TYR_PHOSPHATASE_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dual specificity phosphatase, catalytic domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H5N2_LEIBR

TriTrypDb:

LbrM.09.0570 , LBRM2903_090011200

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5N2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5N2

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0044237	cellular metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.568
CLV_C14_Caspase3-7	81	85	PF00656	0.665
CLV_NRD_NRD_1	148	150	PF00675	0.530
CLV_NRD_NRD_1	196	198	PF00675	0.560
CLV_NRD_NRD_1	201	203	PF00675	0.626
CLV_NRD_NRD_1	270	272	PF00675	0.540
CLV_NRD_NRD_1	42	44	PF00675	0.488
CLV_NRD_NRD_1	540	542	PF00675	0.385
CLV_NRD_NRD_1	553	555	PF00675	0.448
CLV_PCSK_FUR_1	551	555	PF00082	0.415
CLV_PCSK_KEX2_1	148	150	PF00082	0.530
CLV_PCSK_KEX2_1	196	198	PF00082	0.591
CLV_PCSK_KEX2_1	201	203	PF00082	0.604
CLV_PCSK_KEX2_1	223	225	PF00082	0.583
CLV_PCSK_KEX2_1	250	252	PF00082	0.401
CLV_PCSK_KEX2_1	270	272	PF00082	0.579
CLV_PCSK_KEX2_1	366	368	PF00082	0.502
CLV_PCSK_KEX2_1	42	44	PF00082	0.488
CLV_PCSK_KEX2_1	540	542	PF00082	0.384
CLV_PCSK_KEX2_1	551	553	PF00082	0.394
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.583
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.467
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.502
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.476
CLV_PCSK_PC7_1	192	198	PF00082	0.474
CLV_PCSK_SKI1_1	171	175	PF00082	0.459
CLV_PCSK_SKI1_1	319	323	PF00082	0.619
CLV_PCSK_SKI1_1	394	398	PF00082	0.282
DEG_APCC_DBOX_1	168	176	PF00400	0.315
DEG_APCC_DBOX_1	393	401	PF00400	0.389
DEG_Nend_UBRbox_2	1	3	PF02207	0.546
DEG_SCF_FBW7_1	93	100	PF00400	0.521
DEG_SCF_FBW7_2	184	190	PF00400	0.347
DEG_SPOP_SBC_1	153	157	PF00917	0.425
DEG_SPOP_SBC_1	50	54	PF00917	0.573
DEG_SPOP_SBC_1	97	101	PF00917	0.658
DOC_CKS1_1	184	189	PF01111	0.355
DOC_CKS1_1	357	362	PF01111	0.425
DOC_MAPK_gen_1	167	176	PF00069	0.330
DOC_MAPK_gen_1	391	399	PF00069	0.448
DOC_MAPK_gen_1	551	561	PF00069	0.402
DOC_MAPK_MEF2A_6	167	176	PF00069	0.402
DOC_MAPK_MEF2A_6	182	191	PF00069	0.522
DOC_MAPK_MEF2A_6	391	399	PF00069	0.448
DOC_MAPK_MEF2A_6	551	559	PF00069	0.399
DOC_MAPK_NFAT4_5	169	177	PF00069	0.308
DOC_PP1_RVXF_1	190	196	PF00149	0.340
DOC_PP2B_LxvP_1	114	117	PF13499	0.621
DOC_PP2B_LxvP_1	395	398	PF13499	0.370
DOC_USP7_MATH_1	153	157	PF00917	0.436
DOC_USP7_MATH_1	200	204	PF00917	0.559
DOC_USP7_MATH_1	227	231	PF00917	0.684
DOC_USP7_MATH_1	292	296	PF00917	0.618
DOC_USP7_MATH_1	317	321	PF00917	0.646
DOC_USP7_MATH_1	487	491	PF00917	0.385
DOC_USP7_MATH_1	50	54	PF00917	0.798
DOC_USP7_MATH_1	95	99	PF00917	0.684
DOC_WW_Pin1_4	183	188	PF00397	0.376
DOC_WW_Pin1_4	309	314	PF00397	0.603
DOC_WW_Pin1_4	333	338	PF00397	0.622
DOC_WW_Pin1_4	356	361	PF00397	0.584
DOC_WW_Pin1_4	399	404	PF00397	0.459
DOC_WW_Pin1_4	408	413	PF00397	0.412
DOC_WW_Pin1_4	93	98	PF00397	0.586
LIG_14-3-3_CanoR_1	192	196	PF00244	0.392
LIG_14-3-3_CanoR_1	202	212	PF00244	0.570
LIG_14-3-3_CanoR_1	224	234	PF00244	0.537
LIG_14-3-3_CanoR_1	26	32	PF00244	0.522
LIG_14-3-3_CanoR_1	289	297	PF00244	0.577
LIG_14-3-3_CanoR_1	325	332	PF00244	0.422
LIG_Actin_WH2_1	169	184	PF00022	0.334
LIG_Actin_WH2_2	168	184	PF00022	0.336
LIG_BRCT_BRCA1_1	491	495	PF00533	0.348
LIG_deltaCOP1_diTrp_1	339	343	PF00928	0.464
LIG_deltaCOP1_diTrp_1	503	507	PF00928	0.345
LIG_FHA_1	184	190	PF00498	0.385
LIG_FHA_1	385	391	PF00498	0.587
LIG_FHA_1	412	418	PF00498	0.332
LIG_FHA_1	517	523	PF00498	0.543
LIG_FHA_2	334	340	PF00498	0.419
LIG_FHA_2	371	377	PF00498	0.607
LIG_GBD_Chelix_1	27	35	PF00786	0.406
LIG_LIR_Gen_1	135	144	PF02991	0.443
LIG_LIR_Nem_3	135	139	PF02991	0.440
LIG_LIR_Nem_3	247	252	PF02991	0.388
LIG_LIR_Nem_3	339	343	PF02991	0.503
LIG_LIR_Nem_3	389	395	PF02991	0.388
LIG_LIR_Nem_3	45	51	PF02991	0.521
LIG_LYPXL_yS_3	512	515	PF13949	0.390
LIG_Pex14_1	504	508	PF04695	0.350
LIG_Pex14_2	34	38	PF04695	0.420
LIG_Pex14_2	495	499	PF04695	0.336
LIG_RPA_C_Fungi	486	498	PF08784	0.276
LIG_SH2_CRK	249	253	PF00017	0.391
LIG_SH2_NCK_1	358	362	PF00017	0.427
LIG_SH2_STAP1	158	162	PF00017	0.510
LIG_SH2_STAT5	106	109	PF00017	0.467
LIG_SH2_STAT5	132	135	PF00017	0.400
LIG_SH2_STAT5	358	361	PF00017	0.426
LIG_SH2_STAT5	410	413	PF00017	0.392
LIG_SH3_3	109	115	PF00018	0.568
LIG_SH3_3	208	214	PF00018	0.527
LIG_SH3_3	307	313	PF00018	0.483
LIG_SH3_3	354	360	PF00018	0.394
LIG_SH3_CIN85_PxpxPR_1	115	120	PF14604	0.642
LIG_TRAF2_1	423	426	PF00917	0.476
LIG_TYR_ITIM	390	395	PF00017	0.443
MOD_CDC14_SPxK_1	316	319	PF00782	0.689
MOD_CDK_SPK_2	183	188	PF00069	0.376
MOD_CDK_SPxK_1	313	319	PF00069	0.671
MOD_CDK_SPxxK_3	399	406	PF00069	0.548
MOD_CK1_1	151	157	PF00069	0.646
MOD_CK1_1	203	209	PF00069	0.533
MOD_CK1_1	241	247	PF00069	0.402
MOD_CK1_1	277	283	PF00069	0.627
MOD_CK1_1	295	301	PF00069	0.497
MOD_CK1_1	312	318	PF00069	0.478
MOD_CK1_1	333	339	PF00069	0.460
MOD_CK1_1	356	362	PF00069	0.523
MOD_CK1_1	402	408	PF00069	0.453
MOD_CK1_1	52	58	PF00069	0.610
MOD_CK1_1	98	104	PF00069	0.486
MOD_CK2_1	153	159	PF00069	0.474
MOD_CK2_1	241	247	PF00069	0.505
MOD_CK2_1	370	376	PF00069	0.545
MOD_CK2_1	99	105	PF00069	0.473
MOD_CMANNOS	504	507	PF00535	0.341
MOD_Cter_Amidation	40	43	PF01082	0.430
MOD_GlcNHglycan	15	18	PF01048	0.517
MOD_GlcNHglycan	229	232	PF01048	0.546
MOD_GlcNHglycan	294	297	PF01048	0.548
MOD_GlcNHglycan	298	301	PF01048	0.415
MOD_GlcNHglycan	319	322	PF01048	0.629
MOD_GlcNHglycan	332	335	PF01048	0.422
MOD_GlcNHglycan	382	385	PF01048	0.608
MOD_GlcNHglycan	466	471	PF01048	0.569
MOD_GlcNHglycan	491	494	PF01048	0.277
MOD_GSK3_1	1	8	PF00069	0.709
MOD_GSK3_1	148	155	PF00069	0.563
MOD_GSK3_1	200	207	PF00069	0.621
MOD_GSK3_1	287	294	PF00069	0.655
MOD_GSK3_1	295	302	PF00069	0.460
MOD_GSK3_1	309	316	PF00069	0.475
MOD_GSK3_1	349	356	PF00069	0.430
MOD_GSK3_1	380	387	PF00069	0.562
MOD_GSK3_1	408	415	PF00069	0.481
MOD_GSK3_1	49	56	PF00069	0.731
MOD_GSK3_1	516	523	PF00069	0.564
MOD_GSK3_1	93	100	PF00069	0.783
MOD_NEK2_1	191	196	PF00069	0.514
MOD_NEK2_1	542	547	PF00069	0.354
MOD_NEK2_1	78	83	PF00069	0.675
MOD_NEK2_1	87	92	PF00069	0.592
MOD_PIKK_1	69	75	PF00454	0.630
MOD_PKA_1	148	154	PF00069	0.400
MOD_PKA_2	148	154	PF00069	0.400
MOD_PKA_2	191	197	PF00069	0.470
MOD_PKA_2	200	206	PF00069	0.570
MOD_PKA_2	277	283	PF00069	0.555
MOD_PKA_2	324	330	PF00069	0.494
MOD_PKA_2	380	386	PF00069	0.545
MOD_PKB_1	202	210	PF00069	0.613
MOD_Plk_1	158	164	PF00069	0.506
MOD_Plk_1	353	359	PF00069	0.384
MOD_Plk_4	353	359	PF00069	0.384
MOD_Plk_4	412	418	PF00069	0.368
MOD_Plk_4	542	548	PF00069	0.359
MOD_ProDKin_1	183	189	PF00069	0.364
MOD_ProDKin_1	309	315	PF00069	0.606
MOD_ProDKin_1	333	339	PF00069	0.613
MOD_ProDKin_1	356	362	PF00069	0.586
MOD_ProDKin_1	399	405	PF00069	0.460
MOD_ProDKin_1	408	414	PF00069	0.405
MOD_ProDKin_1	93	99	PF00069	0.586
MOD_SUMO_for_1	365	368	PF00179	0.499
MOD_SUMO_rev_2	461	470	PF00179	0.493
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.558
TRG_DiLeu_BaLyEn_6	391	396	PF01217	0.333
TRG_DiLeu_BaLyEn_6	510	515	PF01217	0.368
TRG_ENDOCYTIC_2	249	252	PF00928	0.401
TRG_ENDOCYTIC_2	392	395	PF00928	0.356
TRG_ENDOCYTIC_2	410	413	PF00928	0.392
TRG_ENDOCYTIC_2	512	515	PF00928	0.390
TRG_ER_diArg_1	148	150	PF00400	0.532
TRG_ER_diArg_1	169	172	PF00400	0.333
TRG_ER_diArg_1	195	197	PF00400	0.571
TRG_ER_diArg_1	201	204	PF00400	0.625
TRG_ER_diArg_1	269	271	PF00400	0.515
TRG_ER_diArg_1	540	542	PF00400	0.387
TRG_ER_diArg_1	550	553	PF00400	0.569
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	306	311	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	540	544	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	553	558	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F1	Leptomonas seymouri	36%	100%
A0A3S7WQM8	Leishmania donovani	68%	98%
A4HTX6	Leishmania infantum	67%	99%
E9AMQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	97%
Q4QHW9	Leishmania major	66%	99%