Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5Q2_LEIBR

TriTrypDb:

LbrM.09.0790 , LBRM2903_090013100

Length:

534

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5Q2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5Q2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	324	328	PF00656	0.735
CLV_C14_Caspase3-7	416	420	PF00656	0.514
CLV_NRD_NRD_1	216	218	PF00675	0.553
CLV_NRD_NRD_1	330	332	PF00675	0.591
CLV_NRD_NRD_1	334	336	PF00675	0.585
CLV_NRD_NRD_1	434	436	PF00675	0.455
CLV_NRD_NRD_1	48	50	PF00675	0.578
CLV_NRD_NRD_1	60	62	PF00675	0.609
CLV_PCSK_KEX2_1	216	218	PF00082	0.555
CLV_PCSK_KEX2_1	330	332	PF00082	0.591
CLV_PCSK_KEX2_1	334	336	PF00082	0.577
CLV_PCSK_KEX2_1	373	375	PF00082	0.774
CLV_PCSK_KEX2_1	434	436	PF00082	0.455
CLV_PCSK_KEX2_1	467	469	PF00082	0.374
CLV_PCSK_KEX2_1	48	50	PF00082	0.578
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.774
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.374
CLV_PCSK_PC7_1	330	336	PF00082	0.526
CLV_PCSK_PC7_1	463	469	PF00082	0.377
CLV_PCSK_SKI1_1	111	115	PF00082	0.524
CLV_PCSK_SKI1_1	118	122	PF00082	0.504
CLV_PCSK_SKI1_1	207	211	PF00082	0.561
CLV_PCSK_SKI1_1	216	220	PF00082	0.582
CLV_PCSK_SKI1_1	229	233	PF00082	0.506
CLV_PCSK_SKI1_1	48	52	PF00082	0.573
CLV_PCSK_SKI1_1	482	486	PF00082	0.439
DEG_COP1_1	237	249	PF00400	0.503
DEG_ODPH_VHL_1	271	284	PF01847	0.599
DEG_SCF_FBW7_1	152	158	PF00400	0.558
DEG_SPOP_SBC_1	299	303	PF00917	0.532
DOC_CKS1_1	14	19	PF01111	0.528
DOC_CKS1_1	152	157	PF01111	0.555
DOC_CKS1_1	392	397	PF01111	0.788
DOC_MAPK_gen_1	10	20	PF00069	0.544
DOC_MAPK_MEF2A_6	497	506	PF00069	0.482
DOC_MAPK_NFAT4_5	501	509	PF00069	0.488
DOC_PP1_RVXF_1	203	209	PF00149	0.533
DOC_USP7_MATH_1	155	159	PF00917	0.755
DOC_USP7_MATH_1	26	30	PF00917	0.784
DOC_USP7_MATH_1	275	279	PF00917	0.735
DOC_USP7_MATH_1	299	303	PF00917	0.662
DOC_USP7_MATH_1	304	308	PF00917	0.592
DOC_USP7_MATH_1	312	316	PF00917	0.472
DOC_USP7_MATH_1	34	38	PF00917	0.604
DOC_USP7_MATH_1	39	43	PF00917	0.483
DOC_USP7_MATH_1	66	70	PF00917	0.577
DOC_WW_Pin1_4	13	18	PF00397	0.627
DOC_WW_Pin1_4	151	156	PF00397	0.555
DOC_WW_Pin1_4	168	173	PF00397	0.681
DOC_WW_Pin1_4	209	214	PF00397	0.550
DOC_WW_Pin1_4	24	29	PF00397	0.653
DOC_WW_Pin1_4	271	276	PF00397	0.621
DOC_WW_Pin1_4	292	297	PF00397	0.643
DOC_WW_Pin1_4	391	396	PF00397	0.682
DOC_WW_Pin1_4	67	72	PF00397	0.682
DOC_WW_Pin1_4	80	85	PF00397	0.643
LIG_14-3-3_CanoR_1	111	117	PF00244	0.514
LIG_14-3-3_CanoR_1	135	140	PF00244	0.518
LIG_14-3-3_CanoR_1	207	213	PF00244	0.551
LIG_14-3-3_CanoR_1	48	55	PF00244	0.575
LIG_14-3-3_CanoR_1	87	97	PF00244	0.685
LIG_APCC_ABBA_1	515	520	PF00400	0.660
LIG_APCC_ABBAyCdc20_2	514	520	PF00400	0.660
LIG_BRCT_BRCA1_1	163	167	PF00533	0.608
LIG_CtBP_PxDLS_1	456	460	PF00389	0.664
LIG_FHA_1	101	107	PF00498	0.670
LIG_FHA_1	121	127	PF00498	0.456
LIG_FHA_1	174	180	PF00498	0.647
LIG_FHA_1	49	55	PF00498	0.573
LIG_FHA_2	401	407	PF00498	0.774
LIG_FHA_2	481	487	PF00498	0.508
LIG_LIR_Apic_2	241	247	PF02991	0.523
LIG_LIR_Gen_1	142	152	PF02991	0.514
LIG_LIR_Gen_1	349	360	PF02991	0.657
LIG_LIR_Gen_1	470	481	PF02991	0.482
LIG_LIR_Nem_3	142	147	PF02991	0.513
LIG_LIR_Nem_3	349	355	PF02991	0.644
LIG_LIR_Nem_3	470	476	PF02991	0.478
LIG_SH2_PTP2	244	247	PF00017	0.504
LIG_SH2_STAT3	360	363	PF00017	0.508
LIG_SH2_STAT5	15	18	PF00017	0.579
LIG_SH2_STAT5	244	247	PF00017	0.551
LIG_SH2_STAT5	360	363	PF00017	0.508
LIG_SH2_STAT5	437	440	PF00017	0.455
LIG_SH3_3	146	152	PF00018	0.543
LIG_SH3_3	157	163	PF00018	0.564
LIG_SH3_3	174	180	PF00018	0.694
LIG_SH3_3	260	266	PF00018	0.592
LIG_SH3_3	389	395	PF00018	0.658
LIG_SH3_3	65	71	PF00018	0.695
LIG_SH3_3	72	78	PF00018	0.647
LIG_SH3_3	83	89	PF00018	0.581
LIG_SUMO_SIM_par_1	418	427	PF11976	0.394
LIG_SUMO_SIM_par_1	452	461	PF11976	0.653
LIG_TRAF2_1	404	407	PF00917	0.676
MOD_CDK_SPK_2	168	173	PF00069	0.673
MOD_CDK_SPK_2	271	276	PF00069	0.742
MOD_CDK_SPK_2	292	297	PF00069	0.556
MOD_CDK_SPxK_1	13	19	PF00069	0.527
MOD_CDK_SPxxK_3	209	216	PF00069	0.545
MOD_CDK_SPxxK_3	80	87	PF00069	0.592
MOD_CK1_1	158	164	PF00069	0.795
MOD_CK1_1	168	174	PF00069	0.646
MOD_CK1_1	238	244	PF00069	0.751
MOD_CK1_1	29	35	PF00069	0.681
MOD_CK1_1	295	301	PF00069	0.735
MOD_CK1_1	315	321	PF00069	0.490
MOD_CK1_1	88	94	PF00069	0.798
MOD_CK2_1	137	143	PF00069	0.738
MOD_CK2_1	150	156	PF00069	0.587
MOD_CK2_1	271	277	PF00069	0.712
MOD_CK2_1	400	406	PF00069	0.701
MOD_CK2_1	447	453	PF00069	0.615
MOD_CK2_1	455	461	PF00069	0.627
MOD_CK2_1	480	486	PF00069	0.507
MOD_Cter_Amidation	214	217	PF01082	0.552
MOD_DYRK1A_RPxSP_1	173	177	PF00069	0.764
MOD_GlcNHglycan	118	121	PF01048	0.592
MOD_GlcNHglycan	139	142	PF01048	0.651
MOD_GlcNHglycan	156	160	PF01048	0.659
MOD_GlcNHglycan	167	170	PF01048	0.689
MOD_GlcNHglycan	241	244	PF01048	0.685
MOD_GlcNHglycan	28	31	PF01048	0.791
MOD_GlcNHglycan	289	293	PF01048	0.727
MOD_GlcNHglycan	297	300	PF01048	0.718
MOD_GlcNHglycan	36	39	PF01048	0.616
MOD_GlcNHglycan	431	434	PF01048	0.390
MOD_GlcNHglycan	449	452	PF01048	0.432
MOD_GlcNHglycan	490	493	PF01048	0.500
MOD_GSK3_1	112	119	PF00069	0.508
MOD_GSK3_1	135	142	PF00069	0.707
MOD_GSK3_1	151	158	PF00069	0.540
MOD_GSK3_1	161	168	PF00069	0.536
MOD_GSK3_1	20	27	PF00069	0.674
MOD_GSK3_1	234	241	PF00069	0.542
MOD_GSK3_1	271	278	PF00069	0.738
MOD_GSK3_1	288	295	PF00069	0.523
MOD_GSK3_1	299	306	PF00069	0.604
MOD_GSK3_1	34	41	PF00069	0.581
MOD_GSK3_1	386	393	PF00069	0.683
MOD_N-GLC_1	239	244	PF02516	0.568
MOD_N-GLC_1	292	297	PF02516	0.556
MOD_N-GLC_1	315	320	PF02516	0.516
MOD_NEK2_1	112	117	PF00069	0.505
MOD_NEK2_1	167	172	PF00069	0.601
MOD_NEK2_1	251	256	PF00069	0.474
MOD_PK_1	374	380	PF00069	0.546
MOD_PKA_1	373	379	PF00069	0.544
MOD_PKA_1	467	473	PF00069	0.595
MOD_PKA_1	48	54	PF00069	0.574
MOD_PKA_2	1	7	PF00069	0.536
MOD_PKA_2	275	281	PF00069	0.508
MOD_PKA_2	287	293	PF00069	0.498
MOD_PKA_2	373	379	PF00069	0.554
MOD_PKA_2	467	473	PF00069	0.380
MOD_PKA_2	48	54	PF00069	0.574
MOD_PKB_1	205	213	PF00069	0.682
MOD_PKB_1	227	235	PF00069	0.492
MOD_Plk_1	155	161	PF00069	0.792
MOD_Plk_1	239	245	PF00069	0.523
MOD_Plk_1	276	282	PF00069	0.509
MOD_Plk_1	374	380	PF00069	0.546
MOD_Plk_2-3	198	204	PF00069	0.566
MOD_Plk_4	256	262	PF00069	0.628
MOD_Plk_4	304	310	PF00069	0.508
MOD_ProDKin_1	13	19	PF00069	0.630
MOD_ProDKin_1	151	157	PF00069	0.555
MOD_ProDKin_1	168	174	PF00069	0.679
MOD_ProDKin_1	209	215	PF00069	0.543
MOD_ProDKin_1	24	30	PF00069	0.653
MOD_ProDKin_1	271	277	PF00069	0.619
MOD_ProDKin_1	292	298	PF00069	0.643
MOD_ProDKin_1	391	397	PF00069	0.681
MOD_ProDKin_1	67	73	PF00069	0.682
MOD_ProDKin_1	80	86	PF00069	0.644
MOD_SUMO_for_1	372	375	PF00179	0.769
TRG_DiLeu_BaEn_1	143	148	PF01217	0.515
TRG_DiLeu_BaEn_4	332	338	PF01217	0.712
TRG_DiLeu_LyEn_5	520	525	PF01217	0.674
TRG_ENDOCYTIC_2	15	18	PF00928	0.532
TRG_ENDOCYTIC_2	473	476	PF00928	0.484
TRG_ER_diArg_1	205	208	PF00400	0.685
TRG_ER_diArg_1	319	322	PF00400	0.612
TRG_ER_diArg_1	329	331	PF00400	0.569
TRG_ER_diArg_1	48	50	PF00400	0.578
TRG_ER_diArg_1	55	58	PF00400	0.584
TRG_Pf-PMV_PEXEL_1	335	340	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	441	445	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILK1	Leptomonas seymouri	38%	100%
A0A3S7WQP0	Leishmania donovani	72%	100%
A4HTZ2	Leishmania infantum	72%	100%
E9AMS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QHV3	Leishmania major	72%	100%