Putative serine peptidase family S51, peptidase E

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclin 1

Species:

Leishmania braziliensis

UniProt:

A4H5P2_LEIBR

TriTrypDb:

LbrM.09.0680 , LBRM2903_090011700

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5P2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5P2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008233	peptidase activity	3	12
GO:0008236	serine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0017171	serine hydrolase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.427
CLV_C14_Caspase3-7	291	295	PF00656	0.405
CLV_NRD_NRD_1	120	122	PF00675	0.235
CLV_NRD_NRD_1	227	229	PF00675	0.303
CLV_NRD_NRD_1	300	302	PF00675	0.547
CLV_PCSK_KEX2_1	120	122	PF00082	0.225
CLV_PCSK_KEX2_1	227	229	PF00082	0.263
CLV_PCSK_KEX2_1	237	239	PF00082	0.215
CLV_PCSK_KEX2_1	299	301	PF00082	0.448
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.235
CLV_PCSK_SKI1_1	171	175	PF00082	0.330
DEG_COP1_1	309	318	PF00400	0.285
DEG_Nend_Nbox_1	1	3	PF02207	0.454
DOC_CKS1_1	42	47	PF01111	0.530
DOC_MAPK_DCC_7	76	85	PF00069	0.530
DOC_MAPK_RevD_3	285	301	PF00069	0.362
DOC_PP2B_LxvP_1	312	315	PF13499	0.342
DOC_PP4_FxxP_1	29	32	PF00568	0.377
DOC_USP7_MATH_1	142	146	PF00917	0.474
DOC_USP7_MATH_1	260	264	PF00917	0.516
DOC_USP7_MATH_1	267	271	PF00917	0.466
DOC_USP7_MATH_1	318	322	PF00917	0.303
DOC_USP7_MATH_1	333	337	PF00917	0.574
DOC_USP7_MATH_1	89	93	PF00917	0.391
DOC_WW_Pin1_4	41	46	PF00397	0.521
LIG_14-3-3_CanoR_1	76	81	PF00244	0.448
LIG_Actin_WH2_2	163	178	PF00022	0.373
LIG_AP2alpha_2	322	324	PF02296	0.399
LIG_APCC_ABBA_1	214	219	PF00400	0.435
LIG_BRCT_BRCA1_1	320	324	PF00533	0.391
LIG_CaM_IQ_9	163	178	PF13499	0.373
LIG_FHA_1	102	108	PF00498	0.373
LIG_FHA_1	231	237	PF00498	0.508
LIG_FHA_1	279	285	PF00498	0.503
LIG_FHA_1	302	308	PF00498	0.498
LIG_FHA_1	314	320	PF00498	0.444
LIG_FHA_1	45	51	PF00498	0.469
LIG_FHA_1	57	63	PF00498	0.379
LIG_FHA_1	68	74	PF00498	0.491
LIG_FHA_2	1	7	PF00498	0.422
LIG_FHA_2	184	190	PF00498	0.556
LIG_FHA_2	272	278	PF00498	0.500
LIG_LIR_Gen_1	196	207	PF02991	0.451
LIG_LIR_Gen_1	229	240	PF02991	0.456
LIG_LIR_Gen_1	248	255	PF02991	0.512
LIG_LIR_Gen_1	258	267	PF02991	0.505
LIG_LIR_Gen_1	321	330	PF02991	0.531
LIG_LIR_Nem_3	196	202	PF02991	0.462
LIG_LIR_Nem_3	24	29	PF02991	0.285
LIG_LIR_Nem_3	248	253	PF02991	0.470
LIG_LIR_Nem_3	258	264	PF02991	0.495
LIG_LIR_Nem_3	321	327	PF02991	0.406
LIG_NRBOX	126	132	PF00104	0.530
LIG_NRBOX	209	215	PF00104	0.373
LIG_NRBOX	307	313	PF00104	0.407
LIG_SH2_NCK_1	261	265	PF00017	0.374
LIG_SH2_NCK_1	60	64	PF00017	0.492
LIG_SH2_PTP2	201	204	PF00017	0.456
LIG_SH2_STAP1	261	265	PF00017	0.413
LIG_SH2_STAT5	165	168	PF00017	0.537
LIG_SH2_STAT5	201	204	PF00017	0.453
LIG_SH2_STAT5	54	57	PF00017	0.425
LIG_SH3_3	261	267	PF00018	0.495
LIG_SH3_3	312	318	PF00018	0.416
LIG_SH3_3	39	45	PF00018	0.530
LIG_SH3_3	82	88	PF00018	0.441
LIG_SUMO_SIM_anti_2	106	111	PF11976	0.491
LIG_SUMO_SIM_par_1	106	111	PF11976	0.435
LIG_SUMO_SIM_par_1	288	294	PF11976	0.463
LIG_TRAF2_1	3	6	PF00917	0.350
LIG_TRAF2_2	82	87	PF00917	0.463
LIG_UBA3_1	252	256	PF00899	0.463
LIG_UBA3_1	38	46	PF00899	0.494
MOD_CDK_SPK_2	41	46	PF00069	0.530
MOD_CK1_1	154	160	PF00069	0.479
MOD_CK2_1	183	189	PF00069	0.524
MOD_GlcNHglycan	110	113	PF01048	0.239
MOD_GlcNHglycan	144	147	PF01048	0.258
MOD_GlcNHglycan	153	156	PF01048	0.248
MOD_GlcNHglycan	158	161	PF01048	0.224
MOD_GlcNHglycan	23	26	PF01048	0.303
MOD_GlcNHglycan	274	277	PF01048	0.403
MOD_GlcNHglycan	336	339	PF01048	0.621
MOD_GSK3_1	108	115	PF00069	0.456
MOD_GSK3_1	150	157	PF00069	0.488
MOD_GSK3_1	193	200	PF00069	0.521
MOD_GSK3_1	267	274	PF00069	0.575
MOD_GSK3_1	302	309	PF00069	0.551
MOD_GSK3_1	37	44	PF00069	0.381
MOD_NEK2_1	166	171	PF00069	0.532
MOD_NEK2_1	195	200	PF00069	0.552
MOD_NEK2_1	21	26	PF00069	0.339
MOD_NEK2_1	218	223	PF00069	0.506
MOD_NEK2_2	112	117	PF00069	0.435
MOD_PIKK_1	218	224	PF00454	0.491
MOD_PKB_1	299	307	PF00069	0.468
MOD_Plk_1	67	73	PF00069	0.463
MOD_Plk_2-3	31	37	PF00069	0.461
MOD_Plk_4	112	118	PF00069	0.425
MOD_Plk_4	161	167	PF00069	0.530
MOD_Plk_4	68	74	PF00069	0.505
MOD_ProDKin_1	41	47	PF00069	0.521
TRG_DiLeu_BaEn_1	68	73	PF01217	0.463
TRG_ENDOCYTIC_2	201	204	PF00928	0.453
TRG_ENDOCYTIC_2	26	29	PF00928	0.336
TRG_ENDOCYTIC_2	261	264	PF00928	0.233
TRG_ER_diArg_1	119	121	PF00400	0.435
TRG_ER_diArg_1	226	228	PF00400	0.491
TRG_ER_diArg_1	299	301	PF00400	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I426	Leptomonas seymouri	74%	100%
A0A0S4KJ65	Bodo saltans	40%	95%
A0A1X0NMP2	Trypanosomatidae	48%	100%
A0A3S7WQM7	Leishmania donovani	85%	100%
A0A422NV72	Trypanosoma rangeli	51%	100%
A4HTY1	Leishmania infantum	85%	100%
D0A9D7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AMR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
P41179	Trypanosoma brucei brucei	34%	100%
Q4QHW4	Leishmania major	84%	100%
V5BII1	Trypanosoma cruzi	48%	97%