Hypothetical tetratricopeptide repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bardet-Biedl syndrome 8 protein

Species:

Leishmania braziliensis

UniProt:

A4H5M0_LEIBR

TriTrypDb:

LbrM.09.0450 , LBRM2903_090010000

Length:

649

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	10
GO:0034464	BBSome	2	10
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	1
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	2
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0030666	endocytic vesicle membrane	5	1
GO:0030669	clathrin-coated endocytic vesicle membrane	6	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0036064	ciliary basal body	3	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0060170	ciliary membrane	5	1
GO:0097730	non-motile cilium	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4H5M0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5M0

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0022607	cellular component assembly	4	10
GO:0030030	cell projection organization	4	10
GO:0030031	cell projection assembly	5	10
GO:0044782	cilium organization	5	10
GO:0060271	cilium assembly	6	10
GO:0070925	organelle assembly	5	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0120031	plasma membrane bounded cell projection assembly	6	10
GO:0120036	plasma membrane bounded cell projection organization	5	10
GO:1905515	non-motile cilium assembly	7	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.501
CLV_NRD_NRD_1	28	30	PF00675	0.382
CLV_NRD_NRD_1	484	486	PF00675	0.375
CLV_NRD_NRD_1	585	587	PF00675	0.500
CLV_PCSK_KEX2_1	27	29	PF00082	0.386
CLV_PCSK_KEX2_1	484	486	PF00082	0.375
CLV_PCSK_KEX2_1	585	587	PF00082	0.493
CLV_PCSK_SKI1_1	181	185	PF00082	0.562
CLV_PCSK_SKI1_1	237	241	PF00082	0.391
CLV_PCSK_SKI1_1	248	252	PF00082	0.504
CLV_PCSK_SKI1_1	327	331	PF00082	0.428
CLV_PCSK_SKI1_1	343	347	PF00082	0.289
CLV_PCSK_SKI1_1	484	488	PF00082	0.381
CLV_PCSK_SKI1_1	585	589	PF00082	0.503
DEG_SCF_FBW7_1	256	262	PF00400	0.500
DEG_SPOP_SBC_1	59	63	PF00917	0.487
DOC_CDC14_PxL_1	592	600	PF14671	0.283
DOC_CKS1_1	253	258	PF01111	0.674
DOC_CYCLIN_RxL_1	515	527	PF00134	0.385
DOC_CYCLIN_RxL_1	579	590	PF00134	0.508
DOC_MAPK_gen_1	235	242	PF00069	0.425
DOC_MAPK_gen_1	27	37	PF00069	0.361
DOC_MAPK_gen_1	327	337	PF00069	0.452
DOC_MAPK_gen_1	481	491	PF00069	0.392
DOC_MAPK_gen_1	641	649	PF00069	0.517
DOC_MAPK_MEF2A_6	235	242	PF00069	0.425
DOC_MAPK_MEF2A_6	473	480	PF00069	0.382
DOC_PP2B_LxvP_1	593	596	PF13499	0.556
DOC_PP2B_PxIxI_1	201	207	PF00149	0.387
DOC_PP4_FxxP_1	350	353	PF00568	0.546
DOC_USP7_MATH_1	106	110	PF00917	0.520
DOC_USP7_MATH_1	114	118	PF00917	0.435
DOC_USP7_MATH_1	150	154	PF00917	0.532
DOC_USP7_MATH_1	246	250	PF00917	0.499
DOC_USP7_MATH_1	259	263	PF00917	0.765
DOC_USP7_MATH_1	271	275	PF00917	0.460
DOC_USP7_MATH_1	305	309	PF00917	0.743
DOC_USP7_MATH_1	354	358	PF00917	0.602
DOC_USP7_MATH_1	364	368	PF00917	0.736
DOC_USP7_MATH_1	59	63	PF00917	0.487
DOC_USP7_UBL2_3	399	403	PF12436	0.314
DOC_USP7_UBL2_3	578	582	PF12436	0.569
DOC_WW_Pin1_4	252	257	PF00397	0.669
DOC_WW_Pin1_4	44	49	PF00397	0.575
LIG_14-3-3_CanoR_1	113	119	PF00244	0.481
LIG_14-3-3_CanoR_1	140	150	PF00244	0.581
LIG_14-3-3_CanoR_1	248	254	PF00244	0.619
LIG_Actin_WH2_2	104	121	PF00022	0.595
LIG_Actin_WH2_2	183	198	PF00022	0.699
LIG_Actin_WH2_2	235	250	PF00022	0.520
LIG_Actin_WH2_2	331	348	PF00022	0.492
LIG_BIR_II_1	1	5	PF00653	0.682
LIG_BIR_III_4	133	137	PF00653	0.495
LIG_BRCT_BRCA1_1	70	74	PF00533	0.502
LIG_Clathr_ClatBox_1	229	233	PF01394	0.372
LIG_deltaCOP1_diTrp_1	321	324	PF00928	0.396
LIG_DLG_GKlike_1	50	58	PF00625	0.503
LIG_eIF4E_1	20	26	PF01652	0.344
LIG_eIF4E_1	344	350	PF01652	0.451
LIG_FHA_1	190	196	PF00498	0.590
LIG_FHA_1	242	248	PF00498	0.474
LIG_FHA_1	255	261	PF00498	0.668
LIG_FHA_1	302	308	PF00498	0.635
LIG_FHA_1	37	43	PF00498	0.399
LIG_FHA_1	389	395	PF00498	0.473
LIG_FHA_1	49	55	PF00498	0.584
LIG_FHA_1	491	497	PF00498	0.392
LIG_FHA_1	505	511	PF00498	0.315
LIG_FHA_1	588	594	PF00498	0.520
LIG_FHA_1	597	603	PF00498	0.430
LIG_FHA_1	75	81	PF00498	0.272
LIG_FHA_2	128	134	PF00498	0.734
LIG_FHA_2	307	313	PF00498	0.698
LIG_FHA_2	407	413	PF00498	0.322
LIG_FHA_2	441	447	PF00498	0.478
LIG_FHA_2	546	552	PF00498	0.423
LIG_FHA_2	561	567	PF00498	0.524
LIG_GBD_Chelix_1	221	229	PF00786	0.367
LIG_LIR_Gen_1	184	195	PF02991	0.663
LIG_LIR_Gen_1	38	48	PF02991	0.421
LIG_LIR_Gen_1	446	454	PF02991	0.464
LIG_LIR_Gen_1	494	505	PF02991	0.356
LIG_LIR_Gen_1	616	626	PF02991	0.481
LIG_LIR_Gen_1	644	649	PF02991	0.526
LIG_LIR_Nem_3	17	23	PF02991	0.347
LIG_LIR_Nem_3	184	190	PF02991	0.663
LIG_LIR_Nem_3	227	231	PF02991	0.422
LIG_LIR_Nem_3	38	44	PF02991	0.384
LIG_LIR_Nem_3	443	448	PF02991	0.443
LIG_LIR_Nem_3	494	500	PF02991	0.305
LIG_LIR_Nem_3	532	537	PF02991	0.367
LIG_LIR_Nem_3	616	622	PF02991	0.428
LIG_LIR_Nem_3	644	649	PF02991	0.526
LIG_MYND_1	10	14	PF01753	0.491
LIG_MYND_1	296	300	PF01753	0.514
LIG_PCNA_PIPBox_1	639	648	PF02747	0.288
LIG_PDZ_Class_2	644	649	PF00595	0.526
LIG_PTB_Apo_2	543	550	PF02174	0.484
LIG_Rb_pABgroove_1	80	88	PF01858	0.303
LIG_SH2_CRK	157	161	PF00017	0.535
LIG_SH2_CRK	448	452	PF00017	0.401
LIG_SH2_CRK	483	487	PF00017	0.365
LIG_SH2_CRK	619	623	PF00017	0.436
LIG_SH2_NCK_1	157	161	PF00017	0.604
LIG_SH2_NCK_1	86	90	PF00017	0.545
LIG_SH2_SRC	231	234	PF00017	0.441
LIG_SH2_SRC	86	89	PF00017	0.538
LIG_SH2_STAP1	21	25	PF00017	0.339
LIG_SH2_STAP1	414	418	PF00017	0.413
LIG_SH2_STAP1	506	510	PF00017	0.382
LIG_SH2_STAT3	506	509	PF00017	0.384
LIG_SH2_STAT5	228	231	PF00017	0.391
LIG_SH2_STAT5	344	347	PF00017	0.489
LIG_SH2_STAT5	401	404	PF00017	0.388
LIG_SH2_STAT5	41	44	PF00017	0.403
LIG_SH2_STAT5	506	509	PF00017	0.483
LIG_SH3_1	196	202	PF00018	0.570
LIG_SH3_3	196	202	PF00018	0.532
LIG_SH3_3	250	256	PF00018	0.640
LIG_SH3_3	278	284	PF00018	0.710
LIG_SH3_3	293	299	PF00018	0.683
LIG_SH3_3	4	10	PF00018	0.517
LIG_SH3_3	627	633	PF00018	0.447
LIG_SUMO_SIM_par_1	42	47	PF11976	0.384
LIG_TRAF2_1	309	312	PF00917	0.712
LIG_TYR_ITIM	617	622	PF00017	0.458
LIG_WRC_WIRS_1	505	510	PF05994	0.504
LIG_WRC_WIRS_1	607	612	PF05994	0.424
MOD_CDC14_SPxK_1	47	50	PF00782	0.465
MOD_CDK_SPxK_1	44	50	PF00069	0.434
MOD_CK1_1	194	200	PF00069	0.659
MOD_CK1_1	249	255	PF00069	0.547
MOD_CK1_1	373	379	PF00069	0.629
MOD_CK2_1	271	277	PF00069	0.504
MOD_CK2_1	306	312	PF00069	0.703
MOD_CK2_1	406	412	PF00069	0.326
MOD_CK2_1	454	460	PF00069	0.376
MOD_CK2_1	545	551	PF00069	0.423
MOD_CK2_1	560	566	PF00069	0.528
MOD_Cter_Amidation	583	586	PF01082	0.498
MOD_GlcNHglycan	248	251	PF01048	0.417
MOD_GlcNHglycan	261	264	PF01048	0.710
MOD_GlcNHglycan	273	276	PF01048	0.529
MOD_GlcNHglycan	372	375	PF01048	0.713
MOD_GlcNHglycan	63	66	PF01048	0.612
MOD_GSK3_1	255	262	PF00069	0.501
MOD_GSK3_1	301	308	PF00069	0.702
MOD_GSK3_1	36	43	PF00069	0.462
MOD_GSK3_1	406	413	PF00069	0.455
MOD_GSK3_1	44	51	PF00069	0.524
MOD_GSK3_1	491	498	PF00069	0.515
MOD_GSK3_1	55	62	PF00069	0.470
MOD_GSK3_1	602	609	PF00069	0.445
MOD_N-GLC_1	114	119	PF02516	0.599
MOD_N-GLC_1	354	359	PF02516	0.608
MOD_N-GLC_1	389	394	PF02516	0.518
MOD_N-GLC_1	545	550	PF02516	0.379
MOD_NEK2_1	141	146	PF00069	0.642
MOD_NEK2_1	42	47	PF00069	0.417
MOD_NEK2_1	454	459	PF00069	0.400
MOD_NEK2_1	587	592	PF00069	0.468
MOD_NEK2_1	602	607	PF00069	0.454
MOD_NEK2_1	615	620	PF00069	0.482
MOD_NEK2_1	68	73	PF00069	0.476
MOD_NEK2_1	74	79	PF00069	0.342
MOD_NEK2_2	114	119	PF00069	0.574
MOD_NEK2_2	191	196	PF00069	0.707
MOD_PIKK_1	525	531	PF00454	0.531
MOD_PK_1	166	172	PF00069	0.677
MOD_PKA_2	364	370	PF00069	0.507
MOD_Plk_1	114	120	PF00069	0.610
MOD_Plk_1	354	360	PF00069	0.534
MOD_Plk_1	389	395	PF00069	0.515
MOD_Plk_1	510	516	PF00069	0.463
MOD_Plk_1	545	551	PF00069	0.312
MOD_Plk_1	615	621	PF00069	0.483
MOD_Plk_1	68	74	PF00069	0.502
MOD_Plk_4	21	27	PF00069	0.353
MOD_Plk_4	249	255	PF00069	0.620
MOD_Plk_4	389	395	PF00069	0.515
MOD_Plk_4	68	74	PF00069	0.504
MOD_Plk_4	81	87	PF00069	0.405
MOD_ProDKin_1	252	258	PF00069	0.670
MOD_ProDKin_1	44	50	PF00069	0.584
MOD_SUMO_rev_2	227	236	PF00179	0.479
MOD_SUMO_rev_2	577	583	PF00179	0.312
TRG_DiLeu_BaEn_2	69	75	PF01217	0.403
TRG_DiLeu_BaLyEn_6	482	487	PF01217	0.390
TRG_DiLeu_BaLyEn_6	583	588	PF01217	0.489
TRG_ENDOCYTIC_2	20	23	PF00928	0.358
TRG_ENDOCYTIC_2	401	404	PF00928	0.413
TRG_ENDOCYTIC_2	41	44	PF00928	0.403
TRG_ENDOCYTIC_2	448	451	PF00928	0.426
TRG_ENDOCYTIC_2	483	486	PF00928	0.367
TRG_ENDOCYTIC_2	619	622	PF00928	0.398
TRG_ER_diArg_1	26	29	PF00400	0.370
TRG_ER_diArg_1	483	485	PF00400	0.376
TRG_ER_diArg_1	585	587	PF00400	0.510
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	484	488	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	585	589	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	624	629	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKM3	Leptomonas seymouri	69%	97%
A0A1X0NMP5	Trypanosomatidae	42%	100%
A0A3S5H6D1	Leishmania donovani	88%	100%
A0A422NV89	Trypanosoma rangeli	44%	100%
A4HTV8	Leishmania infantum	87%	100%
E9AMP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QHY0	Leishmania major	89%	100%
Q8TAM2	Homo sapiens	32%	100%
Q8VD72	Mus musculus	31%	100%
V5DJG5	Trypanosoma cruzi	43%	100%