LeishMANIAdb
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Serine/threonine-protein phosphatase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine-protein phosphatase
Gene product:
serine/threonine protein phosphatase, putative
Species:
Leishmania braziliensis
UniProt:
A4H5M4_LEIBR
TriTrypDb:
LbrM.09.0490 , LBRM2903_090010400
Length:
646

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0005737 cytoplasm 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A4H5M4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5M4

Function

Biological processes
Term Name Level Count
GO:0000724 double-strand break repair via homologous recombination 7 1
GO:0000725 recombinational repair 6 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006259 DNA metabolic process 4 1
GO:0006281 DNA repair 5 1
GO:0006302 double-strand break repair 6 1
GO:0006310 DNA recombination 5 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006950 response to stress 2 1
GO:0006974 DNA damage response 4 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0033554 cellular response to stress 3 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0046483 heterocycle metabolic process 3 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 15
GO:0004721 phosphoprotein phosphatase activity 3 15
GO:0004722 protein serine/threonine phosphatase activity 4 15
GO:0016787 hydrolase activity 2 15
GO:0016788 hydrolase activity, acting on ester bonds 3 15
GO:0016791 phosphatase activity 5 15
GO:0017018 myosin phosphatase activity 5 15
GO:0042578 phosphoric ester hydrolase activity 4 15
GO:0140096 catalytic activity, acting on a protein 2 15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 137 141 PF00656 0.588
CLV_C14_Caspase3-7 582 586 PF00656 0.402
CLV_C14_Caspase3-7 639 643 PF00656 0.675
CLV_MEL_PAP_1 93 99 PF00089 0.497
CLV_NRD_NRD_1 254 256 PF00675 0.607
CLV_NRD_NRD_1 74 76 PF00675 0.557
CLV_PCSK_KEX2_1 254 256 PF00082 0.610
CLV_PCSK_KEX2_1 37 39 PF00082 0.663
CLV_PCSK_KEX2_1 74 76 PF00082 0.557
CLV_PCSK_PC1ET2_1 37 39 PF00082 0.558
CLV_PCSK_SKI1_1 255 259 PF00082 0.609
CLV_PCSK_SKI1_1 336 340 PF00082 0.354
CLV_PCSK_SKI1_1 363 367 PF00082 0.406
CLV_PCSK_SKI1_1 384 388 PF00082 0.302
CLV_PCSK_SKI1_1 415 419 PF00082 0.307
CLV_PCSK_SKI1_1 594 598 PF00082 0.342
DOC_CYCLIN_yClb5_NLxxxL_5 248 257 PF00134 0.455
DOC_MAPK_gen_1 74 81 PF00069 0.502
DOC_PP1_RVXF_1 253 260 PF00149 0.646
DOC_PP2B_LxvP_1 121 124 PF13499 0.588
DOC_PP4_FxxP_1 510 513 PF00568 0.289
DOC_USP7_MATH_1 102 106 PF00917 0.446
DOC_USP7_MATH_1 124 128 PF00917 0.535
DOC_USP7_MATH_1 144 148 PF00917 0.582
DOC_USP7_MATH_1 177 181 PF00917 0.609
DOC_USP7_MATH_1 238 242 PF00917 0.638
DOC_USP7_MATH_1 292 296 PF00917 0.431
DOC_USP7_MATH_1 49 53 PF00917 0.719
DOC_USP7_MATH_1 57 61 PF00917 0.717
DOC_USP7_MATH_2 535 541 PF00917 0.313
DOC_WW_Pin1_4 140 145 PF00397 0.523
DOC_WW_Pin1_4 163 168 PF00397 0.529
DOC_WW_Pin1_4 175 180 PF00397 0.683
DOC_WW_Pin1_4 189 194 PF00397 0.602
DOC_WW_Pin1_4 288 293 PF00397 0.468
DOC_WW_Pin1_4 314 319 PF00397 0.442
DOC_WW_Pin1_4 347 352 PF00397 0.339
DOC_WW_Pin1_4 378 383 PF00397 0.289
DOC_WW_Pin1_4 40 45 PF00397 0.727
DOC_WW_Pin1_4 514 519 PF00397 0.342
DOC_WW_Pin1_4 66 71 PF00397 0.540
LIG_14-3-3_CanoR_1 161 165 PF00244 0.507
LIG_14-3-3_CanoR_1 29 35 PF00244 0.607
LIG_14-3-3_CanoR_1 459 467 PF00244 0.313
LIG_Actin_WH2_2 365 381 PF00022 0.325
LIG_AP2alpha_1 362 366 PF02296 0.289
LIG_AP2alpha_1 567 571 PF02296 0.406
LIG_BIR_III_2 176 180 PF00653 0.605
LIG_BRCT_BRCA1_1 460 464 PF00533 0.309
LIG_BRCT_BRCA1_1 499 503 PF00533 0.406
LIG_deltaCOP1_diTrp_1 454 464 PF00928 0.272
LIG_EH1_1 366 374 PF00400 0.348
LIG_eIF4E_1 367 373 PF01652 0.272
LIG_EVH1_1 100 104 PF00568 0.532
LIG_FHA_1 141 147 PF00498 0.525
LIG_FHA_1 273 279 PF00498 0.580
LIG_FHA_1 305 311 PF00498 0.514
LIG_FHA_1 468 474 PF00498 0.294
LIG_FHA_1 552 558 PF00498 0.437
LIG_FHA_2 628 634 PF00498 0.597
LIG_LIR_Apic_2 507 513 PF02991 0.290
LIG_LIR_Apic_2 529 535 PF02991 0.272
LIG_LIR_Gen_1 185 196 PF02991 0.471
LIG_LIR_Gen_1 374 382 PF02991 0.288
LIG_LIR_Gen_1 461 471 PF02991 0.308
LIG_LIR_Nem_3 185 191 PF02991 0.475
LIG_LIR_Nem_3 374 378 PF02991 0.348
LIG_LIR_Nem_3 461 467 PF02991 0.308
LIG_NRP_CendR_1 645 646 PF00754 0.586
LIG_OCRL_FandH_1 354 366 PF00620 0.272
LIG_Pex14_2 279 283 PF04695 0.483
LIG_Pex14_2 362 366 PF04695 0.289
LIG_Pex14_2 567 571 PF04695 0.363
LIG_Pex14_2 573 577 PF04695 0.331
LIG_PTB_Apo_2 277 284 PF02174 0.547
LIG_PTB_Apo_2 295 302 PF02174 0.420
LIG_PTB_Apo_2 434 441 PF02174 0.406
LIG_PTB_Phospho_1 295 301 PF10480 0.416
LIG_SH2_CRK 301 305 PF00017 0.368
LIG_SH2_CRK 523 527 PF00017 0.406
LIG_SH2_STAT3 133 136 PF00017 0.535
LIG_SH2_STAT5 150 153 PF00017 0.741
LIG_SH2_STAT5 16 19 PF00017 0.384
LIG_SH2_STAT5 303 306 PF00017 0.352
LIG_SH2_STAT5 353 356 PF00017 0.272
LIG_SH2_STAT5 367 370 PF00017 0.313
LIG_SH2_STAT5 380 383 PF00017 0.366
LIG_SH2_STAT5 391 394 PF00017 0.336
LIG_SH2_STAT5 404 407 PF00017 0.317
LIG_SH2_STAT5 478 481 PF00017 0.388
LIG_SH2_STAT5 575 578 PF00017 0.272
LIG_SH2_STAT5 604 607 PF00017 0.415
LIG_SH2_STAT5 636 639 PF00017 0.672
LIG_SH3_3 224 230 PF00018 0.615
LIG_SH3_3 345 351 PF00018 0.406
LIG_SH3_3 407 413 PF00018 0.302
LIG_SH3_3 98 104 PF00018 0.622
LIG_SUMO_SIM_anti_2 111 116 PF11976 0.412
LIG_SUMO_SIM_anti_2 398 403 PF11976 0.302
LIG_SUMO_SIM_anti_2 492 500 PF11976 0.353
LIG_SUMO_SIM_anti_2 78 84 PF11976 0.499
LIG_SUMO_SIM_par_1 111 116 PF11976 0.528
LIG_SUMO_SIM_par_1 15 23 PF11976 0.504
LIG_SUMO_SIM_par_1 612 618 PF11976 0.327
LIG_TRAF2_1 579 582 PF00917 0.272
LIG_TRAF2_1 630 633 PF00917 0.639
LIG_TRAF2_1 9 12 PF00917 0.533
LIG_UBA3_1 328 336 PF00899 0.439
LIG_UBA3_1 405 409 PF00899 0.300
LIG_WRC_WIRS_1 305 310 PF05994 0.512
LIG_WRC_WIRS_1 372 377 PF05994 0.272
LIG_WRC_WIRS_1 506 511 PF05994 0.289
MOD_CDC14_SPxK_1 192 195 PF00782 0.597
MOD_CDK_SPxK_1 189 195 PF00069 0.598
MOD_CDK_SPxK_1 378 384 PF00069 0.289
MOD_CDK_SPxxK_3 514 521 PF00069 0.313
MOD_CK1_1 156 162 PF00069 0.619
MOD_CK1_1 163 169 PF00069 0.576
MOD_CK1_1 189 195 PF00069 0.584
MOD_CK1_1 291 297 PF00069 0.393
MOD_CK1_1 33 39 PF00069 0.633
MOD_CK1_1 347 353 PF00069 0.364
MOD_CK1_1 40 46 PF00069 0.774
MOD_CK1_1 60 66 PF00069 0.620
MOD_CK1_1 80 86 PF00069 0.745
MOD_CK2_1 6 12 PF00069 0.544
MOD_CK2_1 627 633 PF00069 0.668
MOD_CK2_1 85 91 PF00069 0.634
MOD_GlcNHglycan 209 212 PF01048 0.705
MOD_GlcNHglycan 233 236 PF01048 0.759
MOD_GlcNHglycan 39 42 PF01048 0.729
MOD_GlcNHglycan 428 431 PF01048 0.276
MOD_GlcNHglycan 432 435 PF01048 0.276
MOD_GlcNHglycan 487 490 PF01048 0.370
MOD_GlcNHglycan 49 52 PF01048 0.652
MOD_GlcNHglycan 499 502 PF01048 0.402
MOD_GlcNHglycan 591 594 PF01048 0.408
MOD_GlcNHglycan 601 604 PF01048 0.390
MOD_GlcNHglycan 87 90 PF01048 0.716
MOD_GlcNHglycan 93 96 PF01048 0.675
MOD_GSK3_1 102 109 PF00069 0.517
MOD_GSK3_1 119 126 PF00069 0.444
MOD_GSK3_1 140 147 PF00069 0.557
MOD_GSK3_1 152 159 PF00069 0.562
MOD_GSK3_1 163 170 PF00069 0.589
MOD_GSK3_1 288 295 PF00069 0.447
MOD_GSK3_1 33 40 PF00069 0.643
MOD_GSK3_1 426 433 PF00069 0.384
MOD_GSK3_1 594 601 PF00069 0.322
MOD_GSK3_1 60 67 PF00069 0.747
MOD_N-GLC_1 436 441 PF02516 0.406
MOD_N-GLC_1 514 519 PF02516 0.383
MOD_N-GLC_1 537 542 PF02516 0.417
MOD_N-GLC_1 75 80 PF02516 0.742
MOD_N-GLC_2 312 314 PF02516 0.463
MOD_N-GLC_2 330 332 PF02516 0.405
MOD_NEK2_1 106 111 PF00069 0.584
MOD_NEK2_1 129 134 PF00069 0.566
MOD_NEK2_1 151 156 PF00069 0.577
MOD_NEK2_1 207 212 PF00069 0.691
MOD_NEK2_1 324 329 PF00069 0.337
MOD_NEK2_1 505 510 PF00069 0.201
MOD_NEK2_1 558 563 PF00069 0.289
MOD_NEK2_1 587 592 PF00069 0.390
MOD_NEK2_1 599 604 PF00069 0.335
MOD_NEK2_1 64 69 PF00069 0.741
MOD_NEK2_2 404 409 PF00069 0.406
MOD_NEK2_2 436 441 PF00069 0.289
MOD_PIKK_1 156 162 PF00454 0.702
MOD_PK_1 344 350 PF00069 0.372
MOD_PKA_1 37 43 PF00069 0.523
MOD_PKA_2 151 157 PF00069 0.586
MOD_PKA_2 160 166 PF00069 0.528
MOD_PKA_2 194 200 PF00069 0.660
MOD_PKA_2 201 207 PF00069 0.518
MOD_PKA_2 37 43 PF00069 0.505
MOD_PKA_2 458 464 PF00069 0.313
MOD_PKA_2 485 491 PF00069 0.365
MOD_PKA_2 551 557 PF00069 0.335
MOD_PKA_2 91 97 PF00069 0.652
MOD_Plk_1 106 112 PF00069 0.493
MOD_Plk_1 129 135 PF00069 0.533
MOD_Plk_1 152 158 PF00069 0.478
MOD_Plk_1 261 267 PF00069 0.646
MOD_Plk_1 395 401 PF00069 0.289
MOD_Plk_1 423 429 PF00069 0.277
MOD_Plk_1 436 442 PF00069 0.348
MOD_Plk_2-3 537 543 PF00069 0.351
MOD_Plk_2-3 635 641 PF00069 0.496
MOD_Plk_4 108 114 PF00069 0.508
MOD_Plk_4 124 130 PF00069 0.399
MOD_Plk_4 201 207 PF00069 0.593
MOD_Plk_4 423 429 PF00069 0.285
MOD_Plk_4 505 511 PF00069 0.289
MOD_Plk_4 60 66 PF00069 0.607
MOD_Plk_4 77 83 PF00069 0.535
MOD_ProDKin_1 140 146 PF00069 0.519
MOD_ProDKin_1 163 169 PF00069 0.530
MOD_ProDKin_1 175 181 PF00069 0.682
MOD_ProDKin_1 189 195 PF00069 0.604
MOD_ProDKin_1 288 294 PF00069 0.448
MOD_ProDKin_1 314 320 PF00069 0.441
MOD_ProDKin_1 347 353 PF00069 0.336
MOD_ProDKin_1 378 384 PF00069 0.289
MOD_ProDKin_1 40 46 PF00069 0.730
MOD_ProDKin_1 514 520 PF00069 0.342
MOD_ProDKin_1 66 72 PF00069 0.538
MOD_SUMO_rev_2 333 338 PF00179 0.378
TRG_DiLeu_BaEn_3 333 339 PF01217 0.367
TRG_DiLeu_BaLyEn_6 619 624 PF01217 0.382
TRG_ENDOCYTIC_2 301 304 PF00928 0.381
TRG_ENDOCYTIC_2 523 526 PF00928 0.348
TRG_ER_diArg_1 253 255 PF00400 0.633
TRG_ER_diArg_1 73 75 PF00400 0.519
TRG_Pf-PMV_PEXEL_1 261 266 PF00026 0.552

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5U5 Leptomonas seymouri 73% 95%
A0A0S4IYE4 Bodo saltans 55% 100%
A0A1X0NPA5 Trypanosomatidae 63% 100%
A0A3Q8I8M6 Leishmania donovani 33% 100%
A0A3R7NXP6 Trypanosoma rangeli 56% 100%
A0A3S5H6D4 Leishmania donovani 85% 99%
A4HTW1 Leishmania infantum 85% 99%
A4HVT0 Leishmania infantum 33% 100%
D0A9C5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 100%
E9AMP8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 99%
E9APH5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
Q4QG03 Leishmania major 33% 100%
Q4QHX7 Leishmania major 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS