Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5N6_LEIBR

TriTrypDb:

LbrM.09.0610 , LBRM2903_090014700

Length:

524

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5N6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5N6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	460	464	PF00656	0.593
CLV_NRD_NRD_1	117	119	PF00675	0.618
CLV_NRD_NRD_1	133	135	PF00675	0.410
CLV_NRD_NRD_1	148	150	PF00675	0.634
CLV_NRD_NRD_1	481	483	PF00675	0.523
CLV_PCSK_FUR_1	146	150	PF00082	0.423
CLV_PCSK_KEX2_1	116	118	PF00082	0.530
CLV_PCSK_KEX2_1	132	134	PF00082	0.551
CLV_PCSK_KEX2_1	148	150	PF00082	0.616
CLV_PCSK_KEX2_1	155	157	PF00082	0.529
CLV_PCSK_KEX2_1	283	285	PF00082	0.536
CLV_PCSK_KEX2_1	518	520	PF00082	0.572
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.495
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.439
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.536
CLV_PCSK_PC1ET2_1	518	520	PF00082	0.572
CLV_PCSK_PC7_1	112	118	PF00082	0.563
CLV_PCSK_SKI1_1	117	121	PF00082	0.566
DEG_Nend_Nbox_1	1	3	PF02207	0.570
DEG_SPOP_SBC_1	71	75	PF00917	0.725
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.660
DOC_MAPK_DCC_7	400	408	PF00069	0.535
DOC_MAPK_gen_1	28	37	PF00069	0.555
DOC_MAPK_MEF2A_6	400	408	PF00069	0.535
DOC_PP2B_LxvP_1	20	23	PF13499	0.685
DOC_PP4_FxxP_1	297	300	PF00568	0.671
DOC_PP4_FxxP_1	371	374	PF00568	0.663
DOC_USP7_MATH_1	265	269	PF00917	0.541
DOC_USP7_MATH_1	290	294	PF00917	0.722
DOC_USP7_MATH_1	378	382	PF00917	0.541
DOC_USP7_MATH_1	42	46	PF00917	0.675
DOC_USP7_MATH_1	72	76	PF00917	0.683
DOC_WW_Pin1_4	312	317	PF00397	0.767
DOC_WW_Pin1_4	320	325	PF00397	0.651
DOC_WW_Pin1_4	406	411	PF00397	0.617
DOC_WW_Pin1_4	507	512	PF00397	0.506
DOC_WW_Pin1_4	9	14	PF00397	0.614
LIG_14-3-3_CanoR_1	256	260	PF00244	0.585
LIG_Actin_WH2_2	85	101	PF00022	0.612
LIG_FHA_1	171	177	PF00498	0.440
LIG_FHA_1	299	305	PF00498	0.569
LIG_FHA_1	71	77	PF00498	0.685
LIG_FHA_2	348	354	PF00498	0.775
LIG_FHA_2	473	479	PF00498	0.529
LIG_LIR_Apic_2	369	374	PF02991	0.658
LIG_LIR_Gen_1	251	261	PF02991	0.503
LIG_LIR_Gen_1	491	500	PF02991	0.598
LIG_LIR_Nem_3	251	257	PF02991	0.504
LIG_LIR_Nem_3	491	495	PF02991	0.568
LIG_LIR_Nem_3	94	98	PF02991	0.466
LIG_PDZ_Class_1	519	524	PF00595	0.489
LIG_PDZ_Wminus1_1	522	524	PF00595	0.653
LIG_PTB_Apo_2	56	63	PF02174	0.688
LIG_SH2_CRK	492	496	PF00017	0.605
LIG_SH2_CRK	95	99	PF00017	0.586
LIG_SH2_GRB2like	358	361	PF00017	0.468
LIG_SH2_NCK_1	431	435	PF00017	0.613
LIG_SH2_PTP2	254	257	PF00017	0.505
LIG_SH2_SRC	358	361	PF00017	0.468
LIG_SH2_STAP1	2	6	PF00017	0.614
LIG_SH2_STAP1	358	362	PF00017	0.472
LIG_SH2_STAP1	431	435	PF00017	0.551
LIG_SH2_STAT5	254	257	PF00017	0.505
LIG_SH2_STAT5	366	369	PF00017	0.560
LIG_SH2_STAT5	370	373	PF00017	0.570
LIG_SH2_STAT5	492	495	PF00017	0.589
LIG_SH2_STAT5	77	80	PF00017	0.550
LIG_SH3_2	442	447	PF14604	0.666
LIG_SH3_3	404	410	PF00018	0.608
LIG_SH3_3	439	445	PF00018	0.656
LIG_SH3_3	505	511	PF00018	0.609
LIG_SH3_3	76	82	PF00018	0.690
LIG_SH3_CIN85_PxpxPR_1	442	447	PF14604	0.666
LIG_TRAF2_1	136	139	PF00917	0.598
LIG_TRAF2_1	141	144	PF00917	0.559
LIG_TYR_ITIM	490	495	PF00017	0.570
LIG_WRC_WIRS_1	1	6	PF05994	0.568
LIG_WW_3	444	448	PF00397	0.672
MOD_CK1_1	12	18	PF00069	0.602
MOD_CK1_1	209	215	PF00069	0.644
MOD_CK1_1	314	320	PF00069	0.668
MOD_CK1_1	45	51	PF00069	0.562
MOD_CK1_1	491	497	PF00069	0.604
MOD_CK1_1	5	11	PF00069	0.666
MOD_CK1_1	75	81	PF00069	0.709
MOD_CK2_1	347	353	PF00069	0.675
MOD_Cter_Amidation	516	519	PF01082	0.570
MOD_GlcNHglycan	301	304	PF01048	0.614
MOD_GlcNHglycan	350	353	PF01048	0.611
MOD_GlcNHglycan	374	377	PF01048	0.692
MOD_GlcNHglycan	380	383	PF01048	0.661
MOD_GlcNHglycan	416	420	PF01048	0.489
MOD_GlcNHglycan	431	434	PF01048	0.548
MOD_GSK3_1	205	212	PF00069	0.504
MOD_GSK3_1	232	239	PF00069	0.727
MOD_GSK3_1	295	302	PF00069	0.640
MOD_GSK3_1	304	311	PF00069	0.761
MOD_GSK3_1	312	319	PF00069	0.660
MOD_GSK3_1	325	332	PF00069	0.805
MOD_GSK3_1	378	385	PF00069	0.638
MOD_GSK3_1	411	418	PF00069	0.569
MOD_GSK3_1	5	12	PF00069	0.570
MOD_GSK3_1	71	78	PF00069	0.658
MOD_N-GLC_1	206	211	PF02516	0.482
MOD_N-GLC_1	45	50	PF02516	0.549
MOD_N-GLC_1	498	503	PF02516	0.639
MOD_NEK2_1	347	352	PF00069	0.601
MOD_NEK2_1	461	466	PF00069	0.554
MOD_NEK2_1	490	495	PF00069	0.570
MOD_NEK2_2	200	205	PF00069	0.434
MOD_NEK2_2	72	77	PF00069	0.731
MOD_PIKK_1	170	176	PF00454	0.478
MOD_PIKK_1	233	239	PF00454	0.492
MOD_PIKK_1	304	310	PF00454	0.708
MOD_PKA_1	283	289	PF00069	0.531
MOD_PKA_2	170	176	PF00069	0.448
MOD_PKA_2	200	206	PF00069	0.470
MOD_PKA_2	255	261	PF00069	0.584
MOD_PKA_2	283	289	PF00069	0.605
MOD_PKA_2	436	442	PF00069	0.683
MOD_PKA_2	461	467	PF00069	0.627
MOD_Plk_1	102	108	PF00069	0.492
MOD_Plk_1	239	245	PF00069	0.462
MOD_Plk_1	290	296	PF00069	0.526
MOD_Plk_1	447	453	PF00069	0.685
MOD_Plk_2-3	161	167	PF00069	0.387
MOD_Plk_4	200	206	PF00069	0.469
MOD_Plk_4	362	368	PF00069	0.566
MOD_Plk_4	436	442	PF00069	0.661
MOD_Plk_4	461	467	PF00069	0.520
MOD_Plk_4	72	78	PF00069	0.788
MOD_Plk_4	91	97	PF00069	0.475
MOD_ProDKin_1	312	318	PF00069	0.768
MOD_ProDKin_1	320	326	PF00069	0.648
MOD_ProDKin_1	406	412	PF00069	0.617
MOD_ProDKin_1	507	513	PF00069	0.502
MOD_ProDKin_1	9	15	PF00069	0.614
MOD_SUMO_for_1	126	129	PF00179	0.483
MOD_SUMO_for_1	141	144	PF00179	0.476
MOD_SUMO_rev_2	45	54	PF00179	0.608
MOD_SUMO_rev_2	478	485	PF00179	0.609
TRG_ENDOCYTIC_2	254	257	PF00928	0.505
TRG_ENDOCYTIC_2	492	495	PF00928	0.585
TRG_ENDOCYTIC_2	95	98	PF00928	0.573
TRG_ER_diArg_1	132	134	PF00400	0.448
TRG_ER_diArg_1	145	148	PF00400	0.562
TRG_ER_diArg_1	227	230	PF00400	0.545
TRG_NLS_MonoExtN_4	115	120	PF00514	0.541
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J5	Leptomonas seymouri	45%	100%
A0A3Q8IBX4	Leishmania donovani	74%	100%
A4HU08	Leishmania infantum	74%	100%
E9AMT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QHT7	Leishmania major	72%	100%