Putative DNA photolyase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA photolyase, putative

Species:

Leishmania braziliensis

UniProt:

A4H5L0_LEIBR

TriTrypDb:

LbrM.09.0350 , LBRM2903_090009000

Length:

959

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5L0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5L0

Function

Biological processes
Term	Name	Level	Count
GO:0000719	photoreactive repair	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006290	pyrimidine dimer repair	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0003904	deoxyribodipyrimidine photo-lyase activity	5	8
GO:0003913	DNA photolyase activity	4	8
GO:0016829	lyase activity	2	11
GO:0016830	carbon-carbon lyase activity	3	8
GO:0140097	catalytic activity, acting on DNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8
GO:0000166	nucleotide binding	3	1
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0005488	binding	1	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0050660	flavin adenine dinucleotide binding	4	1
GO:0071949	FAD binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.468
CLV_C14_Caspase3-7	578	582	PF00656	0.610
CLV_NRD_NRD_1	377	379	PF00675	0.337
CLV_NRD_NRD_1	385	387	PF00675	0.271
CLV_NRD_NRD_1	610	612	PF00675	0.608
CLV_NRD_NRD_1	635	637	PF00675	0.314
CLV_NRD_NRD_1	668	670	PF00675	0.327
CLV_NRD_NRD_1	703	705	PF00675	0.301
CLV_NRD_NRD_1	938	940	PF00675	0.710
CLV_PCSK_FUR_1	608	612	PF00082	0.598
CLV_PCSK_KEX2_1	377	379	PF00082	0.337
CLV_PCSK_KEX2_1	385	387	PF00082	0.289
CLV_PCSK_KEX2_1	610	612	PF00082	0.608
CLV_PCSK_KEX2_1	668	670	PF00082	0.327
CLV_PCSK_KEX2_1	955	957	PF00082	0.683
CLV_PCSK_PC1ET2_1	955	957	PF00082	0.683
CLV_PCSK_SKI1_1	254	258	PF00082	0.267
CLV_PCSK_SKI1_1	546	550	PF00082	0.452
CLV_PCSK_SKI1_1	651	655	PF00082	0.466
CLV_PCSK_SKI1_1	682	686	PF00082	0.479
CLV_PCSK_SKI1_1	738	742	PF00082	0.274
CLV_Separin_Metazoa	640	644	PF03568	0.393
CLV_Separin_Metazoa	789	793	PF03568	0.464
DEG_APCC_DBOX_1	545	553	PF00400	0.462
DEG_APCC_DBOX_1	659	667	PF00400	0.349
DEG_APCC_DBOX_1	737	745	PF00400	0.444
DEG_SCF_FBW7_1	35	40	PF00400	0.673
DEG_SPOP_SBC_1	192	196	PF00917	0.614
DEG_SPOP_SBC_1	259	263	PF00917	0.561
DOC_CKS1_1	151	156	PF01111	0.594
DOC_CKS1_1	481	486	PF01111	0.544
DOC_CYCLIN_RxL_1	925	934	PF00134	0.454
DOC_CYCLIN_yCln2_LP_2	339	345	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	481	487	PF00134	0.469
DOC_MAPK_DCC_7	349	359	PF00069	0.457
DOC_MAPK_DCC_7	843	851	PF00069	0.457
DOC_MAPK_gen_1	332	341	PF00069	0.444
DOC_MAPK_gen_1	377	384	PF00069	0.501
DOC_MAPK_gen_1	620	630	PF00069	0.420
DOC_MAPK_HePTP_8	331	343	PF00069	0.444
DOC_MAPK_MEF2A_6	334	343	PF00069	0.444
DOC_MAPK_MEF2A_6	623	630	PF00069	0.403
DOC_MAPK_RevD_3	622	637	PF00069	0.449
DOC_PP1_RVXF_1	680	686	PF00149	0.480
DOC_PP2B_LxvP_1	161	164	PF13499	0.580
DOC_PP2B_LxvP_1	339	342	PF13499	0.444
DOC_PP2B_PxIxI_1	428	434	PF00149	0.519
DOC_PP4_FxxP_1	304	307	PF00568	0.444
DOC_PP4_FxxP_1	77	80	PF00568	0.499
DOC_PP4_FxxP_1	787	790	PF00568	0.475
DOC_USP7_MATH_1	187	191	PF00917	0.725
DOC_USP7_MATH_1	274	278	PF00917	0.547
DOC_USP7_MATH_1	305	309	PF00917	0.468
DOC_USP7_MATH_1	574	578	PF00917	0.490
DOC_USP7_MATH_1	790	794	PF00917	0.408
DOC_USP7_MATH_1	855	859	PF00917	0.584
DOC_USP7_MATH_1	938	942	PF00917	0.702
DOC_WW_Pin1_4	150	155	PF00397	0.594
DOC_WW_Pin1_4	241	246	PF00397	0.660
DOC_WW_Pin1_4	314	319	PF00397	0.462
DOC_WW_Pin1_4	33	38	PF00397	0.663
DOC_WW_Pin1_4	480	485	PF00397	0.537
DOC_WW_Pin1_4	622	627	PF00397	0.334
DOC_WW_Pin1_4	631	636	PF00397	0.299
DOC_WW_Pin1_4	69	74	PF00397	0.701
DOC_WW_Pin1_4	76	81	PF00397	0.572
DOC_WW_Pin1_4	896	901	PF00397	0.560
LIG_14-3-3_CanoR_1	212	216	PF00244	0.514
LIG_14-3-3_CanoR_1	235	243	PF00244	0.470
LIG_14-3-3_CanoR_1	450	455	PF00244	0.679
LIG_14-3-3_CanoR_1	457	465	PF00244	0.466
LIG_14-3-3_CanoR_1	539	545	PF00244	0.354
LIG_14-3-3_CanoR_1	682	688	PF00244	0.481
LIG_14-3-3_CanoR_1	762	766	PF00244	0.457
LIG_14-3-3_CanoR_1	857	864	PF00244	0.665
LIG_Actin_WH2_2	375	390	PF00022	0.532
LIG_AP2alpha_2	768	770	PF02296	0.444
LIG_BIR_II_1	1	5	PF00653	0.481
LIG_BRCT_BRCA1_1	418	422	PF00533	0.451
LIG_BRCT_BRCA1_1	73	77	PF00533	0.535
LIG_Clathr_ClatBox_1	475	479	PF01394	0.342
LIG_deltaCOP1_diTrp_1	670	679	PF00928	0.308
LIG_deltaCOP1_diTrp_1	752	759	PF00928	0.444
LIG_FHA_1	151	157	PF00498	0.650
LIG_FHA_1	172	178	PF00498	0.763
LIG_FHA_1	30	36	PF00498	0.734
LIG_FHA_1	336	342	PF00498	0.533
LIG_FHA_1	48	54	PF00498	0.728
LIG_FHA_1	498	504	PF00498	0.476
LIG_FHA_1	512	518	PF00498	0.494
LIG_FHA_1	524	530	PF00498	0.481
LIG_FHA_1	599	605	PF00498	0.406
LIG_FHA_1	692	698	PF00498	0.444
LIG_FHA_1	728	734	PF00498	0.444
LIG_FHA_1	877	883	PF00498	0.449
LIG_FHA_2	22	28	PF00498	0.723
LIG_FHA_2	226	232	PF00498	0.507
LIG_FHA_2	530	536	PF00498	0.448
LIG_LIR_Apic_2	303	307	PF02991	0.500
LIG_LIR_Apic_2	74	80	PF02991	0.513
LIG_LIR_Apic_2	785	790	PF02991	0.475
LIG_LIR_Gen_1	566	574	PF02991	0.628
LIG_LIR_Gen_1	625	635	PF02991	0.390
LIG_LIR_Gen_1	670	679	PF02991	0.375
LIG_LIR_Gen_1	899	910	PF02991	0.654
LIG_LIR_Gen_1	9	18	PF02991	0.620
LIG_LIR_Nem_3	300	304	PF02991	0.458
LIG_LIR_Nem_3	534	540	PF02991	0.346
LIG_LIR_Nem_3	566	572	PF02991	0.620
LIG_LIR_Nem_3	625	630	PF02991	0.400
LIG_LIR_Nem_3	681	687	PF02991	0.487
LIG_LIR_Nem_3	764	770	PF02991	0.444
LIG_LIR_Nem_3	899	905	PF02991	0.525
LIG_LIR_Nem_3	9	14	PF02991	0.612
LIG_LIR_Nem_3	915	920	PF02991	0.608
LIG_LYPXL_SIV_4	509	517	PF13949	0.440
LIG_MYND_3	549	553	PF01753	0.511
LIG_NRBOX	740	746	PF00104	0.444
LIG_PCNA_yPIPBox_3	590	604	PF02747	0.456
LIG_PDZ_Class_2	954	959	PF00595	0.662
LIG_PTB_Apo_2	772	779	PF02174	0.427
LIG_PTB_Phospho_1	772	778	PF10480	0.427
LIG_REV1ctd_RIR_1	311	317	PF16727	0.475
LIG_SH2_CRK	537	541	PF00017	0.362
LIG_SH2_NCK_1	510	514	PF00017	0.437
LIG_SH2_PTP2	627	630	PF00017	0.394
LIG_SH2_PTP2	902	905	PF00017	0.393
LIG_SH2_SRC	372	375	PF00017	0.457
LIG_SH2_SRC	776	779	PF00017	0.501
LIG_SH2_STAP1	557	561	PF00017	0.503
LIG_SH2_STAP1	617	621	PF00017	0.418
LIG_SH2_STAP1	878	882	PF00017	0.492
LIG_SH2_STAT3	17	20	PF00017	0.635
LIG_SH2_STAT3	867	870	PF00017	0.618
LIG_SH2_STAT5	17	20	PF00017	0.508
LIG_SH2_STAT5	215	218	PF00017	0.408
LIG_SH2_STAT5	223	226	PF00017	0.504
LIG_SH2_STAT5	627	630	PF00017	0.315
LIG_SH2_STAT5	796	799	PF00017	0.529
LIG_SH2_STAT5	807	810	PF00017	0.403
LIG_SH2_STAT5	822	825	PF00017	0.444
LIG_SH2_STAT5	840	843	PF00017	0.444
LIG_SH2_STAT5	878	881	PF00017	0.483
LIG_SH2_STAT5	902	905	PF00017	0.606
LIG_SH3_3	153	159	PF00018	0.662
LIG_SH3_3	32	38	PF00018	0.678
LIG_SH3_3	503	509	PF00018	0.419
LIG_SH3_3	70	76	PF00018	0.697
LIG_SH3_3	820	826	PF00018	0.410
LIG_SH3_3	870	876	PF00018	0.575
LIG_SH3_3	885	891	PF00018	0.613
LIG_SUMO_SIM_anti_2	24	30	PF11976	0.505
LIG_SUMO_SIM_anti_2	500	505	PF11976	0.353
LIG_SUMO_SIM_par_1	159	165	PF11976	0.650
LIG_SUMO_SIM_par_1	2	7	PF11976	0.660
LIG_SUMO_SIM_par_1	255	264	PF11976	0.413
LIG_SUMO_SIM_par_1	425	435	PF11976	0.595
LIG_TRAF2_1	394	397	PF00917	0.501
LIG_TRAF2_1	531	534	PF00917	0.491
LIG_TRAF2_1	568	571	PF00917	0.555
LIG_UBA3_1	139	144	PF00899	0.611
LIG_WRC_WIRS_1	301	306	PF05994	0.360
LIG_WW_1	819	822	PF00397	0.281
MOD_CDC14_SPxK_1	317	320	PF00782	0.296
MOD_CDC14_SPxK_1	634	637	PF00782	0.306
MOD_CDK_SPK_2	631	636	PF00069	0.299
MOD_CDK_SPxK_1	314	320	PF00069	0.296
MOD_CDK_SPxK_1	631	637	PF00069	0.304
MOD_CK1_1	101	107	PF00069	0.700
MOD_CK1_1	188	194	PF00069	0.734
MOD_CK1_1	453	459	PF00069	0.626
MOD_CK1_1	60	66	PF00069	0.717
MOD_CK2_1	187	193	PF00069	0.646
MOD_CK2_1	21	27	PF00069	0.732
MOD_CK2_1	391	397	PF00069	0.362
MOD_CK2_1	529	535	PF00069	0.424
MOD_CK2_1	857	863	PF00069	0.552
MOD_CK2_1	928	934	PF00069	0.707
MOD_GlcNHglycan	104	107	PF01048	0.683
MOD_GlcNHglycan	119	122	PF01048	0.537
MOD_GlcNHglycan	186	190	PF01048	0.785
MOD_GlcNHglycan	245	248	PF01048	0.734
MOD_GlcNHglycan	276	279	PF01048	0.352
MOD_GlcNHglycan	412	415	PF01048	0.682
MOD_GlcNHglycan	438	441	PF01048	0.686
MOD_GlcNHglycan	452	455	PF01048	0.599
MOD_GlcNHglycan	559	562	PF01048	0.574
MOD_GlcNHglycan	859	862	PF01048	0.581
MOD_GlcNHglycan	885	888	PF01048	0.598
MOD_GlcNHglycan	914	917	PF01048	0.500
MOD_GlcNHglycan	940	943	PF01048	0.682
MOD_GSK3_1	187	194	PF00069	0.708
MOD_GSK3_1	29	36	PF00069	0.699
MOD_GSK3_1	449	456	PF00069	0.645
MOD_GSK3_1	611	618	PF00069	0.480
MOD_GSK3_1	98	105	PF00069	0.613
MOD_N-GLC_1	457	462	PF02516	0.607
MOD_NEK2_1	139	144	PF00069	0.611
MOD_NEK2_1	177	182	PF00069	0.512
MOD_NEK2_1	29	34	PF00069	0.598
MOD_NEK2_1	324	329	PF00069	0.300
MOD_NEK2_1	335	340	PF00069	0.300
MOD_NEK2_1	367	372	PF00069	0.274
MOD_NEK2_1	416	421	PF00069	0.442
MOD_NEK2_1	470	475	PF00069	0.374
MOD_NEK2_1	555	560	PF00069	0.552
MOD_NEK2_1	664	669	PF00069	0.338
MOD_NEK2_1	683	688	PF00069	0.350
MOD_NEK2_1	727	732	PF00069	0.281
MOD_NEK2_2	790	795	PF00069	0.242
MOD_NEK2_2	950	955	PF00069	0.548
MOD_PIKK_1	171	177	PF00454	0.690
MOD_PIKK_1	29	35	PF00454	0.543
MOD_PIKK_1	367	373	PF00454	0.281
MOD_PIKK_1	572	578	PF00454	0.492
MOD_PIKK_1	615	621	PF00454	0.412
MOD_PKA_2	211	217	PF00069	0.461
MOD_PKA_2	234	240	PF00069	0.444
MOD_PKA_2	449	455	PF00069	0.617
MOD_PKA_2	504	510	PF00069	0.384
MOD_PKA_2	562	568	PF00069	0.669
MOD_PKA_2	609	615	PF00069	0.502
MOD_PKA_2	664	670	PF00069	0.333
MOD_PKA_2	761	767	PF00069	0.281
MOD_PKA_2	938	944	PF00069	0.699
MOD_PKB_1	386	394	PF00069	0.404
MOD_Plk_1	497	503	PF00069	0.460
MOD_Plk_1	862	868	PF00069	0.501
MOD_Plk_1	99	105	PF00069	0.773
MOD_Plk_2-3	396	402	PF00069	0.337
MOD_Plk_2-3	761	767	PF00069	0.281
MOD_Plk_4	211	217	PF00069	0.418
MOD_Plk_4	289	295	PF00069	0.374
MOD_Plk_4	305	311	PF00069	0.348
MOD_Plk_4	388	394	PF00069	0.413
MOD_Plk_4	471	477	PF00069	0.336
MOD_Plk_4	499	505	PF00069	0.473
MOD_Plk_4	540	546	PF00069	0.601
MOD_Plk_4	599	605	PF00069	0.406
MOD_Plk_4	898	904	PF00069	0.648
MOD_Plk_4	928	934	PF00069	0.582
MOD_ProDKin_1	150	156	PF00069	0.597
MOD_ProDKin_1	241	247	PF00069	0.658
MOD_ProDKin_1	314	320	PF00069	0.307
MOD_ProDKin_1	33	39	PF00069	0.665
MOD_ProDKin_1	480	486	PF00069	0.541
MOD_ProDKin_1	622	628	PF00069	0.331
MOD_ProDKin_1	631	637	PF00069	0.304
MOD_ProDKin_1	69	75	PF00069	0.699
MOD_ProDKin_1	76	82	PF00069	0.567
MOD_ProDKin_1	896	902	PF00069	0.560
MOD_SUMO_for_1	333	336	PF00179	0.242
MOD_SUMO_rev_2	699	707	PF00179	0.281
MOD_SUMO_rev_2	921	927	PF00179	0.439
TRG_DiLeu_BaEn_1	584	589	PF01217	0.307
TRG_DiLeu_BaLyEn_6	157	162	PF01217	0.700
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.718
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.584
TRG_DiLeu_BaLyEn_6	339	344	PF01217	0.281
TRG_DiLeu_LyEn_5	426	431	PF01217	0.551
TRG_ENDOCYTIC_2	301	304	PF00928	0.281
TRG_ENDOCYTIC_2	537	540	PF00928	0.359
TRG_ENDOCYTIC_2	627	630	PF00928	0.354
TRG_ENDOCYTIC_2	638	641	PF00928	0.287
TRG_ENDOCYTIC_2	767	770	PF00928	0.281
TRG_ENDOCYTIC_2	902	905	PF00928	0.393
TRG_ER_diArg_1	377	379	PF00400	0.413
TRG_ER_diArg_1	384	386	PF00400	0.389
TRG_NES_CRM1_1	322	336	PF08389	0.295

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXX3	Leptomonas seymouri	63%	95%
A0A1X0NMQ9	Trypanosomatidae	56%	100%
A0A3S7WQJ5	Leishmania donovani	83%	100%
A0A422N7E2	Trypanosoma rangeli	56%	100%
A4HTU9	Leishmania infantum	83%	100%
D0A9A9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AMN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QHY9	Leishmania major	83%	100%
V5B2X6	Trypanosoma cruzi	58%	100%