Metal-dependent protein hydrolase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised protein family (UPF0160), putative

Species:

Leishmania braziliensis

UniProt:

A4H5R5_LEIBR

TriTrypDb:

LbrM.09.0920 , LBRM2903_090014400

Length:

398

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5R5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5R5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.577
CLV_C14_Caspase3-7	189	193	PF00656	0.479
CLV_NRD_NRD_1	117	119	PF00675	0.217
CLV_NRD_NRD_1	223	225	PF00675	0.318
CLV_NRD_NRD_1	282	284	PF00675	0.331
CLV_NRD_NRD_1	3	5	PF00675	0.478
CLV_NRD_NRD_1	345	347	PF00675	0.295
CLV_PCSK_KEX2_1	223	225	PF00082	0.311
CLV_PCSK_KEX2_1	282	284	PF00082	0.374
CLV_PCSK_SKI1_1	391	395	PF00082	0.297
CLV_PCSK_SKI1_1	5	9	PF00082	0.559
DEG_SPOP_SBC_1	28	32	PF00917	0.537
DEG_SPOP_SBC_1	337	341	PF00917	0.574
DOC_CKS1_1	114	119	PF01111	0.494
DOC_USP7_MATH_1	150	154	PF00917	0.466
DOC_USP7_MATH_1	337	341	PF00917	0.563
DOC_WW_Pin1_4	113	118	PF00397	0.483
LIG_14-3-3_CanoR_1	124	132	PF00244	0.496
LIG_14-3-3_CanoR_1	163	171	PF00244	0.550
LIG_APCC_ABBA_1	292	297	PF00400	0.504
LIG_APCC_ABBAyCdc20_2	291	297	PF00400	0.504
LIG_BIR_II_1	1	5	PF00653	0.546
LIG_BRCT_BRCA1_1	339	343	PF00533	0.574
LIG_Clathr_ClatBox_1	307	311	PF01394	0.508
LIG_Clathr_ClatBox_1	394	398	PF01394	0.354
LIG_FHA_1	312	318	PF00498	0.554
LIG_FHA_1	6	12	PF00498	0.374
LIG_FHA_2	272	278	PF00498	0.417
LIG_FHA_2	28	34	PF00498	0.437
LIG_FHA_2	339	345	PF00498	0.574
LIG_LIR_Gen_1	181	191	PF02991	0.505
LIG_LIR_Gen_1	256	267	PF02991	0.493
LIG_LIR_Nem_3	181	187	PF02991	0.505
LIG_LIR_Nem_3	256	262	PF02991	0.498
LIG_LIR_Nem_3	263	267	PF02991	0.489
LIG_SH2_CRK	351	355	PF00017	0.598
LIG_SH2_GRB2like	184	187	PF00017	0.528
LIG_SH2_SRC	103	106	PF00017	0.586
LIG_SH2_SRC	143	146	PF00017	0.525
LIG_SH2_STAP1	184	188	PF00017	0.574
LIG_SH2_STAT5	10	13	PF00017	0.426
LIG_SH2_STAT5	143	146	PF00017	0.494
LIG_SH2_STAT5	264	267	PF00017	0.546
LIG_SH2_STAT5	322	325	PF00017	0.494
LIG_SUMO_SIM_anti_2	16	23	PF11976	0.590
LIG_SUMO_SIM_par_1	305	311	PF11976	0.539
LIG_SUMO_SIM_par_1	393	398	PF11976	0.488
LIG_TYR_ITIM	349	354	PF00017	0.598
MOD_CDK_SPK_2	113	118	PF00069	0.494
MOD_CDK_SPxK_1	113	119	PF00069	0.574
MOD_CK1_1	167	173	PF00069	0.606
MOD_CK1_1	34	40	PF00069	0.621
MOD_CK2_1	150	156	PF00069	0.534
MOD_CK2_1	169	175	PF00069	0.466
MOD_CK2_1	27	33	PF00069	0.481
MOD_CK2_1	271	277	PF00069	0.598
MOD_CK2_1	338	344	PF00069	0.546
MOD_GlcNHglycan	1	4	PF01048	0.592
MOD_GlcNHglycan	126	129	PF01048	0.294
MOD_GlcNHglycan	287	291	PF01048	0.302
MOD_GlcNHglycan	356	362	PF01048	0.315
MOD_GlcNHglycan	37	40	PF01048	0.585
MOD_GlcNHglycan	373	376	PF01048	0.290
MOD_GSK3_1	106	113	PF00069	0.491
MOD_GSK3_1	120	127	PF00069	0.472
MOD_GSK3_1	150	157	PF00069	0.477
MOD_GSK3_1	16	23	PF00069	0.529
MOD_GSK3_1	162	169	PF00069	0.549
MOD_GSK3_1	27	34	PF00069	0.513
MOD_GSK3_1	44	51	PF00069	0.347
MOD_N-GLC_1	219	224	PF02516	0.347
MOD_N-GLC_1	48	53	PF02516	0.284
MOD_NEK2_1	110	115	PF00069	0.491
MOD_NEK2_1	120	125	PF00069	0.494
MOD_NEK2_1	265	270	PF00069	0.526
MOD_NEK2_1	286	291	PF00069	0.554
MOD_NEK2_1	295	300	PF00069	0.560
MOD_NEK2_2	150	155	PF00069	0.504
MOD_PKA_2	123	129	PF00069	0.494
MOD_PKA_2	154	160	PF00069	0.560
MOD_PKA_2	162	168	PF00069	0.491
MOD_PKA_2	26	32	PF00069	0.521
MOD_Plk_4	154	160	PF00069	0.548
MOD_Plk_4	16	22	PF00069	0.523
MOD_Plk_4	207	213	PF00069	0.598
MOD_Plk_4	260	266	PF00069	0.574
MOD_ProDKin_1	113	119	PF00069	0.483
TRG_DiLeu_BaEn_2	365	371	PF01217	0.525
TRG_ENDOCYTIC_2	132	135	PF00928	0.494
TRG_ENDOCYTIC_2	184	187	PF00928	0.483
TRG_ENDOCYTIC_2	264	267	PF00928	0.508
TRG_ENDOCYTIC_2	322	325	PF00928	0.494
TRG_ENDOCYTIC_2	351	354	PF00928	0.598
TRG_ER_diArg_1	100	103	PF00400	0.417
TRG_ER_diArg_1	223	225	PF00400	0.579
TRG_ER_diArg_1	75	78	PF00400	0.490
TRG_ER_FFAT_1	252	263	PF00635	0.528
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILK4	Leptomonas seymouri	77%	100%
A0A1X0NMG9	Trypanosomatidae	44%	92%
A0A3S7WQQ4	Leishmania donovani	88%	100%
A0A422N2F9	Trypanosoma rangeli	57%	100%
A4HU05	Leishmania infantum	88%	100%
D0A9H0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AMT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O17606	Caenorhabditis elegans	43%	100%
P40093	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
Q4QHU0	Leishmania major	86%	97%
Q55G91	Dictyostelium discoideum	40%	100%
Q58DG1	Bos taurus	44%	100%
Q641W2	Rattus norvegicus	43%	100%
Q9HB07	Homo sapiens	44%	100%
Q9JK81	Mus musculus	43%	100%
Q9P7T6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
V5D8M5	Trypanosoma cruzi	54%	100%