Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5L4_LEIBR

TriTrypDb:

LbrM.09.0390 , LBRM2903_090009400

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5L4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5L4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	288	292	PF00656	0.775
CLV_C14_Caspase3-7	310	314	PF00656	0.699
CLV_C14_Caspase3-7	442	446	PF00656	0.626
CLV_NRD_NRD_1	222	224	PF00675	0.631
CLV_NRD_NRD_1	274	276	PF00675	0.487
CLV_NRD_NRD_1	416	418	PF00675	0.528
CLV_NRD_NRD_1	460	462	PF00675	0.515
CLV_NRD_NRD_1	86	88	PF00675	0.457
CLV_PCSK_KEX2_1	222	224	PF00082	0.631
CLV_PCSK_KEX2_1	274	276	PF00082	0.598
CLV_PCSK_KEX2_1	284	286	PF00082	0.653
CLV_PCSK_KEX2_1	300	302	PF00082	0.562
CLV_PCSK_KEX2_1	416	418	PF00082	0.506
CLV_PCSK_KEX2_1	437	439	PF00082	0.617
CLV_PCSK_KEX2_1	86	88	PF00082	0.457
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.664
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.562
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.617
CLV_PCSK_SKI1_1	149	153	PF00082	0.487
CLV_PCSK_SKI1_1	251	255	PF00082	0.441
CLV_PCSK_SKI1_1	348	352	PF00082	0.466
CLV_PCSK_SKI1_1	71	75	PF00082	0.389
CLV_PCSK_SKI1_1	89	93	PF00082	0.323
DEG_APCC_DBOX_1	250	258	PF00400	0.427
DEG_SPOP_SBC_1	47	51	PF00917	0.509
DOC_ANK_TNKS_1	14	21	PF00023	0.364
DOC_ANK_TNKS_1	437	444	PF00023	0.440
DOC_CKS1_1	448	453	PF01111	0.554
DOC_CYCLIN_RxL_1	345	355	PF00134	0.511
DOC_CYCLIN_RxL_1	68	77	PF00134	0.531
DOC_CYCLIN_RxL_1	86	94	PF00134	0.514
DOC_MAPK_gen_1	133	142	PF00069	0.460
DOC_MAPK_gen_1	248	256	PF00069	0.513
DOC_MAPK_gen_1	262	269	PF00069	0.625
DOC_MAPK_MEF2A_6	248	256	PF00069	0.478
DOC_MAPK_RevD_3	73	87	PF00069	0.402
DOC_PP4_FxxP_1	56	59	PF00568	0.513
DOC_USP7_MATH_1	120	124	PF00917	0.760
DOC_USP7_MATH_1	308	312	PF00917	0.645
DOC_USP7_MATH_1	39	43	PF00917	0.590
DOC_USP7_MATH_1	45	49	PF00917	0.502
DOC_USP7_MATH_1	52	56	PF00917	0.484
DOC_USP7_UBL2_3	145	149	PF12436	0.597
DOC_WW_Pin1_4	34	39	PF00397	0.718
DOC_WW_Pin1_4	447	452	PF00397	0.610
DOC_WW_Pin1_4	48	53	PF00397	0.511
LIG_14-3-3_CanoR_1	119	125	PF00244	0.643
LIG_14-3-3_CanoR_1	222	227	PF00244	0.646
LIG_14-3-3_CterR_2	461	464	PF00244	0.436
LIG_FHA_1	119	125	PF00498	0.531
LIG_FHA_1	2	8	PF00498	0.312
LIG_FHA_1	271	277	PF00498	0.481
LIG_FHA_1	332	338	PF00498	0.534
LIG_FHA_1	52	58	PF00498	0.502
LIG_FHA_2	199	205	PF00498	0.395
LIG_FHA_2	213	219	PF00498	0.466
LIG_FHA_2	448	454	PF00498	0.545
LIG_Integrin_RGD_1	15	17	PF01839	0.407
LIG_LIR_Apic_2	53	59	PF02991	0.526
LIG_LIR_Nem_3	423	428	PF02991	0.500
LIG_MAD2	138	146	PF02301	0.446
LIG_NRBOX	346	352	PF00104	0.450
LIG_SH2_CRK	425	429	PF00017	0.553
LIG_SH2_SRC	97	100	PF00017	0.319
LIG_SH2_STAT5	182	185	PF00017	0.400
LIG_SH2_STAT5	97	100	PF00017	0.438
LIG_SH3_3	140	146	PF00018	0.461
LIG_SH3_3	445	451	PF00018	0.657
LIG_SH3_3	78	84	PF00018	0.331
LIG_SH3_4	145	152	PF00018	0.616
LIG_SUMO_SIM_par_1	452	460	PF11976	0.373
LIG_TRAF2_1	105	108	PF00917	0.374
LIG_TRAF2_1	170	173	PF00917	0.346
LIG_TYR_ITSM	421	428	PF00017	0.552
LIG_UBA3_1	454	462	PF00899	0.575
MOD_CK1_1	211	217	PF00069	0.510
MOD_CK1_1	394	400	PF00069	0.652
MOD_CK1_1	46	52	PF00069	0.582
MOD_CK2_1	198	204	PF00069	0.387
MOD_CK2_1	212	218	PF00069	0.477
MOD_CK2_1	436	442	PF00069	0.453
MOD_GlcNHglycan	156	160	PF01048	0.688
MOD_GlcNHglycan	192	195	PF01048	0.447
MOD_GlcNHglycan	210	213	PF01048	0.329
MOD_GlcNHglycan	235	238	PF01048	0.556
MOD_GlcNHglycan	280	283	PF01048	0.557
MOD_GlcNHglycan	41	44	PF01048	0.653
MOD_GlcNHglycan	439	442	PF01048	0.576
MOD_GlcNHglycan	45	48	PF01048	0.667
MOD_GSK3_1	208	215	PF00069	0.445
MOD_GSK3_1	218	225	PF00069	0.554
MOD_GSK3_1	30	37	PF00069	0.560
MOD_GSK3_1	331	338	PF00069	0.474
MOD_GSK3_1	39	46	PF00069	0.612
MOD_GSK3_1	47	54	PF00069	0.542
MOD_N-GLC_1	320	325	PF02516	0.693
MOD_N-GLC_1	39	44	PF02516	0.635
MOD_NEK2_1	190	195	PF00069	0.543
MOD_NEK2_1	208	213	PF00069	0.300
MOD_NEK2_1	29	34	PF00069	0.511
MOD_NEK2_1	436	441	PF00069	0.554
MOD_NEK2_1	74	79	PF00069	0.358
MOD_PIKK_1	226	232	PF00454	0.621
MOD_PIKK_1	322	328	PF00454	0.614
MOD_PIKK_1	339	345	PF00454	0.608
MOD_PIKK_1	394	400	PF00454	0.410
MOD_PK_1	222	228	PF00069	0.614
MOD_PKA_1	222	228	PF00069	0.649
MOD_PKA_1	300	306	PF00069	0.703
MOD_PKA_1	437	443	PF00069	0.531
MOD_PKA_2	118	124	PF00069	0.531
MOD_PKA_2	222	228	PF00069	0.649
MOD_PKA_2	278	284	PF00069	0.627
MOD_PKA_2	300	306	PF00069	0.771
MOD_PKA_2	331	337	PF00069	0.570
MOD_PKA_2	339	345	PF00069	0.538
MOD_PKA_2	391	397	PF00069	0.513
MOD_PKA_2	437	443	PF00069	0.531
MOD_Plk_2-3	198	204	PF00069	0.503
MOD_Plk_4	222	228	PF00069	0.642
MOD_Plk_4	444	450	PF00069	0.583
MOD_Plk_4	52	58	PF00069	0.625
MOD_Plk_4	74	80	PF00069	0.300
MOD_ProDKin_1	34	40	PF00069	0.723
MOD_ProDKin_1	447	453	PF00069	0.604
MOD_ProDKin_1	48	54	PF00069	0.504
MOD_SUMO_for_1	381	384	PF00179	0.502
MOD_SUMO_rev_2	355	361	PF00179	0.510
MOD_SUMO_rev_2	93	98	PF00179	0.433
TRG_DiLeu_BaEn_2	203	209	PF01217	0.495
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.557
TRG_ENDOCYTIC_2	425	428	PF00928	0.563
TRG_ER_diArg_1	274	276	PF00400	0.385
TRG_ER_diArg_1	415	417	PF00400	0.560
TRG_ER_diArg_1	86	89	PF00400	0.351
TRG_Pf-PMV_PEXEL_1	274	278	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	406	410	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	89	93	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N2	Leptomonas seymouri	55%	99%
A0A1X0NPB5	Trypanosomatidae	24%	100%
A0A3R7K7T1	Trypanosoma rangeli	29%	100%
A0A3S7WQL0	Leishmania donovani	77%	100%
A4HTV2	Leishmania infantum	76%	78%
D0A9B2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AMP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QHY6	Leishmania major	79%	100%