Histone h1-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone h1-like protein

Species:

Leishmania braziliensis

UniProt:

A4H5N7_LEIBR

TriTrypDb:

LbrM.09.0620 , LBRM2903_090014800

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 4
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5N7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5N7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.531
CLV_NRD_NRD_1	147	149	PF00675	0.814
CLV_NRD_NRD_1	158	160	PF00675	0.588
CLV_NRD_NRD_1	166	168	PF00675	0.436
CLV_NRD_NRD_1	299	301	PF00675	0.563
CLV_NRD_NRD_1	325	327	PF00675	0.467
CLV_NRD_NRD_1	374	376	PF00675	0.566
CLV_NRD_NRD_1	380	382	PF00675	0.554
CLV_NRD_NRD_1	436	438	PF00675	0.773
CLV_NRD_NRD_1	451	453	PF00675	0.701
CLV_NRD_NRD_1	462	464	PF00675	0.588
CLV_NRD_NRD_1	469	471	PF00675	0.685
CLV_PCSK_KEX2_1	147	149	PF00082	0.815
CLV_PCSK_KEX2_1	158	160	PF00082	0.592
CLV_PCSK_KEX2_1	166	168	PF00082	0.433
CLV_PCSK_KEX2_1	321	323	PF00082	0.569
CLV_PCSK_KEX2_1	325	327	PF00082	0.520
CLV_PCSK_KEX2_1	374	376	PF00082	0.602
CLV_PCSK_KEX2_1	436	438	PF00082	0.599
CLV_PCSK_KEX2_1	469	471	PF00082	0.570
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.586
CLV_PCSK_PC1ET2_1	469	471	PF00082	0.563
CLV_PCSK_PC7_1	432	438	PF00082	0.537
CLV_PCSK_SKI1_1	13	17	PF00082	0.560
CLV_PCSK_SKI1_1	3	7	PF00082	0.539
CLV_PCSK_SKI1_1	321	325	PF00082	0.482
CLV_PCSK_SKI1_1	369	373	PF00082	0.573
CLV_PCSK_SKI1_1	416	420	PF00082	0.626
DEG_Nend_Nbox_1	1	3	PF02207	0.558
DOC_CYCLIN_yCln2_LP_2	285	291	PF00134	0.660
DOC_MAPK_gen_1	388	397	PF00069	0.538
DOC_PP2B_LxvP_1	285	288	PF13499	0.657
DOC_USP7_MATH_1	131	135	PF00917	0.561
DOC_USP7_MATH_1	141	145	PF00917	0.540
DOC_USP7_MATH_1	259	263	PF00917	0.611
DOC_USP7_MATH_1	350	354	PF00917	0.836
DOC_USP7_MATH_1	389	393	PF00917	0.545
DOC_USP7_MATH_1	40	44	PF00917	0.622
DOC_USP7_MATH_1	465	469	PF00917	0.547
DOC_USP7_MATH_1	48	52	PF00917	0.541
DOC_USP7_UBL2_3	337	341	PF12436	0.533
DOC_USP7_UBL2_3	410	414	PF12436	0.581
DOC_USP7_UBL2_3	417	421	PF12436	0.683
DOC_USP7_UBL2_3	449	453	PF12436	0.648
DOC_USP7_UBL2_3	460	464	PF12436	0.569
DOC_USP7_UBL2_3	480	484	PF12436	0.624
DOC_WW_Pin1_4	183	188	PF00397	0.479
DOC_WW_Pin1_4	356	361	PF00397	0.586
DOC_WW_Pin1_4	419	424	PF00397	0.567
LIG_14-3-3_CanoR_1	218	224	PF00244	0.432
LIG_14-3-3_CanoR_1	247	255	PF00244	0.448
LIG_14-3-3_CanoR_1	308	314	PF00244	0.738
LIG_14-3-3_CanoR_1	470	474	PF00244	0.741
LIG_BRCT_BRCA1_1	21	25	PF00533	0.482
LIG_FHA_1	187	193	PF00498	0.495
LIG_FHA_1	484	490	PF00498	0.550
LIG_FHA_2	147	153	PF00498	0.533
LIG_FHA_2	224	230	PF00498	0.519
LIG_FHA_2	276	282	PF00498	0.746
LIG_FHA_2	342	348	PF00498	0.565
LIG_Integrin_RGD_1	272	274	PF01839	0.522
LIG_NRBOX	1	7	PF00104	0.461
LIG_NRP_CendR_1	492	494	PF00754	0.551
LIG_PCNA_yPIPBox_3	104	112	PF02747	0.511
LIG_Pex14_2	25	29	PF04695	0.537
LIG_SH2_STAT5	10	13	PF00017	0.478
LIG_SH3_1	471	477	PF00018	0.552
LIG_SH3_3	181	187	PF00018	0.483
LIG_SH3_3	336	342	PF00018	0.672
LIG_SH3_3	471	477	PF00018	0.667
LIG_SH3_4	372	379	PF00018	0.560
LIG_SH3_4	449	456	PF00018	0.712
LIG_SUMO_SIM_anti_2	122	128	PF11976	0.599
MOD_CDC14_SPxK_1	359	362	PF00782	0.542
MOD_CDK_SPxK_1	356	362	PF00069	0.550
MOD_CK1_1	133	139	PF00069	0.664
MOD_CK1_1	172	178	PF00069	0.534
MOD_CK1_1	18	24	PF00069	0.569
MOD_CK1_1	186	192	PF00069	0.424
MOD_CK1_1	264	270	PF00069	0.709
MOD_CK1_1	43	49	PF00069	0.605
MOD_CK1_1	455	461	PF00069	0.689
MOD_CK1_1	483	489	PF00069	0.551
MOD_CK1_1	55	61	PF00069	0.606
MOD_CK1_1	99	105	PF00069	0.531
MOD_CK2_1	223	229	PF00069	0.443
MOD_CK2_1	275	281	PF00069	0.659
MOD_CK2_1	341	347	PF00069	0.560
MOD_CK2_1	91	97	PF00069	0.540
MOD_GlcNHglycan	171	174	PF01048	0.525
MOD_GlcNHglycan	25	28	PF01048	0.656
MOD_GlcNHglycan	266	269	PF01048	0.604
MOD_GlcNHglycan	305	308	PF01048	0.704
MOD_GlcNHglycan	317	320	PF01048	0.562
MOD_GlcNHglycan	399	402	PF01048	0.744
MOD_GlcNHglycan	45	48	PF01048	0.444
MOD_GlcNHglycan	457	460	PF01048	0.591
MOD_GlcNHglycan	471	474	PF01048	0.656
MOD_GlcNHglycan	62	65	PF01048	0.587
MOD_GSK3_1	130	137	PF00069	0.523
MOD_GSK3_1	15	22	PF00069	0.601
MOD_GSK3_1	219	226	PF00069	0.522
MOD_GSK3_1	303	310	PF00069	0.711
MOD_GSK3_1	341	348	PF00069	0.662
MOD_GSK3_1	352	359	PF00069	0.763
MOD_GSK3_1	448	455	PF00069	0.663
MOD_GSK3_1	465	472	PF00069	0.662
MOD_GSK3_1	48	55	PF00069	0.602
MOD_GSK3_1	60	67	PF00069	0.569
MOD_LATS_1	343	349	PF00433	0.570
MOD_N-GLC_1	152	157	PF02516	0.515
MOD_N-GLC_1	207	212	PF02516	0.434
MOD_N-GLC_1	99	104	PF02516	0.620
MOD_NEK2_1	16	21	PF00069	0.671
MOD_NEK2_1	191	196	PF00069	0.479
MOD_NEK2_1	207	212	PF00069	0.434
MOD_NEK2_1	52	57	PF00069	0.604
MOD_NEK2_1	96	101	PF00069	0.514
MOD_NEK2_2	389	394	PF00069	0.543
MOD_NEK2_2	64	69	PF00069	0.692
MOD_PIKK_1	172	178	PF00454	0.458
MOD_PIKK_1	191	197	PF00454	0.473
MOD_PIKK_1	253	259	PF00454	0.628
MOD_PIKK_1	261	267	PF00454	0.520
MOD_PIKK_1	452	458	PF00454	0.574
MOD_PIKK_1	52	58	PF00454	0.627
MOD_PKA_1	452	458	PF00069	0.703
MOD_PKA_1	469	475	PF00069	0.566
MOD_PKA_2	146	152	PF00069	0.530
MOD_PKA_2	223	229	PF00069	0.435
MOD_PKA_2	307	313	PF00069	0.716
MOD_PKA_2	469	475	PF00069	0.672
MOD_PKA_2	6	12	PF00069	0.619
MOD_PKB_1	167	175	PF00069	0.533
MOD_Plk_1	121	127	PF00069	0.682
MOD_Plk_1	134	140	PF00069	0.604
MOD_Plk_1	207	213	PF00069	0.436
MOD_Plk_4	121	127	PF00069	0.682
MOD_Plk_4	275	281	PF00069	0.659
MOD_Plk_4	48	54	PF00069	0.568
MOD_Plk_4	6	12	PF00069	0.458
MOD_Plk_4	91	97	PF00069	0.523
MOD_ProDKin_1	183	189	PF00069	0.481
MOD_ProDKin_1	356	362	PF00069	0.586
MOD_ProDKin_1	419	425	PF00069	0.566
MOD_SUMO_for_1	214	217	PF00179	0.437
TRG_DiLeu_BaLyEn_6	319	324	PF01217	0.490
TRG_ER_diArg_1	146	148	PF00400	0.593
TRG_ER_diArg_1	158	160	PF00400	0.594
TRG_ER_diArg_1	166	169	PF00400	0.415
TRG_ER_diArg_1	324	326	PF00400	0.658
TRG_ER_diArg_1	373	375	PF00400	0.566
TRG_NLS_Bipartite_1	452	473	PF00514	0.560
TRG_NLS_MonoExtC_3	459	464	PF00514	0.566
TRG_NLS_MonoExtN_4	414	420	PF00514	0.626
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILW1	Leptomonas seymouri	43%	96%
A0A3Q8I7H5	Leishmania donovani	65%	100%
A4HU09	Leishmania infantum	65%	100%
E9AMT9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	96%
Q4QHT6	Leishmania major	58%	93%