Putative ef-hand protein 5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ef-hand protein 5, putative

Species:

Leishmania braziliensis

UniProt:

A4H5R8_LEIBR

TriTrypDb:

LbrM.09.0950 , LBRM2903_090015100 , LBRM2903_090015200

Length:

186

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5R8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5R8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	119	123	PF00082	0.383
CLV_PCSK_SKI1_1	136	140	PF00082	0.315
CLV_PCSK_SKI1_1	33	37	PF00082	0.617
CLV_PCSK_SKI1_1	49	53	PF00082	0.476
DOC_MAPK_gen_1	135	143	PF00069	0.506
DOC_MAPK_MEF2A_6	174	183	PF00069	0.428
DOC_USP7_MATH_1	161	165	PF00917	0.525
DOC_WW_Pin1_4	4	9	PF00397	0.654
LIG_BIR_II_1	1	5	PF00653	0.676
LIG_FHA_1	105	111	PF00498	0.424
LIG_FHA_1	128	134	PF00498	0.350
LIG_FHA_2	161	167	PF00498	0.559
LIG_FHA_2	74	80	PF00498	0.443
LIG_GBD_Chelix_1	175	183	PF00786	0.247
LIG_LIR_Gen_1	171	180	PF02991	0.324
LIG_LIR_Gen_1	98	106	PF02991	0.378
LIG_LIR_Nem_3	171	175	PF02991	0.327
LIG_LIR_Nem_3	46	51	PF02991	0.438
LIG_LIR_Nem_3	64	69	PF02991	0.384
LIG_LIR_Nem_3	98	102	PF02991	0.373
LIG_Pex14_2	138	142	PF04695	0.387
LIG_SH2_CRK	172	176	PF00017	0.410
LIG_SH2_CRK	48	52	PF00017	0.487
LIG_SH3_3	16	22	PF00018	0.667
LIG_SUMO_SIM_anti_2	155	166	PF11976	0.453
LIG_TRAF2_1	114	117	PF00917	0.514
LIG_TRAF2_1	150	153	PF00917	0.421
LIG_TRAF2_1	163	166	PF00917	0.387
LIG_TRAF2_1	76	79	PF00917	0.415
LIG_TYR_ITIM	170	175	PF00017	0.415
LIG_UBA3_1	103	108	PF00899	0.531
MOD_CK1_1	164	170	PF00069	0.386
MOD_CK1_1	25	31	PF00069	0.525
MOD_CK1_1	4	10	PF00069	0.450
MOD_CK1_1	58	64	PF00069	0.366
MOD_CK2_1	111	117	PF00069	0.418
MOD_CK2_1	141	147	PF00069	0.413
MOD_CK2_1	160	166	PF00069	0.320
MOD_CK2_1	58	64	PF00069	0.448
MOD_CK2_1	73	79	PF00069	0.420
MOD_GlcNHglycan	143	146	PF01048	0.633
MOD_GlcNHglycan	149	152	PF01048	0.415
MOD_GlcNHglycan	24	27	PF01048	0.603
MOD_GlcNHglycan	28	31	PF01048	0.595
MOD_GlcNHglycan	38	41	PF01048	0.558
MOD_GSK3_1	127	134	PF00069	0.345
MOD_GSK3_1	160	167	PF00069	0.309
MOD_GSK3_1	22	29	PF00069	0.607
MOD_N-GLC_1	127	132	PF02516	0.496
MOD_N-GLC_1	36	41	PF02516	0.495
MOD_NEK2_1	1	6	PF00069	0.532
MOD_NEK2_1	141	146	PF00069	0.416
MOD_NEK2_1	36	41	PF00069	0.620
MOD_PIKK_1	9	15	PF00454	0.672
MOD_Plk_1	111	117	PF00069	0.473
MOD_Plk_2-3	111	117	PF00069	0.575
MOD_Plk_4	55	61	PF00069	0.397
MOD_ProDKin_1	4	10	PF00069	0.653
TRG_DiLeu_BaEn_1	101	106	PF01217	0.421
TRG_DiLeu_BaEn_1	153	158	PF01217	0.424
TRG_DiLeu_BaEn_1	80	85	PF01217	0.448
TRG_DiLeu_BaEn_2	97	103	PF01217	0.504
TRG_DiLeu_BaEn_4	155	161	PF01217	0.531
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.284
TRG_ENDOCYTIC_2	172	175	PF00928	0.338
TRG_ENDOCYTIC_2	48	51	PF00928	0.522
TRG_ENDOCYTIC_2	66	69	PF00928	0.484
TRG_NES_CRM1_1	113	126	PF08389	0.279
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.287

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P206	Leptomonas seymouri	27%	100%
A0A0N0P2H6	Leptomonas seymouri	74%	100%
A0A0S4IS38	Bodo saltans	27%	100%
A0A0S4IXG9	Bodo saltans	25%	100%
A0A0S4J1R1	Bodo saltans	36%	100%
A0A0S4J7U6	Bodo saltans	28%	100%
A0A0S4JFC8	Bodo saltans	27%	100%
A0A1X0NEW2	Trypanosomatidae	32%	97%
A0A1X0NMM5	Trypanosomatidae	27%	100%
A0A1X0NN63	Trypanosomatidae	42%	96%
A0A3R7LX73	Trypanosoma rangeli	45%	92%
A0A3S5H6E1	Leishmania donovani	81%	100%
A0A422N447	Trypanosoma rangeli	26%	100%
A0A422N5Z1	Trypanosoma rangeli	29%	98%
A2WN93	Oryza sativa subsp. indica	27%	100%
A2WNH1	Oryza sativa subsp. indica	27%	100%
A2Y609	Oryza sativa subsp. indica	28%	100%
A3E3H0	Pfiesteria piscicida	26%	100%
A3E4D8	Prorocentrum minimum	26%	100%
A3E4F9	Karlodinium veneficum	26%	100%
A4H5R9	Leishmania braziliensis	27%	100%
A4HU12	Leishmania infantum	82%	100%
A4HU13	Leishmania infantum	27%	100%
A4UHC0	Alexandrium fundyense	26%	100%
A8CEP3	Saccharina japonica	26%	100%
A8I1Q0	Heterocapsa triquetra	26%	100%
B1PSN3	Leishmania donovani	27%	100%
C9ZUM6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	95%
D0A9H7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	95%
D0A9H8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A9H9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AMU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E9AMU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
O02367	Ciona intestinalis	28%	100%
O16305	Caenorhabditis elegans	27%	100%
O23320	Arabidopsis thaliana	26%	100%
O82018	Mougeotia scalaris	28%	100%
O82659	Arabidopsis thaliana	28%	100%
O94739	Pleurotus ostreatus	24%	100%
O96081	Halocynthia roretzi	26%	100%
O96102	Physarum polycephalum	27%	100%
O97341	Suberites domuncula	29%	100%
P02585	Homo sapiens	27%	100%
P02586	Oryctolagus cuniculus	27%	100%
P02587	Sus scrofa	26%	100%
P02588	Gallus gallus	26%	100%
P02589	Pelophylax lessonae	28%	100%
P02591	Oryctolagus cuniculus	25%	100%
P02594	Electrophorus electricus	29%	100%
P02595	Patinopecten sp.	27%	100%
P02597	Gallus gallus	27%	100%
P02598	Tetrahymena pyriformis	26%	100%
P02599	Dictyostelium discoideum	27%	100%
P04352	Chlamydomonas reinhardtii	29%	100%
P04353	Spinacia oleracea	27%	100%
P04464	Triticum aestivum	27%	100%
P05419	Gallus gallus	27%	100%
P05434	Chlamydomonas reinhardtii	31%	100%
P05932	Arbacia punctulata	27%	100%
P05933	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
P05936	Coturnix japonica	25%	100%
P07463	Paramecium tetraurelia	26%	100%
P09860	Gallus gallus	25%	100%
P0DH95	Arabidopsis thaliana	28%	100%
P0DH96	Arabidopsis thaliana	28%	100%
P0DH97	Arabidopsis thaliana	26%	100%
P0DH98	Arabidopsis thaliana	26%	100%
P0DP23	Homo sapiens	28%	100%
P0DP24	Homo sapiens	28%	100%
P0DP25	Homo sapiens	28%	100%
P0DP26	Mus musculus	28%	100%
P0DP27	Mus musculus	28%	100%
P0DP28	Mus musculus	28%	100%
P0DP29	Rattus norvegicus	28%	100%
P0DP30	Rattus norvegicus	28%	100%
P0DP31	Rattus norvegicus	28%	100%
P0DP33	Xenopus laevis	28%	100%
P0DP34	Xenopus laevis	28%	100%
P0DP35	Xenopus laevis	28%	100%
P10246	Meleagris gallopavo	26%	100%
P11118	Euglena gracilis	28%	100%
P11120	Pleurotus cornucopiae	24%	100%
P11121	Pyuridae sp.	27%	100%
P13868	Solanum tuberosum	26%	100%
P14533	Doryteuthis pealeii	26%	100%
P17928	Medicago sativa	26%	100%
P18061	Trypanosoma cruzi	27%	100%
P19123	Mus musculus	25%	100%
P20801	Mus musculus	30%	100%
P21251	Stichopus japonicus	28%	100%
P23286	Candida albicans	26%	100%
P24044	Plasmodium falciparum	25%	100%
P25027	Trypanosoma brucei brucei	42%	97%
P27161	Solanum lycopersicum	27%	100%
P27163	Petunia hybrida	27%	100%
P27164	Petunia hybrida	26%	100%
P27165	Phytophthora infestans	25%	100%
P27166	Stylonychia lemnae	26%	100%
P27482	Homo sapiens	27%	100%
P41040	Zea mays	26%	100%
P41041	Pneumocystis carinii	28%	100%
P41045	Leishmania tarentolae	77%	100%
P41048	Trypanosoma cruzi	45%	89%
P41049	Trypanosoma cruzi	44%	89%
P41208	Homo sapiens	27%	100%
P41209	Mus musculus	29%	100%
P41210	Atriplex nummularia	28%	100%
P43645	Spermatozopsis similis	29%	100%
P43646	Tetraselmis striata	29%	100%
P48976	Malus domestica	25%	100%
P53440	Naegleria gruberi	25%	100%
P54213	Dunaliella salina	31%	100%
P59220	Arabidopsis thaliana	26%	100%
P60204	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	100%
P60205	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	27%	100%
P60206	Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)	27%	100%
P61859	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	27%	100%
P61860	Colletotrichum trifolii	27%	100%
P61861	Colletotrichum gloeosporioides	27%	100%
P62144	Anas platyrhynchos	28%	100%
P62145	Aplysia californica	28%	100%
P62146	Arbacia punctulata	28%	100%
P62147	Branchiostoma floridae	28%	100%
P62148	Branchiostoma lanceolatum	28%	100%
P62149	Gallus gallus	28%	100%
P62150	Oryzias latipes	28%	100%
P62151	Tetronarce californica	28%	100%
P62152	Drosophila melanogaster	28%	100%
P62153	Halocynthia roretzi	28%	100%
P62154	Locusta migratoria	28%	100%
P62156	Oncorhynchus sp.	28%	100%
P62157	Bos taurus	28%	100%
P62160	Oryctolagus cuniculus	28%	100%
P62162	Hordeum vulgare	27%	100%
P62163	Glycine max	27%	100%
P62184	Renilla reniformis	27%	100%
P62199	Petunia hybrida	26%	100%
P62200	Daucus carota	26%	100%
P62201	Lilium longiflorum	26%	100%
P62202	Bryonia dioica	26%	100%
P62203	Plasmodium falciparum (isolate 3D7)	25%	100%
P63315	Bos taurus	25%	100%
P63316	Homo sapiens	25%	100%
P63317	Sus scrofa	25%	100%
P69097	Trypanosoma brucei brucei	27%	100%
P69098	Trypanosoma brucei gambiense	27%	100%
P80322	Branchiostoma lanceolatum	30%	100%
P81660	Anguilla anguilla	29%	100%
P84339	Agaricus bisporus	23%	100%
P93087	Capsicum annuum	26%	100%
P93171	Helianthus annuus	26%	100%
Q03509	Arabidopsis thaliana	27%	100%
Q06827	Scherffelia dubia	30%	100%
Q0IQB6	Oryza sativa subsp. japonica	25%	100%
Q0IUU4	Oryza sativa subsp. japonica	26%	100%
Q0JNL7	Oryza sativa subsp. japonica	27%	100%
Q0JNS6	Oryza sativa subsp. japonica	27%	100%
Q12798	Homo sapiens	29%	100%
Q2R1Z5	Oryza sativa subsp. japonica	26%	100%
Q2TBN3	Bos taurus	29%	100%
Q32LE3	Bos taurus	28%	100%
Q338P8	Oryza sativa subsp. japonica	26%	97%
Q39752	Fagus sylvatica	25%	100%
Q40302	Macrocystis pyrifera	25%	100%
Q40642	Oryza sativa subsp. indica	28%	99%
Q4QHT2	Leishmania major	28%	100%
Q4QHT4	Leishmania major	81%	100%
Q5RAD2	Pongo abelii	28%	100%
Q5U206	Rattus norvegicus	27%	100%
Q682T9	Arabidopsis thaliana	26%	100%
Q6F332	Oryza sativa subsp. japonica	28%	100%
Q6IT78	Ctenopharyngodon idella	28%	100%
Q6PI52	Danio rerio	28%	100%
Q6R520	Oreochromis mossambicus	27%	100%
Q6YNX6	Ovis aries	28%	100%
Q71UH5	Globisporangium splendens	25%	100%
Q71UH6	Perca flavescens	28%	100%
Q7DMN9	Solanum tuberosum	26%	100%
Q7F0J0	Oryza sativa subsp. japonica	27%	100%
Q7T3T2	Epinephelus akaara	28%	100%
Q7Y052	Euphorbia characias	26%	100%
Q84MN0	Oryza sativa subsp. japonica	29%	100%
Q8S1Y9	Oryza sativa subsp. japonica	28%	99%
Q8STF0	Strongylocentrotus intermedius	28%	100%
Q8X187	Paxillus involutus	24%	100%
Q95NI4	Halichondria okadai	28%	100%
Q95NR9	Metridium senile	28%	100%
Q9D6P8	Mus musculus	27%	100%
Q9GRJ1	Lumbricus rubellus	28%	100%
Q9HFY6	Blastocladiella emersonii	26%	100%
Q9LIK5	Arabidopsis thaliana	25%	100%
Q9R1K9	Mus musculus	28%	100%
Q9U6D3	Myxine glutinosa	28%	100%
Q9UB37	Branchiostoma lanceolatum	28%	100%
Q9UWF0	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	27%	100%
Q9XZP2	Branchiostoma floridae	27%	100%
V5DQ66	Trypanosoma cruzi	30%	98%