Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5K4_LEIBR

TriTrypDb:

LbrM.09.0290 , LBRM2903_090008200

Length:

239

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5K4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5K4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	184	190	PF00089	0.453
CLV_NRD_NRD_1	165	167	PF00675	0.648
CLV_NRD_NRD_1	8	10	PF00675	0.423
CLV_PCSK_KEX2_1	165	167	PF00082	0.648
CLV_PCSK_KEX2_1	8	10	PF00082	0.400
CLV_PCSK_SKI1_1	165	169	PF00082	0.641
CLV_PCSK_SKI1_1	40	44	PF00082	0.356
DEG_APCC_DBOX_1	39	47	PF00400	0.419
DOC_CDC14_PxL_1	112	120	PF14671	0.518
DOC_MAPK_MEF2A_6	22	29	PF00069	0.466
DOC_PP4_FxxP_1	168	171	PF00568	0.620
DOC_USP7_MATH_1	11	15	PF00917	0.586
DOC_USP7_MATH_1	55	59	PF00917	0.573
DOC_WW_Pin1_4	106	111	PF00397	0.670
DOC_WW_Pin1_4	66	71	PF00397	0.544
LIG_14-3-3_CanoR_1	187	195	PF00244	0.706
LIG_14-3-3_CanoR_1	53	62	PF00244	0.643
LIG_FHA_1	122	128	PF00498	0.412
LIG_FHA_1	190	196	PF00498	0.563
LIG_FHA_1	69	75	PF00498	0.474
LIG_FHA_1	84	90	PF00498	0.471
LIG_FHA_2	142	148	PF00498	0.512
LIG_FHA_2	172	178	PF00498	0.468
LIG_HP1_1	25	29	PF01393	0.447
LIG_LIR_Gen_1	135	146	PF02991	0.319
LIG_LIR_Nem_3	135	141	PF02991	0.321
LIG_SH2_CRK	138	142	PF00017	0.337
LIG_SH2_STAP1	138	142	PF00017	0.446
LIG_SH2_STAP1	19	23	PF00017	0.414
LIG_SH2_STAT5	194	197	PF00017	0.673
LIG_SH3_3	64	70	PF00018	0.642
LIG_SUMO_SIM_anti_2	124	129	PF11976	0.452
LIG_SUMO_SIM_anti_2	132	140	PF11976	0.465
LIG_SUMO_SIM_par_1	68	75	PF11976	0.493
LIG_SUMO_SIM_par_1	85	91	PF11976	0.472
LIG_TRAF2_1	101	104	PF00917	0.503
LIG_TRAF2_1	174	177	PF00917	0.461
LIG_TYR_ITIM	136	141	PF00017	0.371
MOD_CK1_1	140	146	PF00069	0.517
MOD_CK1_1	189	195	PF00069	0.464
MOD_CK1_1	68	74	PF00069	0.520
MOD_CK1_1	91	97	PF00069	0.745
MOD_CK2_1	11	17	PF00069	0.461
MOD_CK2_1	141	147	PF00069	0.559
MOD_CK2_1	171	177	PF00069	0.507
MOD_CK2_1	98	104	PF00069	0.500
MOD_GlcNHglycan	155	158	PF01048	0.577
MOD_GlcNHglycan	227	230	PF01048	0.365
MOD_GlcNHglycan	57	60	PF01048	0.512
MOD_GlcNHglycan	93	96	PF01048	0.559
MOD_GSK3_1	11	18	PF00069	0.308
MOD_GSK3_1	137	144	PF00069	0.591
MOD_GSK3_1	186	193	PF00069	0.498
MOD_GSK3_1	61	68	PF00069	0.631
MOD_GSK3_1	94	101	PF00069	0.741
MOD_NEK2_1	123	128	PF00069	0.475
MOD_NEK2_1	188	193	PF00069	0.608
MOD_NEK2_1	215	220	PF00069	0.457
MOD_PKA_1	172	178	PF00069	0.547
MOD_PKA_2	186	192	PF00069	0.545
MOD_PKB_1	96	104	PF00069	0.498
MOD_Plk_1	189	195	PF00069	0.464
MOD_Plk_2-3	197	203	PF00069	0.531
MOD_Plk_4	123	129	PF00069	0.380
MOD_Plk_4	137	143	PF00069	0.440
MOD_Plk_4	190	196	PF00069	0.533
MOD_Plk_4	62	68	PF00069	0.555
MOD_Plk_4	83	89	PF00069	0.470
MOD_ProDKin_1	106	112	PF00069	0.660
MOD_ProDKin_1	66	72	PF00069	0.547
MOD_SUMO_for_1	219	222	PF00179	0.463
MOD_SUMO_rev_2	101	106	PF00179	0.503
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.372
TRG_ENDOCYTIC_2	138	141	PF00928	0.315
TRG_ER_diArg_1	164	166	PF00400	0.647
TRG_ER_diArg_1	8	10	PF00400	0.400
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R6	Leptomonas seymouri	45%	95%
A0A3S7WQM1	Leishmania donovani	71%	100%
A4HTU2	Leishmania infantum	71%	100%
D0A9A4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AMM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	99%
Q4QHZ6	Leishmania major	72%	98%
V5B2V2	Trypanosoma cruzi	31%	100%