Ras family protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ras family protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4H5R6_LEIBR

TriTrypDb:

LbrM.09.0930 , LBRM2903_090014500

Length:

326

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4H5R6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5R6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006904	vesicle docking involved in exocytosis	3	1
GO:0008104	protein localization	4	2
GO:0009306	protein secretion	4	1
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0017157	regulation of exocytosis	5	1
GO:0022406	membrane docking	2	1
GO:0032879	regulation of localization	3	1
GO:0032940	secretion by cell	3	1
GO:0033036	macromolecule localization	2	2
GO:0035592	establishment of protein localization to extracellular region	4	1
GO:0045184	establishment of protein localization	3	2
GO:0046903	secretion	4	1
GO:0048278	vesicle docking	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051046	regulation of secretion	5	1
GO:0051049	regulation of transport	4	1
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	2
GO:0060627	regulation of vesicle-mediated transport	4	1
GO:0065007	biological regulation	1	1
GO:0070727	cellular macromolecule localization	3	2
GO:0071692	protein localization to extracellular region	5	1
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0140029	exocytic process	2	1
GO:0140056	organelle localization by membrane tethering	3	1
GO:0140352	export from cell	2	1
GO:1903530	regulation of secretion by cell	4	1
GO:0006886	intracellular protein transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0003924	GTPase activity	7	13
GO:0005488	binding	1	13
GO:0005525	GTP binding	5	13
GO:0016462	pyrophosphatase activity	5	13
GO:0016787	hydrolase activity	2	13
GO:0016817	hydrolase activity, acting on acid anhydrides	3	13
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	13
GO:0019001	guanyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032561	guanyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	99	101	PF00675	0.199
CLV_PCSK_KEX2_1	231	233	PF00082	0.659
CLV_PCSK_KEX2_1	3	5	PF00082	0.419
CLV_PCSK_KEX2_1	78	80	PF00082	0.284
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.659
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.419
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.284
CLV_PCSK_SKI1_1	308	312	PF00082	0.187
CLV_PCSK_SKI1_1	84	88	PF00082	0.256
DEG_APCC_DBOX_1	59	67	PF00400	0.378
DEG_Nend_Nbox_1	1	3	PF02207	0.432
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.432
DOC_MAPK_DCC_7	3	12	PF00069	0.419
DOC_MAPK_gen_1	3	12	PF00069	0.419
DOC_MAPK_MEF2A_6	3	12	PF00069	0.633
DOC_MAPK_MEF2A_6	88	97	PF00069	0.302
DOC_PP1_RVXF_1	146	152	PF00149	0.284
DOC_PP2B_LxvP_1	40	43	PF13499	0.417
DOC_PP2B_PxIxI_1	90	96	PF00149	0.284
DOC_USP7_MATH_1	205	209	PF00917	0.635
DOC_USP7_MATH_1	238	242	PF00917	0.663
DOC_USP7_MATH_1	43	47	PF00917	0.499
DOC_WW_Pin1_4	216	221	PF00397	0.707
DOC_WW_Pin1_4	45	50	PF00397	0.441
LIG_14-3-3_CanoR_1	181	187	PF00244	0.317
LIG_14-3-3_CanoR_1	21	27	PF00244	0.445
LIG_14-3-3_CanoR_1	232	236	PF00244	0.596
LIG_BRCT_BRCA1_1	8	12	PF00533	0.565
LIG_eIF4E_1	58	64	PF01652	0.373
LIG_FHA_1	85	91	PF00498	0.336
LIG_HP1_1	257	261	PF01393	0.378
LIG_LIR_Gen_1	9	20	PF02991	0.425
LIG_LIR_LC3C_4	315	319	PF02991	0.317
LIG_LIR_Nem_3	157	163	PF02991	0.342
LIG_LIR_Nem_3	185	189	PF02991	0.341
LIG_LIR_Nem_3	55	61	PF02991	0.491
LIG_LIR_Nem_3	9	15	PF02991	0.426
LIG_LYPXL_yS_3	58	61	PF13949	0.396
LIG_PTB_Apo_2	162	169	PF02174	0.284
LIG_PTB_Phospho_1	162	168	PF10480	0.284
LIG_Rb_pABgroove_1	172	180	PF01858	0.317
LIG_SH2_NCK_1	168	172	PF00017	0.319
LIG_SH2_STAP1	300	304	PF00017	0.378
LIG_SH2_STAT5	199	202	PF00017	0.423
LIG_SH2_STAT5	80	83	PF00017	0.261
LIG_SH2_STAT5	89	92	PF00017	0.261
LIG_SH3_3	214	220	PF00018	0.483
LIG_SH3_3	23	29	PF00018	0.438
LIG_SH3_3	31	37	PF00018	0.628
LIG_SH3_3	47	53	PF00018	0.513
LIG_SH3_3	5	11	PF00018	0.422
LIG_SUMO_SIM_par_1	22	27	PF11976	0.434
LIG_SUMO_SIM_par_1	62	68	PF11976	0.341
LIG_TYR_ITIM	56	61	PF00017	0.432
MOD_CK1_1	114	120	PF00069	0.542
MOD_CK1_1	122	128	PF00069	0.587
MOD_CK1_1	303	309	PF00069	0.278
MOD_Cter_Amidation	229	232	PF01082	0.661
MOD_GlcNHglycan	114	117	PF01048	0.487
MOD_GlcNHglycan	121	124	PF01048	0.614
MOD_GlcNHglycan	133	136	PF01048	0.596
MOD_GlcNHglycan	140	143	PF01048	0.494
MOD_GlcNHglycan	153	157	PF01048	0.187
MOD_GlcNHglycan	186	189	PF01048	0.480
MOD_GlcNHglycan	207	210	PF01048	0.602
MOD_GlcNHglycan	240	243	PF01048	0.608
MOD_GlcNHglycan	301	305	PF01048	0.274
MOD_GlcNHglycan	45	48	PF01048	0.420
MOD_GSK3_1	111	118	PF00069	0.510
MOD_GSK3_1	138	145	PF00069	0.529
MOD_GSK3_1	299	306	PF00069	0.284
MOD_GSK3_1	6	13	PF00069	0.420
MOD_N-GLC_1	15	20	PF02516	0.424
MOD_NEK2_1	15	20	PF00069	0.426
MOD_PK_1	231	237	PF00069	0.553
MOD_PKA_1	231	237	PF00069	0.642
MOD_PKA_2	112	118	PF00069	0.496
MOD_PKA_2	231	237	PF00069	0.649
MOD_PKB_1	278	286	PF00069	0.378
MOD_PKB_1	4	12	PF00069	0.428
MOD_Plk_1	15	21	PF00069	0.426
MOD_Plk_1	266	272	PF00069	0.368
MOD_Plk_4	231	237	PF00069	0.451
MOD_ProDKin_1	216	222	PF00069	0.709
MOD_ProDKin_1	45	51	PF00069	0.443
TRG_ENDOCYTIC_2	160	163	PF00928	0.319
TRG_ENDOCYTIC_2	58	61	PF00928	0.458
TRG_ER_diArg_1	277	280	PF00400	0.380
TRG_ER_diArg_1	4	7	PF00400	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5E3	Leptomonas seymouri	25%	100%
A0A0N1I9K4	Leptomonas seymouri	24%	100%
A0A0N1PE58	Leptomonas seymouri	63%	100%
A0A1X0NN55	Trypanosomatidae	42%	100%
A0A1X0NQG4	Trypanosomatidae	27%	100%
A0A3Q8I8G7	Leishmania donovani	79%	100%
A0A3Q8IK84	Leishmania donovani	33%	100%
A0A3R7N3U0	Trypanosoma rangeli	41%	100%
A0A3R7RHV7	Trypanosoma rangeli	28%	100%
A0A3S5H6H3	Leishmania donovani	25%	100%
A0A3S7WV84	Leishmania donovani	22%	100%
A4H6A5	Leishmania braziliensis	25%	100%
A4H9M3	Leishmania braziliensis	22%	100%
A4HU06	Leishmania infantum	78%	100%
A4HUM9	Leishmania infantum	25%	100%
A4HXY7	Leishmania infantum	22%	100%
A4I946	Leishmania infantum	33%	100%
A5D7F5	Bos taurus	30%	100%
D0A5C0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AMT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9ANC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ARQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
E9B420	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q4Q404	Leishmania major	33%	100%
Q4QDS9	Leishmania major	22%	100%
Q4QH97	Leishmania major	26%	86%
Q4QHT9	Leishmania major	74%	100%
Q5M7D1	Xenopus laevis	28%	100%
Q5RDE5	Pongo abelii	30%	100%
Q6IMK3	Danio rerio	30%	100%
Q6IML7	Rattus norvegicus	29%	100%
Q6IMM1	Gallus gallus	30%	100%
Q7ZYF1	Xenopus laevis	29%	100%
Q8CFP6	Mus musculus	29%	100%
Q9NZQ0	Homo sapiens	30%	100%