Prolyl endopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oligopeptidase b

Species:

Leishmania braziliensis

UniProt:

A4H5Q8_LEIBR

TriTrypDb:

LbrM.09.0850 , LBRM2903_090013700

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005829	cytosol	2	1

Expansion

Sequence features

A4H5Q8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5Q8

PDB structure(s): 2xe4_A

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004175	endopeptidase activity	4	12
GO:0004252	serine-type endopeptidase activity	5	12
GO:0008233	peptidase activity	3	12
GO:0008236	serine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0017171	serine hydrolase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0070012	oligopeptidase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	223	227	PF00656	0.540
CLV_NRD_NRD_1	282	284	PF00675	0.277
CLV_NRD_NRD_1	366	368	PF00675	0.275
CLV_NRD_NRD_1	462	464	PF00675	0.441
CLV_NRD_NRD_1	55	57	PF00675	0.303
CLV_PCSK_KEX2_1	366	368	PF00082	0.290
CLV_PCSK_KEX2_1	462	464	PF00082	0.409
CLV_PCSK_KEX2_1	546	548	PF00082	0.301
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.301
CLV_PCSK_SKI1_1	113	117	PF00082	0.306
CLV_PCSK_SKI1_1	463	467	PF00082	0.440
CLV_PCSK_SKI1_1	542	546	PF00082	0.316
CLV_PCSK_SKI1_1	595	599	PF00082	0.372
CLV_PCSK_SKI1_1	672	676	PF00082	0.247
CLV_PCSK_SKI1_1	719	723	PF00082	0.335
CLV_Separin_Metazoa	292	296	PF03568	0.506
DEG_APCC_DBOX_1	366	374	PF00400	0.475
DEG_APCC_DBOX_1	55	63	PF00400	0.406
DOC_CKS1_1	425	430	PF01111	0.464
DOC_CKS1_1	565	570	PF01111	0.330
DOC_MAPK_gen_1	18	25	PF00069	0.537
DOC_MAPK_gen_1	299	307	PF00069	0.414
DOC_MAPK_MEF2A_6	647	656	PF00069	0.341
DOC_PP2B_PxIxI_1	651	657	PF00149	0.395
DOC_PP4_FxxP_1	660	663	PF00568	0.390
DOC_PP4_MxPP_1	38	41	PF00568	0.464
DOC_USP7_MATH_2	331	337	PF00917	0.406
DOC_USP7_UBL2_3	542	546	PF12436	0.301
DOC_USP7_UBL2_3	672	676	PF12436	0.301
DOC_USP7_UBL2_3	701	705	PF12436	0.436
DOC_WW_Pin1_4	424	429	PF00397	0.464
DOC_WW_Pin1_4	564	569	PF00397	0.330
DOC_WW_Pin1_4	638	643	PF00397	0.326
LIG_14-3-3_CanoR_1	262	266	PF00244	0.406
LIG_14-3-3_CanoR_1	372	377	PF00244	0.475
LIG_14-3-3_CanoR_1	441	445	PF00244	0.445
LIG_14-3-3_CanoR_1	462	468	PF00244	0.448
LIG_14-3-3_CanoR_1	547	551	PF00244	0.301
LIG_APCC_ABBA_1	242	247	PF00400	0.464
LIG_APCC_ABBAyCdc20_2	83	89	PF00400	0.566
LIG_BIR_II_1	1	5	PF00653	0.660
LIG_BRCT_BRCA1_1	694	698	PF00533	0.301
LIG_Clathr_ClatBox_1	688	692	PF01394	0.301
LIG_deltaCOP1_diTrp_1	205	215	PF00928	0.467
LIG_deltaCOP1_diTrp_1	621	625	PF00928	0.339
LIG_FHA_1	110	116	PF00498	0.492
LIG_FHA_1	262	268	PF00498	0.460
LIG_FHA_1	272	278	PF00498	0.460
LIG_FHA_1	351	357	PF00498	0.503
LIG_FHA_1	373	379	PF00498	0.481
LIG_FHA_1	400	406	PF00498	0.513
LIG_FHA_1	441	447	PF00498	0.476
LIG_FHA_2	200	206	PF00498	0.502
LIG_FHA_2	217	223	PF00498	0.440
LIG_FHA_2	428	434	PF00498	0.478
LIG_FHA_2	464	470	PF00498	0.434
LIG_FHA_2	547	553	PF00498	0.301
LIG_FHA_2	607	613	PF00498	0.301
LIG_FHA_2	616	622	PF00498	0.334
LIG_LIR_Apic_2	412	416	PF02991	0.561
LIG_LIR_Apic_2	623	628	PF02991	0.330
LIG_LIR_Apic_2	658	663	PF02991	0.220
LIG_LIR_Gen_1	336	343	PF02991	0.515
LIG_LIR_Gen_1	371	380	PF02991	0.506
LIG_LIR_Gen_1	421	428	PF02991	0.495
LIG_LIR_Gen_1	549	557	PF02991	0.301
LIG_LIR_Nem_3	105	111	PF02991	0.458
LIG_LIR_Nem_3	119	123	PF02991	0.490
LIG_LIR_Nem_3	184	188	PF02991	0.573
LIG_LIR_Nem_3	213	218	PF02991	0.445
LIG_LIR_Nem_3	24	28	PF02991	0.427
LIG_LIR_Nem_3	336	341	PF02991	0.490
LIG_LIR_Nem_3	421	425	PF02991	0.500
LIG_LIR_Nem_3	430	434	PF02991	0.461
LIG_LIR_Nem_3	549	553	PF02991	0.301
LIG_LIR_Nem_3	630	636	PF02991	0.301
LIG_LIR_Nem_3	639	643	PF02991	0.301
LIG_LYPXL_yS_3	651	654	PF13949	0.301
LIG_NRP_CendR_1	730	731	PF00754	0.540
LIG_PTB_Apo_2	246	253	PF02174	0.566
LIG_SH2_CRK	123	127	PF00017	0.575
LIG_SH2_CRK	422	426	PF00017	0.566
LIG_SH2_NCK_1	413	417	PF00017	0.524
LIG_SH2_NCK_1	640	644	PF00017	0.259
LIG_SH2_SRC	103	106	PF00017	0.519
LIG_SH2_SRC	27	30	PF00017	0.578
LIG_SH2_SRC	413	416	PF00017	0.518
LIG_SH2_SRC	521	524	PF00017	0.274
LIG_SH2_SRC	537	540	PF00017	0.377
LIG_SH2_SRC	87	90	PF00017	0.496
LIG_SH2_STAP1	111	115	PF00017	0.495
LIG_SH2_STAP1	181	185	PF00017	0.512
LIG_SH2_STAP1	303	307	PF00017	0.475
LIG_SH2_STAP1	422	426	PF00017	0.554
LIG_SH2_STAP1	634	638	PF00017	0.444
LIG_SH2_STAP1	87	91	PF00017	0.556
LIG_SH2_STAT3	303	306	PF00017	0.566
LIG_SH2_STAT5	103	106	PF00017	0.474
LIG_SH2_STAT5	108	111	PF00017	0.503
LIG_SH2_STAT5	123	126	PF00017	0.512
LIG_SH2_STAT5	217	220	PF00017	0.464
LIG_SH2_STAT5	27	30	PF00017	0.529
LIG_SH2_STAT5	360	363	PF00017	0.566
LIG_SH2_STAT5	48	51	PF00017	0.579
LIG_SH2_STAT5	514	517	PF00017	0.327
LIG_SH2_STAT5	543	546	PF00017	0.350
LIG_SH2_STAT5	71	74	PF00017	0.495
LIG_SH3_2	37	42	PF14604	0.488
LIG_SH3_3	101	107	PF00018	0.490
LIG_SH3_3	129	135	PF00018	0.428
LIG_SH3_3	185	191	PF00018	0.406
LIG_SH3_3	325	331	PF00018	0.482
LIG_SH3_3	34	40	PF00018	0.517
LIG_SH3_3	482	488	PF00018	0.412
LIG_SH3_3	610	616	PF00018	0.311
LIG_SUMO_SIM_anti_2	311	317	PF11976	0.457
LIG_SUMO_SIM_anti_2	58	63	PF11976	0.440
LIG_SUMO_SIM_par_1	311	317	PF11976	0.464
LIG_TRAF2_1	162	165	PF00917	0.406
LIG_TYR_ITIM	638	643	PF00017	0.268
LIG_UBA3_1	279	284	PF00899	0.451
LIG_WW_1	40	43	PF00397	0.561
LIG_WW_3	39	43	PF00397	0.475
MOD_CK1_1	269	275	PF00069	0.484
MOD_CK1_1	336	342	PF00069	0.521
MOD_CK1_1	424	430	PF00069	0.475
MOD_CK1_1	440	446	PF00069	0.506
MOD_CK2_1	173	179	PF00069	0.488
MOD_CK2_1	199	205	PF00069	0.566
MOD_CK2_1	216	222	PF00069	0.566
MOD_CK2_1	615	621	PF00069	0.315
MOD_CMANNOS	622	625	PF00535	0.340
MOD_Cter_Amidation	364	367	PF01082	0.275
MOD_GlcNHglycan	174	178	PF01048	0.306
MOD_GlcNHglycan	252	255	PF01048	0.299
MOD_GlcNHglycan	258	261	PF01048	0.289
MOD_GlcNHglycan	576	579	PF01048	0.301
MOD_GlcNHglycan	657	660	PF01048	0.238
MOD_GlcNHglycan	694	697	PF01048	0.301
MOD_GlcNHglycan	698	701	PF01048	0.301
MOD_GlcNHglycan	709	712	PF01048	0.301
MOD_GlcNHglycan	75	78	PF01048	0.412
MOD_GlcNHglycan	9	12	PF01048	0.635
MOD_GlcNHglycan	96	102	PF01048	0.280
MOD_GSK3_1	169	176	PF00069	0.490
MOD_GSK3_1	195	202	PF00069	0.563
MOD_GSK3_1	216	223	PF00069	0.538
MOD_GSK3_1	268	275	PF00069	0.466
MOD_GSK3_1	368	375	PF00069	0.475
MOD_GSK3_1	420	427	PF00069	0.490
MOD_GSK3_1	542	549	PF00069	0.319
MOD_GSK3_1	611	618	PF00069	0.312
MOD_GSK3_1	692	699	PF00069	0.309
MOD_LATS_1	525	531	PF00433	0.444
MOD_N-GLC_1	6	11	PF02516	0.560
MOD_NEK2_1	210	215	PF00069	0.439
MOD_NEK2_1	350	355	PF00069	0.563
MOD_NEK2_1	405	410	PF00069	0.522
MOD_NEK2_1	420	425	PF00069	0.513
MOD_NEK2_1	483	488	PF00069	0.442
MOD_NEK2_1	582	587	PF00069	0.220
MOD_NEK2_1	655	660	PF00069	0.220
MOD_NEK2_1	721	726	PF00069	0.510
MOD_PIKK_1	266	272	PF00454	0.518
MOD_PIKK_1	405	411	PF00454	0.505
MOD_PIKK_1	483	489	PF00454	0.582
MOD_PIKK_1	566	572	PF00454	0.420
MOD_PKA_1	186	192	PF00069	0.561
MOD_PKA_1	546	552	PF00069	0.301
MOD_PKA_2	261	267	PF00069	0.436
MOD_PKA_2	440	446	PF00069	0.445
MOD_PKA_2	546	552	PF00069	0.301
MOD_Plk_1	210	216	PF00069	0.506
MOD_Plk_1	220	226	PF00069	0.518
MOD_Plk_1	336	342	PF00069	0.590
MOD_Plk_1	420	426	PF00069	0.547
MOD_Plk_4	211	217	PF00069	0.516
MOD_Plk_4	427	433	PF00069	0.478
MOD_Plk_4	473	479	PF00069	0.374
MOD_Plk_4	582	588	PF00069	0.220
MOD_ProDKin_1	424	430	PF00069	0.464
MOD_ProDKin_1	564	570	PF00069	0.330
MOD_ProDKin_1	638	644	PF00069	0.326
MOD_SUMO_for_1	127	130	PF00179	0.406
MOD_SUMO_rev_2	179	188	PF00179	0.566
MOD_SUMO_rev_2	221	229	PF00179	0.475
MOD_SUMO_rev_2	393	399	PF00179	0.433
MOD_SUMO_rev_2	498	508	PF00179	0.358
MOD_SUMO_rev_2	558	566	PF00179	0.305
TRG_ENDOCYTIC_2	123	126	PF00928	0.571
TRG_ENDOCYTIC_2	360	363	PF00928	0.545
TRG_ENDOCYTIC_2	422	425	PF00928	0.464
TRG_ENDOCYTIC_2	48	51	PF00928	0.566
TRG_ENDOCYTIC_2	634	637	PF00928	0.312
TRG_ENDOCYTIC_2	640	643	PF00928	0.317
TRG_ENDOCYTIC_2	651	654	PF00928	0.301
TRG_ER_diArg_1	294	297	PF00400	0.444
TRG_ER_diArg_1	462	464	PF00400	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J4	Leptomonas seymouri	83%	100%
A0A0S4IIS9	Bodo saltans	24%	100%
A0A0S4J065	Bodo saltans	25%	79%
A0A0S4JND1	Bodo saltans	57%	98%
A0A1X0NKN5	Trypanosomatidae	24%	80%
A0A1X0NMH6	Trypanosomatidae	66%	100%
A0A3Q8IGZ3	Leishmania donovani	87%	100%
A0A3Q8IJI4	Leishmania donovani	24%	100%
A0A3S5H5P5	Leishmania donovani	24%	81%
A0A422N761	Trypanosoma rangeli	65%	100%
A4H4J9	Leishmania braziliensis	25%	81%
A4HSS5	Leishmania infantum	24%	81%
A4HTZ8	Leishmania infantum	87%	100%
A4ICB5	Leishmania infantum	24%	100%
A5LFV8	Macaca fascicularis	25%	100%
C9ZTC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	81%
D0A9G2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E2JFG1	Amanita bisporigera	23%	96%
E2JFG2	Amanita bisporigera	25%	100%
E9AKR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	81%
E9AMS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
E9AUB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
H2E7Q7	Galerina marginata (strain CBS 339.88)	24%	99%
H2E7Q8	Galerina marginata (strain CBS 339.88)	25%	100%
O07834	Pseudoxanthomonas mexicana	37%	100%
O70196	Rattus norvegicus	26%	100%
P23687	Sus scrofa	26%	100%
P24555	Escherichia coli (strain K12)	35%	100%
P27028	Elizabethkingia meningoseptica	26%	100%
P27195	Elizabethkingia miricola	26%	100%
P48147	Homo sapiens	26%	100%
P55627	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	26%	97%
P55656	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	27%	100%
Q06903	Aeromonas hydrophila	27%	100%
Q4J6C6	Homo sapiens	25%	100%
Q4Q080	Leishmania major	24%	98%
Q4QHU7	Leishmania major	86%	100%
Q4QJ45	Leishmania major	24%	100%
Q59536	Moraxella lacunata	37%	100%
Q5HZA6	Rattus norvegicus	25%	100%
Q5RAK4	Pongo abelii	25%	100%
Q8C167	Mus musculus	25%	100%
Q9QUR6	Mus musculus	26%	100%
Q9XTA2	Bos taurus	26%	100%
V5B5S3	Trypanosoma cruzi	25%	85%
V5B860	Trypanosoma cruzi	64%	100%