	PF00069	0.651
MOD_GSK3_1	310	317	PF00069	0.618
MOD_GSK3_1	324	331	PF00069	0.566
MOD_GSK3_1	38	45	PF00069	0.804
MOD_GSK3_1	433	440	PF00069	0.593
MOD_GSK3_1	464	471	PF00069	0.672
MOD_GSK3_1	488	495	PF00069	0.803
MOD_GSK3_1	585	592	PF00069	0.694
MOD_GSK3_1	62	69	PF00069	0.752
MOD_N-GLC_1	215	220	PF02516	0.400
MOD_N-GLC_1	475	480	PF02516	0.487
MOD_N-GLC_1	532	537	PF02516	0.512
MOD_N-GLC_1	577	582	PF02516	0.483
MOD_N-GLC_2	410	412	PF02516	0.411
MOD_NEK2_1	156	161	PF00069	0.581
MOD_NEK2_1	19	24	PF00069	0.327
MOD_NEK2_1	233	238	PF00069	0.615
MOD_NEK2_1	259	264	PF00069	0.590
MOD_NEK2_1	269	274	PF00069	0.554
MOD_NEK2_1	315	320	PF00069	0.625
MOD_NEK2_1	358	363	PF00069	0.595
MOD_NEK2_1	603	608	PF00069	0.586
MOD_NEK2_1	7	12	PF00069	0.524
MOD_NEK2_2	501	506	PF00069	0.606
MOD_PIKK_1	259	265	PF00454	0.619
MOD_PIKK_1	397	403	PF00454	0.689
MOD_PIKK_1	45	51	PF00454	0.838
MOD_PIKK_1	72	78	PF00454	0.843
MOD_PKA_1	245	251	PF00069	0.692
MOD_PKA_1	30	36	PF00069	0.837
MOD_PKA_2	62	68	PF00069	0.849
MOD_Plk_1	225	231	PF00069	0.654
MOD_Plk_1	246	252	PF00069	0.655
MOD_Plk_1	269	275	PF00069	0.614
MOD_Plk_1	315	321	PF00069	0.627
MOD_Plk_1	334	340	PF00069	0.443
MOD_Plk_1	347	353	PF00069	0.612
MOD_Plk_1	365	371	PF00069	0.574
MOD_Plk_2-3	365	371	PF00069	0.620
MOD_Plk_4	179	185	PF00069	0.614
MOD_Plk_4	19	25	PF00069	0.531
MOD_Plk_4	269	275	PF00069	0.639
MOD_Plk_4	347	353	PF00069	0.568
MOD_Plk_4	475	481	PF00069	0.659
MOD_Plk_4	548	554	PF00069	0.609
MOD_Plk_4	579	585	PF00069	0.569
MOD_ProDKin_1	170	176	PF00069	0.618
MOD_ProDKin_1	310	316	PF00069	0.669
MOD_ProDKin_1	492	498	PF00069	0.777
MOD_ProDKin_1	558	564	PF00069	0.748
MOD_SUMO_for_1	362	365	PF00179	0.623
MOD_SUMO_rev_2	113	122	PF00179	0.741
MOD_SUMO_rev_2	146	153	PF00179	0.688
MOD_SUMO_rev_2	398	406	PF00179	0.652
TRG_DiLeu_BaEn_2	604	610	PF01217	0.630
TRG_ENDOCYTIC_2	299	302	PF00928	0.612
TRG_ENDOCYTIC_2	411	414	PF00928	0.566
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUN6	Leptomonas seymouri	68%	99%
A0A0S4JT82	Bodo saltans	46%	100%
A0A1X0NI07	Trypanosomatidae	49%	100%
A0A3R7MXK0	Trypanosoma rangeli	44%	100%
A0A3S7WQS4	Leishmania donovani	85%	100%
A4HU23	Leishmania infantum	85%	100%
D0A9K1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AMV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QHS3	Leishmania major	84%	100%
V5CK09	Trypanosoma cruzi	50%	100%