Inward rectifier potassium channel protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5M5_LEIBR

TriTrypDb:

LbrM.09.0500 , LBRM2903_090010500

Length:

672

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4H5M5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5M5

Function

Biological processes
Term	Name	Level	Count
GO:0032879	regulation of localization	3	6
GO:0034762	regulation of transmembrane transport	4	6
GO:0034765	regulation of monoatomic ion transmembrane transport	5	6
GO:0043269	regulation of monoatomic ion transport	5	6
GO:0050789	regulation of biological process	2	6
GO:0050794	regulation of cellular process	3	6
GO:0051049	regulation of transport	4	6
GO:0065007	biological regulation	1	6
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006813	potassium ion transport	7	1
GO:0009987	cellular process	1	1
GO:0030001	metal ion transport	6	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0071805	potassium ion transmembrane transport	6	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:0098657	import into cell	4	1
GO:0098659	inorganic cation import across plasma membrane	5	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098662	inorganic cation transmembrane transport	5	1
GO:0098739	import across plasma membrane	3	1
GO:0099587	inorganic ion import across plasma membrane	4	1
GO:1990573	potassium ion import across plasma membrane	6	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	6
GO:0005216	monoatomic ion channel activity	4	6
GO:0005242	inward rectifier potassium channel activity	7	6
GO:0005244	voltage-gated monoatomic ion channel activity	4	6
GO:0005249	voltage-gated potassium channel activity	6	6
GO:0005261	monoatomic cation channel activity	5	6
GO:0005267	potassium channel activity	6	6
GO:0008324	monoatomic cation transmembrane transporter activity	4	6
GO:0015075	monoatomic ion transmembrane transporter activity	3	6
GO:0015079	potassium ion transmembrane transporter activity	6	6
GO:0015267	channel activity	4	6
GO:0015276	ligand-gated monoatomic ion channel activity	5	6
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	6
GO:0022803	passive transmembrane transporter activity	3	6
GO:0022832	voltage-gated channel activity	6	6
GO:0022834	ligand-gated channel activity	6	6
GO:0022836	gated channel activity	5	6
GO:0022843	voltage-gated monoatomic cation channel activity	5	6
GO:0022857	transmembrane transporter activity	2	6
GO:0022890	inorganic cation transmembrane transporter activity	4	6
GO:0046873	metal ion transmembrane transporter activity	5	6
GO:0099094	ligand-gated monoatomic cation channel activity	6	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	357	359	PF00675	0.770
CLV_NRD_NRD_1	395	397	PF00675	0.785
CLV_NRD_NRD_1	429	431	PF00675	0.752
CLV_NRD_NRD_1	71	73	PF00675	0.444
CLV_PCSK_KEX2_1	356	358	PF00082	0.872
CLV_PCSK_KEX2_1	394	396	PF00082	0.780
CLV_PCSK_KEX2_1	429	431	PF00082	0.804
CLV_PCSK_KEX2_1	486	488	PF00082	0.841
CLV_PCSK_KEX2_1	619	621	PF00082	0.702
CLV_PCSK_KEX2_1	71	73	PF00082	0.471
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.872
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.841
CLV_PCSK_PC1ET2_1	619	621	PF00082	0.702
CLV_PCSK_PC7_1	391	397	PF00082	0.780
CLV_PCSK_PC7_1	425	431	PF00082	0.693
CLV_PCSK_SKI1_1	12	16	PF00082	0.661
CLV_PCSK_SKI1_1	238	242	PF00082	0.669
CLV_PCSK_SKI1_1	258	262	PF00082	0.442
CLV_PCSK_SKI1_1	323	327	PF00082	0.688
CLV_PCSK_SKI1_1	487	491	PF00082	0.707
CLV_PCSK_SKI1_1	72	76	PF00082	0.463
CLV_PCSK_SKI1_1	91	95	PF00082	0.478
DEG_APCC_DBOX_1	71	79	PF00400	0.636
DEG_Nend_Nbox_1	1	3	PF02207	0.850
DEG_SPOP_SBC_1	476	480	PF00917	0.482
DOC_CYCLIN_yClb1_LxF_4	256	261	PF00134	0.306
DOC_MAPK_HePTP_8	556	568	PF00069	0.493
DOC_MAPK_MEF2A_6	25	33	PF00069	0.755
DOC_MAPK_MEF2A_6	559	568	PF00069	0.495
DOC_MAPK_MEF2A_6	643	651	PF00069	0.335
DOC_PP1_RVXF_1	236	242	PF00149	0.482
DOC_PP1_RVXF_1	256	262	PF00149	0.249
DOC_PP2B_LxvP_1	29	32	PF13499	0.796
DOC_PP2B_LxvP_1	566	569	PF13499	0.538
DOC_PP4_FxxP_1	34	37	PF00568	0.822
DOC_USP7_MATH_1	342	346	PF00917	0.514
DOC_USP7_MATH_1	371	375	PF00917	0.672
DOC_USP7_MATH_1	439	443	PF00917	0.527
DOC_USP7_MATH_1	447	451	PF00917	0.548
DOC_USP7_MATH_1	453	457	PF00917	0.511
DOC_USP7_MATH_1	468	472	PF00917	0.550
DOC_USP7_MATH_1	476	480	PF00917	0.494
DOC_USP7_MATH_1	497	501	PF00917	0.647
DOC_USP7_MATH_1	74	78	PF00917	0.695
DOC_USP7_MATH_2	21	27	PF00917	0.649
DOC_USP7_UBL2_3	356	360	PF12436	0.645
DOC_WW_Pin1_4	364	369	PF00397	0.494
DOC_WW_Pin1_4	443	448	PF00397	0.486
DOC_WW_Pin1_4	5	10	PF00397	0.669
DOC_WW_Pin1_4	54	59	PF00397	0.820
DOC_WW_Pin1_4	557	562	PF00397	0.428
LIG_14-3-3_CanoR_1	103	113	PF00244	0.667
LIG_14-3-3_CanoR_1	117	122	PF00244	0.661
LIG_14-3-3_CanoR_1	128	133	PF00244	0.565
LIG_14-3-3_CanoR_1	238	247	PF00244	0.473
LIG_14-3-3_CanoR_1	3	8	PF00244	0.846
LIG_14-3-3_CanoR_1	422	432	PF00244	0.646
LIG_14-3-3_CanoR_1	457	464	PF00244	0.495
LIG_14-3-3_CanoR_1	47	53	PF00244	0.656
LIG_14-3-3_CanoR_1	527	535	PF00244	0.426
LIG_14-3-3_CanoR_1	620	628	PF00244	0.319
LIG_14-3-3_CanoR_1	643	651	PF00244	0.335
LIG_14-3-3_CanoR_1	81	90	PF00244	0.824
LIG_APCC_ABBA_1	562	567	PF00400	0.524
LIG_APCC_ABBA_1	97	102	PF00400	0.562
LIG_BRCT_BRCA1_1	504	508	PF00533	0.446
LIG_Clathr_ClatBox_1	657	661	PF01394	0.329
LIG_CtBP_PxDLS_1	659	663	PF00389	0.511
LIG_EH1_1	142	150	PF00400	0.530
LIG_eIF4E_1	143	149	PF01652	0.530
LIG_FHA_1	131	137	PF00498	0.630
LIG_FHA_1	202	208	PF00498	0.636
LIG_FHA_1	230	236	PF00498	0.530
LIG_FHA_1	548	554	PF00498	0.302
LIG_FHA_1	64	70	PF00498	0.645
LIG_FHA_1	92	98	PF00498	0.681
LIG_FHA_2	341	347	PF00498	0.488
LIG_FHA_2	433	439	PF00498	0.491
LIG_FHA_2	578	584	PF00498	0.450
LIG_FHA_2	6	12	PF00498	0.672
LIG_FHA_2	606	612	PF00498	0.508
LIG_FHA_2	621	627	PF00498	0.323
LIG_FHA_2	666	672	PF00498	0.621
LIG_GBD_Chelix_1	140	148	PF00786	0.433
LIG_HP1_1	322	326	PF01393	0.476
LIG_LIR_Gen_1	129	140	PF02991	0.636
LIG_LIR_Gen_1	211	220	PF02991	0.465
LIG_LIR_Gen_1	242	251	PF02991	0.490
LIG_LIR_Gen_1	650	659	PF02991	0.489
LIG_LIR_Nem_3	115	121	PF02991	0.664
LIG_LIR_Nem_3	122	127	PF02991	0.566
LIG_LIR_Nem_3	129	135	PF02991	0.480
LIG_LIR_Nem_3	169	175	PF02991	0.374
LIG_LIR_Nem_3	211	215	PF02991	0.465
LIG_LIR_Nem_3	242	247	PF02991	0.413
LIG_LIR_Nem_3	57	63	PF02991	0.649
LIG_LIR_Nem_3	650	654	PF02991	0.492
LIG_PDZ_Class_1	667	672	PF00595	0.445
LIG_Pex14_1	257	261	PF04695	0.483
LIG_PTB_Apo_2	211	218	PF02174	0.530
LIG_SH2_GRB2like	212	215	PF00017	0.530
LIG_SH2_GRB2like	653	656	PF00017	0.478
LIG_SH2_PTP2	212	215	PF00017	0.530
LIG_SH2_SRC	143	146	PF00017	0.530
LIG_SH2_SRC	212	215	PF00017	0.530
LIG_SH2_SRC	535	538	PF00017	0.374
LIG_SH2_STAP1	138	142	PF00017	0.530
LIG_SH2_STAT3	290	293	PF00017	0.514
LIG_SH2_STAT5	125	128	PF00017	0.578
LIG_SH2_STAT5	143	146	PF00017	0.369
LIG_SH2_STAT5	172	175	PF00017	0.530
LIG_SH2_STAT5	212	215	PF00017	0.465
LIG_SH2_STAT5	535	538	PF00017	0.494
LIG_SH2_STAT5	622	625	PF00017	0.441
LIG_SH2_STAT5	653	656	PF00017	0.478
LIG_SH3_3	11	17	PF00018	0.774
LIG_SH3_3	365	371	PF00018	0.632
LIG_SH3_3	42	48	PF00018	0.729
LIG_SH3_3	558	564	PF00018	0.421
LIG_Sin3_3	222	229	PF02671	0.602
LIG_SUMO_SIM_par_1	131	137	PF11976	0.609
LIG_SUMO_SIM_par_1	145	151	PF11976	0.336
LIG_SUMO_SIM_par_1	204	211	PF11976	0.530
LIG_SUMO_SIM_par_1	600	606	PF11976	0.469
LIG_SUMO_SIM_par_1	658	664	PF11976	0.349
LIG_TRAF2_1	623	626	PF00917	0.333
LIG_TRAF2_1	8	11	PF00917	0.673
LIG_WRC_WIRS_1	113	118	PF05994	0.702
LIG_WW_1	37	40	PF00397	0.578
MOD_CDC14_SPxK_1	446	449	PF00782	0.602
MOD_CDK_SPxK_1	443	449	PF00069	0.603
MOD_CDK_SPxxK_3	5	12	PF00069	0.580
MOD_CK1_1	193	199	PF00069	0.392
MOD_CK1_1	201	207	PF00069	0.246
MOD_CK1_1	442	448	PF00069	0.739
MOD_CK1_1	451	457	PF00069	0.595
MOD_CK1_1	462	468	PF00069	0.535
MOD_CK1_1	470	476	PF00069	0.543
MOD_CK1_1	477	483	PF00069	0.734
MOD_CK1_1	502	508	PF00069	0.557
MOD_CK1_1	574	580	PF00069	0.774
MOD_CK1_1	612	618	PF00069	0.636
MOD_CK1_1	642	648	PF00069	0.411
MOD_CK1_1	77	83	PF00069	0.747
MOD_CK2_1	309	315	PF00069	0.571
MOD_CK2_1	375	381	PF00069	0.714
MOD_CK2_1	432	438	PF00069	0.610
MOD_CK2_1	5	11	PF00069	0.578
MOD_CK2_1	577	583	PF00069	0.549
MOD_CK2_1	605	611	PF00069	0.616
MOD_CK2_1	620	626	PF00069	0.375
MOD_CK2_1	663	669	PF00069	0.741
MOD_Cter_Amidation	427	430	PF01082	0.624
MOD_GlcNHglycan	168	171	PF01048	0.530
MOD_GlcNHglycan	200	203	PF01048	0.343
MOD_GlcNHglycan	373	376	PF01048	0.794
MOD_GlcNHglycan	407	410	PF01048	0.837
MOD_GlcNHglycan	441	444	PF01048	0.809
MOD_GlcNHglycan	451	454	PF01048	0.644
MOD_GlcNHglycan	466	469	PF01048	0.654
MOD_GlcNHglycan	473	476	PF01048	0.651
MOD_GlcNHglycan	479	482	PF01048	0.582
MOD_GlcNHglycan	540	543	PF01048	0.409
MOD_GlcNHglycan	576	579	PF01048	0.779
MOD_GlcNHglycan	580	583	PF01048	0.748
MOD_GlcNHglycan	611	614	PF01048	0.564
MOD_GSK3_1	126	133	PF00069	0.572
MOD_GSK3_1	19	26	PF00069	0.597
MOD_GSK3_1	239	246	PF00069	0.583
MOD_GSK3_1	310	317	PF00069	0.687
MOD_GSK3_1	360	367	PF00069	0.811
MOD_GSK3_1	371	378	PF00069	0.704
MOD_GSK3_1	39	46	PF00069	0.655
MOD_GSK3_1	439	446	PF00069	0.709
MOD_GSK3_1	447	454	PF00069	0.741
MOD_GSK3_1	455	462	PF00069	0.614
MOD_GSK3_1	463	470	PF00069	0.628
MOD_GSK3_1	471	478	PF00069	0.621
MOD_GSK3_1	485	492	PF00069	0.843
MOD_GSK3_1	538	545	PF00069	0.527
MOD_GSK3_1	574	581	PF00069	0.704
MOD_GSK3_1	583	590	PF00069	0.678
MOD_GSK3_1	605	612	PF00069	0.623
MOD_GSK3_1	614	621	PF00069	0.490
MOD_GSK3_1	63	70	PF00069	0.759
MOD_GSK3_1	663	670	PF00069	0.747
MOD_NEK2_1	126	131	PF00069	0.608
MOD_NEK2_1	136	141	PF00069	0.365
MOD_NEK2_1	148	153	PF00069	0.483
MOD_NEK2_1	208	213	PF00069	0.530
MOD_NEK2_1	24	29	PF00069	0.799
MOD_NEK2_1	309	314	PF00069	0.707
MOD_NEK2_1	403	408	PF00069	0.865
MOD_NEK2_1	464	469	PF00069	0.851
MOD_NEK2_1	526	531	PF00069	0.601
MOD_NEK2_2	112	117	PF00069	0.704
MOD_NEK2_2	48	53	PF00069	0.556
MOD_PIKK_1	126	132	PF00454	0.608
MOD_PIKK_1	414	420	PF00454	0.613
MOD_PIKK_1	61	67	PF00454	0.587
MOD_PKA_2	376	382	PF00069	0.622
MOD_PKA_2	448	454	PF00069	0.747
MOD_PKA_2	456	462	PF00069	0.644
MOD_PKA_2	526	532	PF00069	0.492
MOD_PKA_2	642	648	PF00069	0.411
MOD_PKB_1	117	125	PF00069	0.673
MOD_Plk_1	497	503	PF00069	0.577
MOD_Plk_4	119	125	PF00069	0.663
MOD_Plk_4	208	214	PF00069	0.530
MOD_Plk_4	24	30	PF00069	0.799
MOD_Plk_4	542	548	PF00069	0.420
MOD_Plk_4	653	659	PF00069	0.344
MOD_Plk_4	74	80	PF00069	0.779
MOD_ProDKin_1	364	370	PF00069	0.611
MOD_ProDKin_1	443	449	PF00069	0.603
MOD_ProDKin_1	5	11	PF00069	0.578
MOD_ProDKin_1	54	60	PF00069	0.791
MOD_ProDKin_1	557	563	PF00069	0.519
MOD_SUMO_rev_2	19	27	PF00179	0.805
MOD_SUMO_rev_2	330	335	PF00179	0.595
MOD_SUMO_rev_2	378	384	PF00179	0.645
TRG_ENDOCYTIC_2	143	146	PF00928	0.509
TRG_ENDOCYTIC_2	172	175	PF00928	0.530
TRG_ENDOCYTIC_2	212	215	PF00928	0.465
TRG_ER_diArg_1	394	396	PF00400	0.622
TRG_ER_diArg_1	71	73	PF00400	0.542
TRG_NES_CRM1_1	23	35	PF08389	0.544
TRG_NLS_MonoCore_2	355	360	PF00514	0.609
TRG_NLS_MonoExtC_3	355	360	PF00514	0.609
TRG_NLS_MonoExtN_4	353	360	PF00514	0.765
TRG_Pf-PMV_PEXEL_1	91	96	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQM3	Leishmania donovani	62%	90%
A4HTW2	Leishmania infantum	62%	90%
E9AMP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	93%
Q4QHX6	Leishmania major	60%	91%