Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5P3_LEIBR

TriTrypDb:

LbrM.09.0700 , LBRM2903_090011900

Length:

781

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5P3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5P3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.578
CLV_C14_Caspase3-7	204	208	PF00656	0.732
CLV_C14_Caspase3-7	497	501	PF00656	0.553
CLV_C14_Caspase3-7	655	659	PF00656	0.523
CLV_C14_Caspase3-7	774	778	PF00656	0.574
CLV_NRD_NRD_1	186	188	PF00675	0.749
CLV_NRD_NRD_1	348	350	PF00675	0.692
CLV_NRD_NRD_1	476	478	PF00675	0.457
CLV_NRD_NRD_1	507	509	PF00675	0.518
CLV_NRD_NRD_1	601	603	PF00675	0.532
CLV_NRD_NRD_1	644	646	PF00675	0.646
CLV_NRD_NRD_1	765	767	PF00675	0.643
CLV_NRD_NRD_1	81	83	PF00675	0.738
CLV_PCSK_FUR_1	522	526	PF00082	0.762
CLV_PCSK_KEX2_1	150	152	PF00082	0.802
CLV_PCSK_KEX2_1	185	187	PF00082	0.760
CLV_PCSK_KEX2_1	348	350	PF00082	0.692
CLV_PCSK_KEX2_1	476	478	PF00082	0.457
CLV_PCSK_KEX2_1	507	509	PF00082	0.516
CLV_PCSK_KEX2_1	524	526	PF00082	0.616
CLV_PCSK_KEX2_1	601	603	PF00082	0.557
CLV_PCSK_KEX2_1	644	646	PF00082	0.646
CLV_PCSK_KEX2_1	767	769	PF00082	0.586
CLV_PCSK_KEX2_1	81	83	PF00082	0.730
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.802
CLV_PCSK_PC1ET2_1	524	526	PF00082	0.767
CLV_PCSK_PC1ET2_1	767	769	PF00082	0.586
CLV_PCSK_SKI1_1	102	106	PF00082	0.587
CLV_PCSK_SKI1_1	156	160	PF00082	0.534
CLV_PCSK_SKI1_1	229	233	PF00082	0.515
CLV_PCSK_SKI1_1	260	264	PF00082	0.540
DEG_SCF_TRCP1_1	112	118	PF00400	0.571
DEG_SPOP_SBC_1	64	68	PF00917	0.634
DOC_CDC14_PxL_1	218	226	PF14671	0.470
DOC_CKS1_1	11	16	PF01111	0.551
DOC_CKS1_1	436	441	PF01111	0.654
DOC_CKS1_1	621	626	PF01111	0.527
DOC_CKS1_1	639	644	PF01111	0.612
DOC_MAPK_gen_1	522	529	PF00069	0.511
DOC_PP1_RVXF_1	765	772	PF00149	0.705
DOC_PP4_FxxP_1	741	744	PF00568	0.700
DOC_USP7_MATH_1	110	114	PF00917	0.652
DOC_USP7_MATH_1	142	146	PF00917	0.562
DOC_USP7_MATH_1	197	201	PF00917	0.543
DOC_USP7_MATH_1	26	30	PF00917	0.688
DOC_USP7_MATH_1	42	46	PF00917	0.632
DOC_USP7_MATH_1	420	424	PF00917	0.655
DOC_USP7_MATH_1	56	60	PF00917	0.620
DOC_USP7_MATH_1	648	652	PF00917	0.679
DOC_USP7_MATH_1	73	77	PF00917	0.514
DOC_USP7_UBL2_3	246	250	PF12436	0.544
DOC_WW_Pin1_4	10	15	PF00397	0.554
DOC_WW_Pin1_4	118	123	PF00397	0.727
DOC_WW_Pin1_4	324	329	PF00397	0.686
DOC_WW_Pin1_4	336	341	PF00397	0.754
DOC_WW_Pin1_4	342	347	PF00397	0.698
DOC_WW_Pin1_4	361	366	PF00397	0.577
DOC_WW_Pin1_4	435	440	PF00397	0.643
DOC_WW_Pin1_4	593	598	PF00397	0.392
DOC_WW_Pin1_4	60	65	PF00397	0.681
DOC_WW_Pin1_4	620	625	PF00397	0.523
DOC_WW_Pin1_4	638	643	PF00397	0.612
LIG_14-3-3_CanoR_1	102	111	PF00244	0.618
LIG_14-3-3_CanoR_1	127	132	PF00244	0.558
LIG_14-3-3_CanoR_1	187	197	PF00244	0.657
LIG_14-3-3_CanoR_1	239	245	PF00244	0.610
LIG_14-3-3_CanoR_1	27	31	PF00244	0.556
LIG_14-3-3_CanoR_1	307	311	PF00244	0.660
LIG_14-3-3_CanoR_1	348	355	PF00244	0.690
LIG_14-3-3_CanoR_1	395	404	PF00244	0.574
LIG_14-3-3_CanoR_1	476	486	PF00244	0.374
LIG_14-3-3_CanoR_1	569	575	PF00244	0.672
LIG_14-3-3_CanoR_1	62	72	PF00244	0.676
LIG_14-3-3_CanoR_1	733	737	PF00244	0.675
LIG_Actin_WH2_2	244	262	PF00022	0.540
LIG_Actin_WH2_2	719	735	PF00022	0.641
LIG_BIR_III_2	669	673	PF00653	0.476
LIG_BRCT_BRCA1_1	338	342	PF00533	0.583
LIG_BRCT_BRCA1_1	380	384	PF00533	0.427
LIG_BRCT_BRCA1_1	696	700	PF00533	0.750
LIG_FHA_1	261	267	PF00498	0.481
LIG_FHA_1	378	384	PF00498	0.443
LIG_FHA_1	559	565	PF00498	0.741
LIG_FHA_1	604	610	PF00498	0.478
LIG_FHA_1	630	636	PF00498	0.559
LIG_FHA_1	737	743	PF00498	0.622
LIG_FHA_2	107	113	PF00498	0.583
LIG_FHA_2	202	208	PF00498	0.668
LIG_FHA_2	287	293	PF00498	0.743
LIG_FHA_2	452	458	PF00498	0.450
LIG_FHA_2	561	567	PF00498	0.571
LIG_LIR_Apic_2	216	222	PF02991	0.564
LIG_LIR_Apic_2	739	744	PF02991	0.697
LIG_LIR_Gen_1	220	231	PF02991	0.572
LIG_LIR_Gen_1	3	11	PF02991	0.556
LIG_LIR_Gen_1	364	374	PF02991	0.492
LIG_LIR_Gen_1	381	392	PF02991	0.457
LIG_LIR_Gen_1	489	499	PF02991	0.539
LIG_LIR_Nem_3	220	226	PF02991	0.580
LIG_LIR_Nem_3	3	8	PF02991	0.553
LIG_LIR_Nem_3	364	370	PF02991	0.496
LIG_LIR_Nem_3	381	387	PF02991	0.450
LIG_MYND_3	389	393	PF01753	0.612
LIG_PCNA_yPIPBox_3	569	582	PF02747	0.367
LIG_PTB_Apo_2	611	618	PF02174	0.598
LIG_PTB_Apo_2	709	716	PF02174	0.437
LIG_PTB_Phospho_1	611	617	PF10480	0.599
LIG_SH2_CRK	219	223	PF00017	0.554
LIG_SH2_CRK	315	319	PF00017	0.574
LIG_SH2_CRK	5	9	PF00017	0.558
LIG_SH2_NCK_1	219	223	PF00017	0.586
LIG_SH2_SRC	295	298	PF00017	0.519
LIG_SH2_STAP1	295	299	PF00017	0.521
LIG_SH2_STAP1	379	383	PF00017	0.440
LIG_SH2_STAP1	487	491	PF00017	0.453
LIG_SH2_STAP1	696	700	PF00017	0.750
LIG_SH2_STAT3	335	338	PF00017	0.579
LIG_SH2_STAT3	455	458	PF00017	0.437
LIG_SH2_STAT5	219	222	PF00017	0.559
LIG_SH2_STAT5	379	382	PF00017	0.446
LIG_SH2_STAT5	464	467	PF00017	0.484
LIG_SH2_STAT5	617	620	PF00017	0.560
LIG_SH2_STAT5	646	649	PF00017	0.660
LIG_SH3_1	20	26	PF00018	0.543
LIG_SH3_2	343	348	PF14604	0.564
LIG_SH3_3	20	26	PF00018	0.770
LIG_SH3_3	308	314	PF00018	0.764
LIG_SH3_3	337	343	PF00018	0.711
LIG_SH3_3	616	622	PF00018	0.453
LIG_SUMO_SIM_anti_2	632	637	PF11976	0.500
LIG_SUMO_SIM_par_1	581	587	PF11976	0.452
LIG_TRAF2_1	454	457	PF00917	0.409
LIG_WRC_WIRS_1	87	92	PF05994	0.556
MOD_CDC14_SPxK_1	345	348	PF00782	0.554
MOD_CDK_SPxK_1	10	16	PF00069	0.554
MOD_CDK_SPxK_1	342	348	PF00069	0.566
MOD_CDK_SPxK_1	620	626	PF00069	0.527
MOD_CDK_SPxK_1	638	644	PF00069	0.612
MOD_CDK_SPxxK_3	118	125	PF00069	0.698
MOD_CDK_SPxxK_3	342	349	PF00069	0.565
MOD_CDK_SPxxK_3	638	645	PF00069	0.655
MOD_CK1_1	106	112	PF00069	0.557
MOD_CK1_1	115	121	PF00069	0.615
MOD_CK1_1	201	207	PF00069	0.677
MOD_CK1_1	274	280	PF00069	0.594
MOD_CK1_1	326	332	PF00069	0.532
MOD_CK1_1	549	555	PF00069	0.700
MOD_CK1_1	567	573	PF00069	0.482
MOD_CK1_1	596	602	PF00069	0.396
MOD_CK1_1	63	69	PF00069	0.649
MOD_CK1_1	751	757	PF00069	0.495
MOD_CK1_1	89	95	PF00069	0.651
MOD_CK2_1	338	344	PF00069	0.622
MOD_CK2_1	451	457	PF00069	0.462
MOD_CK2_1	560	566	PF00069	0.563
MOD_Cter_Amidation	522	525	PF01082	0.758
MOD_GlcNHglycan	112	115	PF01048	0.702
MOD_GlcNHglycan	276	279	PF01048	0.598
MOD_GlcNHglycan	297	300	PF01048	0.722
MOD_GlcNHglycan	42	45	PF01048	0.737
MOD_GlcNHglycan	532	535	PF01048	0.598
MOD_GlcNHglycan	536	539	PF01048	0.654
MOD_GlcNHglycan	548	551	PF01048	0.772
MOD_GlcNHglycan	566	569	PF01048	0.551
MOD_GlcNHglycan	658	661	PF01048	0.542
MOD_GlcNHglycan	701	704	PF01048	0.625
MOD_GlcNHglycan	707	710	PF01048	0.552
MOD_GlcNHglycan	750	753	PF01048	0.573
MOD_GSK3_1	102	109	PF00069	0.650
MOD_GSK3_1	112	119	PF00069	0.716
MOD_GSK3_1	123	130	PF00069	0.588
MOD_GSK3_1	138	145	PF00069	0.667
MOD_GSK3_1	173	180	PF00069	0.569
MOD_GSK3_1	197	204	PF00069	0.672
MOD_GSK3_1	246	253	PF00069	0.625
MOD_GSK3_1	267	274	PF00069	0.634
MOD_GSK3_1	286	293	PF00069	0.409
MOD_GSK3_1	338	345	PF00069	0.612
MOD_GSK3_1	379	386	PF00069	0.506
MOD_GSK3_1	414	421	PF00069	0.552
MOD_GSK3_1	42	49	PF00069	0.659
MOD_GSK3_1	530	537	PF00069	0.704
MOD_GSK3_1	539	546	PF00069	0.807
MOD_GSK3_1	548	555	PF00069	0.657
MOD_GSK3_1	56	63	PF00069	0.558
MOD_GSK3_1	560	567	PF00069	0.642
MOD_GSK3_1	570	577	PF00069	0.593
MOD_GSK3_1	6	13	PF00069	0.557
MOD_GSK3_1	603	610	PF00069	0.537
MOD_GSK3_1	64	71	PF00069	0.601
MOD_GSK3_1	695	702	PF00069	0.625
MOD_GSK3_1	732	739	PF00069	0.612
MOD_LATS_1	100	106	PF00433	0.586
MOD_N-GLC_1	530	535	PF02516	0.565
MOD_NEK2_1	123	128	PF00069	0.751
MOD_NEK2_1	240	245	PF00069	0.606
MOD_NEK2_1	267	272	PF00069	0.637
MOD_NEK2_1	286	291	PF00069	0.406
MOD_NEK2_1	305	310	PF00069	0.742
MOD_NEK2_1	323	328	PF00069	0.643
MOD_NEK2_1	414	419	PF00069	0.514
MOD_NEK2_1	502	507	PF00069	0.632
MOD_NEK2_1	548	553	PF00069	0.671
MOD_NEK2_1	560	565	PF00069	0.590
MOD_NEK2_1	603	608	PF00069	0.492
MOD_NEK2_1	72	77	PF00069	0.697
MOD_NEK2_1	732	737	PF00069	0.668
MOD_NEK2_2	379	384	PF00069	0.491
MOD_PIKK_1	164	170	PF00454	0.640
MOD_PIKK_1	188	194	PF00454	0.532
MOD_PIKK_1	268	274	PF00454	0.559
MOD_PIKK_1	438	444	PF00454	0.583
MOD_PIKK_1	502	508	PF00454	0.638
MOD_PIKK_1	567	573	PF00454	0.712
MOD_PKA_1	348	354	PF00069	0.513
MOD_PKA_2	106	112	PF00069	0.693
MOD_PKA_2	240	246	PF00069	0.604
MOD_PKA_2	26	32	PF00069	0.644
MOD_PKA_2	306	312	PF00069	0.706
MOD_PKA_2	347	353	PF00069	0.702
MOD_PKA_2	546	552	PF00069	0.748
MOD_PKA_2	564	570	PF00069	0.655
MOD_PKA_2	732	738	PF00069	0.672
MOD_Plk_4	179	185	PF00069	0.777
MOD_Plk_4	306	312	PF00069	0.652
MOD_Plk_4	326	332	PF00069	0.454
MOD_Plk_4	379	385	PF00069	0.456
MOD_Plk_4	574	580	PF00069	0.570
MOD_Plk_4	737	743	PF00069	0.693
MOD_ProDKin_1	10	16	PF00069	0.554
MOD_ProDKin_1	118	124	PF00069	0.728
MOD_ProDKin_1	324	330	PF00069	0.691
MOD_ProDKin_1	336	342	PF00069	0.753
MOD_ProDKin_1	361	367	PF00069	0.647
MOD_ProDKin_1	435	441	PF00069	0.634
MOD_ProDKin_1	593	599	PF00069	0.386
MOD_ProDKin_1	60	66	PF00069	0.680
MOD_ProDKin_1	620	626	PF00069	0.527
MOD_ProDKin_1	638	644	PF00069	0.612
TRG_DiLeu_BaLyEn_6	669	674	PF01217	0.649
TRG_ENDOCYTIC_2	315	318	PF00928	0.572
TRG_ENDOCYTIC_2	5	8	PF00928	0.559
TRG_ENDOCYTIC_2	617	620	PF00928	0.533
TRG_ER_diArg_1	184	187	PF00400	0.755
TRG_ER_diArg_1	239	242	PF00400	0.617
TRG_ER_diArg_1	600	602	PF00400	0.576
TRG_ER_diArg_1	643	645	PF00400	0.649
TRG_ER_diArg_1	766	769	PF00400	0.648
TRG_ER_diArg_1	80	82	PF00400	0.735
TRG_NES_CRM1_1	230	245	PF08389	0.421
TRG_Pf-PMV_PEXEL_1	508	512	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	601	605	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC90	Leptomonas seymouri	58%	100%
A0A3S7WQN2	Leishmania donovani	81%	100%
A4HTY3	Leishmania infantum	81%	100%
D0A9D9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AMR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QHW2	Leishmania major	82%	98%