Prefoldin-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

prefoldin subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4H5R2_LEIBR

TriTrypDb:

LbrM.09.0890 , LBRM2903_090014100

Length:

212

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000785	chromatin	2	1
GO:0016592	mediator complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4H5R2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5R2

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0045944	positive regulation of transcription by RNA polymerase II	8	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003712	transcription coregulator activity	2	1
GO:0140110	transcription regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	170	172	PF00675	0.334
CLV_NRD_NRD_1	178	180	PF00675	0.298
CLV_PCSK_KEX2_1	114	116	PF00082	0.726
CLV_PCSK_KEX2_1	178	180	PF00082	0.317
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.709
CLV_PCSK_SKI1_1	167	171	PF00082	0.331
CLV_PCSK_SKI1_1	179	183	PF00082	0.235
CLV_PCSK_SKI1_1	186	190	PF00082	0.161
CLV_PCSK_SKI1_1	196	200	PF00082	0.264
CLV_Separin_Metazoa	187	191	PF03568	0.385
DEG_SCF_FBW7_1	6	12	PF00400	0.643
DOC_CKS1_1	137	142	PF01111	0.453
DOC_CKS1_1	6	11	PF01111	0.645
DOC_CYCLIN_yClb5_NLxxxL_5	38	47	PF00134	0.530
DOC_MAPK_gen_1	126	133	PF00069	0.499
DOC_MAPK_gen_1	184	191	PF00069	0.451
DOC_MAPK_MEF2A_6	126	133	PF00069	0.456
DOC_PP4_FxxP_1	137	140	PF00568	0.453
DOC_USP7_MATH_1	110	114	PF00917	0.641
DOC_USP7_MATH_1	15	19	PF00917	0.646
DOC_USP7_MATH_1	9	13	PF00917	0.640
DOC_USP7_UBL2_3	122	126	PF12436	0.337
DOC_WW_Pin1_4	105	110	PF00397	0.670
DOC_WW_Pin1_4	136	141	PF00397	0.453
DOC_WW_Pin1_4	16	21	PF00397	0.579
DOC_WW_Pin1_4	5	10	PF00397	0.654
DOC_WW_Pin1_4	95	100	PF00397	0.648
LIG_14-3-3_CanoR_1	196	205	PF00244	0.515
LIG_14-3-3_CanoR_1	75	80	PF00244	0.574
LIG_BIR_II_1	1	5	PF00653	0.687
LIG_BIR_III_1	1	5	PF00653	0.506
LIG_BIR_III_3	1	5	PF00653	0.506
LIG_FHA_1	137	143	PF00498	0.529
LIG_FHA_1	197	203	PF00498	0.577
LIG_FHA_2	82	88	PF00498	0.614
LIG_LIR_Apic_2	119	124	PF02991	0.666
LIG_LIR_Gen_1	51	61	PF02991	0.591
LIG_LIR_Gen_1	74	82	PF02991	0.606
LIG_LIR_Nem_3	51	57	PF02991	0.592
LIG_LIR_Nem_3	74	79	PF02991	0.660
LIG_PDZ_Class_2	207	212	PF00595	0.620
LIG_SH2_CRK	121	125	PF00017	0.413
LIG_SH2_CRK	150	154	PF00017	0.453
LIG_SH2_CRK	54	58	PF00017	0.588
LIG_SH2_GRB2like	150	153	PF00017	0.453
LIG_SH2_NCK_1	54	58	PF00017	0.536
LIG_SH2_STAP1	54	58	PF00017	0.537
LIG_SH2_STAT5	138	141	PF00017	0.538
LIG_SH3_3	1	7	PF00018	0.607
LIG_SH3_3	154	160	PF00018	0.469
LIG_SH3_3	8	14	PF00018	0.622
LIG_SH3_4	122	129	PF00018	0.337
LIG_TYR_ITIM	148	153	PF00017	0.295
LIG_WRC_WIRS_1	76	81	PF05994	0.658
MOD_CK1_1	95	101	PF00069	0.619
MOD_CK2_1	159	165	PF00069	0.302
MOD_CK2_1	7	13	PF00069	0.575
MOD_CK2_1	75	81	PF00069	0.634
MOD_GlcNHglycan	145	148	PF01048	0.199
MOD_GlcNHglycan	94	97	PF01048	0.676
MOD_GSK3_1	5	12	PF00069	0.659
MOD_GSK3_1	71	78	PF00069	0.557
MOD_N-GLC_1	105	110	PF02516	0.627
MOD_N-GLC_1	182	187	PF02516	0.413
MOD_NEK2_1	34	39	PF00069	0.497
MOD_NEK2_1	53	58	PF00069	0.564
MOD_NEK2_1	94	99	PF00069	0.605
MOD_PIKK_1	45	51	PF00454	0.553
MOD_PK_1	172	178	PF00069	0.199
MOD_PKA_1	172	178	PF00069	0.355
MOD_PKB_1	194	202	PF00069	0.413
MOD_Plk_4	172	178	PF00069	0.199
MOD_Plk_4	34	40	PF00069	0.496
MOD_Plk_4	75	81	PF00069	0.552
MOD_ProDKin_1	105	111	PF00069	0.671
MOD_ProDKin_1	136	142	PF00069	0.295
MOD_ProDKin_1	16	22	PF00069	0.576
MOD_ProDKin_1	5	11	PF00069	0.649
MOD_ProDKin_1	95	101	PF00069	0.649
TRG_DiLeu_BaEn_2	164	170	PF01217	0.290
TRG_ENDOCYTIC_2	150	153	PF00928	0.295
TRG_ENDOCYTIC_2	54	57	PF00928	0.590
TRG_ENDOCYTIC_2	76	79	PF00928	0.664
TRG_ER_diArg_1	177	179	PF00400	0.413
TRG_ER_diArg_1	193	196	PF00400	0.187
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I625	Leptomonas seymouri	71%	100%
A0A0S4JD64	Bodo saltans	35%	86%
A0A1X0NN73	Trypanosomatidae	40%	100%
A0A3S7WQQ1	Leishmania donovani	88%	99%
A0A422N2I2	Trypanosoma rangeli	44%	100%
A4HU02	Leishmania infantum	88%	99%
D0A9G6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AMT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q4QHU3	Leishmania major	84%	100%