LeishMANIAdb
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CHASE domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CHASE domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H5K6_LEIBR
TriTrypDb:
LbrM.09.0310 , LBRM2903_090008400 *
Length:
783

Annotations

LeishMANIAdb annotations

Appears to be an enzyme-linked receptor, putatively a receptor nucleotide cyclase (cAMP synthase).. Expanded on the Leishmaniid lineage. The first helical segment is very similar to a signal peptide.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A4H5K6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5K6

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 3
GO:0006163 purine nucleotide metabolic process 5 3
GO:0006164 purine nucleotide biosynthetic process 6 3
GO:0006171 cAMP biosynthetic process 8 3
GO:0006725 cellular aromatic compound metabolic process 3 3
GO:0006753 nucleoside phosphate metabolic process 4 3
GO:0006793 phosphorus metabolic process 3 3
GO:0006796 phosphate-containing compound metabolic process 4 3
GO:0006807 nitrogen compound metabolic process 2 3
GO:0008152 metabolic process 1 3
GO:0009058 biosynthetic process 2 3
GO:0009117 nucleotide metabolic process 5 3
GO:0009150 purine ribonucleotide metabolic process 6 3
GO:0009152 purine ribonucleotide biosynthetic process 7 3
GO:0009165 nucleotide biosynthetic process 6 3
GO:0009187 cyclic nucleotide metabolic process 6 3
GO:0009190 cyclic nucleotide biosynthetic process 7 3
GO:0009259 ribonucleotide metabolic process 5 3
GO:0009260 ribonucleotide biosynthetic process 6 3
GO:0009987 cellular process 1 3
GO:0018130 heterocycle biosynthetic process 4 3
GO:0019438 aromatic compound biosynthetic process 4 3
GO:0019637 organophosphate metabolic process 3 3
GO:0019693 ribose phosphate metabolic process 4 3
GO:0034641 cellular nitrogen compound metabolic process 3 3
GO:0034654 nucleobase-containing compound biosynthetic process 4 3
GO:0044237 cellular metabolic process 2 3
GO:0044238 primary metabolic process 2 3
GO:0044249 cellular biosynthetic process 3 3
GO:0044271 cellular nitrogen compound biosynthetic process 4 3
GO:0044281 small molecule metabolic process 2 3
GO:0046058 cAMP metabolic process 7 3
GO:0046390 ribose phosphate biosynthetic process 5 3
GO:0046483 heterocycle metabolic process 3 3
GO:0052652 cyclic purine nucleotide metabolic process 6 3
GO:0055086 nucleobase-containing small molecule metabolic process 3 3
GO:0071704 organic substance metabolic process 2 3
GO:0072521 purine-containing compound metabolic process 4 3
GO:0072522 purine-containing compound biosynthetic process 5 3
GO:0090407 organophosphate biosynthetic process 4 3
GO:1901135 carbohydrate derivative metabolic process 3 3
GO:1901137 carbohydrate derivative biosynthetic process 4 3
GO:1901293 nucleoside phosphate biosynthetic process 5 3
GO:1901360 organic cyclic compound metabolic process 3 3
GO:1901362 organic cyclic compound biosynthetic process 4 3
GO:1901564 organonitrogen compound metabolic process 3 3
GO:1901566 organonitrogen compound biosynthetic process 4 3
GO:1901576 organic substance biosynthetic process 3 3
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 342 346 PF00656 0.286
CLV_C14_Caspase3-7 425 429 PF00656 0.353
CLV_NRD_NRD_1 154 156 PF00675 0.403
CLV_NRD_NRD_1 391 393 PF00675 0.519
CLV_NRD_NRD_1 5 7 PF00675 0.369
CLV_NRD_NRD_1 508 510 PF00675 0.604
CLV_NRD_NRD_1 631 633 PF00675 0.661
CLV_NRD_NRD_1 714 716 PF00675 0.718
CLV_NRD_NRD_1 743 745 PF00675 0.645
CLV_PCSK_KEX2_1 154 156 PF00082 0.403
CLV_PCSK_KEX2_1 391 393 PF00082 0.519
CLV_PCSK_KEX2_1 5 7 PF00082 0.369
CLV_PCSK_KEX2_1 508 510 PF00082 0.604
CLV_PCSK_KEX2_1 714 716 PF00082 0.718
CLV_PCSK_SKI1_1 399 403 PF00082 0.598
CLV_PCSK_SKI1_1 407 411 PF00082 0.544
CLV_PCSK_SKI1_1 501 505 PF00082 0.699
CLV_PCSK_SKI1_1 653 657 PF00082 0.642
CLV_PCSK_SKI1_1 669 673 PF00082 0.619
CLV_PCSK_SKI1_1 715 719 PF00082 0.533
DEG_APCC_DBOX_1 464 472 PF00400 0.344
DEG_Nend_Nbox_1 1 3 PF02207 0.525
DEG_SPOP_SBC_1 365 369 PF00917 0.416
DEG_SPOP_SBC_1 503 507 PF00917 0.426
DEG_SPOP_SBC_1 549 553 PF00917 0.443
DEG_SPOP_SBC_1 589 593 PF00917 0.456
DEG_SPOP_SBC_1 766 770 PF00917 0.462
DOC_CDC14_PxL_1 49 57 PF14671 0.538
DOC_CYCLIN_yCln2_LP_2 700 706 PF00134 0.445
DOC_MAPK_gen_1 262 270 PF00069 0.578
DOC_MAPK_gen_1 508 515 PF00069 0.344
DOC_MAPK_MEF2A_6 432 440 PF00069 0.336
DOC_MAPK_MEF2A_6 508 517 PF00069 0.332
DOC_MAPK_MEF2A_6 682 690 PF00069 0.392
DOC_PP2B_LxvP_1 704 707 PF13499 0.455
DOC_PP4_FxxP_1 447 450 PF00568 0.401
DOC_PP4_FxxP_1 720 723 PF00568 0.435
DOC_USP7_MATH_1 253 257 PF00917 0.564
DOC_USP7_MATH_1 260 264 PF00917 0.498
DOC_USP7_MATH_1 448 452 PF00917 0.412
DOC_USP7_MATH_1 549 553 PF00917 0.553
DOC_WW_Pin1_4 116 121 PF00397 0.649
DOC_WW_Pin1_4 170 175 PF00397 0.572
DOC_WW_Pin1_4 550 555 PF00397 0.468
DOC_WW_Pin1_4 606 611 PF00397 0.461
DOC_WW_Pin1_4 634 639 PF00397 0.484
DOC_WW_Pin1_4 757 762 PF00397 0.531
DOC_WW_Pin1_4 767 772 PF00397 0.545
LIG_14-3-3_CanoR_1 128 133 PF00244 0.554
LIG_14-3-3_CanoR_1 146 153 PF00244 0.647
LIG_14-3-3_CanoR_1 223 231 PF00244 0.507
LIG_14-3-3_CanoR_1 262 268 PF00244 0.556
LIG_14-3-3_CanoR_1 407 413 PF00244 0.332
LIG_14-3-3_CanoR_1 608 616 PF00244 0.453
LIG_14-3-3_CanoR_1 632 638 PF00244 0.502
LIG_14-3-3_CanoR_1 714 723 PF00244 0.446
LIG_14-3-3_CanoR_1 79 84 PF00244 0.612
LIG_BRCT_BRCA1_1 697 701 PF00533 0.283
LIG_CtBP_PxDLS_1 174 178 PF00389 0.507
LIG_DCNL_PONY_1 1 4 PF03556 0.521
LIG_DLG_GKlike_1 79 87 PF00625 0.486
LIG_FHA_1 189 195 PF00498 0.556
LIG_FHA_1 220 226 PF00498 0.609
LIG_FHA_1 339 345 PF00498 0.422
LIG_FHA_1 366 372 PF00498 0.397
LIG_FHA_1 650 656 PF00498 0.485
LIG_FHA_1 659 665 PF00498 0.397
LIG_FHA_1 676 682 PF00498 0.458
LIG_FHA_1 69 75 PF00498 0.652
LIG_FHA_2 128 134 PF00498 0.587
LIG_FHA_2 231 237 PF00498 0.552
LIG_FHA_2 244 250 PF00498 0.516
LIG_FHA_2 452 458 PF00498 0.406
LIG_FHA_2 772 778 PF00498 0.447
LIG_GBD_Chelix_1 290 298 PF00786 0.246
LIG_LIR_Apic_2 430 436 PF02991 0.342
LIG_LIR_Apic_2 718 723 PF02991 0.447
LIG_LIR_Gen_1 137 145 PF02991 0.582
LIG_LIR_Gen_1 18 28 PF02991 0.533
LIG_LIR_Gen_1 236 242 PF02991 0.618
LIG_LIR_Gen_1 266 275 PF02991 0.578
LIG_LIR_Gen_1 279 289 PF02991 0.252
LIG_LIR_Gen_1 673 681 PF02991 0.509
LIG_LIR_Gen_1 695 705 PF02991 0.293
LIG_LIR_Nem_3 137 143 PF02991 0.582
LIG_LIR_Nem_3 18 23 PF02991 0.581
LIG_LIR_Nem_3 236 241 PF02991 0.623
LIG_LIR_Nem_3 24 29 PF02991 0.561
LIG_LIR_Nem_3 255 261 PF02991 0.451
LIG_LIR_Nem_3 266 270 PF02991 0.572
LIG_LIR_Nem_3 279 284 PF02991 0.251
LIG_LIR_Nem_3 673 677 PF02991 0.499
LIG_LIR_Nem_3 680 686 PF02991 0.409
LIG_LIR_Nem_3 695 700 PF02991 0.320
LIG_LIR_Nem_3 75 80 PF02991 0.559
LIG_LYPXL_yS_3 557 560 PF13949 0.447
LIG_MYND_1 53 57 PF01753 0.523
LIG_PCNA_PIPBox_1 724 733 PF02747 0.424
LIG_SH2_CRK 140 144 PF00017 0.557
LIG_SH2_CRK 20 24 PF00017 0.542
LIG_SH2_CRK 476 480 PF00017 0.322
LIG_SH2_CRK 674 678 PF00017 0.452
LIG_SH2_CRK 697 701 PF00017 0.398
LIG_SH2_CRK 751 755 PF00017 0.403
LIG_SH2_NCK_1 140 144 PF00017 0.557
LIG_SH2_NCK_1 20 24 PF00017 0.574
LIG_SH2_NCK_1 304 308 PF00017 0.392
LIG_SH2_PTP2 258 261 PF00017 0.477
LIG_SH2_PTP2 267 270 PF00017 0.548
LIG_SH2_SRC 683 686 PF00017 0.418
LIG_SH2_STAP1 238 242 PF00017 0.560
LIG_SH2_STAP1 304 308 PF00017 0.392
LIG_SH2_STAP1 412 416 PF00017 0.387
LIG_SH2_STAP1 697 701 PF00017 0.283
LIG_SH2_STAT3 358 361 PF00017 0.423
LIG_SH2_STAT5 210 213 PF00017 0.575
LIG_SH2_STAT5 258 261 PF00017 0.477
LIG_SH2_STAT5 267 270 PF00017 0.548
LIG_SH2_STAT5 370 373 PF00017 0.399
LIG_SH2_STAT5 516 519 PF00017 0.358
LIG_SH2_STAT5 692 695 PF00017 0.406
LIG_SH2_STAT5 73 76 PF00017 0.577
LIG_SH3_3 117 123 PF00018 0.562
LIG_SH3_3 538 544 PF00018 0.414
LIG_SH3_3 635 641 PF00018 0.425
LIG_SUMO_SIM_anti_2 273 279 PF11976 0.502
LIG_SUMO_SIM_anti_2 286 291 PF11976 0.250
LIG_SUMO_SIM_par_1 276 282 PF11976 0.404
LIG_TRAF2_1 233 236 PF00917 0.506
LIG_TRAF2_1 385 388 PF00917 0.407
LIG_TYR_ITIM 681 686 PF00017 0.397
LIG_UBA3_1 514 523 PF00899 0.306
MOD_CDC14_SPxK_1 637 640 PF00782 0.422
MOD_CDK_SPxK_1 634 640 PF00069 0.421
MOD_CDK_SPxxK_3 757 764 PF00069 0.434
MOD_CK1_1 121 127 PF00069 0.631
MOD_CK1_1 21 27 PF00069 0.510
MOD_CK1_1 216 222 PF00069 0.601
MOD_CK1_1 243 249 PF00069 0.503
MOD_CK1_1 263 269 PF00069 0.587
MOD_CK1_1 369 375 PF00069 0.398
MOD_CK1_1 451 457 PF00069 0.387
MOD_CK1_1 507 513 PF00069 0.400
MOD_CK1_1 552 558 PF00069 0.475
MOD_CK1_1 609 615 PF00069 0.501
MOD_CK1_1 695 701 PF00069 0.281
MOD_CK1_1 760 766 PF00069 0.510
MOD_CK2_1 127 133 PF00069 0.673
MOD_CK2_1 230 236 PF00069 0.526
MOD_CK2_1 381 387 PF00069 0.431
MOD_CK2_1 451 457 PF00069 0.464
MOD_CK2_1 771 777 PF00069 0.467
MOD_GlcNHglycan 136 139 PF01048 0.487
MOD_GlcNHglycan 383 386 PF01048 0.460
MOD_GlcNHglycan 468 471 PF01048 0.622
MOD_GlcNHglycan 509 512 PF01048 0.612
MOD_GlcNHglycan 57 60 PF01048 0.441
MOD_GlcNHglycan 573 576 PF01048 0.687
MOD_GlcNHglycan 578 582 PF01048 0.746
MOD_GlcNHglycan 6 9 PF01048 0.404
MOD_GSK3_1 127 134 PF00069 0.665
MOD_GSK3_1 145 152 PF00069 0.573
MOD_GSK3_1 166 173 PF00069 0.626
MOD_GSK3_1 213 220 PF00069 0.664
MOD_GSK3_1 230 237 PF00069 0.586
MOD_GSK3_1 266 273 PF00069 0.644
MOD_GSK3_1 279 286 PF00069 0.335
MOD_GSK3_1 365 372 PF00069 0.404
MOD_GSK3_1 423 430 PF00069 0.479
MOD_GSK3_1 503 510 PF00069 0.467
MOD_GSK3_1 548 555 PF00069 0.473
MOD_GSK3_1 55 62 PF00069 0.612
MOD_GSK3_1 68 75 PF00069 0.577
MOD_GSK3_1 762 769 PF00069 0.499
MOD_GSK3_1 79 86 PF00069 0.558
MOD_N-GLC_1 170 175 PF02516 0.458
MOD_N-GLC_1 188 193 PF02516 0.390
MOD_N-GLC_1 217 222 PF02516 0.386
MOD_N-GLC_1 231 236 PF02516 0.319
MOD_N-GLC_1 273 278 PF02516 0.273
MOD_N-GLC_1 549 554 PF02516 0.647
MOD_N-GLC_1 562 567 PF02516 0.633
MOD_N-GLC_1 59 64 PF02516 0.526
MOD_N-GLC_1 68 73 PF02516 0.377
MOD_NEK2_1 270 275 PF00069 0.567
MOD_NEK2_1 283 288 PF00069 0.363
MOD_NEK2_1 366 371 PF00069 0.433
MOD_NEK2_1 381 386 PF00069 0.257
MOD_NEK2_1 408 413 PF00069 0.328
MOD_NEK2_1 427 432 PF00069 0.377
MOD_NEK2_1 466 471 PF00069 0.396
MOD_NEK2_1 562 567 PF00069 0.438
MOD_NEK2_1 693 698 PF00069 0.437
MOD_NEK2_1 83 88 PF00069 0.566
MOD_NEK2_2 253 258 PF00069 0.560
MOD_NEK2_2 597 602 PF00069 0.437
MOD_OFUCOSY 588 594 PF10250 0.633
MOD_PIKK_1 231 237 PF00454 0.592
MOD_PIKK_1 738 744 PF00454 0.378
MOD_PIKK_1 83 89 PF00454 0.495
MOD_PKA_2 127 133 PF00069 0.578
MOD_PKA_2 138 144 PF00069 0.586
MOD_PKA_2 145 151 PF00069 0.628
MOD_PKA_2 263 269 PF00069 0.582
MOD_PKA_2 4 10 PF00069 0.613
MOD_PKA_2 507 513 PF00069 0.368
MOD_PKA_2 631 637 PF00069 0.445
MOD_Plk_1 18 24 PF00069 0.500
MOD_Plk_1 243 249 PF00069 0.549
MOD_Plk_1 273 279 PF00069 0.425
MOD_Plk_1 562 568 PF00069 0.450
MOD_Plk_1 59 65 PF00069 0.579
MOD_Plk_4 131 137 PF00069 0.560
MOD_Plk_4 138 144 PF00069 0.478
MOD_Plk_4 243 249 PF00069 0.478
MOD_Plk_4 253 259 PF00069 0.508
MOD_Plk_4 263 269 PF00069 0.566
MOD_Plk_4 273 279 PF00069 0.480
MOD_Plk_4 283 289 PF00069 0.267
MOD_Plk_4 366 372 PF00069 0.395
MOD_Plk_4 448 454 PF00069 0.390
MOD_Plk_4 477 483 PF00069 0.327
MOD_Plk_4 509 515 PF00069 0.370
MOD_Plk_4 59 65 PF00069 0.578
MOD_Plk_4 695 701 PF00069 0.281
MOD_Plk_4 79 85 PF00069 0.568
MOD_ProDKin_1 116 122 PF00069 0.645
MOD_ProDKin_1 170 176 PF00069 0.564
MOD_ProDKin_1 550 556 PF00069 0.468
MOD_ProDKin_1 606 612 PF00069 0.460
MOD_ProDKin_1 634 640 PF00069 0.485
MOD_ProDKin_1 757 763 PF00069 0.533
MOD_ProDKin_1 767 773 PF00069 0.545
MOD_SUMO_rev_2 613 623 PF00179 0.424
MOD_SUMO_rev_2 626 634 PF00179 0.406
TRG_DiLeu_BaEn_1 405 410 PF01217 0.421
TRG_DiLeu_BaEn_1 685 690 PF01217 0.414
TRG_DiLeu_BaEn_4 327 333 PF01217 0.438
TRG_DiLeu_BaLyEn_6 404 409 PF01217 0.436
TRG_ENDOCYTIC_2 140 143 PF00928 0.555
TRG_ENDOCYTIC_2 20 23 PF00928 0.542
TRG_ENDOCYTIC_2 238 241 PF00928 0.565
TRG_ENDOCYTIC_2 258 261 PF00928 0.417
TRG_ENDOCYTIC_2 267 270 PF00928 0.548
TRG_ENDOCYTIC_2 476 479 PF00928 0.377
TRG_ENDOCYTIC_2 557 560 PF00928 0.493
TRG_ENDOCYTIC_2 674 677 PF00928 0.451
TRG_ENDOCYTIC_2 683 686 PF00928 0.382
TRG_ENDOCYTIC_2 697 700 PF00928 0.375
TRG_ENDOCYTIC_2 751 754 PF00928 0.404
TRG_ER_diArg_1 153 155 PF00400 0.629
TRG_ER_diArg_1 261 264 PF00400 0.611
TRG_ER_diArg_1 391 393 PF00400 0.319
TRG_ER_diArg_1 4 6 PF00400 0.572
TRG_ER_diArg_1 713 715 PF00400 0.510
TRG_Pf-PMV_PEXEL_1 627 631 PF00026 0.623
TRG_Pf-PMV_PEXEL_1 653 657 PF00026 0.674

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H6C4 Leishmania donovani 41% 92%
A0A3S7WQJ6 Leishmania donovani 67% 85%
A4HTU4 Leishmania infantum 67% 85%
E9AMN1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 68% 85%
Q4QHZ4 Leishmania major 66% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS