Nucleotid_trans domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5N9_LEIBR

TriTrypDb:

LbrM.09.0650 , LBRM2903_090012600

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 12
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5N9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5N9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	44	48	PF00656	0.547
CLV_NRD_NRD_1	180	182	PF00675	0.311
CLV_NRD_NRD_1	203	205	PF00675	0.479
CLV_NRD_NRD_1	286	288	PF00675	0.334
CLV_PCSK_KEX2_1	180	182	PF00082	0.337
CLV_PCSK_KEX2_1	203	205	PF00082	0.479
CLV_PCSK_KEX2_1	234	236	PF00082	0.453
CLV_PCSK_KEX2_1	286	288	PF00082	0.454
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.515
CLV_PCSK_SKI1_1	180	184	PF00082	0.388
CLV_PCSK_SKI1_1	203	207	PF00082	0.468
DEG_APCC_DBOX_1	203	211	PF00400	0.503
DOC_MAPK_MEF2A_6	105	113	PF00069	0.405
DOC_MAPK_MEF2A_6	117	125	PF00069	0.381
DOC_MAPK_MEF2A_6	29	37	PF00069	0.367
DOC_PP4_FxxP_1	269	272	PF00568	0.484
DOC_SPAK_OSR1_1	235	239	PF12202	0.532
DOC_USP7_MATH_1	243	247	PF00917	0.564
DOC_USP7_MATH_1	261	265	PF00917	0.312
DOC_WW_Pin1_4	117	122	PF00397	0.526
DOC_WW_Pin1_4	145	150	PF00397	0.358
DOC_WW_Pin1_4	169	174	PF00397	0.402
DOC_WW_Pin1_4	300	305	PF00397	0.469
LIG_14-3-3_CanoR_1	180	189	PF00244	0.398
LIG_14-3-3_CanoR_1	26	32	PF00244	0.359
LIG_BRCT_BRCA1_1	185	189	PF00533	0.388
LIG_deltaCOP1_diTrp_1	174	179	PF00928	0.444
LIG_Dynein_DLC8_1	179	185	PF01221	0.368
LIG_eIF4E_1	216	222	PF01652	0.377
LIG_FHA_1	1	7	PF00498	0.490
LIG_FHA_1	118	124	PF00498	0.421
LIG_FHA_1	170	176	PF00498	0.455
LIG_FHA_1	32	38	PF00498	0.433
LIG_FHA_1	54	60	PF00498	0.502
LIG_FHA_2	82	88	PF00498	0.466
LIG_LIR_Nem_3	157	163	PF02991	0.336
LIG_LIR_Nem_3	75	80	PF02991	0.495
LIG_MLH1_MIPbox_1	185	189	PF16413	0.388
LIG_SH2_CRK	77	81	PF00017	0.473
LIG_SH2_STAT3	188	191	PF00017	0.378
LIG_SH2_STAT5	167	170	PF00017	0.434
LIG_SH2_STAT5	188	191	PF00017	0.378
LIG_SH2_STAT5	38	41	PF00017	0.459
LIG_SH3_1	134	140	PF00018	0.419
LIG_SH3_2	304	309	PF14604	0.515
LIG_SH3_3	134	140	PF00018	0.332
LIG_SH3_3	237	243	PF00018	0.523
LIG_SH3_3	269	275	PF00018	0.460
LIG_SH3_3	30	36	PF00018	0.378
LIG_SH3_3	301	307	PF00018	0.536
LIG_SH3_3	89	95	PF00018	0.391
LIG_SUMO_SIM_anti_2	129	135	PF11976	0.344
LIG_WRC_WIRS_1	28	33	PF05994	0.316
LIG_WW_3	273	277	PF00397	0.437
LIG_WW_3	310	314	PF00397	0.543
MOD_CDK_SPK_2	300	305	PF00069	0.469
MOD_CK2_1	168	174	PF00069	0.527
MOD_CK2_1	79	85	PF00069	0.542
MOD_GlcNHglycan	243	246	PF01048	0.653
MOD_GSK3_1	113	120	PF00069	0.537
MOD_GSK3_1	27	34	PF00069	0.447
MOD_NEK2_1	113	118	PF00069	0.422
MOD_NEK2_2	261	266	PF00069	0.314
MOD_NEK2_2	27	32	PF00069	0.355
MOD_PIKK_1	180	186	PF00454	0.513
MOD_PK_1	225	231	PF00069	0.522
MOD_PK_1	234	240	PF00069	0.378
MOD_PKA_1	180	186	PF00069	0.334
MOD_PKA_1	234	240	PF00069	0.500
MOD_PKA_2	180	186	PF00069	0.368
MOD_PKA_2	234	240	PF00069	0.500
MOD_Plk_1	128	134	PF00069	0.415
MOD_Plk_2-3	190	196	PF00069	0.334
MOD_Plk_4	225	231	PF00069	0.569
MOD_Plk_4	250	256	PF00069	0.575
MOD_ProDKin_1	117	123	PF00069	0.516
MOD_ProDKin_1	145	151	PF00069	0.363
MOD_ProDKin_1	169	175	PF00069	0.399
MOD_ProDKin_1	300	306	PF00069	0.473
MOD_SUMO_rev_2	228	236	PF00179	0.502
TRG_DiLeu_BaEn_1	104	109	PF01217	0.349
TRG_DiLeu_BaEn_1	202	207	PF01217	0.317
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.445
TRG_ENDOCYTIC_2	77	80	PF00928	0.438
TRG_ER_diArg_1	179	181	PF00400	0.335
TRG_ER_diArg_1	285	287	PF00400	0.535
TRG_ER_diArg_1	291	294	PF00400	0.347
TRG_Pf-PMV_PEXEL_1	204	209	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P758	Leptomonas seymouri	65%	97%
A0A0S4J3K3	Bodo saltans	35%	80%
A0A0S4J3X3	Bodo saltans	35%	84%
A0A1X0NMM8	Trypanosomatidae	52%	91%
A0A3R7NP68	Trypanosoma rangeli	51%	94%
A0A3S7WQN6	Leishmania donovani	86%	100%
A4H5Q0	Leishmania braziliensis	99%	100%
A4HTZ0	Leishmania infantum	86%	100%
D0A8W8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	94%
E9AMS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QHV5	Leishmania major	86%	100%
V5BSP2	Trypanosoma cruzi	47%	82%