Elongation factor-1 gamma

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

elongation factor-1 gamma

Species:

Leishmania braziliensis

UniProt:

A4H5S5_LEIBR

TriTrypDb:

LbrM.09.1020 , LBRM2903_090016000

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5S5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5S5

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0003746	translation elongation factor activity	4	13
GO:0005488	binding	1	13
GO:0008135	translation factor activity, RNA binding	3	13
GO:0045182	translation regulator activity	1	13
GO:0090079	translation regulator activity, nucleic acid binding	2	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.359
CLV_NRD_NRD_1	323	325	PF00675	0.312
CLV_PCSK_KEX2_1	265	267	PF00082	0.312
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.312
CLV_PCSK_SKI1_1	147	151	PF00082	0.319
CLV_PCSK_SKI1_1	325	329	PF00082	0.312
CLV_PCSK_SKI1_1	394	398	PF00082	0.426
DOC_MAPK_gen_1	324	332	PF00069	0.312
DOC_MAPK_MEF2A_6	325	334	PF00069	0.312
DOC_USP7_MATH_1	91	95	PF00917	0.470
DOC_USP7_UBL2_3	215	219	PF12436	0.635
DOC_USP7_UBL2_3	226	230	PF12436	0.618
DOC_USP7_UBL2_3	243	247	PF12436	0.695
DOC_USP7_UBL2_3	81	85	PF12436	0.490
DOC_WW_Pin1_4	40	45	PF00397	0.382
DOC_WW_Pin1_4	48	53	PF00397	0.283
DOC_WW_Pin1_4	87	92	PF00397	0.419
LIG_14-3-3_CanoR_1	154	158	PF00244	0.331
LIG_14-3-3_CanoR_1	189	195	PF00244	0.312
LIG_BIR_III_2	252	256	PF00653	0.443
LIG_BIR_III_4	286	290	PF00653	0.305
LIG_BRCT_BRCA1_1	160	164	PF00533	0.392
LIG_CtBP_PxDLS_1	177	182	PF00389	0.392
LIG_deltaCOP1_diTrp_1	141	149	PF00928	0.332
LIG_deltaCOP1_diTrp_1	98	103	PF00928	0.368
LIG_EH1_1	327	335	PF00400	0.312
LIG_EVH1_2	255	259	PF00568	0.312
LIG_FHA_1	146	152	PF00498	0.312
LIG_FHA_1	198	204	PF00498	0.398
LIG_FHA_1	271	277	PF00498	0.313
LIG_FHA_1	307	313	PF00498	0.327
LIG_FHA_1	380	386	PF00498	0.359
LIG_FHA_2	130	136	PF00498	0.427
LIG_FHA_2	154	160	PF00498	0.312
LIG_FHA_2	336	342	PF00498	0.222
LIG_FHA_2	88	94	PF00498	0.411
LIG_LIR_Gen_1	288	297	PF02991	0.445
LIG_LIR_Gen_1	367	376	PF02991	0.401
LIG_LIR_Gen_1	98	108	PF02991	0.369
LIG_LIR_Nem_3	118	123	PF02991	0.180
LIG_LIR_Nem_3	288	293	PF02991	0.321
LIG_LIR_Nem_3	367	371	PF02991	0.393
LIG_LIR_Nem_3	98	103	PF02991	0.370
LIG_LYPXL_SIV_4	24	32	PF13949	0.392
LIG_Pex14_1	207	211	PF04695	0.575
LIG_Pex14_2	164	168	PF04695	0.312
LIG_SH2_CRK	191	195	PF00017	0.324
LIG_SH2_CRK	25	29	PF00017	0.222
LIG_SH2_GRB2like	25	28	PF00017	0.392
LIG_SH2_GRB2like	268	271	PF00017	0.312
LIG_SH2_NCK_1	25	29	PF00017	0.392
LIG_SH2_SRC	25	28	PF00017	0.392
LIG_SH2_STAP1	290	294	PF00017	0.318
LIG_SH2_STAT5	115	118	PF00017	0.392
LIG_SH2_STAT5	280	283	PF00017	0.312
LIG_SH2_STAT5	290	293	PF00017	0.312
LIG_SH2_STAT5	3	6	PF00017	0.276
LIG_SH2_STAT5	384	387	PF00017	0.368
LIG_SH2_STAT5	65	68	PF00017	0.392
LIG_SH3_3	273	279	PF00018	0.312
LIG_SH3_3	387	393	PF00018	0.400
LIG_SUMO_SIM_anti_2	200	205	PF11976	0.400
LIG_TRAF2_1	132	135	PF00917	0.443
LIG_TRAF2_1	231	234	PF00917	0.669
LIG_UBA3_1	72	81	PF00899	0.443
MOD_CDK_SPxxK_3	48	55	PF00069	0.331
MOD_CK1_1	58	64	PF00069	0.392
MOD_CK2_1	129	135	PF00069	0.371
MOD_CK2_1	335	341	PF00069	0.222
MOD_CK2_1	6	12	PF00069	0.222
MOD_CK2_1	87	93	PF00069	0.394
MOD_GlcNHglycan	80	84	PF01048	0.424
MOD_GSK3_1	129	136	PF00069	0.418
MOD_GSK3_1	266	273	PF00069	0.312
MOD_GSK3_1	87	94	PF00069	0.514
MOD_N-GLC_1	40	45	PF02516	0.331
MOD_N-GLC_1	48	53	PF02516	0.331
MOD_NEK2_1	116	121	PF00069	0.523
MOD_NEK2_1	133	138	PF00069	0.286
MOD_NEK2_1	190	195	PF00069	0.312
MOD_NEK2_1	5	10	PF00069	0.323
MOD_NEK2_1	92	97	PF00069	0.413
MOD_PIKK_1	13	19	PF00454	0.222
MOD_PIKK_1	92	98	PF00454	0.367
MOD_PKA_2	116	122	PF00069	0.259
MOD_PKA_2	153	159	PF00069	0.312
MOD_Plk_1	133	139	PF00069	0.443
MOD_Plk_1	158	164	PF00069	0.392
MOD_Plk_1	92	98	PF00069	0.447
MOD_Plk_2-3	153	159	PF00069	0.312
MOD_Plk_4	190	196	PF00069	0.312
MOD_ProDKin_1	40	46	PF00069	0.382
MOD_ProDKin_1	48	54	PF00069	0.283
MOD_ProDKin_1	87	93	PF00069	0.412
MOD_SUMO_for_1	225	228	PF00179	0.645
MOD_SUMO_for_1	231	234	PF00179	0.669
MOD_SUMO_for_1	242	245	PF00179	0.746
MOD_SUMO_rev_2	222	231	PF00179	0.771
MOD_SUMO_rev_2	238	248	PF00179	0.633
MOD_SUMO_rev_2	364	374	PF00179	0.524
TRG_DiLeu_BaEn_2	144	150	PF01217	0.312
TRG_ENDOCYTIC_2	191	194	PF00928	0.324
TRG_ENDOCYTIC_2	25	28	PF00928	0.392
TRG_ENDOCYTIC_2	290	293	PF00928	0.312
TRG_ENDOCYTIC_2	3	6	PF00928	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSJ4	Leptomonas seymouri	80%	100%
A0A1X0NID9	Trypanosomatidae	68%	98%
A0A3Q8I8H5	Leishmania donovani	91%	100%
A0A3R7LEF5	Trypanosoma rangeli	61%	89%
A0A3S7WQR4	Leishmania donovani	91%	100%
A2Q127	Equus caballus	33%	92%
A4HU18	Leishmania infantum	91%	89%
A4HU19	Leishmania infantum	91%	100%
D0A9I7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	87%
D0A9K2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AMU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O04487	Arabidopsis thaliana	37%	97%
P12261	Artemia salina	29%	94%
P26641	Homo sapiens	33%	92%
P26642	Xenopus laevis	31%	92%
P29547	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	97%
P29694	Oryctolagus cuniculus	34%	92%
P34715	Trypanosoma cruzi	66%	98%
P36008	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	98%
P40921	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	99%
P54412	Caenorhabditis elegans	31%	100%
Q29387	Sus scrofa	33%	93%
Q3SZV3	Bos taurus	32%	92%
Q4R7H5	Macaca fascicularis	33%	92%
Q5Z627	Oryza sativa subsp. japonica	37%	97%
Q66NE0	Leishmania major	89%	100%
Q68FR6	Rattus norvegicus	34%	92%
Q6PE25	Danio rerio	33%	91%
Q6YW46	Oryza sativa subsp. japonica	38%	96%
Q90YC0	Carassius auratus	32%	91%
Q91375	Xenopus laevis	30%	92%
Q9D8N0	Mus musculus	34%	92%
Q9FUM1	Prunus avium	36%	95%
Q9FVT2	Arabidopsis thaliana	37%	98%
Q9NJH0	Drosophila melanogaster	30%	94%
Q9ZRI7	Oryza sativa subsp. japonica	38%	96%