Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplastid kinetochore protein 10, putative (fragment)

Species:

Leishmania braziliensis

UniProt:

A4H5L6_LEIBR

TriTrypDb:

LbrM.09.0410 , LBRM2903_090009700

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5L6

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0004672	protein kinase activity	3	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	52	56	PF00656	0.875
CLV_C14_Caspase3-7	69	73	PF00656	0.578
CLV_NRD_NRD_1	153	155	PF00675	0.738
CLV_NRD_NRD_1	57	59	PF00675	0.883
CLV_NRD_NRD_1	77	79	PF00675	0.528
CLV_PCSK_KEX2_1	155	157	PF00082	0.768
CLV_PCSK_KEX2_1	57	59	PF00082	0.883
CLV_PCSK_KEX2_1	62	64	PF00082	0.789
CLV_PCSK_KEX2_1	77	79	PF00082	0.528
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.768
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.876
CLV_PCSK_PC7_1	58	64	PF00082	0.875
CLV_PCSK_SKI1_1	103	107	PF00082	0.872
CLV_PCSK_SKI1_1	173	177	PF00082	0.745
DEG_APCC_DBOX_1	192	200	PF00400	0.647
DEG_Nend_UBRbox_2	1	3	PF02207	0.857
DOC_CYCLIN_RxL_1	132	142	PF00134	0.746
DOC_MAPK_gen_1	154	164	PF00069	0.728
DOC_MAPK_gen_1	170	179	PF00069	0.459
DOC_MAPK_MEF2A_6	173	181	PF00069	0.748
DOC_PP4_MxPP_1	96	99	PF00568	0.718
DOC_SPAK_OSR1_1	133	137	PF12202	0.749
DOC_USP7_MATH_1	15	19	PF00917	0.846
DOC_USP7_MATH_1	30	34	PF00917	0.595
DOC_USP7_MATH_1	56	60	PF00917	0.876
LIG_deltaCOP1_diTrp_1	223	231	PF00928	0.636
LIG_EH1_1	133	141	PF00400	0.743
LIG_FHA_1	104	110	PF00498	0.866
LIG_FHA_1	33	39	PF00498	0.863
LIG_FHA_1	69	75	PF00498	0.866
LIG_FHA_2	67	73	PF00498	0.846
LIG_LIR_Apic_2	106	110	PF02991	0.864
LIG_LIR_Gen_1	158	165	PF02991	0.706
LIG_LIR_Nem_3	116	122	PF02991	0.812
LIG_LIR_Nem_3	131	137	PF02991	0.493
LIG_LIR_Nem_3	142	148	PF02991	0.534
LIG_LIR_Nem_3	158	162	PF02991	0.428
LIG_SH2_CRK	107	111	PF00017	0.858
LIG_SH2_CRK	159	163	PF00017	0.693
LIG_SH2_NCK_1	23	27	PF00017	0.845
LIG_SH2_PTP2	120	123	PF00017	0.815
LIG_SH2_STAP1	171	175	PF00017	0.732
LIG_SH2_STAT5	120	123	PF00017	0.815
LIG_SH2_STAT5	159	162	PF00017	0.698
LIG_SH2_STAT5	171	174	PF00017	0.533
LIG_SH2_STAT5	202	205	PF00017	0.636
LIG_SH3_3	92	98	PF00018	0.864
LIG_UBA3_1	221	227	PF00899	0.635
MOD_CK1_1	33	39	PF00069	0.746
MOD_GlcNHglycan	17	20	PF01048	0.776
MOD_GlcNHglycan	206	209	PF01048	0.632
MOD_GlcNHglycan	32	35	PF01048	0.600
MOD_GlcNHglycan	58	61	PF01048	0.874
MOD_GSK3_1	47	54	PF00069	0.862
MOD_LATS_1	45	51	PF00433	0.852
MOD_N-GLC_1	204	209	PF02516	0.638
MOD_NEK2_1	1	6	PF00069	0.854
MOD_NEK2_1	49	54	PF00069	0.861
MOD_PIKK_1	128	134	PF00454	0.768
MOD_PIKK_1	21	27	PF00454	0.728
MOD_PIKK_1	49	55	PF00454	0.748
MOD_PKA_1	103	109	PF00069	0.872
MOD_PKA_2	56	62	PF00069	0.874
MOD_Plk_1	1	7	PF00069	0.737
MOD_Plk_4	135	141	PF00069	0.742
MOD_SUMO_for_1	175	178	PF00179	0.738
TRG_ENDOCYTIC_2	120	123	PF00928	0.815
TRG_ENDOCYTIC_2	159	162	PF00928	0.698
TRG_NLS_MonoCore_2	100	105	PF00514	0.860
TRG_NLS_MonoExtN_4	98	105	PF00514	0.847

Homologs


Protein	Taxonomy	Sequence identity	Coverage
B8Y466	PIG	30%	42%
O35491	MOUSE	37%	47%
O35492	MOUSE	38%	37%
O35493	MOUSE	40%	49%
O43781	HUMAN	29%	40%
O54781	MOUSE	32%	35%
O70551	MOUSE	32%	36%
P22518	MOUSE	40%	49%
P32350	YEAST	35%	32%
P49759	HUMAN	40%	49%
P49760	HUMAN	37%	47%
P49761	HUMAN	38%	37%
P51566	ARATH	38%	50%
P51567	ARATH	43%	55%
P51568	ARATH	41%	59%
P78362	HUMAN	32%	34%
Q07538	SCHPO	32%	49%
Q0IJ08	XENTR	31%	31%
Q10156	SCHPO	31%	34%
Q13627	HUMAN	31%	31%
Q2TAE3	XENLA	31%	31%
Q3SX21	BOVIN	38%	48%
Q4R6S5	MACFA	29%	41%
Q4V8A3	RAT	28%	40%
Q5RD27	PONAB	33%	36%
Q5U4C9	MOUSE	29%	39%
Q5ZIU3	CHICK	25%	45%
Q61214	MOUSE	31%	31%
Q63117	RAT	38%	48%
Q63470	RAT	31%	31%
Q8BI55	MOUSE	32%	37%
Q922Y0	MOUSE	28%	40%
Q92630	HUMAN	29%	39%
Q96SB4	HUMAN	32%	36%
Q9HAZ1	HUMAN	40%	49%
Q9NR20	HUMAN	32%	45%
Q9P6P3	SCHPO	29%	44%
Q9UPE1	HUMAN	34%	41%
Q9V3D5	DROME	30%	33%
Q9Y463	HUMAN	32%	37%
Q9Z0G2	MOUSE	32%	42%
Q9Z188	MOUSE	32%	37%