ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania braziliensis

UniProt:

A4H5L1_LEIBR

TriTrypDb:

LbrM.09.0360 , LBRM2903_090009100

Length:

209

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5L1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5L1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	194	196	PF00675	0.222
CLV_NRD_NRD_1	67	69	PF00675	0.536
CLV_PCSK_KEX2_1	194	196	PF00082	0.222
CLV_PCSK_KEX2_1	67	69	PF00082	0.536
CLV_PCSK_SKI1_1	148	152	PF00082	0.503
CLV_PCSK_SKI1_1	169	173	PF00082	0.369
CLV_PCSK_SKI1_1	53	57	PF00082	0.443
DEG_SPOP_SBC_1	180	184	PF00917	0.304
DEG_SPOP_SBC_1	6	10	PF00917	0.523
DOC_CDC14_PxL_1	150	158	PF14671	0.304
DOC_PP4_FxxP_1	151	154	PF00568	0.366
DOC_USP7_MATH_1	18	22	PF00917	0.655
DOC_USP7_MATH_1	6	10	PF00917	0.591
DOC_WW_Pin1_4	10	15	PF00397	0.522
LIG_14-3-3_CanoR_1	22	31	PF00244	0.534
LIG_14-3-3_CanoR_1	40	50	PF00244	0.340
LIG_BIR_II_1	1	5	PF00653	0.679
LIG_EVH1_2	154	158	PF00568	0.304
LIG_FHA_1	181	187	PF00498	0.451
LIG_FHA_2	22	28	PF00498	0.607
LIG_LIR_Nem_3	88	93	PF02991	0.467
LIG_Pex14_2	145	149	PF04695	0.505
LIG_Pex14_2	158	162	PF04695	0.304
LIG_SH2_CRK	140	144	PF00017	0.436
LIG_SH2_CRK	197	201	PF00017	0.304
LIG_SUMO_SIM_par_1	115	120	PF11976	0.299
LIG_TRAF2_1	58	61	PF00917	0.454
MOD_CK1_1	21	27	PF00069	0.671
MOD_CK2_1	21	27	PF00069	0.632
MOD_CK2_1	55	61	PF00069	0.460
MOD_GlcNHglycan	100	105	PF01048	0.534
MOD_GlcNHglycan	205	208	PF01048	0.438
MOD_GSK3_1	1	8	PF00069	0.613
MOD_GSK3_1	18	25	PF00069	0.700
MOD_NEK2_1	1	6	PF00069	0.679
MOD_NEK2_1	203	208	PF00069	0.480
MOD_PIKK_1	41	47	PF00454	0.359
MOD_PIKK_1	77	83	PF00454	0.422
MOD_PKA_2	21	27	PF00069	0.585
MOD_PKA_2	39	45	PF00069	0.377
MOD_Plk_1	100	106	PF00069	0.460
MOD_Plk_4	196	202	PF00069	0.227
MOD_ProDKin_1	10	16	PF00069	0.523
TRG_DiLeu_BaEn_1	52	57	PF01217	0.451
TRG_DiLeu_BaEn_3	165	171	PF01217	0.278
TRG_DiLeu_BaEn_4	60	66	PF01217	0.459
TRG_ENDOCYTIC_2	140	143	PF00928	0.499
TRG_ENDOCYTIC_2	197	200	PF00928	0.304
TRG_ER_diArg_1	186	189	PF00400	0.227
TRG_ER_diArg_1	67	69	PF00400	0.536
TRG_ER_diArg_1	82	85	PF00400	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCZ4	Leptomonas seymouri	50%	88%
A0A3S7WQK8	Leishmania donovani	78%	100%
A4HTV0	Leishmania infantum	78%	100%
E9AMN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QHY8	Leishmania major	78%	100%