CULT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5N4_LEIBR

TriTrypDb:

LbrM.09.0590 , LBRM2903_090011400

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	6	1
GO:0032991	protein-containing complex	1	1
GO:0080008	Cul4-RING E3 ubiquitin ligase complex	5	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4H5N4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5N4

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.549
CLV_C14_Caspase3-7	319	323	PF00656	0.702
CLV_C14_Caspase3-7	402	406	PF00656	0.357
CLV_NRD_NRD_1	216	218	PF00675	0.560
CLV_NRD_NRD_1	233	235	PF00675	0.476
CLV_NRD_NRD_1	385	387	PF00675	0.426
CLV_PCSK_FUR_1	214	218	PF00082	0.422
CLV_PCSK_FUR_1	382	386	PF00082	0.438
CLV_PCSK_KEX2_1	216	218	PF00082	0.701
CLV_PCSK_KEX2_1	384	386	PF00082	0.429
CLV_PCSK_KEX2_1	387	389	PF00082	0.428
CLV_PCSK_PC1ET2_1	387	389	PF00082	0.432
CLV_PCSK_SKI1_1	397	401	PF00082	0.347
DEG_APCC_DBOX_1	396	404	PF00400	0.346
DEG_APCC_DBOX_1	81	89	PF00400	0.387
DEG_SCF_FBW7_1	86	93	PF00400	0.296
DEG_SPOP_SBC_1	255	259	PF00917	0.615
DOC_CKS1_1	424	429	PF01111	0.393
DOC_CYCLIN_RxL_1	394	402	PF00134	0.353
DOC_MAPK_MEF2A_6	87	94	PF00069	0.415
DOC_PP1_RVXF_1	372	379	PF00149	0.502
DOC_PP2B_LxvP_1	162	165	PF13499	0.506
DOC_PP2B_LxvP_1	300	303	PF13499	0.710
DOC_PP4_FxxP_1	429	432	PF00568	0.479
DOC_USP7_MATH_1	11	15	PF00917	0.579
DOC_USP7_MATH_1	255	259	PF00917	0.671
DOC_USP7_MATH_1	262	266	PF00917	0.789
DOC_USP7_MATH_1	290	294	PF00917	0.625
DOC_USP7_MATH_1	295	299	PF00917	0.703
DOC_USP7_MATH_1	303	307	PF00917	0.619
DOC_USP7_MATH_1	34	38	PF00917	0.354
DOC_USP7_MATH_1	368	372	PF00917	0.421
DOC_USP7_MATH_1	432	436	PF00917	0.495
DOC_USP7_MATH_2	262	268	PF00917	0.531
DOC_WW_Pin1_4	1	6	PF00397	0.768
DOC_WW_Pin1_4	13	18	PF00397	0.609
DOC_WW_Pin1_4	280	285	PF00397	0.658
DOC_WW_Pin1_4	298	303	PF00397	0.523
DOC_WW_Pin1_4	423	428	PF00397	0.364
DOC_WW_Pin1_4	64	69	PF00397	0.475
DOC_WW_Pin1_4	86	91	PF00397	0.498
LIG_14-3-3_CanoR_1	214	224	PF00244	0.484
LIG_14-3-3_CanoR_1	292	300	PF00244	0.625
LIG_14-3-3_CanoR_1	471	481	PF00244	0.448
LIG_14-3-3_CanoR_1	96	100	PF00244	0.646
LIG_Actin_WH2_2	202	218	PF00022	0.345
LIG_APCC_ABBA_1	60	65	PF00400	0.362
LIG_BIR_II_1	1	5	PF00653	0.663
LIG_BIR_III_4	150	154	PF00653	0.662
LIG_CtBP_PxDLS_1	5	9	PF00389	0.512
LIG_EH1_1	366	374	PF00400	0.496
LIG_EH1_1	416	424	PF00400	0.467
LIG_eIF4E_1	367	373	PF01652	0.416
LIG_FHA_1	315	321	PF00498	0.565
LIG_FHA_1	391	397	PF00498	0.492
LIG_FHA_1	441	447	PF00498	0.575
LIG_FHA_1	87	93	PF00498	0.359
LIG_FHA_2	225	231	PF00498	0.507
LIG_FHA_2	317	323	PF00498	0.704
LIG_LIR_Apic_2	426	432	PF02991	0.444
LIG_LIR_Gen_1	37	47	PF02991	0.414
LIG_LIR_Gen_1	411	419	PF02991	0.448
LIG_LIR_Gen_1	89	99	PF02991	0.355
LIG_LIR_Nem_3	180	185	PF02991	0.404
LIG_LIR_Nem_3	352	356	PF02991	0.365
LIG_LIR_Nem_3	37	42	PF02991	0.368
LIG_LIR_Nem_3	411	416	PF02991	0.483
LIG_LIR_Nem_3	89	94	PF02991	0.305
LIG_SH2_CRK	424	428	PF00017	0.510
LIG_SH2_GRB2like	413	416	PF00017	0.336
LIG_SH2_PTP2	91	94	PF00017	0.357
LIG_SH2_STAP1	185	189	PF00017	0.348
LIG_SH2_STAP1	56	60	PF00017	0.426
LIG_SH2_STAT5	314	317	PF00017	0.561
LIG_SH2_STAT5	91	94	PF00017	0.357
LIG_SH3_1	424	430	PF00018	0.555
LIG_SH3_3	120	126	PF00018	0.514
LIG_SH3_3	14	20	PF00018	0.518
LIG_SH3_3	142	148	PF00018	0.552
LIG_SH3_3	362	368	PF00018	0.483
LIG_SH3_3	424	430	PF00018	0.555
LIG_SH3_3	439	445	PF00018	0.477
LIG_SUMO_SIM_par_1	267	273	PF11976	0.535
LIG_TRAF2_1	238	241	PF00917	0.650
LIG_TRAF2_2	135	140	PF00917	0.542
LIG_TRAF2_2	145	150	PF00917	0.529
LIG_TYR_ITSM	87	94	PF00017	0.300
MOD_CDK_SPK_2	13	18	PF00069	0.510
MOD_CK1_1	177	183	PF00069	0.300
MOD_CK1_1	218	224	PF00069	0.499
MOD_CK1_1	225	231	PF00069	0.514
MOD_CK1_1	298	304	PF00069	0.701
MOD_CK1_1	316	322	PF00069	0.588
MOD_CK1_1	323	329	PF00069	0.599
MOD_CK1_1	4	10	PF00069	0.770
MOD_CK1_1	435	441	PF00069	0.537
MOD_CK1_1	475	481	PF00069	0.571
MOD_CK1_1	98	104	PF00069	0.585
MOD_CK2_1	220	226	PF00069	0.499
MOD_CK2_1	486	492	PF00069	0.706
MOD_GlcNHglycan	1	4	PF01048	0.638
MOD_GlcNHglycan	101	104	PF01048	0.584
MOD_GlcNHglycan	182	185	PF01048	0.360
MOD_GlcNHglycan	219	223	PF01048	0.609
MOD_GlcNHglycan	266	269	PF01048	0.637
MOD_GlcNHglycan	293	296	PF01048	0.735
MOD_GlcNHglycan	334	337	PF01048	0.691
MOD_GlcNHglycan	434	437	PF01048	0.490
MOD_GlcNHglycan	483	486	PF01048	0.602
MOD_GlcNHglycan	73	76	PF01048	0.413
MOD_GlcNHglycan	97	100	PF01048	0.538
MOD_GSK3_1	169	176	PF00069	0.513
MOD_GSK3_1	218	225	PF00069	0.632
MOD_GSK3_1	250	257	PF00069	0.587
MOD_GSK3_1	291	298	PF00069	0.620
MOD_GSK3_1	308	315	PF00069	0.632
MOD_GSK3_1	316	323	PF00069	0.587
MOD_GSK3_1	431	438	PF00069	0.608
MOD_GSK3_1	440	447	PF00069	0.562
MOD_GSK3_1	481	488	PF00069	0.681
MOD_GSK3_1	7	14	PF00069	0.589
MOD_GSK3_1	86	93	PF00069	0.296
MOD_GSK3_1	95	102	PF00069	0.423
MOD_N-GLC_1	323	328	PF02516	0.549
MOD_N-GLC_1	481	486	PF02516	0.585
MOD_NEK2_1	224	229	PF00069	0.505
MOD_NEK2_1	343	348	PF00069	0.419
MOD_NEK2_2	158	163	PF00069	0.562
MOD_NEK2_2	90	95	PF00069	0.402
MOD_PIKK_1	109	115	PF00454	0.547
MOD_PIKK_1	257	263	PF00454	0.622
MOD_PKA_2	116	122	PF00069	0.565
MOD_PKA_2	215	221	PF00069	0.556
MOD_PKA_2	291	297	PF00069	0.619
MOD_PKA_2	403	409	PF00069	0.550
MOD_PKA_2	432	438	PF00069	0.538
MOD_PKA_2	95	101	PF00069	0.570
MOD_Plk_1	177	183	PF00069	0.363
MOD_Plk_2-3	308	314	PF00069	0.706
MOD_Plk_4	177	183	PF00069	0.325
MOD_Plk_4	34	40	PF00069	0.409
MOD_Plk_4	368	374	PF00069	0.426
MOD_ProDKin_1	1	7	PF00069	0.768
MOD_ProDKin_1	13	19	PF00069	0.601
MOD_ProDKin_1	280	286	PF00069	0.663
MOD_ProDKin_1	298	304	PF00069	0.523
MOD_ProDKin_1	423	429	PF00069	0.374
MOD_ProDKin_1	64	70	PF00069	0.464
MOD_ProDKin_1	86	92	PF00069	0.496
TRG_ENDOCYTIC_2	413	416	PF00928	0.464
TRG_ENDOCYTIC_2	91	94	PF00928	0.357
TRG_ER_diArg_1	214	217	PF00400	0.561
TRG_ER_diArg_1	382	385	PF00400	0.442
TRG_ER_diArg_1	386	389	PF00400	0.413
TRG_NLS_Bipartite_1	216	238	PF00514	0.495
TRG_NLS_MonoExtN_4	232	238	PF00514	0.639
TRG_NLS_MonoExtN_4	384	390	PF00514	0.350
TRG_Pf-PMV_PEXEL_1	275	279	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	397	402	PF00026	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U2	Leptomonas seymouri	40%	100%
A0A3S7WQQ0	Leishmania donovani	71%	100%
A4HTX8	Leishmania infantum	71%	100%
E9AMQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4QHW7	Leishmania major	70%	99%