Putative leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H5N0_LEIBR

TriTrypDb:

LbrM.09.0550 , LBRM2903_090011000

Length:

988

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	8
GO:0000151	ubiquitin ligase complex	3	1
GO:0005930	axoneme	2	1
GO:0019005	SCF ubiquitin ligase complex	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4H5N0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5N0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.638
CLV_C14_Caspase3-7	282	286	PF00656	0.454
CLV_C14_Caspase3-7	362	366	PF00656	0.491
CLV_C14_Caspase3-7	605	609	PF00656	0.371
CLV_C14_Caspase3-7	722	726	PF00656	0.657
CLV_NRD_NRD_1	521	523	PF00675	0.610
CLV_NRD_NRD_1	671	673	PF00675	0.460
CLV_NRD_NRD_1	940	942	PF00675	0.565
CLV_PCSK_KEX2_1	130	132	PF00082	0.682
CLV_PCSK_KEX2_1	521	523	PF00082	0.610
CLV_PCSK_KEX2_1	671	673	PF00082	0.348
CLV_PCSK_KEX2_1	920	922	PF00082	0.790
CLV_PCSK_KEX2_1	940	942	PF00082	0.487
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.477
CLV_PCSK_PC1ET2_1	920	922	PF00082	0.790
CLV_PCSK_SKI1_1	148	152	PF00082	0.762
CLV_PCSK_SKI1_1	494	498	PF00082	0.536
CLV_PCSK_SKI1_1	517	521	PF00082	0.459
CLV_PCSK_SKI1_1	604	608	PF00082	0.548
CLV_PCSK_SKI1_1	731	735	PF00082	0.596
CLV_PCSK_SKI1_1	917	921	PF00082	0.799
DEG_APCC_DBOX_1	459	467	PF00400	0.518
DEG_APCC_DBOX_1	493	501	PF00400	0.586
DEG_SPOP_SBC_1	777	781	PF00917	0.536
DOC_CDC14_PxL_1	288	296	PF14671	0.579
DOC_CYCLIN_RxL_1	319	328	PF00134	0.580
DOC_CYCLIN_RxL_1	445	453	PF00134	0.445
DOC_CYCLIN_RxL_1	735	748	PF00134	0.706
DOC_CYCLIN_yCln2_LP_2	399	402	PF00134	0.572
DOC_MAPK_DCC_7	322	331	PF00069	0.574
DOC_MAPK_DCC_7	482	491	PF00069	0.586
DOC_MAPK_gen_1	417	426	PF00069	0.560
DOC_MAPK_gen_1	460	468	PF00069	0.514
DOC_MAPK_gen_1	482	491	PF00069	0.497
DOC_MAPK_HePTP_8	479	491	PF00069	0.578
DOC_MAPK_MEF2A_6	10	18	PF00069	0.509
DOC_MAPK_MEF2A_6	322	331	PF00069	0.574
DOC_MAPK_MEF2A_6	405	414	PF00069	0.310
DOC_MAPK_MEF2A_6	462	470	PF00069	0.317
DOC_MAPK_MEF2A_6	482	491	PF00069	0.541
DOC_PP2B_LxvP_1	324	327	PF13499	0.428
DOC_PP2B_LxvP_1	38	41	PF13499	0.529
DOC_PP2B_LxvP_1	398	401	PF13499	0.497
DOC_PP2B_LxvP_1	487	490	PF13499	0.526
DOC_PP2B_LxvP_1	500	503	PF13499	0.480
DOC_PP4_MxPP_1	44	47	PF00568	0.519
DOC_SPAK_OSR1_1	557	561	PF12202	0.321
DOC_USP7_MATH_1	157	161	PF00917	0.680
DOC_USP7_MATH_1	19	23	PF00917	0.583
DOC_USP7_MATH_1	211	215	PF00917	0.684
DOC_USP7_MATH_1	228	232	PF00917	0.328
DOC_USP7_MATH_1	24	28	PF00917	0.552
DOC_USP7_MATH_1	241	245	PF00917	0.507
DOC_USP7_MATH_1	260	264	PF00917	0.422
DOC_USP7_MATH_1	278	282	PF00917	0.500
DOC_USP7_MATH_1	57	61	PF00917	0.656
DOC_USP7_MATH_1	684	688	PF00917	0.673
DOC_USP7_MATH_1	762	766	PF00917	0.748
DOC_USP7_MATH_1	787	791	PF00917	0.632
DOC_USP7_MATH_1	800	804	PF00917	0.672
DOC_USP7_MATH_1	915	919	PF00917	0.757
DOC_USP7_MATH_1	929	933	PF00917	0.676
DOC_USP7_MATH_1	947	951	PF00917	0.791
DOC_USP7_MATH_1	979	983	PF00917	0.598
DOC_WW_Pin1_4	10	15	PF00397	0.640
DOC_WW_Pin1_4	758	763	PF00397	0.513
DOC_WW_Pin1_4	878	883	PF00397	0.715
DOC_WW_Pin1_4	887	892	PF00397	0.688
DOC_WW_Pin1_4	943	948	PF00397	0.679
LIG_14-3-3_CanoR_1	259	265	PF00244	0.620
LIG_14-3-3_CanoR_1	267	272	PF00244	0.534
LIG_14-3-3_CanoR_1	322	327	PF00244	0.323
LIG_14-3-3_CanoR_1	405	412	PF00244	0.534
LIG_14-3-3_CanoR_1	420	425	PF00244	0.342
LIG_14-3-3_CanoR_1	431	439	PF00244	0.379
LIG_14-3-3_CanoR_1	504	510	PF00244	0.551
LIG_14-3-3_CanoR_1	538	543	PF00244	0.570
LIG_14-3-3_CanoR_1	557	565	PF00244	0.281
LIG_14-3-3_CanoR_1	604	611	PF00244	0.541
LIG_14-3-3_CanoR_1	766	770	PF00244	0.656
LIG_14-3-3_CanoR_1	94	103	PF00244	0.640
LIG_14-3-3_CanoR_1	940	944	PF00244	0.764
LIG_APCC_ABBA_1	968	973	PF00400	0.538
LIG_BIR_II_1	1	5	PF00653	0.776
LIG_BRCT_BRCA1_1	249	253	PF00533	0.433
LIG_BRCT_BRCA1_1	269	273	PF00533	0.549
LIG_BRCT_BRCA1_1	540	544	PF00533	0.452
LIG_BRCT_BRCA1_1	802	806	PF00533	0.791
LIG_FHA_1	266	272	PF00498	0.558
LIG_FHA_1	310	316	PF00498	0.492
LIG_FHA_1	343	349	PF00498	0.572
LIG_FHA_1	362	368	PF00498	0.595
LIG_FHA_1	371	377	PF00498	0.528
LIG_FHA_1	382	388	PF00498	0.529
LIG_FHA_1	401	407	PF00498	0.543
LIG_FHA_1	421	427	PF00498	0.254
LIG_FHA_1	525	531	PF00498	0.597
LIG_FHA_1	554	560	PF00498	0.308
LIG_FHA_1	595	601	PF00498	0.518
LIG_FHA_1	660	666	PF00498	0.584
LIG_FHA_1	762	768	PF00498	0.559
LIG_FHA_2	178	184	PF00498	0.469
LIG_FHA_2	211	217	PF00498	0.413
LIG_FHA_2	280	286	PF00498	0.574
LIG_FHA_2	541	547	PF00498	0.563
LIG_FHA_2	603	609	PF00498	0.514
LIG_Integrin_isoDGR_2	524	526	PF01839	0.655
LIG_LIR_Gen_1	226	233	PF02991	0.402
LIG_LIR_Gen_1	467	478	PF02991	0.329
LIG_LIR_Gen_1	552	560	PF02991	0.313
LIG_LIR_Gen_1	591	600	PF02991	0.415
LIG_LIR_Gen_1	863	872	PF02991	0.715
LIG_LIR_Nem_3	226	230	PF02991	0.404
LIG_LIR_Nem_3	467	473	PF02991	0.320
LIG_LIR_Nem_3	552	558	PF02991	0.564
LIG_LIR_Nem_3	591	595	PF02991	0.441
LIG_LIR_Nem_3	863	867	PF02991	0.720
LIG_MAD2	448	456	PF02301	0.439
LIG_NRBOX	232	238	PF00104	0.623
LIG_NRBOX	338	344	PF00104	0.543
LIG_PCNA_yPIPBox_3	504	514	PF02747	0.328
LIG_Pex14_2	269	273	PF04695	0.549
LIG_SH2_CRK	165	169	PF00017	0.529
LIG_SH2_CRK	227	231	PF00017	0.448
LIG_SH2_NCK_1	227	231	PF00017	0.361
LIG_SH2_SRC	353	356	PF00017	0.489
LIG_SH2_STAT5	190	193	PF00017	0.566
LIG_SH2_STAT5	196	199	PF00017	0.588
LIG_SH2_STAT5	353	356	PF00017	0.489
LIG_SH2_STAT5	391	394	PF00017	0.447
LIG_SH3_3	197	203	PF00018	0.666
LIG_SH3_3	658	664	PF00018	0.610
LIG_SH3_3	756	762	PF00018	0.631
LIG_SUMO_SIM_anti_2	121	129	PF11976	0.676
LIG_SUMO_SIM_anti_2	396	401	PF11976	0.427
LIG_SUMO_SIM_anti_2	464	472	PF11976	0.520
LIG_SUMO_SIM_anti_2	597	602	PF11976	0.556
LIG_SUMO_SIM_par_1	12	20	PF11976	0.505
LIG_SUMO_SIM_par_1	121	129	PF11976	0.647
LIG_SUMO_SIM_par_1	372	377	PF11976	0.566
LIG_SUMO_SIM_par_1	383	388	PF11976	0.398
LIG_SUMO_SIM_par_1	422	427	PF11976	0.415
LIG_SUMO_SIM_par_1	448	453	PF11976	0.568
LIG_SUMO_SIM_par_1	857	863	PF11976	0.602
LIG_TRAF2_1	863	866	PF00917	0.784
LIG_TRAF2_1	906	909	PF00917	0.810
LIG_TRAF2_1	911	914	PF00917	0.733
LIG_TRAF2_1	985	988	PF00917	0.808
LIG_TYR_ITIM	225	230	PF00017	0.440
LIG_UBA3_1	123	130	PF00899	0.435
LIG_WRC_WIRS_1	266	271	PF05994	0.470
LIG_WRC_WIRS_1	589	594	PF05994	0.357
LIG_WRC_WIRS_1	861	866	PF05994	0.724
LIG_WW_3	40	44	PF00397	0.640
MOD_CDK_SPK_2	758	763	PF00069	0.513
MOD_CK1_1	175	181	PF00069	0.501
MOD_CK1_1	27	33	PF00069	0.621
MOD_CK1_1	281	287	PF00069	0.459
MOD_CK1_1	290	296	PF00069	0.445
MOD_CK1_1	506	512	PF00069	0.595
MOD_CK1_1	545	551	PF00069	0.500
MOD_CK1_1	561	567	PF00069	0.391
MOD_CK1_1	584	590	PF00069	0.609
MOD_CK1_1	594	600	PF00069	0.291
MOD_CK1_1	632	638	PF00069	0.585
MOD_CK1_1	761	767	PF00069	0.623
MOD_CK1_1	821	827	PF00069	0.785
MOD_CK1_1	844	850	PF00069	0.593
MOD_CK1_1	860	866	PF00069	0.550
MOD_CK1_1	878	884	PF00069	0.811
MOD_CK1_1	890	896	PF00069	0.726
MOD_CK1_1	897	903	PF00069	0.687
MOD_CK1_1	942	948	PF00069	0.765
MOD_CK1_1	950	956	PF00069	0.635
MOD_CK2_1	210	216	PF00069	0.676
MOD_CK2_1	322	328	PF00069	0.429
MOD_CK2_1	540	546	PF00069	0.569
MOD_CK2_1	721	727	PF00069	0.541
MOD_CK2_1	765	771	PF00069	0.539
MOD_CK2_1	787	793	PF00069	0.651
MOD_CK2_1	860	866	PF00069	0.779
MOD_CK2_1	903	909	PF00069	0.760
MOD_DYRK1A_RPxSP_1	758	762	PF00069	0.506
MOD_GlcNHglycan	134	137	PF01048	0.514
MOD_GlcNHglycan	191	194	PF01048	0.541
MOD_GlcNHglycan	213	216	PF01048	0.666
MOD_GlcNHglycan	241	244	PF01048	0.516
MOD_GlcNHglycan	255	258	PF01048	0.619
MOD_GlcNHglycan	26	29	PF01048	0.551
MOD_GlcNHglycan	360	364	PF01048	0.575
MOD_GlcNHglycan	375	379	PF01048	0.574
MOD_GlcNHglycan	393	396	PF01048	0.258
MOD_GlcNHglycan	425	429	PF01048	0.444
MOD_GlcNHglycan	577	580	PF01048	0.444
MOD_GlcNHglycan	583	586	PF01048	0.495
MOD_GlcNHglycan	59	62	PF01048	0.460
MOD_GlcNHglycan	695	698	PF01048	0.708
MOD_GlcNHglycan	711	714	PF01048	0.681
MOD_GlcNHglycan	747	750	PF01048	0.688
MOD_GlcNHglycan	788	792	PF01048	0.796
MOD_GlcNHglycan	820	823	PF01048	0.783
MOD_GlcNHglycan	833	836	PF01048	0.668
MOD_GlcNHglycan	896	899	PF01048	0.646
MOD_GlcNHglycan	931	934	PF01048	0.724
MOD_GlcNHglycan	949	952	PF01048	0.810
MOD_GSK3_1	10	17	PF00069	0.713
MOD_GSK3_1	132	139	PF00069	0.563
MOD_GSK3_1	359	366	PF00069	0.637
MOD_GSK3_1	370	377	PF00069	0.467
MOD_GSK3_1	381	388	PF00069	0.362
MOD_GSK3_1	400	407	PF00069	0.571
MOD_GSK3_1	420	427	PF00069	0.225
MOD_GSK3_1	538	545	PF00069	0.539
MOD_GSK3_1	584	591	PF00069	0.412
MOD_GSK3_1	680	687	PF00069	0.396
MOD_GSK3_1	711	718	PF00069	0.660
MOD_GSK3_1	758	765	PF00069	0.518
MOD_GSK3_1	889	896	PF00069	0.790
MOD_GSK3_1	915	922	PF00069	0.795
MOD_GSK3_1	939	946	PF00069	0.762
MOD_GSK3_1	949	956	PF00069	0.713
MOD_LATS_1	265	271	PF00433	0.571
MOD_LATS_1	572	578	PF00433	0.586
MOD_N-GLC_1	440	445	PF02516	0.471
MOD_N-GLC_1	841	846	PF02516	0.621
MOD_N-GLC_2	275	277	PF02516	0.352
MOD_N-GLC_2	370	372	PF02516	0.326
MOD_NEK2_1	1	6	PF00069	0.707
MOD_NEK2_1	210	215	PF00069	0.563
MOD_NEK2_1	253	258	PF00069	0.444
MOD_NEK2_1	287	292	PF00069	0.472
MOD_NEK2_1	316	321	PF00069	0.345
MOD_NEK2_1	34	39	PF00069	0.707
MOD_NEK2_1	374	379	PF00069	0.425
MOD_NEK2_1	385	390	PF00069	0.402
MOD_NEK2_1	406	411	PF00069	0.430
MOD_NEK2_1	424	429	PF00069	0.344
MOD_NEK2_1	439	444	PF00069	0.464
MOD_NEK2_1	469	474	PF00069	0.450
MOD_NEK2_1	558	563	PF00069	0.478
MOD_NEK2_1	778	783	PF00069	0.787
MOD_NEK2_1	831	836	PF00069	0.781
MOD_NEK2_2	260	265	PF00069	0.478
MOD_NEK2_2	533	538	PF00069	0.409
MOD_NEK2_2	684	689	PF00069	0.461
MOD_NEK2_2	915	920	PF00069	0.761
MOD_PIKK_1	316	322	PF00454	0.535
MOD_PIKK_1	385	391	PF00454	0.311
MOD_PIKK_1	503	509	PF00454	0.583
MOD_PIKK_1	558	564	PF00454	0.584
MOD_PIKK_1	875	881	PF00454	0.565
MOD_PIKK_1	900	906	PF00454	0.789
MOD_PK_1	111	117	PF00069	0.388
MOD_PK_1	267	273	PF00069	0.564
MOD_PK_1	538	544	PF00069	0.565
MOD_PKA_2	132	138	PF00069	0.642
MOD_PKA_2	404	410	PF00069	0.534
MOD_PKA_2	430	436	PF00069	0.559
MOD_PKA_2	503	509	PF00069	0.548
MOD_PKA_2	688	694	PF00069	0.647
MOD_PKA_2	762	768	PF00069	0.749
MOD_PKA_2	9	15	PF00069	0.755
MOD_PKA_2	939	945	PF00069	0.749
MOD_PKA_2	953	959	PF00069	0.649
MOD_Plk_1	19	25	PF00069	0.581
MOD_Plk_1	533	539	PF00069	0.499
MOD_Plk_1	545	551	PF00069	0.471
MOD_Plk_1	635	641	PF00069	0.576
MOD_Plk_1	979	985	PF00069	0.657
MOD_Plk_4	111	117	PF00069	0.535
MOD_Plk_4	172	178	PF00069	0.720
MOD_Plk_4	228	234	PF00069	0.565
MOD_Plk_4	406	412	PF00069	0.557
MOD_Plk_4	496	502	PF00069	0.549
MOD_Plk_4	588	594	PF00069	0.371
MOD_Plk_4	715	721	PF00069	0.612
MOD_ProDKin_1	10	16	PF00069	0.641
MOD_ProDKin_1	758	764	PF00069	0.515
MOD_ProDKin_1	878	884	PF00069	0.715
MOD_ProDKin_1	887	893	PF00069	0.687
MOD_ProDKin_1	943	949	PF00069	0.680
MOD_SUMO_for_1	69	72	PF00179	0.518
MOD_SUMO_rev_2	375	384	PF00179	0.326
TRG_DiLeu_BaEn_1	121	126	PF01217	0.621
TRG_DiLeu_BaEn_4	121	127	PF01217	0.674
TRG_DiLeu_BaEn_4	534	540	PF01217	0.486
TRG_DiLeu_BaEn_4	72	78	PF01217	0.505
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.597
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.617
TRG_DiLeu_BaLyEn_6	737	742	PF01217	0.447
TRG_ENDOCYTIC_2	165	168	PF00928	0.532
TRG_ENDOCYTIC_2	227	230	PF00928	0.449
TRG_ER_diArg_1	343	346	PF00400	0.512
TRG_ER_diArg_1	460	463	PF00400	0.313
TRG_ER_diArg_1	520	522	PF00400	0.610
TRG_ER_diArg_1	671	673	PF00400	0.449
TRG_NES_CRM1_1	365	380	PF08389	0.333
TRG_NES_CRM1_1	647	659	PF08389	0.551
TRG_NES_CRM1_1	973	987	PF08389	0.557
TRG_Pf-PMV_PEXEL_1	235	240	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	448	453	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	557	562	PF00026	0.316
TRG_Pf-PMV_PEXEL_1	604	608	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	640	644	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	671	675	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	740	745	PF00026	0.703
TRG_Pf-PMV_PEXEL_1	921	925	PF00026	0.782

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NN23	Trypanosomatidae	27%	76%
A0A3S7WQP1	Leishmania donovani	71%	99%
A0A422NV64	Trypanosoma rangeli	27%	91%
A4HTW7	Leishmania infantum	71%	99%
D0A9D1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	94%
E9AMQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QHX1	Leishmania major	70%	99%