DEAD/DEAH box helicase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DEAD/DEAH box helicase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H5R4_LEIBR

TriTrypDb:

LbrM.09.0910 , LBRM2903_090014300

Length:

776

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 14
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5R4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5R4

PDB structure(s): 7am2_BW

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003676	nucleic acid binding	3	16
GO:0003724	RNA helicase activity	3	15
GO:0003743	translation initiation factor activity	4	15
GO:0003824	catalytic activity	1	16
GO:0004386	helicase activity	2	16
GO:0005488	binding	1	16
GO:0005524	ATP binding	5	16
GO:0008135	translation factor activity, RNA binding	3	15
GO:0008186	ATP-dependent activity, acting on RNA	2	15
GO:0016787	hydrolase activity	2	16
GO:0017076	purine nucleotide binding	4	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0045182	translation regulator activity	1	15
GO:0090079	translation regulator activity, nucleic acid binding	2	15
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:0140098	catalytic activity, acting on RNA	3	15
GO:0140640	catalytic activity, acting on a nucleic acid	2	16
GO:0140657	ATP-dependent activity	1	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.478
CLV_C14_Caspase3-7	440	444	PF00656	0.490
CLV_MEL_PAP_1	76	82	PF00089	0.318
CLV_NRD_NRD_1	189	191	PF00675	0.291
CLV_NRD_NRD_1	226	228	PF00675	0.257
CLV_NRD_NRD_1	260	262	PF00675	0.264
CLV_NRD_NRD_1	318	320	PF00675	0.264
CLV_NRD_NRD_1	326	328	PF00675	0.391
CLV_NRD_NRD_1	356	358	PF00675	0.542
CLV_NRD_NRD_1	369	371	PF00675	0.521
CLV_NRD_NRD_1	507	509	PF00675	0.337
CLV_NRD_NRD_1	544	546	PF00675	0.283
CLV_NRD_NRD_1	665	667	PF00675	0.546
CLV_NRD_NRD_1	719	721	PF00675	0.433
CLV_NRD_NRD_1	725	727	PF00675	0.473
CLV_PCSK_FUR_1	187	191	PF00082	0.264
CLV_PCSK_FUR_1	258	262	PF00082	0.264
CLV_PCSK_KEX2_1	189	191	PF00082	0.284
CLV_PCSK_KEX2_1	228	230	PF00082	0.264
CLV_PCSK_KEX2_1	260	262	PF00082	0.264
CLV_PCSK_KEX2_1	296	298	PF00082	0.256
CLV_PCSK_KEX2_1	356	358	PF00082	0.542
CLV_PCSK_KEX2_1	507	509	PF00082	0.262
CLV_PCSK_KEX2_1	719	721	PF00082	0.462
CLV_PCSK_KEX2_1	725	727	PF00082	0.519
CLV_PCSK_KEX2_1	739	741	PF00082	0.449
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.264
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.270
CLV_PCSK_PC1ET2_1	739	741	PF00082	0.637
CLV_PCSK_SKI1_1	105	109	PF00082	0.407
CLV_PCSK_SKI1_1	192	196	PF00082	0.257
CLV_PCSK_SKI1_1	236	240	PF00082	0.273
CLV_PCSK_SKI1_1	251	255	PF00082	0.264
CLV_PCSK_SKI1_1	260	264	PF00082	0.264
CLV_PCSK_SKI1_1	500	504	PF00082	0.356
CLV_PCSK_SKI1_1	621	625	PF00082	0.356
CLV_PCSK_SKI1_1	63	67	PF00082	0.522
CLV_PCSK_SKI1_1	685	689	PF00082	0.447
CLV_PCSK_SKI1_1	7	11	PF00082	0.630
CLV_PCSK_SKI1_1	736	740	PF00082	0.619
DEG_APCC_DBOX_1	472	480	PF00400	0.380
DEG_COP1_1	443	452	PF00400	0.611
DOC_CKS1_1	133	138	PF01111	0.329
DOC_CYCLIN_RxL_1	187	199	PF00134	0.474
DOC_CYCLIN_RxL_1	255	266	PF00134	0.478
DOC_CYCLIN_RxL_1	565	575	PF00134	0.553
DOC_MAPK_gen_1	177	186	PF00069	0.464
DOC_MAPK_gen_1	187	196	PF00069	0.509
DOC_MAPK_gen_1	236	245	PF00069	0.447
DOC_MAPK_gen_1	255	264	PF00069	0.464
DOC_MAPK_gen_1	370	377	PF00069	0.425
DOC_MAPK_gen_1	507	513	PF00069	0.549
DOC_MAPK_gen_1	598	608	PF00069	0.627
DOC_MAPK_gen_1	610	617	PF00069	0.427
DOC_MAPK_JIP1_4	190	196	PF00069	0.382
DOC_MAPK_MEF2A_6	239	247	PF00069	0.451
DOC_MAPK_MEF2A_6	361	368	PF00069	0.484
DOC_MAPK_MEF2A_6	370	379	PF00069	0.530
DOC_MAPK_MEF2A_6	568	576	PF00069	0.464
DOC_MAPK_RevD_3	245	261	PF00069	0.464
DOC_PP1_RVXF_1	478	485	PF00149	0.403
DOC_PP1_RVXF_1	506	513	PF00149	0.522
DOC_PP2B_LxvP_1	195	198	PF13499	0.464
DOC_PP2B_LxvP_1	59	62	PF13499	0.546
DOC_PP4_FxxP_1	494	497	PF00568	0.503
DOC_PP4_FxxP_1	580	583	PF00568	0.453
DOC_PP4_FxxP_1	768	771	PF00568	0.558
DOC_USP7_MATH_1	19	23	PF00917	0.621
DOC_USP7_MATH_1	277	281	PF00917	0.478
DOC_USP7_MATH_1	35	39	PF00917	0.567
DOC_USP7_MATH_1	421	425	PF00917	0.712
DOC_USP7_MATH_1	43	47	PF00917	0.549
DOC_USP7_MATH_1	448	452	PF00917	0.694
DOC_USP7_MATH_1	456	460	PF00917	0.600
DOC_USP7_UBL2_3	621	625	PF12436	0.500
DOC_WW_Pin1_4	118	123	PF00397	0.505
DOC_WW_Pin1_4	132	137	PF00397	0.399
DOC_WW_Pin1_4	47	52	PF00397	0.591
DOC_WW_Pin1_4	759	764	PF00397	0.648
DOC_WW_Pin1_4	90	95	PF00397	0.418
DOC_WW_Pin1_4	97	102	PF00397	0.414
LIG_14-3-3_CanoR_1	327	332	PF00244	0.583
LIG_14-3-3_CanoR_1	453	459	PF00244	0.530
LIG_14-3-3_CanoR_1	473	477	PF00244	0.415
LIG_14-3-3_CanoR_1	658	664	PF00244	0.410
LIG_14-3-3_CanoR_1	7	12	PF00244	0.673
LIG_APCC_ABBA_1	570	575	PF00400	0.464
LIG_APCC_ABBAyCdc20_2	545	551	PF00400	0.464
LIG_BIR_II_1	1	5	PF00653	0.733
LIG_BIR_III_3	1	5	PF00653	0.528
LIG_BRCT_BRCA1_1	220	224	PF00533	0.478
LIG_BRCT_BRCA1_1	40	44	PF00533	0.568
LIG_BRCT_BRCA1_1	527	531	PF00533	0.575
LIG_eIF4E_1	232	238	PF01652	0.455
LIG_FHA_1	107	113	PF00498	0.398
LIG_FHA_1	197	203	PF00498	0.485
LIG_FHA_1	257	263	PF00498	0.495
LIG_FHA_1	306	312	PF00498	0.492
LIG_FHA_1	316	322	PF00498	0.488
LIG_FHA_1	361	367	PF00498	0.445
LIG_FHA_1	426	432	PF00498	0.630
LIG_FHA_1	493	499	PF00498	0.424
LIG_FHA_1	517	523	PF00498	0.530
LIG_FHA_1	555	561	PF00498	0.484
LIG_FHA_1	56	62	PF00498	0.512
LIG_FHA_1	582	588	PF00498	0.446
LIG_FHA_1	648	654	PF00498	0.466
LIG_FHA_2	140	146	PF00498	0.478
LIG_FHA_2	239	245	PF00498	0.496
LIG_FHA_2	435	441	PF00498	0.584
LIG_FHA_2	460	466	PF00498	0.429
LIG_LIR_Apic_2	164	170	PF02991	0.482
LIG_LIR_Apic_2	180	185	PF02991	0.482
LIG_LIR_Gen_1	308	317	PF02991	0.478
LIG_LIR_Gen_1	360	369	PF02991	0.497
LIG_LIR_Gen_1	41	51	PF02991	0.586
LIG_LIR_Gen_1	520	531	PF02991	0.438
LIG_LIR_Gen_1	547	553	PF02991	0.515
LIG_LIR_Gen_1	659	664	PF02991	0.415
LIG_LIR_Nem_3	266	272	PF02991	0.447
LIG_LIR_Nem_3	308	313	PF02991	0.557
LIG_LIR_Nem_3	360	365	PF02991	0.452
LIG_LIR_Nem_3	41	47	PF02991	0.599
LIG_LIR_Nem_3	469	474	PF02991	0.530
LIG_LIR_Nem_3	520	526	PF02991	0.485
LIG_LIR_Nem_3	547	552	PF02991	0.515
LIG_LIR_Nem_3	659	663	PF02991	0.410
LIG_LIR_Nem_3	683	687	PF02991	0.420
LIG_NRBOX	364	370	PF00104	0.396
LIG_PCNA_yPIPBox_3	141	151	PF02747	0.553
LIG_PCNA_yPIPBox_3	702	712	PF02747	0.387
LIG_Pex14_1	684	688	PF04695	0.421
LIG_Pex14_2	300	304	PF04695	0.464
LIG_REV1ctd_RIR_1	510	518	PF16727	0.553
LIG_SH2_CRK	182	186	PF00017	0.457
LIG_SH2_GRB2like	172	175	PF00017	0.464
LIG_SH2_PTP2	310	313	PF00017	0.478
LIG_SH2_PTP2	660	663	PF00017	0.390
LIG_SH2_SRC	677	680	PF00017	0.438
LIG_SH2_STAP1	549	553	PF00017	0.553
LIG_SH2_STAT5	167	170	PF00017	0.468
LIG_SH2_STAT5	269	272	PF00017	0.453
LIG_SH2_STAT5	302	305	PF00017	0.489
LIG_SH2_STAT5	310	313	PF00017	0.496
LIG_SH2_STAT5	323	326	PF00017	0.363
LIG_SH2_STAT5	466	469	PF00017	0.453
LIG_SH2_STAT5	474	477	PF00017	0.382
LIG_SH2_STAT5	589	592	PF00017	0.444
LIG_SH2_STAT5	660	663	PF00017	0.395
LIG_SH2_STAT5	677	680	PF00017	0.361
LIG_SH3_3	130	136	PF00018	0.486
LIG_SH3_3	244	250	PF00018	0.550
LIG_SH3_3	372	378	PF00018	0.520
LIG_SH3_3	487	493	PF00018	0.408
LIG_SH3_3	684	690	PF00018	0.546
LIG_SH3_3	760	766	PF00018	0.543
LIG_SH3_3	768	774	PF00018	0.535
LIG_SUMO_SIM_anti_2	241	247	PF11976	0.466
LIG_SUMO_SIM_anti_2	659	665	PF11976	0.470
LIG_SUMO_SIM_par_1	428	437	PF11976	0.610
LIG_TYR_ITIM	267	272	PF00017	0.293
LIG_TYR_ITSM	306	313	PF00017	0.328
LIG_UBA3_1	193	200	PF00899	0.353
LIG_UBA3_1	365	371	PF00899	0.403
LIG_UBA3_1	616	625	PF00899	0.245
LIG_WRC_WIRS_1	112	117	PF05994	0.337
MOD_CDC14_SPxK_1	50	53	PF00782	0.437
MOD_CDC14_SPxK_1	93	96	PF00782	0.450
MOD_CDK_SPxK_1	47	53	PF00069	0.596
MOD_CDK_SPxK_1	90	96	PF00069	0.433
MOD_CK1_1	134	140	PF00069	0.465
MOD_CK1_1	22	28	PF00069	0.672
MOD_CK1_1	223	229	PF00069	0.251
MOD_CK1_1	38	44	PF00069	0.630
MOD_CK1_1	45	51	PF00069	0.674
MOD_CK1_1	459	465	PF00069	0.632
MOD_CK1_1	554	560	PF00069	0.308
MOD_CK1_1	659	665	PF00069	0.400
MOD_CK2_1	139	145	PF00069	0.308
MOD_CK2_1	395	401	PF00069	0.487
MOD_CK2_1	434	440	PF00069	0.735
MOD_CK2_1	72	78	PF00069	0.411
MOD_Cter_Amidation	325	328	PF01082	0.397
MOD_Cter_Amidation	505	508	PF01082	0.353
MOD_GlcNHglycan	15	18	PF01048	0.580
MOD_GlcNHglycan	220	223	PF01048	0.397
MOD_GlcNHglycan	395	398	PF01048	0.445
MOD_GlcNHglycan	445	448	PF01048	0.731
MOD_GlcNHglycan	450	453	PF01048	0.718
MOD_GlcNHglycan	454	457	PF01048	0.698
MOD_GlcNHglycan	459	462	PF01048	0.675
MOD_GlcNHglycan	527	530	PF01048	0.405
MOD_GlcNHglycan	553	556	PF01048	0.293
MOD_GlcNHglycan	617	620	PF01048	0.369
MOD_GlcNHglycan	771	774	PF01048	0.677
MOD_GSK3_1	214	221	PF00069	0.381
MOD_GSK3_1	223	230	PF00069	0.153
MOD_GSK3_1	311	318	PF00069	0.347
MOD_GSK3_1	327	334	PF00069	0.504
MOD_GSK3_1	38	45	PF00069	0.697
MOD_GSK3_1	421	428	PF00069	0.611
MOD_GSK3_1	448	455	PF00069	0.716
MOD_GSK3_1	581	588	PF00069	0.264
MOD_GSK3_1	68	75	PF00069	0.435
MOD_GSK3_1	78	85	PF00069	0.442
MOD_GSK3_1	88	95	PF00069	0.409
MOD_N-GLC_1	680	685	PF02516	0.420
MOD_NEK2_1	131	136	PF00069	0.420
MOD_NEK2_1	20	25	PF00069	0.723
MOD_NEK2_1	238	243	PF00069	0.327
MOD_NEK2_1	256	261	PF00069	0.328
MOD_NEK2_1	278	283	PF00069	0.294
MOD_NEK2_1	395	400	PF00069	0.555
MOD_NEK2_1	42	47	PF00069	0.562
MOD_NEK2_1	531	536	PF00069	0.343
MOD_NEK2_1	656	661	PF00069	0.493
MOD_NEK2_1	673	678	PF00069	0.380
MOD_NEK2_1	72	77	PF00069	0.542
MOD_NEK2_2	734	739	PF00069	0.615
MOD_PIKK_1	305	311	PF00454	0.308
MOD_PIKK_1	70	76	PF00454	0.490
MOD_PKA_1	227	233	PF00069	0.433
MOD_PKA_1	327	333	PF00069	0.408
MOD_PKA_2	452	458	PF00069	0.761
MOD_PKA_2	472	478	PF00069	0.558
MOD_PKA_2	506	512	PF00069	0.416
MOD_PKA_2	665	671	PF00069	0.534
MOD_PKA_2	78	84	PF00069	0.492
MOD_Plk_1	673	679	PF00069	0.424
MOD_Plk_1	680	686	PF00069	0.421
MOD_Plk_2-3	425	431	PF00069	0.737
MOD_Plk_4	150	156	PF00069	0.308
MOD_Plk_4	238	244	PF00069	0.310
MOD_Plk_4	531	537	PF00069	0.317
MOD_Plk_4	585	591	PF00069	0.309
MOD_Plk_4	659	665	PF00069	0.431
MOD_ProDKin_1	118	124	PF00069	0.498
MOD_ProDKin_1	132	138	PF00069	0.395
MOD_ProDKin_1	47	53	PF00069	0.590
MOD_ProDKin_1	759	765	PF00069	0.645
MOD_ProDKin_1	90	96	PF00069	0.414
MOD_ProDKin_1	97	103	PF00069	0.409
MOD_SUMO_rev_2	244	253	PF00179	0.308
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.243
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.295
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.415
TRG_ENDOCYTIC_2	172	175	PF00928	0.294
TRG_ENDOCYTIC_2	269	272	PF00928	0.286
TRG_ENDOCYTIC_2	310	313	PF00928	0.328
TRG_ENDOCYTIC_2	549	552	PF00928	0.433
TRG_ENDOCYTIC_2	660	663	PF00928	0.390
TRG_ER_diArg_1	189	192	PF00400	0.345
TRG_ER_diArg_1	257	260	PF00400	0.308
TRG_ER_diArg_1	348	351	PF00400	0.518
TRG_ER_diArg_1	355	357	PF00400	0.531
TRG_ER_diArg_1	718	720	PF00400	0.450
TRG_NLS_MonoExtC_3	226	231	PF00514	0.328
TRG_NLS_MonoExtN_4	227	232	PF00514	0.328
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	260	265	PF00026	0.320
TRG_Pf-PMV_PEXEL_1	327	331	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	480	485	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ75	Leptomonas seymouri	78%	95%
A0A0S4II81	Bodo saltans	22%	88%
A0A0S4KKU4	Bodo saltans	23%	100%
A0A1X0NMI3	Trypanosomatidae	61%	97%
A0A3S5H6T7	Leishmania donovani	24%	100%
A0A3S7WQS0	Leishmania donovani	88%	100%
A0A422N2G7	Trypanosoma rangeli	65%	100%
A4H7Y3	Leishmania braziliensis	24%	100%
A4HU04	Leishmania infantum	88%	100%
D0A9G9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AMT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AQ10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
Q4QHU1	Leishmania major	87%	100%
V5ASP0	Trypanosoma cruzi	62%	100%