RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H5K9_LEIBR

TriTrypDb:

LbrM.09.0340 , LBRM2903_090008900

Length:

858

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5K9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5K9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0008270	zinc ion binding	6	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4
GO:0046914	transition metal ion binding	5	4
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.699
CLV_C14_Caspase3-7	407	411	PF00656	0.596
CLV_C14_Caspase3-7	571	575	PF00656	0.567
CLV_MEL_PAP_1	261	267	PF00089	0.547
CLV_NRD_NRD_1	218	220	PF00675	0.682
CLV_NRD_NRD_1	419	421	PF00675	0.840
CLV_NRD_NRD_1	441	443	PF00675	0.564
CLV_NRD_NRD_1	848	850	PF00675	0.645
CLV_PCSK_KEX2_1	218	220	PF00082	0.703
CLV_PCSK_KEX2_1	419	421	PF00082	0.840
CLV_PCSK_KEX2_1	440	442	PF00082	0.565
CLV_PCSK_KEX2_1	848	850	PF00082	0.645
CLV_PCSK_SKI1_1	615	619	PF00082	0.566
CLV_PCSK_SKI1_1	701	705	PF00082	0.592
CLV_PCSK_SKI1_1	812	816	PF00082	0.735
CLV_PCSK_SKI1_1	849	853	PF00082	0.620
DEG_COP1_1	551	562	PF00400	0.540
DEG_Nend_UBRbox_1	1	4	PF02207	0.733
DEG_SCF_FBW7_1	202	207	PF00400	0.560
DEG_SCF_FBW7_1	616	622	PF00400	0.797
DEG_SPOP_SBC_1	342	346	PF00917	0.698
DEG_SPOP_SBC_1	521	525	PF00917	0.574
DEG_SPOP_SBC_1	527	531	PF00917	0.532
DOC_CDC14_PxL_1	556	564	PF14671	0.541
DOC_CDC14_PxL_1	85	93	PF14671	0.647
DOC_CKS1_1	19	24	PF01111	0.809
DOC_CKS1_1	336	341	PF01111	0.764
DOC_CKS1_1	565	570	PF01111	0.662
DOC_CKS1_1	616	621	PF01111	0.798
DOC_CKS1_1	659	664	PF01111	0.690
DOC_CKS1_1	738	743	PF01111	0.695
DOC_CYCLIN_yClb3_PxF_3	272	278	PF00134	0.527
DOC_CYCLIN_yCln2_LP_2	738	744	PF00134	0.532
DOC_MAPK_gen_1	355	364	PF00069	0.580
DOC_MAPK_MEF2A_6	355	364	PF00069	0.580
DOC_PP2B_LxvP_1	602	605	PF13499	0.784
DOC_PP2B_LxvP_1	726	729	PF13499	0.744
DOC_PP2B_LxvP_1	821	824	PF13499	0.636
DOC_PP4_MxPP_1	39	42	PF00568	0.528
DOC_PP4_MxPP_1	617	620	PF00568	0.538
DOC_USP7_MATH_1	155	159	PF00917	0.731
DOC_USP7_MATH_1	167	171	PF00917	0.580
DOC_USP7_MATH_1	260	264	PF00917	0.619
DOC_USP7_MATH_1	303	307	PF00917	0.698
DOC_USP7_MATH_1	395	399	PF00917	0.597
DOC_USP7_MATH_1	402	406	PF00917	0.607
DOC_USP7_MATH_1	436	440	PF00917	0.661
DOC_USP7_MATH_1	446	450	PF00917	0.667
DOC_USP7_MATH_1	504	508	PF00917	0.756
DOC_USP7_MATH_1	520	524	PF00917	0.533
DOC_USP7_MATH_1	528	532	PF00917	0.667
DOC_USP7_MATH_1	594	598	PF00917	0.577
DOC_USP7_MATH_1	605	609	PF00917	0.653
DOC_USP7_MATH_1	620	624	PF00917	0.644
DOC_USP7_MATH_1	674	678	PF00917	0.739
DOC_USP7_MATH_1	685	689	PF00917	0.633
DOC_USP7_MATH_1	719	723	PF00917	0.674
DOC_USP7_MATH_1	79	83	PF00917	0.797
DOC_USP7_UBL2_3	2	6	PF12436	0.517
DOC_WW_Pin1_4	125	130	PF00397	0.791
DOC_WW_Pin1_4	18	23	PF00397	0.830
DOC_WW_Pin1_4	200	205	PF00397	0.568
DOC_WW_Pin1_4	230	235	PF00397	0.672
DOC_WW_Pin1_4	24	29	PF00397	0.826
DOC_WW_Pin1_4	335	340	PF00397	0.760
DOC_WW_Pin1_4	350	355	PF00397	0.645
DOC_WW_Pin1_4	389	394	PF00397	0.665
DOC_WW_Pin1_4	421	426	PF00397	0.564
DOC_WW_Pin1_4	452	457	PF00397	0.697
DOC_WW_Pin1_4	474	479	PF00397	0.572
DOC_WW_Pin1_4	513	518	PF00397	0.657
DOC_WW_Pin1_4	564	569	PF00397	0.687
DOC_WW_Pin1_4	574	579	PF00397	0.645
DOC_WW_Pin1_4	615	620	PF00397	0.677
DOC_WW_Pin1_4	64	69	PF00397	0.673
DOC_WW_Pin1_4	644	649	PF00397	0.578
DOC_WW_Pin1_4	658	663	PF00397	0.723
DOC_WW_Pin1_4	737	742	PF00397	0.692
DOC_WW_Pin1_4	75	80	PF00397	0.773
DOC_WW_Pin1_4	91	96	PF00397	0.626
LIG_14-3-3_CanoR_1	144	149	PF00244	0.589
LIG_14-3-3_CanoR_1	178	188	PF00244	0.722
LIG_14-3-3_CanoR_1	218	226	PF00244	0.693
LIG_14-3-3_CanoR_1	307	314	PF00244	0.627
LIG_14-3-3_CanoR_1	419	425	PF00244	0.573
LIG_14-3-3_CanoR_1	464	468	PF00244	0.768
LIG_14-3-3_CanoR_1	576	582	PF00244	0.793
LIG_14-3-3_CanoR_1	652	662	PF00244	0.551
LIG_14-3-3_CanoR_1	758	767	PF00244	0.525
LIG_APCC_ABBA_1	5	10	PF00400	0.524
LIG_BIR_III_2	410	414	PF00653	0.596
LIG_BRCT_BRCA1_1	505	509	PF00533	0.770
LIG_CSL_BTD_1	122	125	PF09270	0.558
LIG_CtBP_PxDLS_1	41	45	PF00389	0.537
LIG_FHA_1	12	18	PF00498	0.819
LIG_FHA_1	205	211	PF00498	0.573
LIG_FHA_1	28	34	PF00498	0.661
LIG_FHA_1	345	351	PF00498	0.684
LIG_FHA_1	404	410	PF00498	0.632
LIG_FHA_1	466	472	PF00498	0.582
LIG_FHA_1	54	60	PF00498	0.649
LIG_FHA_1	578	584	PF00498	0.784
LIG_FHA_1	597	603	PF00498	0.706
LIG_FHA_1	611	617	PF00498	0.506
LIG_FHA_1	745	751	PF00498	0.684
LIG_FHA_1	762	768	PF00498	0.534
LIG_FHA_1	796	802	PF00498	0.554
LIG_FHA_2	343	349	PF00498	0.642
LIG_FHA_2	369	375	PF00498	0.562
LIG_FHA_2	798	804	PF00498	0.645
LIG_GSK3_LRP6_1	18	23	PF00069	0.589
LIG_LIR_Apic_2	122	126	PF02991	0.676
LIG_LIR_Gen_1	128	135	PF02991	0.599
LIG_LIR_Gen_1	516	527	PF02991	0.555
LIG_LIR_Gen_1	606	617	PF02991	0.727
LIG_LIR_Nem_3	128	133	PF02991	0.596
LIG_LIR_Nem_3	162	168	PF02991	0.562
LIG_LIR_Nem_3	516	522	PF02991	0.573
LIG_LIR_Nem_3	606	612	PF02991	0.718
LIG_LIR_Nem_3	699	703	PF02991	0.782
LIG_MLH1_MIPbox_1	505	509	PF16413	0.530
LIG_MYND_1	272	276	PF01753	0.504
LIG_MYND_1	64	68	PF01753	0.555
LIG_SH2_CRK	130	134	PF00017	0.607
LIG_SH2_CRK	165	169	PF00017	0.564
LIG_SH2_CRK	519	523	PF00017	0.565
LIG_SH2_CRK	700	704	PF00017	0.805
LIG_SH2_NCK_1	519	523	PF00017	0.565
LIG_SH2_STAP1	467	471	PF00017	0.570
LIG_SH2_STAT3	731	734	PF00017	0.765
LIG_SH2_STAT5	130	133	PF00017	0.608
LIG_SH2_STAT5	467	470	PF00017	0.559
LIG_SH3_2	773	778	PF14604	0.586
LIG_SH3_3	114	120	PF00018	0.595
LIG_SH3_3	123	129	PF00018	0.805
LIG_SH3_3	16	22	PF00018	0.812
LIG_SH3_3	231	237	PF00018	0.646
LIG_SH3_3	270	276	PF00018	0.787
LIG_SH3_3	28	34	PF00018	0.647
LIG_SH3_3	288	294	PF00018	0.500
LIG_SH3_3	336	342	PF00018	0.755
LIG_SH3_3	388	394	PF00018	0.599
LIG_SH3_3	440	446	PF00018	0.763
LIG_SH3_3	451	457	PF00018	0.695
LIG_SH3_3	535	541	PF00018	0.640
LIG_SH3_3	579	585	PF00018	0.721
LIG_SH3_3	588	594	PF00018	0.558
LIG_SH3_3	613	619	PF00018	0.666
LIG_SH3_3	62	68	PF00018	0.561
LIG_SH3_3	770	776	PF00018	0.693
LIG_SUMO_SIM_anti_2	368	375	PF11976	0.560
LIG_SUMO_SIM_par_1	368	375	PF11976	0.560
LIG_TRAF2_1	363	366	PF00917	0.813
LIG_WW_2	538	541	PF00397	0.536
MOD_CDC14_SPxK_1	581	584	PF00782	0.530
MOD_CDK_SPK_2	350	355	PF00069	0.585
MOD_CDK_SPK_2	658	663	PF00069	0.554
MOD_CDK_SPxK_1	564	570	PF00069	0.533
MOD_CDK_SPxK_1	578	584	PF00069	0.491
MOD_CDK_SPxxK_3	350	357	PF00069	0.586
MOD_CDK_SPxxK_3	91	98	PF00069	0.548
MOD_CK1_1	128	134	PF00069	0.812
MOD_CK1_1	139	145	PF00069	0.619
MOD_CK1_1	170	176	PF00069	0.820
MOD_CK1_1	180	186	PF00069	0.671
MOD_CK1_1	233	239	PF00069	0.580
MOD_CK1_1	305	311	PF00069	0.695
MOD_CK1_1	341	347	PF00069	0.701
MOD_CK1_1	400	406	PF00069	0.838
MOD_CK1_1	448	454	PF00069	0.637
MOD_CK1_1	466	472	PF00069	0.582
MOD_CK1_1	477	483	PF00069	0.696
MOD_CK1_1	484	490	PF00069	0.672
MOD_CK1_1	548	554	PF00069	0.699
MOD_CK1_1	555	561	PF00069	0.611
MOD_CK1_1	608	614	PF00069	0.706
MOD_CK1_1	655	661	PF00069	0.812
MOD_CK1_1	666	672	PF00069	0.632
MOD_CK1_1	722	728	PF00069	0.636
MOD_CK1_1	843	849	PF00069	0.636
MOD_CK1_1	94	100	PF00069	0.546
MOD_CK2_1	169	175	PF00069	0.618
MOD_CK2_1	179	185	PF00069	0.569
MOD_DYRK1A_RPxSP_1	615	619	PF00069	0.551
MOD_DYRK1A_RPxSP_1	663	667	PF00069	0.557
MOD_GlcNHglycan	160	165	PF01048	0.607
MOD_GlcNHglycan	169	172	PF01048	0.592
MOD_GlcNHglycan	192	195	PF01048	0.719
MOD_GlcNHglycan	2	5	PF01048	0.645
MOD_GlcNHglycan	295	298	PF01048	0.599
MOD_GlcNHglycan	307	310	PF01048	0.571
MOD_GlcNHglycan	350	353	PF01048	0.581
MOD_GlcNHglycan	376	379	PF01048	0.735
MOD_GlcNHglycan	397	400	PF01048	0.606
MOD_GlcNHglycan	448	451	PF01048	0.636
MOD_GlcNHglycan	483	486	PF01048	0.767
MOD_GlcNHglycan	531	534	PF01048	0.735
MOD_GlcNHglycan	547	550	PF01048	0.617
MOD_GlcNHglycan	622	625	PF01048	0.767
MOD_GlcNHglycan	655	658	PF01048	0.722
MOD_GlcNHglycan	685	688	PF01048	0.658
MOD_GlcNHglycan	694	697	PF01048	0.525
MOD_GlcNHglycan	710	713	PF01048	0.741
MOD_GlcNHglycan	719	722	PF01048	0.791
MOD_GlcNHglycan	769	773	PF01048	0.673
MOD_GlcNHglycan	789	792	PF01048	0.792
MOD_GSK3_1	115	122	PF00069	0.695
MOD_GSK3_1	139	146	PF00069	0.589
MOD_GSK3_1	166	173	PF00069	0.698
MOD_GSK3_1	179	186	PF00069	0.762
MOD_GSK3_1	200	207	PF00069	0.654
MOD_GSK3_1	209	216	PF00069	0.703
MOD_GSK3_1	303	310	PF00069	0.730
MOD_GSK3_1	338	345	PF00069	0.697
MOD_GSK3_1	346	353	PF00069	0.657
MOD_GSK3_1	368	375	PF00069	0.749
MOD_GSK3_1	379	386	PF00069	0.627
MOD_GSK3_1	400	407	PF00069	0.654
MOD_GSK3_1	432	439	PF00069	0.580
MOD_GSK3_1	445	452	PF00069	0.542
MOD_GSK3_1	474	481	PF00069	0.659
MOD_GSK3_1	500	507	PF00069	0.598
MOD_GSK3_1	509	516	PF00069	0.691
MOD_GSK3_1	522	529	PF00069	0.584
MOD_GSK3_1	545	552	PF00069	0.684
MOD_GSK3_1	554	561	PF00069	0.534
MOD_GSK3_1	574	581	PF00069	0.534
MOD_GSK3_1	592	599	PF00069	0.616
MOD_GSK3_1	611	618	PF00069	0.724
MOD_GSK3_1	626	633	PF00069	0.622
MOD_GSK3_1	64	71	PF00069	0.680
MOD_GSK3_1	651	658	PF00069	0.718
MOD_GSK3_1	679	686	PF00069	0.605
MOD_GSK3_1	692	699	PF00069	0.640
MOD_GSK3_1	715	722	PF00069	0.598
MOD_GSK3_1	75	82	PF00069	0.769
MOD_GSK3_1	757	764	PF00069	0.699
MOD_GSK3_1	793	800	PF00069	0.719
MOD_GSK3_1	815	822	PF00069	0.630
MOD_GSK3_1	849	856	PF00069	0.604
MOD_N-GLC_1	190	195	PF02516	0.694
MOD_N-GLC_1	71	76	PF02516	0.629
MOD_N-GLC_1	787	792	PF02516	0.584
MOD_NEK2_1	102	107	PF00069	0.678
MOD_NEK2_1	11	16	PF00069	0.814
MOD_NEK2_1	179	184	PF00069	0.695
MOD_NEK2_1	278	283	PF00069	0.632
MOD_NEK2_1	463	468	PF00069	0.695
MOD_NEK2_1	509	514	PF00069	0.770
MOD_NEK2_1	545	550	PF00069	0.757
MOD_NEK2_1	554	559	PF00069	0.548
MOD_NEK2_1	692	697	PF00069	0.769
MOD_NEK2_1	730	735	PF00069	0.604
MOD_NEK2_1	838	843	PF00069	0.636
MOD_NEK2_2	504	509	PF00069	0.516
MOD_NEK2_2	674	679	PF00069	0.555
MOD_OFUCOSY	251	257	PF10250	0.557
MOD_PIKK_1	12	18	PF00454	0.819
MOD_PIKK_1	400	406	PF00454	0.598
MOD_PIKK_1	630	636	PF00454	0.622
MOD_PIKK_1	679	685	PF00454	0.684
MOD_PIKK_1	730	736	PF00454	0.763
MOD_PIKK_1	782	788	PF00454	0.721
MOD_PIKK_1	838	844	PF00454	0.636
MOD_PK_1	412	418	PF00069	0.593
MOD_PKA_1	419	425	PF00069	0.728
MOD_PKA_2	143	149	PF00069	0.779
MOD_PKA_2	177	183	PF00069	0.727
MOD_PKA_2	217	223	PF00069	0.805
MOD_PKA_2	317	323	PF00069	0.579
MOD_PKA_2	419	425	PF00069	0.728
MOD_PKA_2	463	469	PF00069	0.777
MOD_PKA_2	651	657	PF00069	0.638
MOD_PKA_2	683	689	PF00069	0.818
MOD_PKA_2	708	714	PF00069	0.573
MOD_PKA_2	757	763	PF00069	0.606
MOD_Plk_1	160	166	PF00069	0.683
MOD_Plk_1	174	180	PF00069	0.791
MOD_Plk_1	184	190	PF00069	0.662
MOD_Plk_1	251	257	PF00069	0.810
MOD_Plk_1	365	371	PF00069	0.557
MOD_Plk_1	605	611	PF00069	0.670
MOD_Plk_4	27	33	PF00069	0.692
MOD_Plk_4	365	371	PF00069	0.557
MOD_Plk_4	504	510	PF00069	0.615
MOD_Plk_4	549	555	PF00069	0.579
MOD_Plk_4	596	602	PF00069	0.702
MOD_ProDKin_1	125	131	PF00069	0.793
MOD_ProDKin_1	18	24	PF00069	0.831
MOD_ProDKin_1	200	206	PF00069	0.568
MOD_ProDKin_1	230	236	PF00069	0.671
MOD_ProDKin_1	335	341	PF00069	0.763
MOD_ProDKin_1	350	356	PF00069	0.645
MOD_ProDKin_1	389	395	PF00069	0.665
MOD_ProDKin_1	421	427	PF00069	0.564
MOD_ProDKin_1	452	458	PF00069	0.690
MOD_ProDKin_1	474	480	PF00069	0.571
MOD_ProDKin_1	513	519	PF00069	0.661
MOD_ProDKin_1	564	570	PF00069	0.691
MOD_ProDKin_1	574	580	PF00069	0.644
MOD_ProDKin_1	615	621	PF00069	0.679
MOD_ProDKin_1	64	70	PF00069	0.678
MOD_ProDKin_1	644	650	PF00069	0.578
MOD_ProDKin_1	658	664	PF00069	0.723
MOD_ProDKin_1	737	743	PF00069	0.694
MOD_ProDKin_1	75	81	PF00069	0.771
MOD_ProDKin_1	91	97	PF00069	0.627
MOD_SUMO_rev_2	405	413	PF00179	0.594
TRG_ENDOCYTIC_2	130	133	PF00928	0.608
TRG_ENDOCYTIC_2	165	168	PF00928	0.564
TRG_ENDOCYTIC_2	519	522	PF00928	0.594
TRG_ENDOCYTIC_2	587	590	PF00928	0.681
TRG_ENDOCYTIC_2	700	703	PF00928	0.807
TRG_ER_diArg_1	217	219	PF00400	0.705
TRG_ER_diArg_1	316	319	PF00400	0.599
TRG_ER_diArg_1	440	442	PF00400	0.565
TRG_Pf-PMV_PEXEL_1	836	840	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	849	854	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H6C5	Leishmania donovani	55%	98%
A4HTU8	Leishmania infantum	55%	98%
E9AMN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	99%
Q4QHZ0	Leishmania major	52%	94%