PUB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PUB domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H5S8_LEIBR

TriTrypDb:

LbrM.09.1050 , LBRM2903_090016300

Length:

312

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5S8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5S8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	181	183	PF00675	0.431
CLV_NRD_NRD_1	31	33	PF00675	0.289
CLV_PCSK_KEX2_1	31	33	PF00082	0.289
CLV_PCSK_SKI1_1	128	132	PF00082	0.599
CLV_PCSK_SKI1_1	145	149	PF00082	0.510
CLV_PCSK_SKI1_1	183	187	PF00082	0.393
CLV_PCSK_SKI1_1	233	237	PF00082	0.449
CLV_PCSK_SKI1_1	295	299	PF00082	0.550
CLV_PCSK_SKI1_1	31	35	PF00082	0.315
CLV_PCSK_SKI1_1	47	51	PF00082	0.357
DEG_APCC_DBOX_1	30	38	PF00400	0.308
DEG_Nend_UBRbox_3	1	3	PF02207	0.596
DOC_CYCLIN_RxL_1	178	188	PF00134	0.455
DOC_MAPK_gen_1	31	39	PF00069	0.289
DOC_MAPK_HePTP_8	29	41	PF00069	0.368
DOC_MAPK_MEF2A_6	32	41	PF00069	0.368
DOC_PP1_RVXF_1	270	277	PF00149	0.388
DOC_PP1_RVXF_1	64	71	PF00149	0.341
DOC_PP4_FxxP_1	41	44	PF00568	0.417
DOC_USP7_MATH_1	162	166	PF00917	0.621
DOC_USP7_MATH_1	245	249	PF00917	0.408
DOC_USP7_UBL2_3	155	159	PF12436	0.447
DOC_USP7_UBL2_3	291	295	PF12436	0.461
DOC_USP7_UBL2_3	50	54	PF12436	0.368
DOC_WW_Pin1_4	130	135	PF00397	0.646
DOC_WW_Pin1_4	86	91	PF00397	0.253
LIG_14-3-3_CanoR_1	182	186	PF00244	0.402
LIG_14-3-3_CanoR_1	190	196	PF00244	0.468
LIG_14-3-3_CanoR_1	275	281	PF00244	0.330
LIG_BRCT_BRCA1_1	73	77	PF00533	0.417
LIG_FHA_1	186	192	PF00498	0.407
LIG_FHA_2	149	155	PF00498	0.704
LIG_FHA_2	165	171	PF00498	0.592
LIG_HCF-1_HBM_1	256	259	PF13415	0.332
LIG_Integrin_isoDGR_2	284	286	PF01839	0.564
LIG_LIR_Apic_2	40	44	PF02991	0.417
LIG_LIR_Gen_1	224	235	PF02991	0.383
LIG_LIR_Gen_1	65	75	PF02991	0.372
LIG_LIR_Gen_1	8	17	PF02991	0.467
LIG_LIR_Gen_1	97	107	PF02991	0.402
LIG_LIR_Nem_3	224	230	PF02991	0.355
LIG_LIR_Nem_3	65	70	PF02991	0.309
LIG_LIR_Nem_3	8	13	PF02991	0.505
LIG_LIR_Nem_3	97	103	PF02991	0.402
LIG_NRBOX	33	39	PF00104	0.368
LIG_PDZ_Class_2	307	312	PF00595	0.377
LIG_PTB_Apo_2	190	197	PF02174	0.392
LIG_PTB_Apo_2	40	47	PF02174	0.356
LIG_REV1ctd_RIR_1	193	203	PF16727	0.474
LIG_SH2_CRK	237	241	PF00017	0.245
LIG_SH2_CRK	261	265	PF00017	0.415
LIG_SH2_STAP1	237	241	PF00017	0.319
LIG_SH2_STAT5	239	242	PF00017	0.258
LIG_SH2_STAT5	289	292	PF00017	0.434
LIG_SH2_STAT5	302	305	PF00017	0.364
LIG_SH3_2	150	155	PF14604	0.452
LIG_SH3_3	147	153	PF00018	0.463
LIG_TYR_ITIM	235	240	PF00017	0.353
MOD_CK1_1	133	139	PF00069	0.539
MOD_CK1_1	89	95	PF00069	0.350
MOD_CK2_1	148	154	PF00069	0.717
MOD_CK2_1	191	197	PF00069	0.360
MOD_CK2_1	98	104	PF00069	0.379
MOD_GlcNHglycan	164	167	PF01048	0.632
MOD_GlcNHglycan	200	204	PF01048	0.376
MOD_GlcNHglycan	243	246	PF01048	0.476
MOD_GSK3_1	181	188	PF00069	0.386
MOD_GSK3_1	241	248	PF00069	0.362
MOD_GSK3_1	9	16	PF00069	0.438
MOD_NEK2_1	185	190	PF00069	0.392
MOD_NEK2_1	59	64	PF00069	0.387
MOD_NEK2_1	70	75	PF00069	0.284
MOD_PIKK_1	164	170	PF00454	0.585
MOD_PIKK_1	245	251	PF00454	0.356
MOD_PKA_1	128	134	PF00069	0.538
MOD_PKA_2	181	187	PF00069	0.403
MOD_PKA_2	191	197	PF00069	0.504
MOD_PKA_2	274	280	PF00069	0.298
MOD_Plk_1	80	86	PF00069	0.303
MOD_Plk_4	181	187	PF00069	0.495
MOD_Plk_4	191	197	PF00069	0.368
MOD_Plk_4	235	241	PF00069	0.257
MOD_Plk_4	80	86	PF00069	0.371
MOD_Plk_4	89	95	PF00069	0.334
MOD_ProDKin_1	130	136	PF00069	0.648
MOD_ProDKin_1	86	92	PF00069	0.253
TRG_DiLeu_BaEn_1	283	288	PF01217	0.515
TRG_DiLeu_BaEn_4	8	14	PF01217	0.463
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.308
TRG_ENDOCYTIC_2	237	240	PF00928	0.372
TRG_ENDOCYTIC_2	261	264	PF00928	0.407
TRG_ER_diArg_1	143	146	PF00400	0.547
TRG_ER_diArg_1	30	32	PF00400	0.289
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBQ0	Leptomonas seymouri	59%	100%
A0A0S4IH55	Bodo saltans	31%	80%
A0A1X0NI65	Trypanosomatidae	42%	100%
A0A3S7WQS2	Leishmania donovani	72%	100%
A0A422N3Q8	Trypanosoma rangeli	40%	100%
A4HU22	Leishmania infantum	73%	100%
D0A9J2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AMV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QHS4	Leishmania major	74%	100%
V5D6M9	Trypanosoma cruzi	39%	100%