LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

AAA domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
AAA domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H5R3_LEIBR
TriTrypDb:
LbrM.09.0900 , LBRM2903_090014200
Length:
559

Annotations

LeishMANIAdb annotations

Probably a secreted protein, similarly to its distant eukaryotic torsin homologs, involved in secretory processes. Also similar to bacterial ClpB ATPases, with chaperoning function.. Might be associated to known or unknown protein secretion pathways.. Localization: Endosomal (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 6, no: 6
NetGPI no yes: 0, no: 12
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5R3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5R3

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 13
GO:0003824 catalytic activity 1 13
GO:0005488 binding 1 13
GO:0005524 ATP binding 5 13
GO:0016462 pyrophosphatase activity 5 13
GO:0016787 hydrolase activity 2 13
GO:0016817 hydrolase activity, acting on acid anhydrides 3 13
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 13
GO:0016887 ATP hydrolysis activity 7 13
GO:0017076 purine nucleotide binding 4 13
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 13
GO:0030554 adenyl nucleotide binding 5 13
GO:0032553 ribonucleotide binding 3 13
GO:0032555 purine ribonucleotide binding 4 13
GO:0032559 adenyl ribonucleotide binding 5 13
GO:0035639 purine ribonucleoside triphosphate binding 4 13
GO:0036094 small molecule binding 2 13
GO:0043167 ion binding 2 13
GO:0043168 anion binding 3 13
GO:0097159 organic cyclic compound binding 2 13
GO:0097367 carbohydrate derivative binding 2 13
GO:1901265 nucleoside phosphate binding 3 13
GO:1901363 heterocyclic compound binding 2 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 219 223 PF00656 0.347
CLV_NRD_NRD_1 144 146 PF00675 0.399
CLV_NRD_NRD_1 16 18 PF00675 0.545
CLV_NRD_NRD_1 333 335 PF00675 0.523
CLV_NRD_NRD_1 476 478 PF00675 0.367
CLV_PCSK_KEX2_1 144 146 PF00082 0.539
CLV_PCSK_KEX2_1 16 18 PF00082 0.545
CLV_PCSK_KEX2_1 476 478 PF00082 0.367
CLV_PCSK_SKI1_1 210 214 PF00082 0.332
CLV_PCSK_SKI1_1 30 34 PF00082 0.546
CLV_PCSK_SKI1_1 515 519 PF00082 0.351
CLV_PCSK_SKI1_1 58 62 PF00082 0.520
DEG_APCC_KENBOX_2 468 472 PF00400 0.361
DEG_SCF_FBW7_1 517 524 PF00400 0.474
DEG_SPOP_SBC_1 291 295 PF00917 0.406
DEG_SPOP_SBC_1 523 527 PF00917 0.526
DEG_SPOP_SBC_1 534 538 PF00917 0.502
DOC_CKS1_1 518 523 PF01111 0.470
DOC_CKS1_1 85 90 PF01111 0.415
DOC_MAPK_DCC_7 125 135 PF00069 0.495
DOC_MAPK_gen_1 125 135 PF00069 0.551
DOC_MAPK_gen_1 158 167 PF00069 0.288
DOC_MAPK_HePTP_8 155 167 PF00069 0.372
DOC_MAPK_MEF2A_6 128 137 PF00069 0.521
DOC_MAPK_MEF2A_6 158 167 PF00069 0.374
DOC_MAPK_MEF2A_6 181 188 PF00069 0.369
DOC_MAPK_MEF2A_6 30 37 PF00069 0.467
DOC_MAPK_MEF2A_6 498 507 PF00069 0.436
DOC_PP1_RVXF_1 502 508 PF00149 0.392
DOC_PP2B_LxvP_1 133 136 PF13499 0.486
DOC_PP4_FxxP_1 4 7 PF00568 0.474
DOC_USP7_MATH_1 291 295 PF00917 0.499
DOC_USP7_MATH_1 347 351 PF00917 0.733
DOC_USP7_MATH_1 44 48 PF00917 0.434
DOC_USP7_MATH_1 521 525 PF00917 0.545
DOC_USP7_MATH_1 534 538 PF00917 0.515
DOC_USP7_MATH_1 65 69 PF00917 0.695
DOC_USP7_MATH_1 80 84 PF00917 0.407
DOC_USP7_UBL2_3 90 94 PF12436 0.437
DOC_WW_Pin1_4 517 522 PF00397 0.446
DOC_WW_Pin1_4 84 89 PF00397 0.453
LIG_14-3-3_CanoR_1 201 209 PF00244 0.313
LIG_14-3-3_CanoR_1 282 290 PF00244 0.514
LIG_14-3-3_CanoR_1 292 301 PF00244 0.638
LIG_14-3-3_CanoR_1 302 309 PF00244 0.460
LIG_14-3-3_CanoR_1 380 386 PF00244 0.550
LIG_14-3-3_CanoR_1 430 440 PF00244 0.392
LIG_APCC_ABBAyCdc20_2 545 551 PF00400 0.520
LIG_BIR_II_1 1 5 PF00653 0.642
LIG_FHA_1 197 203 PF00498 0.337
LIG_FHA_1 29 35 PF00498 0.554
LIG_FHA_1 351 357 PF00498 0.525
LIG_FHA_1 524 530 PF00498 0.652
LIG_FHA_1 98 104 PF00498 0.532
LIG_FHA_2 228 234 PF00498 0.408
LIG_FHA_2 264 270 PF00498 0.480
LIG_FHA_2 447 453 PF00498 0.381
LIG_FHA_2 47 53 PF00498 0.500
LIG_FHA_2 491 497 PF00498 0.349
LIG_LIR_Apic_2 3 7 PF02991 0.473
LIG_LIR_Gen_1 399 408 PF02991 0.491
LIG_LIR_Gen_1 412 423 PF02991 0.354
LIG_LIR_Nem_3 230 235 PF02991 0.404
LIG_LIR_Nem_3 399 403 PF02991 0.428
LIG_LIR_Nem_3 412 418 PF02991 0.366
LIG_LIR_Nem_3 91 95 PF02991 0.409
LIG_NRBOX 150 156 PF00104 0.278
LIG_PDZ_Class_1 554 559 PF00595 0.563
LIG_Pex14_1 315 319 PF04695 0.496
LIG_Pex14_2 37 41 PF04695 0.371
LIG_SH2_CRK 404 408 PF00017 0.368
LIG_SH2_STAP1 411 415 PF00017 0.464
LIG_SH2_STAT5 102 105 PF00017 0.409
LIG_SH2_STAT5 411 414 PF00017 0.436
LIG_SH2_STAT5 417 420 PF00017 0.401
LIG_SH2_STAT5 95 98 PF00017 0.376
LIG_SH3_2 85 90 PF14604 0.400
LIG_SH3_3 162 168 PF00018 0.393
LIG_SH3_3 177 183 PF00018 0.349
LIG_SH3_3 272 278 PF00018 0.368
LIG_SH3_3 359 365 PF00018 0.572
LIG_SH3_3 413 419 PF00018 0.488
LIG_SH3_3 74 80 PF00018 0.434
LIG_SH3_3 82 88 PF00018 0.424
LIG_SUMO_SIM_anti_2 222 228 PF11976 0.258
LIG_SUMO_SIM_anti_2 31 37 PF11976 0.507
LIG_SUMO_SIM_par_1 222 228 PF11976 0.356
LIG_SUMO_SIM_par_1 258 264 PF11976 0.309
LIG_SUMO_SIM_par_1 269 274 PF11976 0.347
LIG_TRAF2_1 493 496 PF00917 0.400
LIG_UBA3_1 103 111 PF00899 0.392
LIG_UBA3_1 169 176 PF00899 0.409
LIG_WRC_WIRS_1 1 6 PF05994 0.474
MOD_CDK_SPxK_1 84 90 PF00069 0.459
MOD_CK1_1 105 111 PF00069 0.592
MOD_CK1_1 12 18 PF00069 0.497
MOD_CK1_1 294 300 PF00069 0.541
MOD_CK1_1 350 356 PF00069 0.621
MOD_CK1_1 431 437 PF00069 0.434
MOD_CK1_1 448 454 PF00069 0.421
MOD_CK1_1 524 530 PF00069 0.644
MOD_CK1_1 533 539 PF00069 0.678
MOD_CK1_1 69 75 PF00069 0.602
MOD_CK2_1 120 126 PF00069 0.586
MOD_CK2_1 233 239 PF00069 0.512
MOD_CK2_1 324 330 PF00069 0.530
MOD_CK2_1 385 391 PF00069 0.502
MOD_CK2_1 46 52 PF00069 0.461
MOD_CK2_1 464 470 PF00069 0.614
MOD_CK2_1 490 496 PF00069 0.336
MOD_CK2_1 533 539 PF00069 0.669
MOD_DYRK1A_RPxSP_1 84 88 PF00069 0.440
MOD_GlcNHglycan 227 230 PF01048 0.362
MOD_GlcNHglycan 24 27 PF01048 0.606
MOD_GlcNHglycan 294 297 PF01048 0.585
MOD_GlcNHglycan 326 329 PF01048 0.628
MOD_GlcNHglycan 358 361 PF01048 0.592
MOD_GlcNHglycan 430 433 PF01048 0.430
MOD_GlcNHglycan 46 49 PF01048 0.738
MOD_GlcNHglycan 466 469 PF01048 0.422
MOD_GlcNHglycan 532 535 PF01048 0.590
MOD_GSK3_1 105 112 PF00069 0.594
MOD_GSK3_1 201 208 PF00069 0.326
MOD_GSK3_1 24 31 PF00069 0.435
MOD_GSK3_1 290 297 PF00069 0.643
MOD_GSK3_1 347 354 PF00069 0.636
MOD_GSK3_1 381 388 PF00069 0.459
MOD_GSK3_1 444 451 PF00069 0.400
MOD_GSK3_1 517 524 PF00069 0.607
MOD_GSK3_1 529 536 PF00069 0.670
MOD_GSK3_1 65 72 PF00069 0.637
MOD_GSK3_1 80 87 PF00069 0.373
MOD_NEK2_1 114 119 PF00069 0.664
MOD_NEK2_1 225 230 PF00069 0.423
MOD_NEK2_1 290 295 PF00069 0.489
MOD_NEK2_1 352 357 PF00069 0.624
MOD_NEK2_1 403 408 PF00069 0.400
MOD_NEK2_1 444 449 PF00069 0.408
MOD_NEK2_1 60 65 PF00069 0.515
MOD_NEK2_2 102 107 PF00069 0.508
MOD_PIKK_1 114 120 PF00454 0.512
MOD_PIKK_1 365 371 PF00454 0.460
MOD_PIKK_1 418 424 PF00454 0.316
MOD_PIKK_1 482 488 PF00454 0.426
MOD_PKA_2 281 287 PF00069 0.484
MOD_PKA_2 291 297 PF00069 0.626
MOD_PKA_2 301 307 PF00069 0.489
MOD_PKA_2 324 330 PF00069 0.640
MOD_PKB_1 300 308 PF00069 0.486
MOD_Plk_1 263 269 PF00069 0.417
MOD_Plk_1 510 516 PF00069 0.406
MOD_Plk_2-3 233 239 PF00069 0.512
MOD_Plk_4 271 277 PF00069 0.454
MOD_Plk_4 403 409 PF00069 0.377
MOD_ProDKin_1 517 523 PF00069 0.459
MOD_ProDKin_1 84 90 PF00069 0.455
MOD_SUMO_rev_2 492 500 PF00179 0.369
TRG_DiLeu_BaEn_2 452 458 PF01217 0.363
TRG_DiLeu_BaLyEn_6 165 170 PF01217 0.404
TRG_DiLeu_BaLyEn_6 440 445 PF01217 0.411
TRG_DiLeu_BaLyEn_6 474 479 PF01217 0.284
TRG_ENDOCYTIC_2 404 407 PF00928 0.375
TRG_ENDOCYTIC_2 417 420 PF00928 0.311
TRG_ER_diArg_1 143 145 PF00400 0.352
TRG_ER_diArg_1 241 244 PF00400 0.346
TRG_ER_diArg_1 475 477 PF00400 0.367
TRG_ER_diArg_1 502 505 PF00400 0.409
TRG_Pf-PMV_PEXEL_1 149 153 PF00026 0.511
TRG_Pf-PMV_PEXEL_1 476 480 PF00026 0.448

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PFB4 Leptomonas seymouri 64% 100%
A0A3Q8I8K7 Leishmania donovani 79% 100%
A0A3Q8ID18 Leishmania donovani 30% 100%
A0A3R7RCD3 Trypanosoma rangeli 36% 100%
A4HU03 Leishmania infantum 79% 100%
A4I131 Leishmania infantum 30% 100%
E9AMT3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 100%
E9AX68 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
Q4QAA8 Leishmania major 30% 100%
Q4QHU2 Leishmania major 79% 100%
V5B864 Trypanosoma cruzi 36% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS