Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5M8_LEIBR

TriTrypDb:

LbrM.09.0530 , LBRM2903_090010800

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5M8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5M8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	144	150	PF00089	0.360
CLV_NRD_NRD_1	106	108	PF00675	0.605
CLV_NRD_NRD_1	164	166	PF00675	0.537
CLV_NRD_NRD_1	188	190	PF00675	0.599
CLV_NRD_NRD_1	253	255	PF00675	0.653
CLV_NRD_NRD_1	271	273	PF00675	0.602
CLV_NRD_NRD_1	55	57	PF00675	0.351
CLV_PCSK_KEX2_1	108	110	PF00082	0.719
CLV_PCSK_KEX2_1	164	166	PF00082	0.537
CLV_PCSK_KEX2_1	188	190	PF00082	0.619
CLV_PCSK_KEX2_1	253	255	PF00082	0.704
CLV_PCSK_KEX2_1	55	57	PF00082	0.367
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.700
CLV_PCSK_PC7_1	104	110	PF00082	0.646
CLV_PCSK_SKI1_1	136	140	PF00082	0.351
CLV_PCSK_SKI1_1	395	399	PF00082	0.597
DEG_ODPH_VHL_1	111	122	PF01847	0.440
DEG_SCF_FBW7_1	274	280	PF00400	0.717
DEG_SPOP_SBC_1	277	281	PF00917	0.520
DOC_CKS1_1	274	279	PF01111	0.718
DOC_CYCLIN_RxL_1	133	143	PF00134	0.467
DOC_CYCLIN_yCln2_LP_2	82	88	PF00134	0.274
DOC_MAPK_gen_1	55	63	PF00069	0.358
DOC_MAPK_MEF2A_6	19	26	PF00069	0.329
DOC_MAPK_MEF2A_6	56	65	PF00069	0.375
DOC_PP1_RVXF_1	134	140	PF00149	0.364
DOC_PP1_RVXF_1	79	85	PF00149	0.282
DOC_PP2B_LxvP_1	63	66	PF13499	0.359
DOC_PP4_FxxP_1	32	35	PF00568	0.479
DOC_PP4_FxxP_1	84	87	PF00568	0.458
DOC_USP7_MATH_1	15	19	PF00917	0.478
DOC_USP7_MATH_1	206	210	PF00917	0.683
DOC_USP7_MATH_1	277	281	PF00917	0.725
DOC_USP7_MATH_1	324	328	PF00917	0.449
DOC_WW_Pin1_4	146	151	PF00397	0.441
DOC_WW_Pin1_4	273	278	PF00397	0.621
DOC_WW_Pin1_4	287	292	PF00397	0.802
DOC_WW_Pin1_4	34	39	PF00397	0.516
LIG_14-3-3_CanoR_1	205	213	PF00244	0.703
LIG_14-3-3_CanoR_1	222	228	PF00244	0.560
LIG_14-3-3_CanoR_1	253	260	PF00244	0.642
LIG_14-3-3_CanoR_1	262	270	PF00244	0.527
LIG_14-3-3_CanoR_1	272	277	PF00244	0.488
LIG_14-3-3_CanoR_1	44	50	PF00244	0.406
LIG_BIR_II_1	1	5	PF00653	0.498
LIG_BRCT_BRCA1_1	175	179	PF00533	0.629
LIG_EH_1	176	180	PF12763	0.642
LIG_FHA_1	115	121	PF00498	0.490
LIG_FHA_1	132	138	PF00498	0.486
LIG_FHA_1	151	157	PF00498	0.375
LIG_FHA_1	222	228	PF00498	0.595
LIG_FHA_1	302	308	PF00498	0.515
LIG_FHA_1	337	343	PF00498	0.528
LIG_FHA_2	128	134	PF00498	0.516
LIG_FHA_2	385	391	PF00498	0.553
LIG_FHA_2	65	71	PF00498	0.509
LIG_LIR_Apic_2	29	35	PF02991	0.451
LIG_LIR_Apic_2	83	87	PF02991	0.455
LIG_LIR_Gen_1	117	127	PF02991	0.491
LIG_LIR_Gen_1	312	322	PF02991	0.368
LIG_LIR_Gen_1	77	87	PF02991	0.289
LIG_LIR_Nem_3	117	122	PF02991	0.436
LIG_LIR_Nem_3	157	162	PF02991	0.502
LIG_LIR_Nem_3	176	182	PF02991	0.633
LIG_LIR_Nem_3	251	255	PF02991	0.510
LIG_LIR_Nem_3	312	317	PF02991	0.379
LIG_LIR_Nem_3	77	82	PF02991	0.476
LIG_Pex14_2	84	88	PF04695	0.466
LIG_REV1ctd_RIR_1	395	399	PF16727	0.622
LIG_SH2_CRK	314	318	PF00017	0.353
LIG_SH2_GRB2like	90	93	PF00017	0.457
LIG_SH2_NCK_1	314	318	PF00017	0.353
LIG_SH2_STAP1	116	120	PF00017	0.478
LIG_SH2_STAP1	314	318	PF00017	0.353
LIG_SH2_STAP1	46	50	PF00017	0.351
LIG_SH2_STAT5	116	119	PF00017	0.399
LIG_SH2_STAT5	336	339	PF00017	0.441
LIG_SH2_STAT5	356	359	PF00017	0.308
LIG_SH2_STAT5	39	42	PF00017	0.440
LIG_SH2_STAT5	49	52	PF00017	0.281
LIG_SH2_STAT5	90	93	PF00017	0.470
LIG_SH3_3	152	158	PF00018	0.385
LIG_SH3_3	32	38	PF00018	0.435
LIG_SH3_3	343	349	PF00018	0.516
LIG_SUMO_SIM_anti_2	2	9	PF11976	0.443
LIG_SUMO_SIM_anti_2	363	369	PF11976	0.521
LIG_SUMO_SIM_par_1	152	157	PF11976	0.376
LIG_SUMO_SIM_par_1	315	321	PF11976	0.439
LIG_TRAF2_1	229	232	PF00917	0.629
LIG_TYR_ITSM	115	122	PF00017	0.494
MOD_CK1_1	184	190	PF00069	0.459
MOD_CK1_1	256	262	PF00069	0.621
MOD_CK1_1	279	285	PF00069	0.674
MOD_CK1_1	329	335	PF00069	0.523
MOD_CK2_1	294	300	PF00069	0.614
MOD_CK2_1	329	335	PF00069	0.530
MOD_CK2_1	384	390	PF00069	0.558
MOD_CK2_1	64	70	PF00069	0.499
MOD_GlcNHglycan	101	104	PF01048	0.676
MOD_GlcNHglycan	2	5	PF01048	0.479
MOD_GlcNHglycan	208	211	PF01048	0.718
MOD_GlcNHglycan	325	329	PF01048	0.546
MOD_GSK3_1	127	134	PF00069	0.527
MOD_GSK3_1	146	153	PF00069	0.418
MOD_GSK3_1	180	187	PF00069	0.611
MOD_GSK3_1	268	275	PF00069	0.656
MOD_GSK3_1	324	331	PF00069	0.562
MOD_GSK3_1	384	391	PF00069	0.554
MOD_GSK3_1	45	52	PF00069	0.428
MOD_N-GLC_1	114	119	PF02516	0.518
MOD_N-GLC_1	127	132	PF02516	0.531
MOD_N-GLC_1	294	299	PF02516	0.629
MOD_N-GLC_2	265	267	PF02516	0.512
MOD_NEK2_1	26	31	PF00069	0.328
MOD_NEK2_1	50	55	PF00069	0.328
MOD_PIKK_1	216	222	PF00454	0.489
MOD_PIKK_1	253	259	PF00454	0.550
MOD_PKA_1	253	259	PF00069	0.638
MOD_PKA_1	272	278	PF00069	0.513
MOD_PKA_2	184	190	PF00069	0.489
MOD_PKA_2	195	201	PF00069	0.553
MOD_PKA_2	221	227	PF00069	0.575
MOD_PKA_2	253	259	PF00069	0.651
MOD_PKA_2	379	385	PF00069	0.506
MOD_Plk_1	132	138	PF00069	0.461
MOD_Plk_1	312	318	PF00069	0.374
MOD_Plk_1	329	335	PF00069	0.414
MOD_Plk_2-3	294	300	PF00069	0.544
MOD_Plk_4	150	156	PF00069	0.385
MOD_Plk_4	312	318	PF00069	0.386
MOD_Plk_4	384	390	PF00069	0.445
MOD_Plk_4	45	51	PF00069	0.417
MOD_Plk_4	74	80	PF00069	0.380
MOD_ProDKin_1	146	152	PF00069	0.435
MOD_ProDKin_1	273	279	PF00069	0.623
MOD_ProDKin_1	287	293	PF00069	0.802
MOD_ProDKin_1	34	40	PF00069	0.513
MOD_SUMO_for_1	337	340	PF00179	0.500
MOD_SUMO_rev_2	390	397	PF00179	0.609
TRG_DiLeu_BaEn_1	312	317	PF01217	0.402
TRG_DiLeu_BaLyEn_6	16	21	PF01217	0.344
TRG_DiLeu_BaLyEn_6	338	343	PF01217	0.506
TRG_ENDOCYTIC_2	119	122	PF00928	0.489
TRG_ENDOCYTIC_2	159	162	PF00928	0.557
TRG_ENDOCYTIC_2	314	317	PF00928	0.355
TRG_ER_diArg_1	202	205	PF00400	0.665
TRG_ER_diArg_1	252	254	PF00400	0.619
TRG_ER_diArg_1	54	56	PF00400	0.350
TRG_NLS_MonoExtN_4	104	111	PF00514	0.621
TRG_Pf-PMV_PEXEL_1	136	141	PF00026	0.349
TRG_Pf-PMV_PEXEL_1	168	173	PF00026	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB46	Leptomonas seymouri	63%	100%
A0A1X0NNC7	Trypanosomatidae	33%	100%
A0A3Q8IAS3	Leishmania donovani	78%	96%
A4HTW5	Leishmania infantum	77%	99%
D0A9C9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AMQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QHX3	Leishmania major	78%	100%