Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5M6_LEIBR

TriTrypDb:

LbrM.09.0510 , LBRM2903_090010600

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4H5M6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5M6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016746	acyltransferase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.437
CLV_NRD_NRD_1	372	374	PF00675	0.428
CLV_PCSK_KEX2_1	180	182	PF00082	0.437
CLV_PCSK_KEX2_1	372	374	PF00082	0.427
CLV_PCSK_SKI1_1	238	242	PF00082	0.363
CLV_PCSK_SKI1_1	38	42	PF00082	0.449
CLV_PCSK_SKI1_1	391	395	PF00082	0.466
CLV_PCSK_SKI1_1	69	73	PF00082	0.354
CLV_PCSK_SKI1_1	81	85	PF00082	0.403
DEG_APCC_DBOX_1	37	45	PF00400	0.475
DEG_APCC_DBOX_1	68	76	PF00400	0.376
DEG_APCC_DBOX_1	80	88	PF00400	0.482
DEG_Nend_UBRbox_2	1	3	PF02207	0.662
DEG_ODPH_VHL_1	21	34	PF01847	0.480
DEG_ODPH_VHL_1	72	85	PF01847	0.431
DOC_CKS1_1	343	348	PF01111	0.536
DOC_CYCLIN_RxL_1	35	43	PF00134	0.433
DOC_CYCLIN_yCln2_LP_2	138	144	PF00134	0.568
DOC_CYCLIN_yCln2_LP_2	343	349	PF00134	0.604
DOC_MAPK_gen_1	113	122	PF00069	0.563
DOC_MAPK_gen_1	180	188	PF00069	0.642
DOC_MAPK_gen_1	372	378	PF00069	0.610
DOC_MAPK_MEF2A_6	372	380	PF00069	0.602
DOC_PP1_RVXF_1	161	167	PF00149	0.583
DOC_PP1_RVXF_1	79	86	PF00149	0.547
DOC_PP2B_LxvP_1	241	244	PF13499	0.599
DOC_PP2B_LxvP_1	71	74	PF13499	0.363
DOC_USP7_MATH_1	108	112	PF00917	0.743
DOC_USP7_MATH_1	324	328	PF00917	0.680
DOC_USP7_MATH_1	329	333	PF00917	0.616
DOC_USP7_UBL2_3	100	104	PF12436	0.581
DOC_WW_Pin1_4	156	161	PF00397	0.543
DOC_WW_Pin1_4	165	170	PF00397	0.424
DOC_WW_Pin1_4	268	273	PF00397	0.634
DOC_WW_Pin1_4	303	308	PF00397	0.628
DOC_WW_Pin1_4	322	327	PF00397	0.664
DOC_WW_Pin1_4	342	347	PF00397	0.537
LIG_14-3-3_CanoR_1	358	363	PF00244	0.730
LIG_14-3-3_CanoR_1	373	379	PF00244	0.664
LIG_14-3-3_CanoR_1	38	48	PF00244	0.420
LIG_14-3-3_CterR_2	400	403	PF00244	0.547
LIG_APCC_ABBAyCdc20_2	391	397	PF00400	0.496
LIG_BRCT_BRCA1_1	183	187	PF00533	0.602
LIG_BRCT_BRCA1_1	281	285	PF00533	0.527
LIG_BRCT_BRCA1_1	41	45	PF00533	0.433
LIG_DLG_GKlike_1	181	188	PF00625	0.643
LIG_EH1_1	34	42	PF00400	0.397
LIG_EH1_1	84	92	PF00400	0.580
LIG_FHA_1	157	163	PF00498	0.546
LIG_FHA_1	16	22	PF00498	0.614
LIG_FHA_1	180	186	PF00498	0.563
LIG_FHA_1	205	211	PF00498	0.607
LIG_FHA_1	290	296	PF00498	0.609
LIG_FHA_1	333	339	PF00498	0.571
LIG_FHA_1	343	349	PF00498	0.445
LIG_FHA_1	359	365	PF00498	0.696
LIG_FHA_1	41	47	PF00498	0.438
LIG_FHA_1	50	56	PF00498	0.416
LIG_FHA_2	150	156	PF00498	0.578
LIG_FHA_2	308	314	PF00498	0.468
LIG_Integrin_isoDGR_2	236	238	PF01839	0.438
LIG_LIR_Apic_2	266	272	PF02991	0.622
LIG_LIR_Apic_2	301	307	PF02991	0.558
LIG_LIR_Gen_1	127	137	PF02991	0.587
LIG_LIR_Gen_1	283	294	PF02991	0.635
LIG_LIR_Gen_1	42	51	PF02991	0.484
LIG_LIR_LC3C_4	119	122	PF02991	0.597
LIG_LIR_Nem_3	127	132	PF02991	0.589
LIG_LIR_Nem_3	2	7	PF02991	0.647
LIG_LIR_Nem_3	283	289	PF02991	0.639
LIG_LIR_Nem_3	337	343	PF02991	0.463
LIG_LIR_Nem_3	42	48	PF02991	0.434
LIG_NRBOX	66	72	PF00104	0.393
LIG_NRBOX	79	85	PF00104	0.489
LIG_PDZ_Class_1	398	403	PF00595	0.539
LIG_Pex14_1	304	308	PF04695	0.653
LIG_Pex14_2	286	290	PF04695	0.650
LIG_SH2_CRK	142	146	PF00017	0.577
LIG_SH2_CRK	269	273	PF00017	0.615
LIG_SH2_NCK_1	269	273	PF00017	0.615
LIG_SH2_STAP1	395	399	PF00017	0.623
LIG_SH2_STAT3	213	216	PF00017	0.587
LIG_SH2_STAT5	178	181	PF00017	0.600
LIG_SH2_STAT5	63	66	PF00017	0.354
LIG_SH3_3	161	167	PF00018	0.554
LIG_SH3_3	17	23	PF00018	0.656
LIG_SH3_3	89	95	PF00018	0.586
LIG_SH3_4	100	107	PF00018	0.762
LIG_SUMO_SIM_par_1	360	365	PF11976	0.599
LIG_SUMO_SIM_par_1	46	54	PF11976	0.388
LIG_TYR_ITIM	338	343	PF00017	0.449
LIG_Vh1_VBS_1	40	58	PF01044	0.449
MOD_CDK_SPxxK_3	156	163	PF00069	0.533
MOD_CDK_SPxxK_3	165	172	PF00069	0.424
MOD_CK1_1	109	115	PF00069	0.686
MOD_CK1_1	299	305	PF00069	0.628
MOD_CK1_1	332	338	PF00069	0.682
MOD_CK2_1	149	155	PF00069	0.596
MOD_CK2_1	307	313	PF00069	0.480
MOD_CMANNOS	173	176	PF00535	0.345
MOD_GlcNHglycan	24	27	PF01048	0.457
MOD_GlcNHglycan	249	252	PF01048	0.436
MOD_GlcNHglycan	256	259	PF01048	0.294
MOD_GlcNHglycan	301	304	PF01048	0.381
MOD_GlcNHglycan	310	313	PF01048	0.257
MOD_GlcNHglycan	317	320	PF01048	0.268
MOD_GlcNHglycan	364	367	PF01048	0.526
MOD_GSK3_1	299	306	PF00069	0.634
MOD_GSK3_1	308	315	PF00069	0.597
MOD_GSK3_1	358	365	PF00069	0.562
MOD_NEK2_1	289	294	PF00069	0.541
MOD_NEK2_1	296	301	PF00069	0.579
MOD_NEK2_1	362	367	PF00069	0.752
MOD_NEK2_1	39	44	PF00069	0.385
MOD_PK_1	28	34	PF00069	0.581
MOD_PKA_2	179	185	PF00069	0.613
MOD_Plk_1	312	318	PF00069	0.602
MOD_Plk_4	124	130	PF00069	0.510
MOD_Plk_4	181	187	PF00069	0.538
MOD_Plk_4	358	364	PF00069	0.557
MOD_Plk_4	40	46	PF00069	0.405
MOD_Plk_4	51	57	PF00069	0.398
MOD_ProDKin_1	156	162	PF00069	0.534
MOD_ProDKin_1	165	171	PF00069	0.420
MOD_ProDKin_1	268	274	PF00069	0.635
MOD_ProDKin_1	303	309	PF00069	0.623
MOD_ProDKin_1	322	328	PF00069	0.673
MOD_ProDKin_1	342	348	PF00069	0.534
MOD_SUMO_rev_2	327	335	PF00179	0.710
MOD_SUMO_rev_2	377	386	PF00179	0.667
TRG_DiLeu_BaEn_2	381	387	PF01217	0.588
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.410
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.392
TRG_ENDOCYTIC_2	142	145	PF00928	0.555
TRG_ENDOCYTIC_2	340	343	PF00928	0.524
TRG_ENDOCYTIC_2	390	393	PF00928	0.649
TRG_ENDOCYTIC_2	63	66	PF00928	0.359
TRG_ER_diArg_1	371	373	PF00400	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK56	Leptomonas seymouri	67%	100%
A0A0S4IZ96	Bodo saltans	27%	100%
A0A1X0NMQ7	Trypanosomatidae	30%	95%
A0A3Q8IBV5	Leishmania donovani	78%	98%
A0A3S5IRZ0	Trypanosoma rangeli	33%	100%
A4HTW3	Leishmania infantum	78%	98%
D0A9C7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AMQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	98%
Q4QHX5	Leishmania major	77%	100%
V5BIH4	Trypanosoma cruzi	30%	100%