Zeta toxin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Zeta toxin

Gene product:

Zeta toxin, putative

Species:

Leishmania braziliensis

UniProt:

A4H5P6_LEIBR

TriTrypDb:

LbrM.09.0730 , LBRM2903_090012200

Length:

637

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5P6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5P6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	4
GO:0003824	catalytic activity	1	4
GO:0005488	binding	1	4
GO:0005524	ATP binding	5	4
GO:0016301	kinase activity	4	4
GO:0016740	transferase activity	2	4
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	4
GO:0017076	purine nucleotide binding	4	4
GO:0030554	adenyl nucleotide binding	5	4
GO:0032553	ribonucleotide binding	3	4
GO:0032555	purine ribonucleotide binding	4	4
GO:0032559	adenyl ribonucleotide binding	5	4
GO:0035639	purine ribonucleoside triphosphate binding	4	4
GO:0036094	small molecule binding	2	4
GO:0043167	ion binding	2	4
GO:0043168	anion binding	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:0097367	carbohydrate derivative binding	2	4
GO:1901265	nucleoside phosphate binding	3	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	568	572	PF00656	0.645
CLV_NRD_NRD_1	328	330	PF00675	0.439
CLV_NRD_NRD_1	478	480	PF00675	0.688
CLV_NRD_NRD_1	481	483	PF00675	0.743
CLV_NRD_NRD_1	598	600	PF00675	0.656
CLV_PCSK_FUR_1	476	480	PF00082	0.527
CLV_PCSK_KEX2_1	328	330	PF00082	0.465
CLV_PCSK_KEX2_1	347	349	PF00082	0.512
CLV_PCSK_KEX2_1	478	480	PF00082	0.703
CLV_PCSK_KEX2_1	481	483	PF00082	0.669
CLV_PCSK_KEX2_1	598	600	PF00082	0.656
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.377
CLV_PCSK_PC7_1	324	330	PF00082	0.399
CLV_PCSK_PC7_1	594	600	PF00082	0.566
CLV_PCSK_SKI1_1	167	171	PF00082	0.333
CLV_PCSK_SKI1_1	197	201	PF00082	0.327
CLV_PCSK_SKI1_1	250	254	PF00082	0.460
CLV_PCSK_SKI1_1	390	394	PF00082	0.366
CLV_PCSK_SKI1_1	426	430	PF00082	0.448
CLV_PCSK_SKI1_1	465	469	PF00082	0.492
CLV_PCSK_SKI1_1	482	486	PF00082	0.637
CLV_PCSK_SKI1_1	552	556	PF00082	0.636
CLV_PCSK_SKI1_1	79	83	PF00082	0.382
DEG_APCC_DBOX_1	73	81	PF00400	0.467
DEG_SCF_FBW7_1	128	135	PF00400	0.648
DEG_SCF_FBW7_1	609	614	PF00400	0.563
DEG_SPOP_SBC_1	106	110	PF00917	0.369
DEG_SPOP_SBC_1	487	491	PF00917	0.494
DOC_CYCLIN_RxL_1	549	556	PF00134	0.620
DOC_CYCLIN_yCln2_LP_2	116	122	PF00134	0.551
DOC_CYCLIN_yCln2_LP_2	140	146	PF00134	0.543
DOC_MAPK_DCC_7	138	148	PF00069	0.546
DOC_MAPK_gen_1	328	334	PF00069	0.369
DOC_MAPK_gen_1	347	353	PF00069	0.357
DOC_MAPK_gen_1	465	474	PF00069	0.516
DOC_MAPK_gen_1	540	549	PF00069	0.748
DOC_MAPK_MEF2A_6	138	146	PF00069	0.560
DOC_MAPK_MEF2A_6	212	219	PF00069	0.453
DOC_MAPK_MEF2A_6	355	363	PF00069	0.338
DOC_MAPK_RevD_3	313	329	PF00069	0.380
DOC_MAPK_RevD_3	332	348	PF00069	0.352
DOC_PP2B_LxvP_1	11	14	PF13499	0.521
DOC_PP2B_LxvP_1	116	119	PF13499	0.511
DOC_PP2B_LxvP_1	140	143	PF13499	0.548
DOC_PP2B_LxvP_1	170	173	PF13499	0.396
DOC_PP2B_LxvP_1	238	241	PF13499	0.403
DOC_USP7_MATH_1	111	115	PF00917	0.446
DOC_USP7_MATH_1	207	211	PF00917	0.573
DOC_USP7_MATH_1	225	229	PF00917	0.205
DOC_USP7_MATH_1	487	491	PF00917	0.535
DOC_USP7_MATH_1	526	530	PF00917	0.612
DOC_USP7_MATH_1	6	10	PF00917	0.541
DOC_USP7_MATH_1	611	615	PF00917	0.718
DOC_USP7_UBL2_3	179	183	PF12436	0.322
DOC_USP7_UBL2_3	501	505	PF12436	0.527
DOC_WW_Pin1_4	128	133	PF00397	0.611
DOC_WW_Pin1_4	43	48	PF00397	0.672
DOC_WW_Pin1_4	607	612	PF00397	0.644
LIG_14-3-3_CanoR_1	38	47	PF00244	0.550
LIG_14-3-3_CanoR_1	380	385	PF00244	0.540
LIG_14-3-3_CanoR_1	482	492	PF00244	0.598
LIG_14-3-3_CanoR_1	540	549	PF00244	0.589
LIG_14-3-3_CanoR_1	57	65	PF00244	0.629
LIG_14-3-3_CanoR_1	598	605	PF00244	0.696
LIG_14-3-3_CanoR_1	74	78	PF00244	0.329
LIG_14-3-3_CanoR_1	8	12	PF00244	0.517
LIG_14-3-3_CanoR_1	92	99	PF00244	0.423
LIG_AP2alpha_2	511	513	PF02296	0.510
LIG_BRCT_BRCA1_1	68	72	PF00533	0.384
LIG_FHA_1	129	135	PF00498	0.512
LIG_FHA_1	244	250	PF00498	0.318
LIG_FHA_1	458	464	PF00498	0.596
LIG_FHA_1	487	493	PF00498	0.497
LIG_FHA_2	420	426	PF00498	0.532
LIG_FHA_2	432	438	PF00498	0.478
LIG_FHA_2	46	52	PF00498	0.506
LIG_GBD_Chelix_1	230	238	PF00786	0.235
LIG_HP1_1	119	123	PF01393	0.520
LIG_LIR_Gen_1	425	436	PF02991	0.408
LIG_LIR_Gen_1	624	634	PF02991	0.610
LIG_LIR_Nem_3	261	267	PF02991	0.334
LIG_LIR_Nem_3	27	32	PF02991	0.486
LIG_LIR_Nem_3	393	398	PF02991	0.399
LIG_LIR_Nem_3	425	431	PF02991	0.418
LIG_LIR_Nem_3	511	516	PF02991	0.600
LIG_LIR_Nem_3	624	629	PF02991	0.618
LIG_LIR_Nem_3	69	75	PF02991	0.455
LIG_LYPXL_yS_3	264	267	PF13949	0.228
LIG_NRBOX	229	235	PF00104	0.235
LIG_NRBOX	321	327	PF00104	0.422
LIG_NRBOX	98	104	PF00104	0.471
LIG_SH2_STAP1	107	111	PF00017	0.533
LIG_SH2_STAT3	168	171	PF00017	0.343
LIG_SH2_STAT3	307	310	PF00017	0.318
LIG_SH2_STAT5	107	110	PF00017	0.548
LIG_SH2_STAT5	168	171	PF00017	0.459
LIG_SH2_STAT5	343	346	PF00017	0.362
LIG_SH2_STAT5	391	394	PF00017	0.437
LIG_SH2_STAT5	75	78	PF00017	0.466
LIG_SH3_3	139	145	PF00018	0.552
LIG_SH3_3	14	20	PF00018	0.503
LIG_SH3_3	360	366	PF00018	0.356
LIG_SH3_3	445	451	PF00018	0.524
LIG_SH3_3	626	632	PF00018	0.664
LIG_SUMO_SIM_par_1	118	127	PF11976	0.543
LIG_SUMO_SIM_par_1	144	150	PF11976	0.521
LIG_SUMO_SIM_par_1	412	420	PF11976	0.413
LIG_WRC_WIRS_1	392	397	PF05994	0.414
LIG_WW_3	537	541	PF00397	0.517
MOD_CK1_1	163	169	PF00069	0.400
MOD_CK1_1	245	251	PF00069	0.405
MOD_CK1_1	43	49	PF00069	0.714
MOD_CK1_1	483	489	PF00069	0.639
MOD_CK1_1	490	496	PF00069	0.630
MOD_CK1_1	531	537	PF00069	0.604
MOD_CK1_1	588	594	PF00069	0.572
MOD_CK1_1	600	606	PF00069	0.711
MOD_CK1_1	607	613	PF00069	0.648
MOD_CK1_1	67	73	PF00069	0.509
MOD_CK2_1	18	24	PF00069	0.561
MOD_CK2_1	267	273	PF00069	0.318
MOD_CK2_1	367	373	PF00069	0.495
MOD_CK2_1	431	437	PF00069	0.479
MOD_CK2_1	45	51	PF00069	0.725
MOD_CK2_1	598	604	PF00069	0.562
MOD_GlcNHglycan	103	106	PF01048	0.488
MOD_GlcNHglycan	111	114	PF01048	0.507
MOD_GlcNHglycan	155	158	PF01048	0.535
MOD_GlcNHglycan	209	212	PF01048	0.538
MOD_GlcNHglycan	222	225	PF01048	0.275
MOD_GlcNHglycan	283	287	PF01048	0.467
MOD_GlcNHglycan	482	485	PF01048	0.681
MOD_GlcNHglycan	497	500	PF01048	0.715
MOD_GlcNHglycan	542	545	PF01048	0.588
MOD_GlcNHglycan	578	581	PF01048	0.609
MOD_GlcNHglycan	66	69	PF01048	0.481
MOD_GSK3_1	101	108	PF00069	0.432
MOD_GSK3_1	124	131	PF00069	0.546
MOD_GSK3_1	173	180	PF00069	0.485
MOD_GSK3_1	39	46	PF00069	0.598
MOD_GSK3_1	405	412	PF00069	0.323
MOD_GSK3_1	431	438	PF00069	0.410
MOD_GSK3_1	482	489	PF00069	0.669
MOD_GSK3_1	526	533	PF00069	0.528
MOD_GSK3_1	560	567	PF00069	0.761
MOD_GSK3_1	571	578	PF00069	0.639
MOD_GSK3_1	584	591	PF00069	0.553
MOD_GSK3_1	600	607	PF00069	0.661
MOD_GSK3_1	612	619	PF00069	0.818
MOD_GSK3_1	630	637	PF00069	0.608
MOD_GSK3_1	64	71	PF00069	0.443
MOD_LATS_1	562	568	PF00433	0.518
MOD_N-GLC_1	43	48	PF02516	0.516
MOD_N-GLC_1	487	492	PF02516	0.653
MOD_NEK2_1	133	138	PF00069	0.703
MOD_NEK2_1	152	157	PF00069	0.485
MOD_NEK2_1	233	238	PF00069	0.318
MOD_NEK2_1	267	272	PF00069	0.325
MOD_NEK2_1	351	356	PF00069	0.468
MOD_NEK2_1	417	422	PF00069	0.424
MOD_NEK2_1	424	429	PF00069	0.289
MOD_NEK2_1	492	497	PF00069	0.534
MOD_NEK2_1	584	589	PF00069	0.586
MOD_NEK2_2	391	396	PF00069	0.487
MOD_PIKK_1	160	166	PF00454	0.616
MOD_PIKK_1	233	239	PF00454	0.318
MOD_PK_1	18	24	PF00069	0.419
MOD_PK_1	328	334	PF00069	0.369
MOD_PKA_1	328	334	PF00069	0.396
MOD_PKA_1	598	604	PF00069	0.593
MOD_PKA_2	153	159	PF00069	0.462
MOD_PKA_2	328	334	PF00069	0.396
MOD_PKA_2	480	486	PF00069	0.596
MOD_PKA_2	584	590	PF00069	0.555
MOD_PKA_2	597	603	PF00069	0.770
MOD_PKA_2	7	13	PF00069	0.577
MOD_PKA_2	73	79	PF00069	0.320
MOD_PKA_2	91	97	PF00069	0.569
MOD_PKB_1	378	386	PF00069	0.516
MOD_Plk_1	409	415	PF00069	0.340
MOD_Plk_1	424	430	PF00069	0.425
MOD_Plk_1	487	493	PF00069	0.497
MOD_Plk_4	177	183	PF00069	0.315
MOD_Plk_4	24	30	PF00069	0.429
MOD_Plk_4	328	334	PF00069	0.387
MOD_Plk_4	431	437	PF00069	0.431
MOD_Plk_4	571	577	PF00069	0.699
MOD_Plk_4	630	636	PF00069	0.689
MOD_ProDKin_1	128	134	PF00069	0.614
MOD_ProDKin_1	43	49	PF00069	0.681
MOD_ProDKin_1	607	613	PF00069	0.645
MOD_SUMO_for_1	366	369	PF00179	0.335
MOD_SUMO_rev_2	600	607	PF00179	0.555
TRG_DiLeu_BaEn_1	335	340	PF01217	0.380
TRG_DiLeu_BaEn_1	630	635	PF01217	0.691
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.466
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.375
TRG_ENDOCYTIC_2	264	267	PF00928	0.228
TRG_ER_diArg_1	253	256	PF00400	0.318
TRG_ER_diArg_1	377	380	PF00400	0.471
TRG_ER_diArg_1	475	478	PF00400	0.584
TRG_ER_diArg_1	479	482	PF00400	0.682
TRG_ER_diArg_1	539	542	PF00400	0.781
TRG_ER_diArg_1	597	599	PF00400	0.747
TRG_NES_CRM1_1	509	521	PF08389	0.510
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.333
TRG_Pf-PMV_PEXEL_1	552	556	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I622	Leptomonas seymouri	46%	96%
A0A3S5H6D7	Leishmania donovani	78%	100%
A4HTY6	Leishmania infantum	78%	100%
E9AMR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QHV9	Leishmania major	77%	97%