O-phosphoseryl-tRNA(Sec) selenium transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

O-phosphoseryl-tRNA(Sec) selenium transferase, putative

Species:

Leishmania braziliensis

UniProt:

A4H5S3_LEIBR

TriTrypDb:

LbrM.09.1000 , LBRM2903_090015800

Length:

650

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4H5S3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5S3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006399	tRNA metabolic process	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0032774	RNA biosynthetic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034654	nucleobase-containing compound biosynthetic process	4	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:0097056	obsolete selenocysteinyl-tRNA(Sec) biosynthetic process	6	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0001514	selenocysteine incorporation	7	1
GO:0006414	translational elongation	5	1
GO:0006417	regulation of translation	6	1
GO:0006451	translational readthrough	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	9
GO:0044260	obsolete cellular macromolecule metabolic process	3	9
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1
GO:0006412	translation	4	8
GO:0006518	peptide metabolic process	4	8
GO:0019538	protein metabolic process	3	8
GO:0043043	peptide biosynthetic process	5	8
GO:0043603	amide metabolic process	3	8
GO:0043604	amide biosynthetic process	4	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1901566	organonitrogen compound biosynthetic process	4	8

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	12
GO:0016785	selenotransferase activity	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0098621	phosphoseryl-selenocysteinyl-tRNA selenium transferase activity	4	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140101	catalytic activity, acting on a tRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	406	410	PF00656	0.446
CLV_NRD_NRD_1	402	404	PF00675	0.289
CLV_NRD_NRD_1	473	475	PF00675	0.294
CLV_PCSK_KEX2_1	402	404	PF00082	0.259
CLV_PCSK_KEX2_1	473	475	PF00082	0.292
CLV_PCSK_SKI1_1	229	233	PF00082	0.722
CLV_PCSK_SKI1_1	279	283	PF00082	0.309
CLV_PCSK_SKI1_1	298	302	PF00082	0.377
CLV_PCSK_SKI1_1	34	38	PF00082	0.466
CLV_PCSK_SKI1_1	403	407	PF00082	0.246
CLV_PCSK_SKI1_1	426	430	PF00082	0.203
CLV_PCSK_SKI1_1	589	593	PF00082	0.270
CLV_PCSK_SKI1_1	59	63	PF00082	0.522
CLV_PCSK_SKI1_1	88	92	PF00082	0.401
DEG_Nend_UBRbox_1	1	4	PF02207	0.474
DEG_SCF_FBW7_1	590	596	PF00400	0.446
DEG_SCF_TRCP1_1	314	319	PF00400	0.441
DEG_SPOP_SBC_1	328	332	PF00917	0.621
DEG_SPOP_SBC_1	362	366	PF00917	0.410
DOC_CKS1_1	590	595	PF01111	0.446
DOC_CYCLIN_RxL_1	108	118	PF00134	0.442
DOC_MAPK_DCC_7	16	26	PF00069	0.464
DOC_MAPK_gen_1	487	496	PF00069	0.508
DOC_MAPK_gen_1	499	507	PF00069	0.417
DOC_MAPK_HePTP_8	168	180	PF00069	0.442
DOC_MAPK_MEF2A_6	171	180	PF00069	0.442
DOC_MAPK_MEF2A_6	455	464	PF00069	0.424
DOC_MAPK_MEF2A_6	533	542	PF00069	0.470
DOC_MAPK_RevD_3	387	403	PF00069	0.446
DOC_PP1_RVXF_1	267	274	PF00149	0.309
DOC_PP1_RVXF_1	414	420	PF00149	0.446
DOC_PP2B_PxIxI_1	21	27	PF00149	0.458
DOC_PP4_FxxP_1	428	431	PF00568	0.400
DOC_USP7_MATH_1	163	167	PF00917	0.400
DOC_USP7_MATH_1	328	332	PF00917	0.662
DOC_USP7_MATH_1	52	56	PF00917	0.428
DOC_USP7_MATH_1	550	554	PF00917	0.446
DOC_USP7_MATH_1	593	597	PF00917	0.499
DOC_USP7_UBL2_3	279	283	PF12436	0.302
DOC_WW_Pin1_4	324	329	PF00397	0.742
DOC_WW_Pin1_4	456	461	PF00397	0.410
DOC_WW_Pin1_4	47	52	PF00397	0.754
DOC_WW_Pin1_4	589	594	PF00397	0.446
LIG_14-3-3_CanoR_1	2	12	PF00244	0.471
LIG_14-3-3_CanoR_1	259	265	PF00244	0.541
LIG_14-3-3_CanoR_1	455	459	PF00244	0.430
LIG_14-3-3_CanoR_1	474	480	PF00244	0.542
LIG_14-3-3_CanoR_1	582	586	PF00244	0.469
LIG_Actin_WH2_2	194	210	PF00022	0.442
LIG_BIR_III_4	286	290	PF00653	0.451
LIG_BRCT_BRCA1_1	334	338	PF00533	0.489
LIG_FAT_LD_1	635	643	PF03623	0.434
LIG_FHA_1	103	109	PF00498	0.271
LIG_FHA_1	145	151	PF00498	0.496
LIG_FHA_1	171	177	PF00498	0.479
LIG_FHA_1	200	206	PF00498	0.418
LIG_FHA_1	213	219	PF00498	0.323
LIG_FHA_1	328	334	PF00498	0.439
LIG_FHA_1	375	381	PF00498	0.514
LIG_FHA_1	81	87	PF00498	0.496
LIG_FHA_2	211	217	PF00498	0.538
LIG_FHA_2	253	259	PF00498	0.619
LIG_FHA_2	404	410	PF00498	0.446
LIG_FHA_2	517	523	PF00498	0.366
LIG_LIR_Apic_2	425	431	PF02991	0.400
LIG_LIR_Apic_2	544	548	PF02991	0.344
LIG_LIR_Apic_2	644	649	PF02991	0.429
LIG_LIR_Gen_1	69	80	PF02991	0.278
LIG_LIR_Nem_3	605	609	PF02991	0.416
LIG_PCNA_PIPBox_1	458	467	PF02747	0.446
LIG_PCNA_yPIPBox_3	171	181	PF02747	0.445
LIG_PDZ_Class_2	645	650	PF00595	0.347
LIG_Pex14_1	480	484	PF04695	0.410
LIG_PTB_Apo_2	391	398	PF02174	0.403
LIG_PTB_Apo_2	478	485	PF02174	0.344
LIG_PTB_Phospho_1	391	397	PF10480	0.403
LIG_PTB_Phospho_1	478	484	PF10480	0.344
LIG_SH2_CRK	545	549	PF00017	0.446
LIG_SH2_STAP1	516	520	PF00017	0.430
LIG_SH2_STAT3	397	400	PF00017	0.400
LIG_SH2_STAT5	270	273	PF00017	0.295
LIG_SH2_STAT5	383	386	PF00017	0.446
LIG_SH2_STAT5	391	394	PF00017	0.400
LIG_SH2_STAT5	72	75	PF00017	0.398
LIG_SH3_3	190	196	PF00018	0.424
LIG_SH3_3	259	265	PF00018	0.597
LIG_SH3_3	268	274	PF00018	0.359
LIG_SH3_3	288	294	PF00018	0.379
LIG_SH3_3	296	302	PF00018	0.502
LIG_SH3_3	350	356	PF00018	0.424
LIG_SH3_3	368	374	PF00018	0.400
LIG_SH3_3	384	390	PF00018	0.402
LIG_SH3_3	517	523	PF00018	0.476
LIG_SH3_3	582	588	PF00018	0.412
LIG_SH3_3	592	598	PF00018	0.435
LIG_SH3_3	614	620	PF00018	0.442
LIG_Sin3_3	190	197	PF02671	0.446
LIG_SUMO_SIM_anti_2	105	110	PF11976	0.219
LIG_SUMO_SIM_anti_2	202	207	PF11976	0.410
LIG_SUMO_SIM_anti_2	503	512	PF11976	0.503
LIG_SUMO_SIM_par_1	173	179	PF11976	0.503
LIG_SUMO_SIM_par_1	503	512	PF11976	0.503
MOD_CK1_1	3	9	PF00069	0.556
MOD_CK1_1	324	330	PF00069	0.669
MOD_CK1_1	331	337	PF00069	0.546
MOD_CK1_1	364	370	PF00069	0.424
MOD_CK1_1	50	56	PF00069	0.658
MOD_CK1_1	583	589	PF00069	0.442
MOD_CK1_1	596	602	PF00069	0.442
MOD_CK1_1	79	85	PF00069	0.542
MOD_CK2_1	210	216	PF00069	0.479
MOD_CK2_1	260	266	PF00069	0.389
MOD_CK2_1	437	443	PF00069	0.481
MOD_CK2_1	516	522	PF00069	0.344
MOD_CK2_1	628	634	PF00069	0.443
MOD_Cter_Amidation	471	474	PF01082	0.325
MOD_DYRK1A_RPxSP_1	589	593	PF00069	0.446
MOD_GlcNHglycan	135	138	PF01048	0.335
MOD_GlcNHglycan	152	155	PF01048	0.138
MOD_GlcNHglycan	239	242	PF01048	0.573
MOD_GlcNHglycan	262	265	PF01048	0.498
MOD_GlcNHglycan	305	308	PF01048	0.666
MOD_GlcNHglycan	314	317	PF01048	0.691
MOD_GlcNHglycan	422	425	PF01048	0.224
MOD_GlcNHglycan	52	55	PF01048	0.645
MOD_GlcNHglycan	68	71	PF01048	0.432
MOD_GSK3_1	1	8	PF00069	0.528
MOD_GSK3_1	10	17	PF00069	0.552
MOD_GSK3_1	232	239	PF00069	0.624
MOD_GSK3_1	310	317	PF00069	0.724
MOD_GSK3_1	324	331	PF00069	0.686
MOD_GSK3_1	34	41	PF00069	0.471
MOD_GSK3_1	345	352	PF00069	0.395
MOD_GSK3_1	432	439	PF00069	0.506
MOD_GSK3_1	534	541	PF00069	0.410
MOD_GSK3_1	589	596	PF00069	0.458
MOD_GSK3_1	76	83	PF00069	0.430
MOD_LATS_1	14	20	PF00433	0.469
MOD_N-GLC_1	236	241	PF02516	0.453
MOD_NEK2_1	1	6	PF00069	0.474
MOD_NEK2_1	115	120	PF00069	0.258
MOD_NEK2_1	138	143	PF00069	0.474
MOD_NEK2_1	144	149	PF00069	0.461
MOD_NEK2_1	227	232	PF00069	0.622
MOD_NEK2_1	236	241	PF00069	0.613
MOD_NEK2_1	303	308	PF00069	0.542
MOD_NEK2_1	333	338	PF00069	0.384
MOD_NEK2_1	363	368	PF00069	0.400
MOD_NEK2_1	464	469	PF00069	0.454
MOD_NEK2_1	580	585	PF00069	0.442
MOD_NEK2_1	80	85	PF00069	0.442
MOD_OFUCOSY	361	368	PF10250	0.200
MOD_PIKK_1	28	34	PF00454	0.444
MOD_PIKK_1	354	360	PF00454	0.446
MOD_PKA_2	1	7	PF00069	0.472
MOD_PKA_2	454	460	PF00069	0.404
MOD_PKA_2	581	587	PF00069	0.354
MOD_PKA_2	76	82	PF00069	0.507
MOD_Plk_1	102	108	PF00069	0.535
MOD_Plk_1	257	263	PF00069	0.592
MOD_Plk_1	374	380	PF00069	0.503
MOD_Plk_1	516	522	PF00069	0.533
MOD_Plk_1	534	540	PF00069	0.402
MOD_Plk_1	57	63	PF00069	0.475
MOD_Plk_4	164	170	PF00069	0.400
MOD_Plk_4	333	339	PF00069	0.521
MOD_Plk_4	432	438	PF00069	0.470
MOD_Plk_4	596	602	PF00069	0.395
MOD_ProDKin_1	324	330	PF00069	0.739
MOD_ProDKin_1	456	462	PF00069	0.410
MOD_ProDKin_1	47	53	PF00069	0.752
MOD_ProDKin_1	589	595	PF00069	0.446
TRG_DiLeu_BaEn_1	634	639	PF01217	0.467
TRG_DiLeu_BaLyEn_6	486	491	PF01217	0.446
TRG_DiLeu_BaLyEn_6	617	622	PF01217	0.442
TRG_ENDOCYTIC_2	72	75	PF00928	0.415
TRG_ER_diArg_1	139	142	PF00400	0.503
TRG_ER_diArg_1	402	404	PF00400	0.494
TRG_ER_diArg_1	484	487	PF00400	0.407
TRG_Pf-PMV_PEXEL_1	477	482	PF00026	0.277
TRG_Pf-PMV_PEXEL_1	489	493	PF00026	0.261
TRG_Pf-PMV_PEXEL_1	574	579	PF00026	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGI4	Leptomonas seymouri	64%	100%
A0A0S4KH93	Bodo saltans	40%	100%
A0A1X0NN47	Trypanosomatidae	46%	96%
A0A3R7N0G5	Trypanosoma rangeli	52%	100%
A0A3S7WQS5	Leishmania donovani	84%	100%
A4HU16	Leishmania infantum	84%	100%
D0A9I4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AMU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q18953	Caenorhabditis elegans	32%	100%
Q28EN2	Xenopus tropicalis	35%	100%
Q4QHS9	Leishmania major	83%	100%
Q54VQ6	Dictyostelium discoideum	34%	100%
Q5RAK7	Pongo abelii	35%	100%
Q61JN8	Caenorhabditis briggsae	32%	100%
Q6P6M7	Mus musculus	34%	100%
Q803A7	Danio rerio	35%	100%
Q9HD40	Homo sapiens	35%	100%
V5BBE8	Trypanosoma cruzi	52%	100%