Cilia- and flagella-associated protein 299

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4464), putative

Species:

Leishmania braziliensis

UniProt:

A4H5Q9_LEIBR

TriTrypDb:

LbrM.09.0860 , LBRM2903_090013800

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005737	cytoplasm	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A4H5Q9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5Q9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.471
CLV_C14_Caspase3-7	4	8	PF00656	0.440
CLV_C14_Caspase3-7	87	91	PF00656	0.488
CLV_NRD_NRD_1	191	193	PF00675	0.194
CLV_NRD_NRD_1	229	231	PF00675	0.194
CLV_NRD_NRD_1	42	44	PF00675	0.288
CLV_NRD_NRD_1	74	76	PF00675	0.231
CLV_PCSK_KEX2_1	152	154	PF00082	0.194
CLV_PCSK_KEX2_1	189	191	PF00082	0.194
CLV_PCSK_KEX2_1	229	231	PF00082	0.194
CLV_PCSK_KEX2_1	42	44	PF00082	0.136
CLV_PCSK_KEX2_1	73	75	PF00082	0.222
CLV_PCSK_KEX2_1	99	101	PF00082	0.194
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.225
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.194
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.271
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.225
CLV_PCSK_SKI1_1	100	104	PF00082	0.268
CLV_PCSK_SKI1_1	108	112	PF00082	0.264
CLV_PCSK_SKI1_1	147	151	PF00082	0.207
CLV_PCSK_SKI1_1	52	56	PF00082	0.207
DOC_CYCLIN_RxL_1	144	154	PF00134	0.470
DOC_MAPK_gen_1	105	115	PF00069	0.394
DOC_MAPK_gen_1	187	197	PF00069	0.394
DOC_MAPK_MEF2A_6	216	223	PF00069	0.429
DOC_USP7_MATH_1	151	155	PF00917	0.452
DOC_USP7_MATH_1	178	182	PF00917	0.336
DOC_USP7_MATH_2	204	210	PF00917	0.448
DOC_USP7_UBL2_3	148	152	PF12436	0.440
DOC_USP7_UBL2_3	189	193	PF12436	0.394
DOC_WW_Pin1_4	168	173	PF00397	0.488
DOC_WW_Pin1_4	198	203	PF00397	0.400
DOC_WW_Pin1_4	88	93	PF00397	0.450
LIG_14-3-3_CanoR_1	133	142	PF00244	0.394
LIG_APCC_ABBAyCdc20_2	192	198	PF00400	0.488
LIG_BIR_II_1	1	5	PF00653	0.498
LIG_BRCT_BRCA1_1	135	139	PF00533	0.456
LIG_BRCT_BRCA1_1	170	174	PF00533	0.394
LIG_Clathr_ClatBox_1	32	36	PF01394	0.488
LIG_FHA_1	104	110	PF00498	0.488
LIG_FHA_1	161	167	PF00498	0.394
LIG_FHA_1	171	177	PF00498	0.394
LIG_FHA_1	67	73	PF00498	0.509
LIG_FHA_1	76	82	PF00498	0.459
LIG_FHA_2	16	22	PF00498	0.470
LIG_FHA_2	2	8	PF00498	0.542
LIG_FHA_2	26	32	PF00498	0.394
LIG_KLC1_Yacidic_2	31	36	PF13176	0.450
LIG_LIR_Gen_1	171	182	PF02991	0.415
LIG_LIR_Gen_1	217	224	PF02991	0.347
LIG_LIR_Nem_3	125	130	PF02991	0.422
LIG_LIR_Nem_3	136	142	PF02991	0.422
LIG_LIR_Nem_3	15	19	PF02991	0.405
LIG_LIR_Nem_3	171	177	PF02991	0.415
LIG_LIR_Nem_3	217	221	PF02991	0.347
LIG_Pex14_2	139	143	PF04695	0.394
LIG_SH2_GRB2like	142	145	PF00017	0.404
LIG_SH2_GRB2like	158	161	PF00017	0.394
LIG_SH2_NCK_1	224	228	PF00017	0.398
LIG_SH2_SRC	224	227	PF00017	0.394
LIG_SH2_STAP1	19	23	PF00017	0.422
LIG_SH2_STAT3	22	25	PF00017	0.394
LIG_SH2_STAT5	118	121	PF00017	0.450
LIG_SH2_STAT5	127	130	PF00017	0.418
LIG_SH2_STAT5	142	145	PF00017	0.393
LIG_SH2_STAT5	218	221	PF00017	0.407
LIG_SH2_STAT5	22	25	PF00017	0.394
LIG_SH2_STAT5	34	37	PF00017	0.394
LIG_SH3_3	196	202	PF00018	0.436
LIG_SH3_5	214	218	PF00018	0.448
LIG_TYR_ITIM	222	227	PF00017	0.488
LIG_UBA3_1	93	99	PF00899	0.449
MOD_CK1_1	154	160	PF00069	0.450
MOD_CK1_1	200	206	PF00069	0.380
MOD_CK2_1	200	206	PF00069	0.448
MOD_CK2_1	53	59	PF00069	0.394
MOD_GlcNHglycan	123	127	PF01048	0.196
MOD_GlcNHglycan	82	85	PF01048	0.238
MOD_GSK3_1	75	82	PF00069	0.398
MOD_GSK3_1	88	95	PF00069	0.482
MOD_N-GLC_1	168	173	PF02516	0.194
MOD_N-GLC_1	206	211	PF02516	0.212
MOD_NEK2_1	103	108	PF00069	0.450
MOD_NEK2_1	177	182	PF00069	0.519
MOD_NEK2_1	66	71	PF00069	0.490
MOD_PKA_1	74	80	PF00069	0.473
MOD_PKA_2	74	80	PF00069	0.503
MOD_Plk_1	122	128	PF00069	0.407
MOD_Plk_1	154	160	PF00069	0.412
MOD_Plk_1	178	184	PF00069	0.437
MOD_Plk_2-3	15	21	PF00069	0.390
MOD_Plk_4	108	114	PF00069	0.404
MOD_Plk_4	154	160	PF00069	0.409
MOD_Plk_4	162	168	PF00069	0.433
MOD_ProDKin_1	168	174	PF00069	0.488
MOD_ProDKin_1	198	204	PF00069	0.400
MOD_ProDKin_1	88	94	PF00069	0.450
MOD_SUMO_for_1	98	101	PF00179	0.425
MOD_SUMO_rev_2	140	150	PF00179	0.488
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.407
TRG_ENDOCYTIC_2	218	221	PF00928	0.382
TRG_ENDOCYTIC_2	224	227	PF00928	0.409
TRG_ER_diArg_1	42	44	PF00400	0.336
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.210

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0T4	Leptomonas seymouri	88%	95%
A0A0S4IMY7	Bodo saltans	69%	100%
A0A1X0NN64	Trypanosomatidae	66%	96%
A0A3S5H6D9	Leishmania donovani	92%	88%
A0A422N781	Trypanosoma rangeli	69%	99%
A2AVJ0	Danio rerio	48%	97%
A4HTZ9	Leishmania infantum	93%	88%
D0A9G3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	99%
E9AMS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	93%
Q2YDG2	Bos taurus	50%	100%
Q4QHU6	Leishmania major	92%	100%
Q5PQ44	Xenopus laevis	53%	100%
Q6V702	Homo sapiens	48%	100%
Q810M1	Mus musculus	50%	100%