Surface antigen-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen-like protein

Species:

Leishmania braziliensis

UniProt:

A4H5P0_LEIBR

TriTrypDb:

LbrM.09.0660 , LBRM2903_090011500

Length:

287

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 85

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 40, no: 9
NetGPI	no	yes: 0, no: 49

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	50
GO:0016020	membrane	2	13
GO:0042995	cell projection	2	50
GO:0043226	organelle	2	50
GO:0043227	membrane-bounded organelle	3	50
GO:0110165	cellular anatomical entity	1	50
GO:0120025	plasma membrane bounded cell projection	3	50
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4H5P0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5P0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.278
CLV_PCSK_SKI1_1	174	178	PF00082	0.525
CLV_PCSK_SKI1_1	221	225	PF00082	0.682
CLV_PCSK_SKI1_1	31	35	PF00082	0.713
DEG_MDM2_SWIB_1	120	127	PF02201	0.406
DEG_Nend_Nbox_1	1	3	PF02207	0.681
DOC_CDC14_PxL_1	269	277	PF14671	0.238
DOC_CYCLIN_RxL_1	128	138	PF00134	0.292
DOC_PP1_RVXF_1	129	136	PF00149	0.307
DOC_PP2B_LxvP_1	255	258	PF13499	0.530
DOC_USP7_MATH_1	150	154	PF00917	0.488
DOC_USP7_MATH_1	164	168	PF00917	0.461
DOC_USP7_MATH_1	230	234	PF00917	0.534
DOC_USP7_MATH_1	251	255	PF00917	0.461
DOC_USP7_MATH_1	33	37	PF00917	0.520
DOC_USP7_MATH_1	82	86	PF00917	0.442
DOC_WW_Pin1_4	239	244	PF00397	0.394
LIG_14-3-3_CanoR_1	252	256	PF00244	0.523
LIG_BRCT_BRCA1_1	232	236	PF00533	0.401
LIG_BRCT_BRCA1_1	84	88	PF00533	0.544
LIG_deltaCOP1_diTrp_1	58	65	PF00928	0.467
LIG_FHA_1	154	160	PF00498	0.365
LIG_FHA_1	200	206	PF00498	0.292
LIG_FHA_1	222	228	PF00498	0.374
LIG_FHA_1	274	280	PF00498	0.329
LIG_FHA_1	38	44	PF00498	0.468
LIG_FHA_1	78	84	PF00498	0.426
LIG_FHA_1	87	93	PF00498	0.466
LIG_FHA_2	59	65	PF00498	0.462
LIG_LIR_Nem_3	122	127	PF02991	0.385
LIG_LIR_Nem_3	138	144	PF02991	0.356
LIG_LIR_Nem_3	193	197	PF02991	0.473
LIG_LIR_Nem_3	67	71	PF02991	0.364
LIG_PDZ_Class_2	282	287	PF00595	0.632
LIG_Pex14_2	120	124	PF04695	0.401
LIG_Pex14_2	45	49	PF04695	0.403
LIG_PTB_Apo_2	222	229	PF02174	0.361
LIG_SH2_STAT3	2	5	PF00017	0.438
LIG_SH2_STAT5	2	5	PF00017	0.438
LIG_SH2_STAT5	70	73	PF00017	0.452
LIG_SH3_3	48	54	PF00018	0.298
LIG_SUMO_SIM_anti_2	202	207	PF11976	0.307
LIG_SUMO_SIM_par_1	201	207	PF11976	0.395
LIG_SUMO_SIM_par_1	75	85	PF11976	0.445
LIG_TRAF2_2	257	262	PF00917	0.412
LIG_TRFH_1	269	273	PF08558	0.241
LIG_WRC_WIRS_1	46	51	PF05994	0.362
LIG_WW_1	257	260	PF00397	0.408
MOD_CK1_1	153	159	PF00069	0.381
MOD_CK1_1	217	223	PF00069	0.440
MOD_CK1_1	72	78	PF00069	0.478
MOD_CK2_1	58	64	PF00069	0.383
MOD_CK2_1	88	94	PF00069	0.486
MOD_CMANNOS	65	68	PF00535	0.497
MOD_GlcNHglycan	162	165	PF01048	0.594
MOD_GlcNHglycan	232	235	PF01048	0.704
MOD_GlcNHglycan	35	38	PF01048	0.667
MOD_GlcNHglycan	84	87	PF01048	0.638
MOD_GSK3_1	160	167	PF00069	0.403
MOD_GSK3_1	217	224	PF00069	0.395
MOD_GSK3_1	241	248	PF00069	0.497
MOD_GSK3_1	33	40	PF00069	0.421
MOD_GSK3_1	45	52	PF00069	0.367
MOD_GSK3_1	72	79	PF00069	0.436
MOD_GSK3_1	82	89	PF00069	0.463
MOD_N-GLC_1	114	119	PF02516	0.576
MOD_N-GLC_1	133	138	PF02516	0.619
MOD_N-GLC_1	160	165	PF02516	0.493
MOD_N-GLC_1	38	43	PF02516	0.479
MOD_NEK2_1	1	6	PF00069	0.748
MOD_NEK2_1	114	119	PF00069	0.444
MOD_NEK2_1	120	125	PF00069	0.421
MOD_NEK2_1	133	138	PF00069	0.324
MOD_NEK2_1	140	145	PF00069	0.371
MOD_NEK2_1	45	50	PF00069	0.333
MOD_NEK2_1	88	93	PF00069	0.417
MOD_NEK2_1	95	100	PF00069	0.448
MOD_NEK2_2	169	174	PF00069	0.305
MOD_OFUCOSY	66	73	PF10250	0.593
MOD_PIKK_1	1	7	PF00454	0.435
MOD_PIKK_1	179	185	PF00454	0.331
MOD_PKA_2	251	257	PF00069	0.422
MOD_Plk_1	38	44	PF00069	0.318
MOD_Plk_4	153	159	PF00069	0.392
MOD_Plk_4	214	220	PF00069	0.450
MOD_Plk_4	273	279	PF00069	0.535
MOD_ProDKin_1	239	245	PF00069	0.396
TRG_ER_diArg_1	129	132	PF00400	0.295

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P276	Leptomonas seymouri	23%	93%
A0A0N0P2E6	Leptomonas seymouri	30%	100%
A0A0N0P2L4	Leptomonas seymouri	31%	97%
A0A0N0P4M2	Leptomonas seymouri	34%	100%
A0A0S4IZ03	Bodo saltans	27%	100%
A0A0S4J592	Bodo saltans	27%	100%
A0A0S4J872	Bodo saltans	29%	72%
A0A0S4KHE4	Bodo saltans	28%	78%
A0A1X0NKN8	Trypanosomatidae	31%	100%
A0A3Q8I9A6	Leishmania donovani	29%	74%
A0A3Q8I9D0	Leishmania donovani	31%	100%
A0A3Q8IIJ9	Leishmania donovani	28%	95%
A0A3S5H6D6	Leishmania donovani	70%	100%
A0A3S7WP69	Leishmania donovani	28%	100%
A0A3S7WPB2	Leishmania donovani	30%	100%
A0A3S7X4J4	Leishmania donovani	28%	95%
A4H4D2	Leishmania braziliensis	28%	100%
A4H4G6	Leishmania braziliensis	27%	99%
A4HJC8	Leishmania braziliensis	25%	95%
A4HSL2	Leishmania infantum	28%	100%
A4HTX9	Leishmania infantum	70%	100%
A4HVB0	Leishmania infantum	24%	71%
A4I6S4	Leishmania infantum	29%	95%
E8NHP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	95%
E9ACQ0	Leishmania major	31%	100%
E9AG65	Leishmania infantum	30%	100%
E9AGG1	Leishmania infantum	27%	100%
E9AGG5	Leishmania infantum	29%	69%
E9AGH0	Leishmania infantum	30%	76%
E9AKJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AKM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AMQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
E9AP02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	85%
E9AP03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	73%
E9AP07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	78%
E9AP08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	68%
E9B1U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	84%
E9B1U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	68%
E9B1U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	95%
Q25331	Leishmania major	32%	75%
Q4Q6B6	Leishmania major	29%	100%
Q4Q6B7	Leishmania major	29%	100%
Q4QGJ4	Leishmania major	32%	75%
Q4QGJ7	Leishmania major	28%	100%
Q4QGK6	Leishmania major	32%	75%
Q4QGL4	Leishmania major	31%	73%
Q4QHW6	Leishmania major	69%	100%
Q4QJB2	Leishmania major	28%	100%