LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

CHASE domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CHASE domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H5K7_LEIBR
TriTrypDb:
LbrM.09.0320 , LBRM2903_090008500 *
Length:
845

Annotations

LeishMANIAdb annotations

Appears to be an enzyme-linked receptor, putatively a receptor nucleotide cyclase (cAMP synthase).. Expanded on the Leishmaniid lineage. The first helical segment is very similar to a signal peptide.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4H5K7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5K7

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 6
GO:0006163 purine nucleotide metabolic process 5 6
GO:0006164 purine nucleotide biosynthetic process 6 6
GO:0006171 cAMP biosynthetic process 8 6
GO:0006725 cellular aromatic compound metabolic process 3 6
GO:0006753 nucleoside phosphate metabolic process 4 6
GO:0006793 phosphorus metabolic process 3 6
GO:0006796 phosphate-containing compound metabolic process 4 6
GO:0006807 nitrogen compound metabolic process 2 6
GO:0008152 metabolic process 1 6
GO:0009058 biosynthetic process 2 6
GO:0009117 nucleotide metabolic process 5 6
GO:0009150 purine ribonucleotide metabolic process 6 6
GO:0009152 purine ribonucleotide biosynthetic process 7 6
GO:0009165 nucleotide biosynthetic process 6 6
GO:0009187 cyclic nucleotide metabolic process 6 6
GO:0009190 cyclic nucleotide biosynthetic process 7 6
GO:0009259 ribonucleotide metabolic process 5 6
GO:0009260 ribonucleotide biosynthetic process 6 6
GO:0009987 cellular process 1 6
GO:0018130 heterocycle biosynthetic process 4 6
GO:0019438 aromatic compound biosynthetic process 4 6
GO:0019637 organophosphate metabolic process 3 6
GO:0019693 ribose phosphate metabolic process 4 6
GO:0034641 cellular nitrogen compound metabolic process 3 6
GO:0034654 nucleobase-containing compound biosynthetic process 4 6
GO:0044237 cellular metabolic process 2 6
GO:0044238 primary metabolic process 2 6
GO:0044249 cellular biosynthetic process 3 6
GO:0044271 cellular nitrogen compound biosynthetic process 4 6
GO:0044281 small molecule metabolic process 2 6
GO:0046058 cAMP metabolic process 7 6
GO:0046390 ribose phosphate biosynthetic process 5 6
GO:0046483 heterocycle metabolic process 3 6
GO:0052652 cyclic purine nucleotide metabolic process 6 6
GO:0055086 nucleobase-containing small molecule metabolic process 3 6
GO:0071704 organic substance metabolic process 2 6
GO:0072521 purine-containing compound metabolic process 4 6
GO:0072522 purine-containing compound biosynthetic process 5 6
GO:0090407 organophosphate biosynthetic process 4 6
GO:1901135 carbohydrate derivative metabolic process 3 6
GO:1901137 carbohydrate derivative biosynthetic process 4 6
GO:1901293 nucleoside phosphate biosynthetic process 5 6
GO:1901360 organic cyclic compound metabolic process 3 6
GO:1901362 organic cyclic compound biosynthetic process 4 6
GO:1901564 organonitrogen compound metabolic process 3 6
GO:1901566 organonitrogen compound biosynthetic process 4 6
GO:1901576 organic substance biosynthetic process 3 6
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 162 166 PF00656 0.394
CLV_C14_Caspase3-7 177 181 PF00656 0.257
CLV_C14_Caspase3-7 385 389 PF00656 0.482
CLV_C14_Caspase3-7 468 472 PF00656 0.542
CLV_C14_Caspase3-7 597 601 PF00656 0.575
CLV_C14_Caspase3-7 651 655 PF00656 0.489
CLV_NRD_NRD_1 205 207 PF00675 0.541
CLV_NRD_NRD_1 285 287 PF00675 0.490
CLV_NRD_NRD_1 434 436 PF00675 0.328
CLV_NRD_NRD_1 566 568 PF00675 0.472
CLV_NRD_NRD_1 602 604 PF00675 0.415
CLV_NRD_NRD_1 638 640 PF00675 0.621
CLV_NRD_NRD_1 789 791 PF00675 0.629
CLV_PCSK_KEX2_1 205 207 PF00082 0.541
CLV_PCSK_KEX2_1 434 436 PF00082 0.328
CLV_PCSK_KEX2_1 566 568 PF00082 0.472
CLV_PCSK_KEX2_1 602 604 PF00082 0.415
CLV_PCSK_KEX2_1 638 640 PF00082 0.621
CLV_PCSK_KEX2_1 789 791 PF00082 0.629
CLV_PCSK_SKI1_1 129 133 PF00082 0.536
CLV_PCSK_SKI1_1 206 210 PF00082 0.444
CLV_PCSK_SKI1_1 442 446 PF00082 0.377
CLV_PCSK_SKI1_1 450 454 PF00082 0.323
CLV_PCSK_SKI1_1 574 578 PF00082 0.421
CLV_PCSK_SKI1_1 603 607 PF00082 0.312
CLV_PCSK_SKI1_1 628 632 PF00082 0.647
CLV_PCSK_SKI1_1 728 732 PF00082 0.671
CLV_PCSK_SKI1_1 744 748 PF00082 0.492
CLV_PCSK_SKI1_1 773 777 PF00082 0.576
CLV_PCSK_SKI1_1 790 794 PF00082 0.583
CLV_Separin_Metazoa 194 198 PF03568 0.288
DEG_APCC_DBOX_1 12 20 PF00400 0.687
DEG_APCC_DBOX_1 507 515 PF00400 0.557
DEG_Nend_UBRbox_1 1 4 PF02207 0.607
DEG_SCF_FBW7_1 172 177 PF00400 0.377
DEG_SPOP_SBC_1 408 412 PF00917 0.554
DOC_AGCK_PIF_1 222 227 PF00069 0.224
DOC_CDC14_PxL_1 292 300 PF14671 0.279
DOC_CDC14_PxL_1 98 106 PF14671 0.359
DOC_CKS1_1 663 668 PF01111 0.440
DOC_CKS1_1 692 697 PF01111 0.400
DOC_CYCLIN_yCln2_LP_2 775 781 PF00134 0.385
DOC_MAPK_DCC_7 628 637 PF00069 0.424
DOC_MAPK_gen_1 286 294 PF00069 0.326
DOC_MAPK_MEF2A_6 20 29 PF00069 0.518
DOC_MAPK_MEF2A_6 475 483 PF00069 0.474
DOC_MAPK_MEF2A_6 628 637 PF00069 0.424
DOC_MAPK_MEF2A_6 757 765 PF00069 0.270
DOC_PP1_RVXF_1 771 777 PF00149 0.412
DOC_PP2B_LxvP_1 104 107 PF13499 0.388
DOC_PP2B_LxvP_1 779 782 PF13499 0.394
DOC_PP2B_PxIxI_1 632 638 PF00149 0.422
DOC_PP4_FxxP_1 147 150 PF00568 0.414
DOC_PP4_FxxP_1 490 493 PF00568 0.552
DOC_PP4_FxxP_1 663 666 PF00568 0.437
DOC_PP4_FxxP_1 795 798 PF00568 0.367
DOC_USP7_MATH_1 188 192 PF00917 0.347
DOC_USP7_MATH_1 491 495 PF00917 0.585
DOC_USP7_MATH_1 570 574 PF00917 0.740
DOC_USP7_MATH_1 608 612 PF00917 0.256
DOC_USP7_MATH_1 621 625 PF00917 0.522
DOC_USP7_MATH_1 671 675 PF00917 0.565
DOC_USP7_MATH_1 715 719 PF00917 0.405
DOC_USP7_MATH_1 821 825 PF00917 0.342
DOC_USP7_UBL2_3 351 355 PF12436 0.498
DOC_WW_Pin1_4 146 151 PF00397 0.403
DOC_WW_Pin1_4 170 175 PF00397 0.413
DOC_WW_Pin1_4 311 316 PF00397 0.503
DOC_WW_Pin1_4 662 667 PF00397 0.527
DOC_WW_Pin1_4 691 696 PF00397 0.467
LIG_14-3-3_CanoR_1 129 134 PF00244 0.419
LIG_14-3-3_CanoR_1 190 199 PF00244 0.480
LIG_14-3-3_CanoR_1 450 456 PF00244 0.547
LIG_14-3-3_CanoR_1 662 666 PF00244 0.479
LIG_14-3-3_CanoR_1 668 676 PF00244 0.606
LIG_14-3-3_CanoR_1 688 693 PF00244 0.535
LIG_14-3-3_CanoR_1 789 798 PF00244 0.421
LIG_Actin_WH2_2 36 53 PF00022 0.243
LIG_Actin_WH2_2 499 514 PF00022 0.614
LIG_BIR_III_2 515 519 PF00653 0.490
LIG_BRCT_BRCA1_1 166 170 PF00533 0.303
LIG_BRCT_BRCA1_1 659 663 PF00533 0.484
LIG_BRCT_BRCA1_1 717 721 PF00533 0.493
LIG_EH_1 238 242 PF12763 0.392
LIG_EH1_1 31 39 PF00400 0.226
LIG_FHA_1 158 164 PF00498 0.294
LIG_FHA_1 190 196 PF00498 0.415
LIG_FHA_1 224 230 PF00498 0.308
LIG_FHA_1 261 267 PF00498 0.414
LIG_FHA_1 289 295 PF00498 0.350
LIG_FHA_1 317 323 PF00498 0.297
LIG_FHA_1 382 388 PF00498 0.606
LIG_FHA_1 409 415 PF00498 0.534
LIG_FHA_1 546 552 PF00498 0.684
LIG_FHA_1 627 633 PF00498 0.603
LIG_FHA_1 709 715 PF00498 0.563
LIG_FHA_1 725 731 PF00498 0.371
LIG_FHA_1 734 740 PF00498 0.374
LIG_FHA_1 751 757 PF00498 0.426
LIG_FHA_2 171 177 PF00498 0.376
LIG_FHA_2 266 272 PF00498 0.387
LIG_FHA_2 288 294 PF00498 0.404
LIG_FHA_2 495 501 PF00498 0.584
LIG_FHA_2 595 601 PF00498 0.577
LIG_IRF3_LxIS_1 81 87 PF10401 0.250
LIG_LIR_Apic_2 473 479 PF02991 0.555
LIG_LIR_Apic_2 660 666 PF02991 0.436
LIG_LIR_Apic_2 793 798 PF02991 0.421
LIG_LIR_Gen_1 226 235 PF02991 0.231
LIG_LIR_Gen_1 251 260 PF02991 0.271
LIG_LIR_Gen_1 649 654 PF02991 0.421
LIG_LIR_Gen_1 748 756 PF02991 0.395
LIG_LIR_Nem_3 221 225 PF02991 0.317
LIG_LIR_Nem_3 226 230 PF02991 0.313
LIG_LIR_Nem_3 23 29 PF02991 0.528
LIG_LIR_Nem_3 251 256 PF02991 0.358
LIG_LIR_Nem_3 283 288 PF02991 0.494
LIG_LIR_Nem_3 527 531 PF02991 0.700
LIG_LIR_Nem_3 548 553 PF02991 0.650
LIG_LIR_Nem_3 649 653 PF02991 0.421
LIG_LIR_Nem_3 748 752 PF02991 0.385
LIG_LIR_Nem_3 755 761 PF02991 0.356
LIG_LIR_Nem_3 770 775 PF02991 0.387
LIG_NRBOX 325 331 PF00104 0.355
LIG_NRBOX 594 600 PF00104 0.586
LIG_PCNA_PIPBox_1 216 225 PF02747 0.262
LIG_PCNA_PIPBox_1 799 808 PF02747 0.394
LIG_PCNA_yPIPBox_3 592 603 PF02747 0.502
LIG_Pex14_1 223 227 PF04695 0.291
LIG_Pex14_2 40 44 PF04695 0.365
LIG_PTB_Apo_2 520 527 PF02174 0.559
LIG_PTB_Phospho_1 520 526 PF10480 0.555
LIG_SH2_CRK 145 149 PF00017 0.245
LIG_SH2_CRK 749 753 PF00017 0.399
LIG_SH2_CRK 758 762 PF00017 0.335
LIG_SH2_CRK 772 776 PF00017 0.415
LIG_SH2_NCK_1 214 218 PF00017 0.374
LIG_SH2_NCK_1 66 70 PF00017 0.411
LIG_SH2_PTP2 185 188 PF00017 0.375
LIG_SH2_PTP2 26 29 PF00017 0.365
LIG_SH2_STAP1 455 459 PF00017 0.563
LIG_SH2_STAP1 57 61 PF00017 0.375
LIG_SH2_STAT3 401 404 PF00017 0.605
LIG_SH2_STAT5 185 188 PF00017 0.375
LIG_SH2_STAT5 255 258 PF00017 0.340
LIG_SH2_STAT5 26 29 PF00017 0.407
LIG_SH2_STAT5 413 416 PF00017 0.543
LIG_SH2_STAT5 550 553 PF00017 0.667
LIG_SH2_STAT5 66 69 PF00017 0.389
LIG_SH2_STAT5 698 701 PF00017 0.420
LIG_SH2_STAT5 767 770 PF00017 0.341
LIG_SH2_STAT5 814 817 PF00017 0.338
LIG_SH2_STAT5 93 96 PF00017 0.358
LIG_SH3_3 201 207 PF00018 0.253
LIG_SH3_3 293 299 PF00018 0.464
LIG_SH3_3 548 554 PF00018 0.599
LIG_SH3_3 627 633 PF00018 0.544
LIG_SUMO_SIM_anti_2 316 324 PF11976 0.305
LIG_SUMO_SIM_anti_2 45 51 PF11976 0.355
LIG_SUMO_SIM_anti_2 572 580 PF11976 0.619
LIG_SUMO_SIM_par_1 159 165 PF11976 0.293
LIG_SUMO_SIM_par_1 262 273 PF11976 0.292
LIG_SUMO_SIM_par_1 318 324 PF11976 0.324
LIG_SUMO_SIM_par_1 683 689 PF11976 0.423
LIG_SUMO_SIM_par_1 77 82 PF11976 0.327
LIG_TRAF2_1 428 431 PF00917 0.652
LIG_TYR_ITIM 756 761 PF00017 0.352
LIG_UBA3_1 47 55 PF00899 0.466
LIG_WRC_WIRS_1 219 224 PF05994 0.368
LIG_WRC_WIRS_1 647 652 PF05994 0.421
LIG_WRC_WIRS_1 716 721 PF05994 0.401
MOD_CDK_SPxK_1 662 668 PF00069 0.440
MOD_CK1_1 412 418 PF00069 0.543
MOD_CK1_1 494 500 PF00069 0.573
MOD_CK1_1 543 549 PF00069 0.669
MOD_CK1_1 569 575 PF00069 0.714
MOD_CK1_1 642 648 PF00069 0.514
MOD_CK1_1 664 670 PF00069 0.648
MOD_CK1_1 674 680 PF00069 0.522
MOD_CK1_1 686 692 PF00069 0.526
MOD_CK1_1 707 713 PF00069 0.410
MOD_CK1_1 96 102 PF00069 0.359
MOD_CK2_1 188 194 PF00069 0.447
MOD_CK2_1 265 271 PF00069 0.391
MOD_CK2_1 424 430 PF00069 0.642
MOD_CK2_1 494 500 PF00069 0.548
MOD_CK2_1 831 837 PF00069 0.520
MOD_Cter_Amidation 564 567 PF01082 0.423
MOD_GlcNHglycan 104 107 PF01048 0.601
MOD_GlcNHglycan 232 235 PF01048 0.447
MOD_GlcNHglycan 245 248 PF01048 0.548
MOD_GlcNHglycan 262 266 PF01048 0.636
MOD_GlcNHglycan 326 329 PF01048 0.349
MOD_GlcNHglycan 426 429 PF01048 0.253
MOD_GlcNHglycan 541 545 PF01048 0.533
MOD_GlcNHglycan 568 571 PF01048 0.417
MOD_GlcNHglycan 621 624 PF01048 0.747
MOD_GlcNHglycan 650 653 PF01048 0.822
MOD_GlcNHglycan 659 662 PF01048 0.770
MOD_GlcNHglycan 673 676 PF01048 0.679
MOD_GSK3_1 119 126 PF00069 0.334
MOD_GSK3_1 170 177 PF00069 0.378
MOD_GSK3_1 230 237 PF00069 0.283
MOD_GSK3_1 261 268 PF00069 0.481
MOD_GSK3_1 316 323 PF00069 0.327
MOD_GSK3_1 408 415 PF00069 0.584
MOD_GSK3_1 466 473 PF00069 0.726
MOD_GSK3_1 526 533 PF00069 0.770
MOD_GSK3_1 555 562 PF00069 0.702
MOD_GSK3_1 566 573 PF00069 0.659
MOD_GSK3_1 577 584 PF00069 0.735
MOD_GSK3_1 639 646 PF00069 0.521
MOD_GSK3_1 653 660 PF00069 0.523
MOD_GSK3_1 662 669 PF00069 0.577
MOD_GSK3_1 670 677 PF00069 0.539
MOD_GSK3_1 704 711 PF00069 0.532
MOD_GSK3_1 822 829 PF00069 0.487
MOD_LATS_1 828 834 PF00433 0.388
MOD_N-GLC_1 102 107 PF02516 0.620
MOD_N-GLC_1 129 134 PF02516 0.508
MOD_N-GLC_1 209 214 PF02516 0.580
MOD_N-GLC_1 230 235 PF02516 0.543
MOD_N-GLC_1 260 265 PF02516 0.591
MOD_N-GLC_1 316 321 PF02516 0.499
MOD_N-GLC_1 626 631 PF02516 0.637
MOD_N-GLC_1 704 709 PF02516 0.645
MOD_NEK2_1 225 230 PF00069 0.313
MOD_NEK2_1 241 246 PF00069 0.322
MOD_NEK2_1 270 275 PF00069 0.427
MOD_NEK2_1 300 305 PF00069 0.315
MOD_NEK2_1 341 346 PF00069 0.538
MOD_NEK2_1 409 414 PF00069 0.576
MOD_NEK2_1 424 429 PF00069 0.568
MOD_NEK2_1 451 456 PF00069 0.542
MOD_NEK2_1 470 475 PF00069 0.717
MOD_NEK2_1 559 564 PF00069 0.618
MOD_NEK2_1 577 582 PF00069 0.587
MOD_NEK2_1 768 773 PF00069 0.392
MOD_NEK2_1 84 89 PF00069 0.397
MOD_NEK2_2 545 550 PF00069 0.665
MOD_PIKK_1 4 10 PF00454 0.674
MOD_PIKK_1 588 594 PF00454 0.662
MOD_PIKK_1 84 90 PF00454 0.357
MOD_PIKK_1 93 99 PF00454 0.314
MOD_PK_1 639 645 PF00069 0.413
MOD_PK_1 757 763 PF00069 0.274
MOD_PKA_1 566 572 PF00069 0.618
MOD_PKA_2 157 163 PF00069 0.402
MOD_PKA_2 189 195 PF00069 0.448
MOD_PKA_2 566 572 PF00069 0.618
MOD_PKA_2 637 643 PF00069 0.435
MOD_PKA_2 661 667 PF00069 0.512
MOD_Plk_1 129 135 PF00069 0.357
MOD_Plk_1 212 218 PF00069 0.472
MOD_Plk_1 270 276 PF00069 0.305
MOD_Plk_1 316 322 PF00069 0.232
MOD_Plk_1 626 632 PF00069 0.437
MOD_Plk_1 64 70 PF00069 0.428
MOD_Plk_4 129 135 PF00069 0.419
MOD_Plk_4 174 180 PF00069 0.351
MOD_Plk_4 218 224 PF00069 0.370
MOD_Plk_4 255 261 PF00069 0.249
MOD_Plk_4 332 338 PF00069 0.377
MOD_Plk_4 409 415 PF00069 0.532
MOD_Plk_4 43 49 PF00069 0.393
MOD_Plk_4 491 497 PF00069 0.578
MOD_Plk_4 545 551 PF00069 0.695
MOD_Plk_4 837 843 PF00069 0.388
MOD_Plk_4 96 102 PF00069 0.379
MOD_ProDKin_1 146 152 PF00069 0.402
MOD_ProDKin_1 170 176 PF00069 0.414
MOD_ProDKin_1 311 317 PF00069 0.500
MOD_ProDKin_1 662 668 PF00069 0.529
MOD_ProDKin_1 691 697 PF00069 0.468
TRG_DiLeu_BaEn_1 448 453 PF01217 0.667
TRG_DiLeu_BaEn_4 370 376 PF01217 0.582
TRG_DiLeu_BaLyEn_6 447 452 PF01217 0.570
TRG_ENDOCYTIC_2 145 148 PF00928 0.403
TRG_ENDOCYTIC_2 199 202 PF00928 0.271
TRG_ENDOCYTIC_2 26 29 PF00928 0.306
TRG_ENDOCYTIC_2 749 752 PF00928 0.390
TRG_ENDOCYTIC_2 758 761 PF00928 0.334
TRG_ENDOCYTIC_2 772 775 PF00928 0.387
TRG_ER_diArg_1 12 15 PF00400 0.713
TRG_ER_diArg_1 204 206 PF00400 0.340
TRG_ER_diArg_1 304 307 PF00400 0.430
TRG_ER_diArg_1 434 436 PF00400 0.528
TRG_ER_diArg_1 602 604 PF00400 0.615
TRG_ER_diArg_1 637 639 PF00400 0.417
TRG_ER_diArg_1 788 790 PF00400 0.424
TRG_Pf-PMV_PEXEL_1 728 732 PF00026 0.725

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5C6 Leptomonas seymouri 49% 98%
A0A1X0NMS3 Trypanosomatidae 32% 93%
A0A3S5H6C4 Leishmania donovani 69% 99%
A4HTU4 Leishmania infantum 45% 100%
A4HTU5 Leishmania infantum 69% 100%
E9AMN1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 92%
E9AMN2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 68% 99%
Q4QHZ3 Leishmania major 68% 100%
Q4QHZ4 Leishmania major 45% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS