Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 3

Species:

Leishmania braziliensis

UniProt:

A4H5M9_LEIBR

TriTrypDb:

LbrM.09.0540 , LBRM2903_090010900

Length:

769

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5M9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5M9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0071889	14-3-3 protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.744
CLV_NRD_NRD_1	265	267	PF00675	0.516
CLV_NRD_NRD_1	463	465	PF00675	0.585
CLV_NRD_NRD_1	755	757	PF00675	0.750
CLV_PCSK_KEX2_1	214	216	PF00082	0.497
CLV_PCSK_KEX2_1	239	241	PF00082	0.533
CLV_PCSK_KEX2_1	328	330	PF00082	0.436
CLV_PCSK_KEX2_1	463	465	PF00082	0.585
CLV_PCSK_KEX2_1	617	619	PF00082	0.577
CLV_PCSK_KEX2_1	755	757	PF00082	0.750
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.497
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.533
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.436
CLV_PCSK_PC1ET2_1	617	619	PF00082	0.594
CLV_PCSK_SKI1_1	112	116	PF00082	0.588
CLV_PCSK_SKI1_1	229	233	PF00082	0.484
CLV_PCSK_SKI1_1	342	346	PF00082	0.512
CLV_PCSK_SKI1_1	400	404	PF00082	0.636
CLV_PCSK_SKI1_1	451	455	PF00082	0.434
CLV_PCSK_SKI1_1	466	470	PF00082	0.501
CLV_PCSK_SKI1_1	542	546	PF00082	0.509
CLV_PCSK_SKI1_1	550	554	PF00082	0.311
CLV_PCSK_SKI1_1	58	62	PF00082	0.398
CLV_PCSK_SKI1_1	683	687	PF00082	0.431
CLV_PCSK_SKI1_1	71	75	PF00082	0.413
DEG_SCF_FBW7_1	634	641	PF00400	0.587
DOC_CKS1_1	726	731	PF01111	0.602
DOC_CYCLIN_yCln2_LP_2	726	732	PF00134	0.618
DOC_MAPK_gen_1	239	247	PF00069	0.526
DOC_MAPK_HePTP_8	526	538	PF00069	0.504
DOC_MAPK_MEF2A_6	436	444	PF00069	0.495
DOC_MAPK_MEF2A_6	529	538	PF00069	0.495
DOC_PP4_FxxP_1	384	387	PF00568	0.641
DOC_USP7_MATH_1	387	391	PF00917	0.637
DOC_USP7_MATH_1	543	547	PF00917	0.551
DOC_USP7_MATH_1	562	566	PF00917	0.733
DOC_USP7_MATH_1	60	64	PF00917	0.309
DOC_USP7_MATH_1	638	642	PF00917	0.707
DOC_USP7_MATH_1	645	649	PF00917	0.774
DOC_USP7_MATH_1	754	758	PF00917	0.790
DOC_USP7_UBL2_3	183	187	PF12436	0.686
DOC_USP7_UBL2_3	529	533	PF12436	0.568
DOC_WW_Pin1_4	627	632	PF00397	0.726
DOC_WW_Pin1_4	634	639	PF00397	0.636
DOC_WW_Pin1_4	641	646	PF00397	0.697
DOC_WW_Pin1_4	675	680	PF00397	0.584
DOC_WW_Pin1_4	699	704	PF00397	0.594
DOC_WW_Pin1_4	725	730	PF00397	0.612
LIG_14-3-3_CanoR_1	158	164	PF00244	0.609
LIG_14-3-3_CanoR_1	259	264	PF00244	0.438
LIG_14-3-3_CanoR_1	329	338	PF00244	0.561
LIG_14-3-3_CanoR_1	34	40	PF00244	0.385
LIG_14-3-3_CanoR_1	484	490	PF00244	0.563
LIG_14-3-3_CanoR_1	542	548	PF00244	0.528
LIG_14-3-3_CanoR_1	727	733	PF00244	0.610
LIG_14-3-3_CanoR_1	755	760	PF00244	0.765
LIG_14-3-3_CanoR_1	92	101	PF00244	0.591
LIG_Actin_WH2_2	44	60	PF00022	0.414
LIG_APCC_ABBAyCdc20_2	248	254	PF00400	0.460
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_BIR_III_2	744	748	PF00653	0.807
LIG_DLG_GKlike_1	711	718	PF00625	0.502
LIG_EVH1_2	548	552	PF00568	0.498
LIG_FHA_1	12	18	PF00498	0.494
LIG_FHA_1	151	157	PF00498	0.535
LIG_FHA_1	25	31	PF00498	0.456
LIG_FHA_1	357	363	PF00498	0.566
LIG_FHA_1	435	441	PF00498	0.580
LIG_FHA_1	46	52	PF00498	0.508
LIG_FHA_2	160	166	PF00498	0.653
LIG_FHA_2	374	380	PF00498	0.560
LIG_FHA_2	499	505	PF00498	0.491
LIG_IBAR_NPY_1	567	569	PF08397	0.610
LIG_LIR_Apic_2	699	703	PF02991	0.693
LIG_LIR_Gen_1	217	226	PF02991	0.580
LIG_LIR_Gen_1	242	252	PF02991	0.488
LIG_LIR_Gen_1	321	327	PF02991	0.584
LIG_LIR_Gen_1	515	526	PF02991	0.556
LIG_LIR_Gen_1	572	581	PF02991	0.619
LIG_LIR_Gen_1	702	713	PF02991	0.717
LIG_LIR_Gen_1	731	737	PF02991	0.519
LIG_LIR_Nem_3	242	247	PF02991	0.461
LIG_LIR_Nem_3	250	255	PF02991	0.402
LIG_LIR_Nem_3	308	314	PF02991	0.505
LIG_LIR_Nem_3	349	355	PF02991	0.502
LIG_LIR_Nem_3	379	384	PF02991	0.555
LIG_LIR_Nem_3	490	496	PF02991	0.565
LIG_LIR_Nem_3	514	520	PF02991	0.564
LIG_LIR_Nem_3	572	576	PF02991	0.678
LIG_LIR_Nem_3	702	708	PF02991	0.714
LIG_LIR_Nem_3	731	736	PF02991	0.518
LIG_PDZ_Class_1	764	769	PF00595	0.555
LIG_Pex14_2	350	354	PF04695	0.470
LIG_PTB_Apo_2	246	253	PF02174	0.523
LIG_REV1ctd_RIR_1	504	512	PF16727	0.428
LIG_REV1ctd_RIR_1	91	101	PF16727	0.447
LIG_SH2_CRK	301	305	PF00017	0.531
LIG_SH2_GRB2like	314	317	PF00017	0.544
LIG_SH2_GRB2like	489	492	PF00017	0.586
LIG_SH2_NCK_1	573	577	PF00017	0.674
LIG_SH2_PTP2	705	708	PF00017	0.502
LIG_SH2_SRC	314	317	PF00017	0.545
LIG_SH2_SRC	392	395	PF00017	0.586
LIG_SH2_SRC	573	576	PF00017	0.676
LIG_SH2_STAP1	489	493	PF00017	0.589
LIG_SH2_STAP1	581	585	PF00017	0.344
LIG_SH2_STAT3	189	192	PF00017	0.706
LIG_SH2_STAT3	489	492	PF00017	0.555
LIG_SH2_STAT3	527	530	PF00017	0.693
LIG_SH2_STAT5	168	171	PF00017	0.678
LIG_SH2_STAT5	189	192	PF00017	0.711
LIG_SH2_STAT5	292	295	PF00017	0.648
LIG_SH2_STAT5	314	317	PF00017	0.431
LIG_SH2_STAT5	392	395	PF00017	0.586
LIG_SH2_STAT5	505	508	PF00017	0.524
LIG_SH2_STAT5	518	521	PF00017	0.565
LIG_SH2_STAT5	551	554	PF00017	0.495
LIG_SH2_STAT5	705	708	PF00017	0.650
LIG_SH2_STAT5	83	86	PF00017	0.481
LIG_SH3_3	531	537	PF00018	0.598
LIG_SH3_3	673	679	PF00018	0.521
LIG_SH3_3	682	688	PF00018	0.483
LIG_SH3_CIN85_PxpxPR_1	627	632	PF14604	0.659
LIG_Sin3_3	479	486	PF02671	0.447
LIG_SUMO_SIM_anti_2	439	444	PF11976	0.419
LIG_SUMO_SIM_anti_2	450	457	PF11976	0.460
LIG_SUMO_SIM_par_1	452	457	PF11976	0.507
LIG_TRAF2_1	162	165	PF00917	0.627
LIG_TRAF2_1	231	234	PF00917	0.497
LIG_TRAF2_1	472	475	PF00917	0.549
LIG_TRAF2_1	670	673	PF00917	0.654
LIG_UBA3_1	180	187	PF00899	0.725
LIG_WW_1	548	551	PF00397	0.491
LIG_WW_3	547	551	PF00397	0.503
MOD_CDK_SPK_2	627	632	PF00069	0.756
MOD_CDK_SPK_2	634	639	PF00069	0.636
MOD_CK1_1	150	156	PF00069	0.508
MOD_CK1_1	170	176	PF00069	0.441
MOD_CK1_1	262	268	PF00069	0.567
MOD_CK1_1	356	362	PF00069	0.549
MOD_CK1_1	395	401	PF00069	0.563
MOD_CK1_1	41	47	PF00069	0.585
MOD_CK1_1	485	491	PF00069	0.558
MOD_CK1_1	561	567	PF00069	0.698
MOD_CK1_1	641	647	PF00069	0.696
MOD_CK1_1	650	656	PF00069	0.741
MOD_CK1_1	699	705	PF00069	0.603
MOD_CK1_1	749	755	PF00069	0.705
MOD_CK1_1	762	768	PF00069	0.679
MOD_CK2_1	159	165	PF00069	0.587
MOD_CK2_1	170	176	PF00069	0.611
MOD_CK2_1	330	336	PF00069	0.478
MOD_CK2_1	373	379	PF00069	0.591
MOD_CK2_1	456	462	PF00069	0.560
MOD_CK2_1	498	504	PF00069	0.457
MOD_CK2_1	601	607	PF00069	0.475
MOD_CK2_1	72	78	PF00069	0.457
MOD_GlcNHglycan	1	4	PF01048	0.709
MOD_GlcNHglycan	149	152	PF01048	0.506
MOD_GlcNHglycan	192	195	PF01048	0.725
MOD_GlcNHglycan	332	335	PF01048	0.605
MOD_GlcNHglycan	484	487	PF01048	0.546
MOD_GlcNHglycan	560	563	PF01048	0.572
MOD_GlcNHglycan	62	65	PF01048	0.332
MOD_GlcNHglycan	640	643	PF01048	0.674
MOD_GlcNHglycan	649	652	PF01048	0.616
MOD_GlcNHglycan	748	751	PF01048	0.702
MOD_GlcNHglycan	752	755	PF01048	0.671
MOD_GlcNHglycan	766	769	PF01048	0.556
MOD_GSK3_1	136	143	PF00069	0.606
MOD_GSK3_1	166	173	PF00069	0.620
MOD_GSK3_1	35	42	PF00069	0.596
MOD_GSK3_1	392	399	PF00069	0.661
MOD_GSK3_1	558	565	PF00069	0.647
MOD_GSK3_1	634	641	PF00069	0.666
MOD_GSK3_1	646	653	PF00069	0.724
MOD_GSK3_1	7	14	PF00069	0.511
MOD_GSK3_1	746	753	PF00069	0.664
MOD_GSK3_1	755	762	PF00069	0.648
MOD_LATS_1	202	208	PF00433	0.540
MOD_N-GLC_1	330	335	PF02516	0.548
MOD_N-GLC_1	457	462	PF02516	0.671
MOD_NEK2_1	136	141	PF00069	0.580
MOD_NEK2_1	147	152	PF00069	0.486
MOD_NEK2_1	190	195	PF00069	0.555
MOD_NEK2_1	39	44	PF00069	0.651
MOD_NEK2_1	396	401	PF00069	0.514
MOD_NEK2_1	454	459	PF00069	0.620
MOD_NEK2_1	553	558	PF00069	0.439
MOD_NEK2_1	593	598	PF00069	0.558
MOD_PIKK_1	140	146	PF00454	0.663
MOD_PIKK_1	188	194	PF00454	0.637
MOD_PIKK_1	204	210	PF00454	0.411
MOD_PIKK_1	92	98	PF00454	0.560
MOD_PKA_1	755	761	PF00069	0.696
MOD_PKA_2	638	644	PF00069	0.695
MOD_PKA_2	696	702	PF00069	0.685
MOD_PKA_2	754	760	PF00069	0.752
MOD_PKB_1	709	717	PF00069	0.502
MOD_PKB_1	90	98	PF00069	0.582
MOD_Plk_1	279	285	PF00069	0.610
MOD_Plk_4	136	142	PF00069	0.605
MOD_Plk_4	21	27	PF00069	0.616
MOD_Plk_4	7	13	PF00069	0.525
MOD_Plk_4	728	734	PF00069	0.609
MOD_ProDKin_1	627	633	PF00069	0.728
MOD_ProDKin_1	634	640	PF00069	0.636
MOD_ProDKin_1	641	647	PF00069	0.699
MOD_ProDKin_1	675	681	PF00069	0.582
MOD_ProDKin_1	699	705	PF00069	0.603
MOD_ProDKin_1	725	731	PF00069	0.604
MOD_SUMO_rev_2	379	384	PF00179	0.551
TRG_DiLeu_BaEn_1	127	132	PF01217	0.517
TRG_DiLeu_BaEn_1	450	455	PF01217	0.447
TRG_DiLeu_BaEn_4	109	115	PF01217	0.585
TRG_DiLeu_BaEn_4	672	678	PF01217	0.561
TRG_ENDOCYTIC_2	160	163	PF00928	0.569
TRG_ENDOCYTIC_2	218	221	PF00928	0.580
TRG_ENDOCYTIC_2	314	317	PF00928	0.433
TRG_ENDOCYTIC_2	352	355	PF00928	0.458
TRG_ENDOCYTIC_2	381	384	PF00928	0.553
TRG_ENDOCYTIC_2	493	496	PF00928	0.547
TRG_ENDOCYTIC_2	517	520	PF00928	0.571
TRG_ENDOCYTIC_2	551	554	PF00928	0.479
TRG_ENDOCYTIC_2	573	576	PF00928	0.676
TRG_ENDOCYTIC_2	705	708	PF00928	0.743
TRG_ER_diArg_1	463	466	PF00400	0.592
TRG_ER_diArg_1	708	711	PF00400	0.689
TRG_ER_diArg_1	90	93	PF00400	0.584
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3D7	Leptomonas seymouri	78%	100%
A0A1X0NMP1	Trypanosomatidae	57%	96%
A0A3R7MX09	Trypanosoma rangeli	57%	97%
A0A3S5H6D5	Leishmania donovani	90%	100%
A4HTW6	Leishmania infantum	90%	100%
D0A9D0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	95%
E9AMQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QHX2	Leishmania major	89%	100%
V5BSM8	Trypanosoma cruzi	56%	96%