Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cdc2-related kinase 12

Species:

Leishmania braziliensis

UniProt:

A4H5K5_LEIBR

TriTrypDb:

LbrM.09.0300 , LBRM2903_090008300

Length:

883

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0016592	mediator complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4H5K5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5K5

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	5	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	5	1
GO:0097472	cyclin-dependent protein kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	293	295	PF00675	0.621
CLV_NRD_NRD_1	434	436	PF00675	0.557
CLV_NRD_NRD_1	5	7	PF00675	0.709
CLV_NRD_NRD_1	580	582	PF00675	0.348
CLV_NRD_NRD_1	601	603	PF00675	0.307
CLV_NRD_NRD_1	802	804	PF00675	0.307
CLV_NRD_NRD_1	870	872	PF00675	0.454
CLV_NRD_NRD_1	879	881	PF00675	0.501
CLV_PCSK_KEX2_1	201	203	PF00082	0.636
CLV_PCSK_KEX2_1	293	295	PF00082	0.557
CLV_PCSK_KEX2_1	434	436	PF00082	0.561
CLV_PCSK_KEX2_1	484	486	PF00082	0.315
CLV_PCSK_KEX2_1	493	495	PF00082	0.307
CLV_PCSK_KEX2_1	5	7	PF00082	0.709
CLV_PCSK_KEX2_1	580	582	PF00082	0.348
CLV_PCSK_KEX2_1	801	803	PF00082	0.308
CLV_PCSK_KEX2_1	870	872	PF00082	0.454
CLV_PCSK_KEX2_1	879	881	PF00082	0.501
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.636
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.307
CLV_PCSK_PC1ET2_1	493	495	PF00082	0.307
CLV_PCSK_PC7_1	797	803	PF00082	0.229
CLV_PCSK_SKI1_1	240	244	PF00082	0.546
CLV_PCSK_SKI1_1	369	373	PF00082	0.518
CLV_PCSK_SKI1_1	418	422	PF00082	0.495
CLV_PCSK_SKI1_1	493	497	PF00082	0.329
CLV_PCSK_SKI1_1	595	599	PF00082	0.316
CLV_PCSK_SKI1_1	612	616	PF00082	0.307
CLV_Separin_Metazoa	828	832	PF03568	0.307
DEG_Nend_UBRbox_3	1	3	PF02207	0.685
DEG_SCF_FBW7_2	851	858	PF00400	0.460
DEG_SPOP_SBC_1	61	65	PF00917	0.688
DOC_CDC14_PxL_1	838	846	PF14671	0.515
DOC_CKS1_1	116	121	PF01111	0.692
DOC_CKS1_1	150	155	PF01111	0.528
DOC_CKS1_1	650	655	PF01111	0.307
DOC_CYCLIN_yCln2_LP_2	330	336	PF00134	0.517
DOC_MAPK_gen_1	434	443	PF00069	0.570
DOC_MAPK_gen_1	484	492	PF00069	0.307
DOC_MAPK_gen_1	559	568	PF00069	0.379
DOC_MAPK_gen_1	595	601	PF00069	0.343
DOC_MAPK_gen_1	602	609	PF00069	0.274
DOC_MAPK_gen_1	612	621	PF00069	0.231
DOC_MAPK_HePTP_8	556	568	PF00069	0.307
DOC_MAPK_MEF2A_6	559	568	PF00069	0.307
DOC_PP2B_LxvP_1	691	694	PF13499	0.379
DOC_PP2B_LxvP_1	830	833	PF13499	0.307
DOC_USP7_MATH_1	12	16	PF00917	0.570
DOC_USP7_MATH_1	210	214	PF00917	0.601
DOC_USP7_MATH_1	254	258	PF00917	0.605
DOC_USP7_MATH_1	262	266	PF00917	0.528
DOC_USP7_MATH_1	341	345	PF00917	0.523
DOC_USP7_MATH_1	398	402	PF00917	0.557
DOC_USP7_MATH_1	403	407	PF00917	0.557
DOC_USP7_MATH_1	505	509	PF00917	0.307
DOC_USP7_MATH_1	546	550	PF00917	0.379
DOC_USP7_MATH_1	571	575	PF00917	0.333
DOC_USP7_MATH_1	61	65	PF00917	0.688
DOC_USP7_MATH_1	642	646	PF00917	0.360
DOC_USP7_MATH_1	707	711	PF00917	0.379
DOC_USP7_UBL2_3	480	484	PF12436	0.307
DOC_WW_Pin1_4	10	15	PF00397	0.702
DOC_WW_Pin1_4	115	120	PF00397	0.689
DOC_WW_Pin1_4	149	154	PF00397	0.536
DOC_WW_Pin1_4	157	162	PF00397	0.533
DOC_WW_Pin1_4	213	218	PF00397	0.638
DOC_WW_Pin1_4	246	251	PF00397	0.566
DOC_WW_Pin1_4	257	262	PF00397	0.729
DOC_WW_Pin1_4	299	304	PF00397	0.672
DOC_WW_Pin1_4	313	318	PF00397	0.688
DOC_WW_Pin1_4	322	327	PF00397	0.588
DOC_WW_Pin1_4	329	334	PF00397	0.589
DOC_WW_Pin1_4	377	382	PF00397	0.506
DOC_WW_Pin1_4	401	406	PF00397	0.561
DOC_WW_Pin1_4	418	423	PF00397	0.642
DOC_WW_Pin1_4	428	433	PF00397	0.601
DOC_WW_Pin1_4	57	62	PF00397	0.619
DOC_WW_Pin1_4	583	588	PF00397	0.379
DOC_WW_Pin1_4	649	654	PF00397	0.307
DOC_WW_Pin1_4	851	856	PF00397	0.459
LIG_14-3-3_CanoR_1	139	148	PF00244	0.604
LIG_14-3-3_CanoR_1	240	250	PF00244	0.552
LIG_14-3-3_CanoR_1	259	265	PF00244	0.504
LIG_14-3-3_CanoR_1	369	378	PF00244	0.666
LIG_14-3-3_CanoR_1	397	405	PF00244	0.562
LIG_14-3-3_CanoR_1	416	421	PF00244	0.487
LIG_14-3-3_CanoR_1	516	525	PF00244	0.295
LIG_14-3-3_CanoR_1	536	540	PF00244	0.229
LIG_14-3-3_CanoR_1	709	718	PF00244	0.307
LIG_14-3-3_CanoR_1	720	728	PF00244	0.307
LIG_14-3-3_CanoR_1	849	854	PF00244	0.429
LIG_BIR_III_4	135	139	PF00653	0.540
LIG_BRCT_BRCA1_1	449	453	PF00533	0.610
LIG_EH1_1	591	599	PF00400	0.223
LIG_FHA_1	129	135	PF00498	0.694
LIG_FHA_1	140	146	PF00498	0.583
LIG_FHA_1	166	172	PF00498	0.630
LIG_FHA_1	214	220	PF00498	0.672
LIG_FHA_1	226	232	PF00498	0.690
LIG_FHA_1	275	281	PF00498	0.581
LIG_FHA_1	366	372	PF00498	0.615
LIG_FHA_1	536	542	PF00498	0.406
LIG_FHA_1	570	576	PF00498	0.307
LIG_FHA_1	650	656	PF00498	0.324
LIG_FHA_1	720	726	PF00498	0.307
LIG_FHA_1	82	88	PF00498	0.609
LIG_FHA_2	247	253	PF00498	0.514
LIG_FHA_2	457	463	PF00498	0.422
LIG_FHA_2	472	478	PF00498	0.307
LIG_FHA_2	584	590	PF00498	0.486
LIG_FHA_2	668	674	PF00498	0.307
LIG_FHA_2	711	717	PF00498	0.307
LIG_FHA_2	769	775	PF00498	0.379
LIG_FHA_2	834	840	PF00498	0.379
LIG_LIR_Apic_2	657	663	PF02991	0.336
LIG_LIR_Gen_1	776	785	PF02991	0.307
LIG_LIR_Gen_1	846	855	PF02991	0.528
LIG_LIR_Nem_3	411	417	PF02991	0.583
LIG_LIR_Nem_3	450	456	PF02991	0.597
LIG_LIR_Nem_3	472	478	PF02991	0.311
LIG_LIR_Nem_3	776	782	PF02991	0.307
LIG_LIR_Nem_3	846	850	PF02991	0.565
LIG_NRBOX	680	686	PF00104	0.379
LIG_PCNA_yPIPBox_3	457	469	PF02747	0.416
LIG_Pex14_2	773	777	PF04695	0.307
LIG_Pex14_2	785	789	PF04695	0.307
LIG_SH2_CRK	847	851	PF00017	0.546
LIG_SH2_NCK_1	570	574	PF00017	0.307
LIG_SH2_STAP1	21	25	PF00017	0.541
LIG_SH2_STAP1	672	676	PF00017	0.307
LIG_SH2_STAT3	557	560	PF00017	0.379
LIG_SH2_STAT5	689	692	PF00017	0.278
LIG_SH2_STAT5	834	837	PF00017	0.404
LIG_SH3_1	147	153	PF00018	0.674
LIG_SH3_2	727	732	PF14604	0.223
LIG_SH3_3	113	119	PF00018	0.707
LIG_SH3_3	147	153	PF00018	0.644
LIG_SH3_3	321	327	PF00018	0.602
LIG_SH3_3	349	355	PF00018	0.527
LIG_SH3_3	375	381	PF00018	0.645
LIG_SH3_3	438	444	PF00018	0.564
LIG_SH3_3	721	727	PF00018	0.297
LIG_SH3_3	730	736	PF00018	0.322
LIG_SUMO_SIM_anti_2	563	568	PF11976	0.307
LIG_SUMO_SIM_par_1	537	543	PF11976	0.279
LIG_SUMO_SIM_par_1	849	854	PF11976	0.429
LIG_TRAF2_1	296	299	PF00917	0.715
LIG_TRAF2_1	306	309	PF00917	0.547
LIG_TRFH_1	689	693	PF08558	0.379
LIG_WW_1	693	696	PF00397	0.307
LIG_WW_2	326	329	PF00397	0.503
MOD_CDC14_SPxK_1	302	305	PF00782	0.665
MOD_CDC14_SPxK_1	431	434	PF00782	0.584
MOD_CDK_SPxK_1	299	305	PF00069	0.674
MOD_CDK_SPxK_1	428	434	PF00069	0.598
MOD_CDK_SPxK_1	851	857	PF00069	0.470
MOD_CDK_SPxxK_3	428	435	PF00069	0.595
MOD_CK1_1	105	111	PF00069	0.685
MOD_CK1_1	154	160	PF00069	0.686
MOD_CK1_1	174	180	PF00069	0.495
MOD_CK1_1	213	219	PF00069	0.559
MOD_CK1_1	233	239	PF00069	0.674
MOD_CK1_1	244	250	PF00069	0.527
MOD_CK1_1	257	263	PF00069	0.588
MOD_CK1_1	365	371	PF00069	0.717
MOD_CK1_1	380	386	PF00069	0.506
MOD_CK1_1	401	407	PF00069	0.607
MOD_CK1_1	471	477	PF00069	0.307
MOD_CK1_1	55	61	PF00069	0.814
MOD_CK1_1	640	646	PF00069	0.315
MOD_CK1_1	654	660	PF00069	0.426
MOD_CK1_1	66	72	PF00069	0.798
MOD_CK1_1	710	716	PF00069	0.379
MOD_CK1_1	719	725	PF00069	0.289
MOD_CK1_1	8	14	PF00069	0.664
MOD_CK2_1	471	477	PF00069	0.311
MOD_CK2_1	505	511	PF00069	0.307
MOD_CK2_1	517	523	PF00069	0.307
MOD_CK2_1	583	589	PF00069	0.429
MOD_CK2_1	66	72	PF00069	0.705
MOD_CK2_1	768	774	PF00069	0.307
MOD_CK2_1	822	828	PF00069	0.307
MOD_Cter_Amidation	291	294	PF01082	0.554
MOD_DYRK1A_RPxSP_1	418	422	PF00069	0.495
MOD_GlcNHglycan	10	13	PF01048	0.579
MOD_GlcNHglycan	135	139	PF01048	0.750
MOD_GlcNHglycan	173	176	PF01048	0.613
MOD_GlcNHglycan	212	215	PF01048	0.674
MOD_GlcNHglycan	233	236	PF01048	0.522
MOD_GlcNHglycan	246	249	PF01048	0.506
MOD_GlcNHglycan	256	259	PF01048	0.614
MOD_GlcNHglycan	264	267	PF01048	0.640
MOD_GlcNHglycan	282	285	PF01048	0.551
MOD_GlcNHglycan	342	346	PF01048	0.593
MOD_GlcNHglycan	382	385	PF01048	0.613
MOD_GlcNHglycan	400	403	PF01048	0.708
MOD_GlcNHglycan	405	408	PF01048	0.640
MOD_GlcNHglycan	410	414	PF01048	0.569
MOD_GlcNHglycan	639	642	PF01048	0.299
MOD_GlcNHglycan	644	647	PF01048	0.332
MOD_GlcNHglycan	65	68	PF01048	0.746
MOD_GlcNHglycan	708	712	PF01048	0.379
MOD_GlcNHglycan	756	759	PF01048	0.223
MOD_GlcNHglycan	824	827	PF01048	0.223
MOD_GlcNHglycan	91	94	PF01048	0.669
MOD_GSK3_1	110	117	PF00069	0.560
MOD_GSK3_1	134	141	PF00069	0.562
MOD_GSK3_1	151	158	PF00069	0.639
MOD_GSK3_1	242	249	PF00069	0.578
MOD_GSK3_1	250	257	PF00069	0.587
MOD_GSK3_1	361	368	PF00069	0.651
MOD_GSK3_1	397	404	PF00069	0.610
MOD_GSK3_1	416	423	PF00069	0.482
MOD_GSK3_1	452	459	PF00069	0.491
MOD_GSK3_1	51	58	PF00069	0.822
MOD_GSK3_1	535	542	PF00069	0.270
MOD_GSK3_1	62	69	PF00069	0.752
MOD_GSK3_1	633	640	PF00069	0.296
MOD_GSK3_1	754	761	PF00069	0.229
MOD_GSK3_1	8	15	PF00069	0.712
MOD_LATS_1	3	9	PF00433	0.560
MOD_LATS_1	395	401	PF00433	0.549
MOD_N-GLC_1	280	285	PF02516	0.670
MOD_NEK2_1	155	160	PF00069	0.565
MOD_NEK2_1	241	246	PF00069	0.592
MOD_NEK2_1	62	67	PF00069	0.698
MOD_NEK2_1	666	671	PF00069	0.307
MOD_NEK2_1	754	759	PF00069	0.223
MOD_NEK2_1	793	798	PF00069	0.379
MOD_NEK2_1	843	848	PF00069	0.562
MOD_NEK2_1	89	94	PF00069	0.671
MOD_NEK2_2	165	170	PF00069	0.636
MOD_NEK2_2	505	510	PF00069	0.307
MOD_PIKK_1	517	523	PF00454	0.229
MOD_PIKK_1	546	552	PF00454	0.379
MOD_PIKK_1	640	646	PF00454	0.229
MOD_PIKK_1	758	764	PF00454	0.229
MOD_PIKK_1	802	808	PF00454	0.307
MOD_PIKK_1	874	880	PF00454	0.487
MOD_PK_1	43	49	PF00069	0.695
MOD_PK_1	651	657	PF00069	0.379
MOD_PK_1	849	855	PF00069	0.424
MOD_PKA_1	5	11	PF00069	0.706
MOD_PKA_1	802	808	PF00069	0.307
MOD_PKA_2	110	116	PF00069	0.707
MOD_PKA_2	138	144	PF00069	0.606
MOD_PKA_2	203	209	PF00069	0.539
MOD_PKA_2	396	402	PF00069	0.558
MOD_PKA_2	5	11	PF00069	0.706
MOD_PKA_2	535	541	PF00069	0.232
MOD_PKA_2	719	725	PF00069	0.307
MOD_PKA_2	802	808	PF00069	0.307
MOD_PKA_2	822	828	PF00069	0.180
MOD_Plk_1	546	552	PF00069	0.445
MOD_Plk_4	122	128	PF00069	0.622
MOD_Plk_4	151	157	PF00069	0.531
MOD_Plk_4	334	340	PF00069	0.520
MOD_Plk_4	385	391	PF00069	0.528
MOD_Plk_4	633	639	PF00069	0.249
MOD_Plk_4	651	657	PF00069	0.478
MOD_Plk_4	768	774	PF00069	0.307
MOD_ProDKin_1	10	16	PF00069	0.700
MOD_ProDKin_1	115	121	PF00069	0.691
MOD_ProDKin_1	149	155	PF00069	0.540
MOD_ProDKin_1	157	163	PF00069	0.530
MOD_ProDKin_1	213	219	PF00069	0.638
MOD_ProDKin_1	246	252	PF00069	0.569
MOD_ProDKin_1	257	263	PF00069	0.728
MOD_ProDKin_1	299	305	PF00069	0.674
MOD_ProDKin_1	313	319	PF00069	0.691
MOD_ProDKin_1	322	328	PF00069	0.588
MOD_ProDKin_1	329	335	PF00069	0.591
MOD_ProDKin_1	377	383	PF00069	0.507
MOD_ProDKin_1	401	407	PF00069	0.559
MOD_ProDKin_1	418	424	PF00069	0.654
MOD_ProDKin_1	428	434	PF00069	0.598
MOD_ProDKin_1	57	63	PF00069	0.619
MOD_ProDKin_1	583	589	PF00069	0.379
MOD_ProDKin_1	649	655	PF00069	0.307
MOD_ProDKin_1	851	857	PF00069	0.452
MOD_SUMO_for_1	339	342	PF00179	0.513
MOD_SUMO_rev_2	669	676	PF00179	0.307
TRG_DiLeu_BaEn_1	589	594	PF01217	0.307
TRG_DiLeu_BaLyEn_6	839	844	PF01217	0.579
TRG_ENDOCYTIC_2	475	478	PF00928	0.307
TRG_ENDOCYTIC_2	779	782	PF00928	0.307
TRG_ENDOCYTIC_2	847	850	PF00928	0.625
TRG_ER_diArg_1	106	109	PF00400	0.553
TRG_ER_diArg_1	202	205	PF00400	0.614
TRG_ER_diArg_1	4	6	PF00400	0.706
TRG_ER_diArg_1	415	418	PF00400	0.472
TRG_ER_diArg_1	434	437	PF00400	0.755
TRG_ER_diArg_1	696	699	PF00400	0.307
TRG_ER_diArg_1	800	803	PF00400	0.309
TRG_ER_diArg_1	869	871	PF00400	0.448
TRG_ER_diArg_1	879	881	PF00400	0.494
TRG_NLS_MonoExtC_3	200	205	PF00514	0.698
TRG_NLS_MonoExtN_4	198	205	PF00514	0.619
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.709
TRG_Pf-PMV_PEXEL_1	602	606	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	743	747	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	879	883	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB28	Leptomonas seymouri	60%	100%
A0A3S7WQK2	Leishmania donovani	77%	100%
E9AMN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QHZ5	Leishmania major	78%	100%