DUF2812 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5L3_LEIBR

TriTrypDb:

LbrM.09.0380 , LBRM2903_090009300

Length:

175

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4H5L3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5L3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	70	74	PF00656	0.631
CLV_NRD_NRD_1	59	61	PF00675	0.410
CLV_PCSK_KEX2_1	59	61	PF00082	0.415
CLV_PCSK_SKI1_1	59	63	PF00082	0.478
DEG_APCC_KENBOX_2	100	104	PF00400	0.611
DEG_ODPH_VHL_1	119	131	PF01847	0.570
DOC_USP7_MATH_1	149	153	PF00917	0.378
DOC_USP7_MATH_1	76	80	PF00917	0.726
LIG_14-3-3_CanoR_1	64	71	PF00244	0.628
LIG_BIR_II_1	1	5	PF00653	0.668
LIG_BIR_III_1	1	5	PF00653	0.668
LIG_BIR_III_3	1	5	PF00653	0.668
LIG_FHA_1	111	117	PF00498	0.579
LIG_FHA_1	169	175	PF00498	0.512
LIG_FHA_1	85	91	PF00498	0.607
LIG_HCF-1_HBM_1	138	141	PF13415	0.478
LIG_LIR_Gen_1	75	81	PF02991	0.656
LIG_LIR_Nem_3	66	71	PF02991	0.601
LIG_LIR_Nem_3	75	80	PF02991	0.604
LIG_NRP_CendR_1	172	175	PF00754	0.570
LIG_Pex14_1	123	127	PF04695	0.506
LIG_Pex14_1	155	159	PF04695	0.366
LIG_Pex14_1	95	99	PF04695	0.579
LIG_Pex14_2	124	128	PF04695	0.542
LIG_REV1ctd_RIR_1	59	68	PF16727	0.621
LIG_SH2_CRK	162	166	PF00017	0.364
LIG_SH2_CRK	24	28	PF00017	0.589
LIG_SH2_CRK	77	81	PF00017	0.614
LIG_SH2_GRB2like	24	27	PF00017	0.613
LIG_SH2_NCK_1	162	166	PF00017	0.340
LIG_SH2_NCK_1	24	28	PF00017	0.583
LIG_SH2_NCK_1	77	81	PF00017	0.631
LIG_SH2_SRC	24	27	PF00017	0.613
LIG_SH2_STAP1	43	47	PF00017	0.568
LIG_SH2_STAP1	77	81	PF00017	0.661
LIG_SH2_STAT5	127	130	PF00017	0.552
LIG_SH2_STAT5	141	144	PF00017	0.236
LIG_SH2_STAT5	159	162	PF00017	0.304
LIG_SH2_STAT5	43	46	PF00017	0.585
LIG_SH3_3	103	109	PF00018	0.583
LIG_TYR_ITSM	64	71	PF00017	0.628
MOD_CK1_1	84	90	PF00069	0.652
MOD_GlcNHglycan	8	11	PF01048	0.420
MOD_GlcNHglycan	83	86	PF01048	0.493
MOD_NEK2_1	160	165	PF00069	0.444
MOD_NEK2_1	81	86	PF00069	0.650
MOD_NEK2_2	76	81	PF00069	0.632
MOD_PIKK_1	16	22	PF00454	0.637
MOD_PIKK_1	163	169	PF00454	0.334
MOD_PIKK_1	41	47	PF00454	0.590
MOD_PIKK_1	49	55	PF00454	0.571
MOD_PKA_2	168	174	PF00069	0.454
MOD_PKA_2	63	69	PF00069	0.711
MOD_Plk_4	149	155	PF00069	0.292
MOD_Plk_4	76	82	PF00069	0.633
TRG_ENDOCYTIC_2	68	71	PF00928	0.601
TRG_ENDOCYTIC_2	77	80	PF00928	0.612
TRG_ER_diArg_1	59	61	PF00400	0.631
TRG_ER_diArg_1	88	91	PF00400	0.560
TRG_Pf-PMV_PEXEL_1	48	53	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J4W7	Bodo saltans	51%	80%
A0A1X0ND78	Trypanosomatidae	54%	66%
A0A3S5H6C7	Leishmania donovani	90%	100%
A4HTV1	Leishmania infantum	90%	100%
D0A9B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	72%
E9AMN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QHY7	Leishmania major	92%	100%