RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania braziliensis

UniProt:

A4H5L9_LEIBR

TriTrypDb:

LbrM.09.0440 , LBRM2903_090009900

Length:

460

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5L9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003677	DNA binding	4	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.210
CLV_C14_Caspase3-7	293	297	PF00656	0.531
CLV_NRD_NRD_1	359	361	PF00675	0.521
CLV_NRD_NRD_1	50	52	PF00675	0.264
CLV_PCSK_KEX2_1	14	16	PF00082	0.385
CLV_PCSK_KEX2_1	359	361	PF00082	0.519
CLV_PCSK_KEX2_1	50	52	PF00082	0.264
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.385
CLV_PCSK_SKI1_1	318	322	PF00082	0.698
CLV_PCSK_SKI1_1	42	46	PF00082	0.291
DEG_APCC_DBOX_1	114	122	PF00400	0.356
DEG_Nend_Nbox_1	1	3	PF02207	0.536
DEG_SIAH_1	212	220	PF03145	0.532
DOC_CYCLIN_RxL_1	39	49	PF00134	0.294
DOC_CYCLIN_yCln2_LP_2	216	219	PF00134	0.701
DOC_CYCLIN_yCln2_LP_2	87	93	PF00134	0.367
DOC_PP2B_LxvP_1	216	219	PF13499	0.735
DOC_PP2B_LxvP_1	436	439	PF13499	0.291
DOC_PP2B_LxvP_1	45	48	PF13499	0.385
DOC_PP2B_LxvP_1	85	88	PF13499	0.291
DOC_USP7_MATH_1	16	20	PF00917	0.461
DOC_USP7_MATH_1	173	177	PF00917	0.571
DOC_USP7_MATH_1	240	244	PF00917	0.647
DOC_USP7_MATH_1	245	249	PF00917	0.517
DOC_USP7_MATH_1	324	328	PF00917	0.540
DOC_USP7_MATH_1	336	340	PF00917	0.521
DOC_WW_Pin1_4	209	214	PF00397	0.658
DOC_WW_Pin1_4	256	261	PF00397	0.521
DOC_WW_Pin1_4	303	308	PF00397	0.527
LIG_14-3-3_CanoR_1	20	27	PF00244	0.407
LIG_14-3-3_CanoR_1	205	213	PF00244	0.711
LIG_14-3-3_CanoR_1	448	457	PF00244	0.320
LIG_14-3-3_CanoR_1	58	68	PF00244	0.367
LIG_BIR_III_4	379	383	PF00653	0.467
LIG_BRCT_BRCA1_1	265	269	PF00533	0.709
LIG_BRCT_BRCA1_1	36	40	PF00533	0.210
LIG_BRCT_BRCA1_1	451	455	PF00533	0.255
LIG_BRCT_BRCA1_1	6	10	PF00533	0.471
LIG_FHA_1	137	143	PF00498	0.524
LIG_FHA_1	420	426	PF00498	0.385
LIG_FHA_1	76	82	PF00498	0.351
LIG_FHA_2	124	130	PF00498	0.479
LIG_FHA_2	350	356	PF00498	0.464
LIG_FHA_2	47	53	PF00498	0.461
LIG_FHA_2	61	67	PF00498	0.203
LIG_LIR_Gen_1	116	125	PF02991	0.453
LIG_LIR_Gen_1	37	48	PF02991	0.272
LIG_LIR_Gen_1	79	90	PF02991	0.291
LIG_LIR_Nem_3	37	43	PF02991	0.260
LIG_LIR_Nem_3	66	71	PF02991	0.298
LIG_LIR_Nem_3	79	85	PF02991	0.373
LIG_PDZ_Class_3	455	460	PF00595	0.555
LIG_SH2_NCK_1	305	309	PF00017	0.688
LIG_SH2_STAT5	25	28	PF00017	0.210
LIG_SH2_STAT5	305	308	PF00017	0.664
LIG_SH2_STAT5	398	401	PF00017	0.445
LIG_SH2_STAT5	54	57	PF00017	0.291
LIG_SH2_STAT5	82	85	PF00017	0.291
LIG_SH3_3	371	377	PF00018	0.456
LIG_SH3_3	436	442	PF00018	0.481
LIG_SUMO_SIM_anti_2	422	427	PF11976	0.385
LIG_TRAF2_1	131	134	PF00917	0.372
LIG_TRAF2_2	218	223	PF00917	0.530
MOD_CDK_SPK_2	209	214	PF00069	0.538
MOD_CDK_SPxxK_3	256	263	PF00069	0.525
MOD_CK1_1	105	111	PF00069	0.370
MOD_CK1_1	136	142	PF00069	0.338
MOD_CK1_1	160	166	PF00069	0.660
MOD_CK1_1	19	25	PF00069	0.434
MOD_CK1_1	209	215	PF00069	0.715
MOD_CK1_1	243	249	PF00069	0.582
MOD_CK1_1	259	265	PF00069	0.678
MOD_CK1_1	32	38	PF00069	0.309
MOD_CK1_1	327	333	PF00069	0.701
MOD_CK1_1	449	455	PF00069	0.341
MOD_CK1_1	69	75	PF00069	0.385
MOD_CK2_1	105	111	PF00069	0.370
MOD_CK2_1	123	129	PF00069	0.541
MOD_CK2_1	292	298	PF00069	0.687
MOD_CK2_1	349	355	PF00069	0.505
MOD_CK2_1	46	52	PF00069	0.465
MOD_CK2_1	60	66	PF00069	0.205
MOD_GlcNHglycan	208	211	PF01048	0.611
MOD_GlcNHglycan	238	241	PF01048	0.786
MOD_GlcNHglycan	247	250	PF01048	0.789
MOD_GlcNHglycan	327	330	PF01048	0.540
MOD_GlcNHglycan	36	39	PF01048	0.265
MOD_GlcNHglycan	448	451	PF01048	0.295
MOD_GlcNHglycan	68	71	PF01048	0.385
MOD_GSK3_1	100	107	PF00069	0.291
MOD_GSK3_1	175	182	PF00069	0.541
MOD_GSK3_1	204	211	PF00069	0.629
MOD_GSK3_1	236	243	PF00069	0.693
MOD_GSK3_1	250	257	PF00069	0.696
MOD_GSK3_1	259	266	PF00069	0.722
MOD_GSK3_1	288	295	PF00069	0.739
MOD_GSK3_1	30	37	PF00069	0.240
MOD_GSK3_1	66	73	PF00069	0.414
MOD_N-GLC_1	105	110	PF02516	0.385
MOD_N-GLC_1	160	165	PF02516	0.653
MOD_N-GLC_1	173	178	PF02516	0.539
MOD_N-GLC_1	263	268	PF02516	0.540
MOD_NEK2_1	208	213	PF00069	0.653
MOD_NEK2_1	235	240	PF00069	0.699
MOD_NEK2_1	334	339	PF00069	0.697
MOD_OFUCOSY	434	441	PF10250	0.340
MOD_PIKK_1	160	166	PF00454	0.781
MOD_PIKK_1	179	185	PF00454	0.503
MOD_PIKK_1	218	224	PF00454	0.728
MOD_PIKK_1	73	79	PF00454	0.282
MOD_PKA_2	19	25	PF00069	0.385
MOD_PKA_2	204	210	PF00069	0.716
MOD_PKA_2	236	242	PF00069	0.679
MOD_PKA_2	342	348	PF00069	0.564
MOD_PKB_1	149	157	PF00069	0.618
MOD_Plk_1	105	111	PF00069	0.385
MOD_Plk_1	4	10	PF00069	0.483
MOD_Plk_4	271	277	PF00069	0.708
MOD_Plk_4	336	342	PF00069	0.652
MOD_Plk_4	419	425	PF00069	0.291
MOD_ProDKin_1	209	215	PF00069	0.658
MOD_ProDKin_1	256	262	PF00069	0.522
MOD_ProDKin_1	303	309	PF00069	0.528
TRG_DiLeu_BaLyEn_6	386	391	PF01217	0.526
TRG_ENDOCYTIC_2	68	71	PF00928	0.298
TRG_ENDOCYTIC_2	82	85	PF00928	0.291
TRG_ER_diArg_1	359	362	PF00400	0.573
TRG_ER_diArg_1	387	390	PF00400	0.544
TRG_Pf-PMV_PEXEL_1	359	364	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	389	394	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I698	Leptomonas seymouri	59%	96%
A0A3S5H6D0	Leishmania donovani	75%	99%
A0A422NV73	Trypanosoma rangeli	37%	100%
A4HTV7	Leishmania infantum	75%	99%
E9AMP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	96%
Q4QHY1	Leishmania major	73%	99%
V5BIH0	Trypanosoma cruzi	39%	100%