Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5K2_LEIBR

TriTrypDb:

LbrM.09.0270 , LBRM2903_090007900

Length:

745

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5K2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5K2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	40	44	PF00656	0.785
CLV_C14_Caspase3-7	641	645	PF00656	0.530
CLV_NRD_NRD_1	117	119	PF00675	0.516
CLV_NRD_NRD_1	177	179	PF00675	0.499
CLV_NRD_NRD_1	181	183	PF00675	0.493
CLV_NRD_NRD_1	184	186	PF00675	0.480
CLV_NRD_NRD_1	198	200	PF00675	0.503
CLV_NRD_NRD_1	290	292	PF00675	0.604
CLV_NRD_NRD_1	315	317	PF00675	0.526
CLV_NRD_NRD_1	343	345	PF00675	0.622
CLV_NRD_NRD_1	484	486	PF00675	0.416
CLV_NRD_NRD_1	546	548	PF00675	0.532
CLV_NRD_NRD_1	694	696	PF00675	0.747
CLV_NRD_NRD_1	713	715	PF00675	0.541
CLV_PCSK_FUR_1	178	182	PF00082	0.518
CLV_PCSK_KEX2_1	116	118	PF00082	0.523
CLV_PCSK_KEX2_1	177	179	PF00082	0.534
CLV_PCSK_KEX2_1	180	182	PF00082	0.529
CLV_PCSK_KEX2_1	184	186	PF00082	0.528
CLV_PCSK_KEX2_1	315	317	PF00082	0.526
CLV_PCSK_KEX2_1	343	345	PF00082	0.622
CLV_PCSK_KEX2_1	484	486	PF00082	0.416
CLV_PCSK_KEX2_1	546	548	PF00082	0.532
CLV_PCSK_KEX2_1	694	696	PF00082	0.747
CLV_PCSK_KEX2_1	713	715	PF00082	0.541
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.421
CLV_PCSK_PC7_1	177	183	PF00082	0.540
CLV_PCSK_SKI1_1	292	296	PF00082	0.604
CLV_PCSK_SKI1_1	316	320	PF00082	0.550
CLV_PCSK_SKI1_1	344	348	PF00082	0.562
CLV_PCSK_SKI1_1	373	377	PF00082	0.460
CLV_PCSK_SKI1_1	547	551	PF00082	0.515
CLV_PCSK_SKI1_1	99	103	PF00082	0.440
DEG_APCC_DBOX_1	290	298	PF00400	0.746
DEG_Nend_Nbox_1	1	3	PF02207	0.346
DOC_CKS1_1	194	199	PF01111	0.707
DOC_CYCLIN_RxL_1	725	735	PF00134	0.370
DOC_CYCLIN_yCln2_LP_2	70	73	PF00134	0.613
DOC_MAPK_DCC_7	736	745	PF00069	0.371
DOC_MAPK_gen_1	291	299	PF00069	0.804
DOC_MAPK_gen_1	312	321	PF00069	0.753
DOC_MAPK_gen_1	733	743	PF00069	0.539
DOC_MAPK_MEF2A_6	291	299	PF00069	0.734
DOC_MAPK_MEF2A_6	312	321	PF00069	0.822
DOC_MAPK_MEF2A_6	684	693	PF00069	0.458
DOC_MAPK_MEF2A_6	736	745	PF00069	0.479
DOC_MAPK_RevD_3	101	117	PF00069	0.585
DOC_PP1_RVXF_1	544	551	PF00149	0.406
DOC_PP2B_LxvP_1	24	27	PF13499	0.645
DOC_PP2B_LxvP_1	287	290	PF13499	0.736
DOC_PP2B_LxvP_1	474	477	PF13499	0.601
DOC_PP2B_LxvP_1	530	533	PF13499	0.623
DOC_PP2B_LxvP_1	70	73	PF13499	0.785
DOC_PP4_FxxP_1	487	490	PF00568	0.730
DOC_PP4_FxxP_1	501	504	PF00568	0.594
DOC_PP4_MxPP_1	469	472	PF00568	0.774
DOC_SPAK_OSR1_1	511	515	PF12202	0.754
DOC_USP7_MATH_1	161	165	PF00917	0.688
DOC_USP7_MATH_1	27	31	PF00917	0.678
DOC_USP7_MATH_1	37	41	PF00917	0.735
DOC_USP7_MATH_1	417	421	PF00917	0.705
DOC_USP7_MATH_1	671	675	PF00917	0.609
DOC_WW_Pin1_4	106	111	PF00397	0.697
DOC_WW_Pin1_4	193	198	PF00397	0.710
DOC_WW_Pin1_4	269	274	PF00397	0.809
DOC_WW_Pin1_4	347	352	PF00397	0.743
DOC_WW_Pin1_4	422	427	PF00397	0.617
DOC_WW_Pin1_4	493	498	PF00397	0.743
LIG_14-3-3_CanoR_1	277	286	PF00244	0.795
LIG_14-3-3_CanoR_1	343	351	PF00244	0.657
LIG_14-3-3_CanoR_1	484	488	PF00244	0.665
LIG_14-3-3_CanoR_1	695	701	PF00244	0.380
LIG_14-3-3_CanoR_1	736	743	PF00244	0.489
LIG_BIR_III_4	129	133	PF00653	0.615
LIG_BIR_III_4	327	331	PF00653	0.817
LIG_BRCT_BRCA1_1	175	179	PF00533	0.754
LIG_DCNL_PONY_1	1	4	PF03556	0.346
LIG_EH1_1	203	211	PF00400	0.717
LIG_eIF4E_1	204	210	PF01652	0.561
LIG_eIF4E_1	234	240	PF01652	0.528
LIG_FHA_1	227	233	PF00498	0.631
LIG_FHA_1	377	383	PF00498	0.769
LIG_FHA_1	393	399	PF00498	0.757
LIG_FHA_1	493	499	PF00498	0.555
LIG_FHA_1	549	555	PF00498	0.382
LIG_FHA_1	567	573	PF00498	0.389
LIG_FHA_1	736	742	PF00498	0.468
LIG_FHA_1	81	87	PF00498	0.725
LIG_FHA_2	221	227	PF00498	0.570
LIG_FHA_2	34	40	PF00498	0.615
LIG_FHA_2	372	378	PF00498	0.641
LIG_FHA_2	635	641	PF00498	0.538
LIG_LIR_Apic_2	486	490	PF02991	0.603
LIG_LIR_Gen_1	202	213	PF02991	0.644
LIG_LIR_Gen_1	43	51	PF02991	0.616
LIG_LIR_Nem_3	202	208	PF02991	0.608
LIG_LIR_Nem_3	619	624	PF02991	0.471
LIG_LIR_Nem_3	699	705	PF02991	0.481
LIG_LYPXL_yS_3	702	705	PF13949	0.488
LIG_MYND_1	69	73	PF01753	0.640
LIG_NRBOX	1	7	PF00104	0.346
LIG_PCNA_yPIPBox_3	682	695	PF02747	0.466
LIG_PCNA_yPIPBox_3	704	714	PF02747	0.361
LIG_PDZ_Class_2	740	745	PF00595	0.400
LIG_PTAP_UEV_1	567	572	PF05743	0.492
LIG_SH2_CRK	67	71	PF00017	0.777
LIG_SH2_CRK	79	83	PF00017	0.600
LIG_SH2_GRB2like	247	250	PF00017	0.715
LIG_SH2_NCK_1	646	650	PF00017	0.555
LIG_SH2_NCK_1	79	83	PF00017	0.711
LIG_SH2_STAP1	126	130	PF00017	0.805
LIG_SH2_STAP1	247	251	PF00017	0.712
LIG_SH2_STAP1	646	650	PF00017	0.444
LIG_SH2_STAT3	365	368	PF00017	0.641
LIG_SH2_STAT3	507	510	PF00017	0.628
LIG_SH2_STAT5	20	23	PF00017	0.454
LIG_SH2_STAT5	424	427	PF00017	0.617
LIG_SH2_STAT5	79	82	PF00017	0.642
LIG_SH3_2	194	199	PF14604	0.687
LIG_SH3_3	191	197	PF00018	0.699
LIG_SH3_3	287	293	PF00018	0.735
LIG_SH3_3	311	317	PF00018	0.743
LIG_SH3_3	348	354	PF00018	0.648
LIG_SH3_3	423	429	PF00018	0.616
LIG_SH3_3	444	450	PF00018	0.744
LIG_SH3_3	456	462	PF00018	0.716
LIG_SH3_3	487	493	PF00018	0.626
LIG_SH3_3	565	571	PF00018	0.410
LIG_SH3_3	66	72	PF00018	0.790
LIG_SUMO_SIM_anti_2	687	692	PF11976	0.459
LIG_SUMO_SIM_par_1	298	304	PF11976	0.795
LIG_SUMO_SIM_par_1	455	460	PF11976	0.712
LIG_TRAF2_1	638	641	PF00917	0.444
LIG_TRAF2_1	72	75	PF00917	0.604
LIG_TYR_ITIM	700	705	PF00017	0.600
LIG_TYR_ITIM	96	101	PF00017	0.544
LIG_UBA3_1	572	578	PF00899	0.377
MOD_CDC14_SPxK_1	496	499	PF00782	0.407
MOD_CDK_SPK_2	106	111	PF00069	0.623
MOD_CDK_SPxK_1	193	199	PF00069	0.641
MOD_CDK_SPxK_1	493	499	PF00069	0.423
MOD_CDK_SPxxK_3	193	200	PF00069	0.741
MOD_CK1_1	128	134	PF00069	0.642
MOD_CK1_1	164	170	PF00069	0.643
MOD_CK1_1	172	178	PF00069	0.608
MOD_CK1_1	279	285	PF00069	0.695
MOD_CK1_1	329	335	PF00069	0.793
MOD_CK1_1	391	397	PF00069	0.672
MOD_CK1_1	399	405	PF00069	0.699
MOD_CK1_1	479	485	PF00069	0.703
MOD_CK1_1	566	572	PF00069	0.609
MOD_CK1_1	590	596	PF00069	0.637
MOD_CK1_1	662	668	PF00069	0.793
MOD_CK1_1	670	676	PF00069	0.643
MOD_CK2_1	106	112	PF00069	0.576
MOD_CK2_1	132	138	PF00069	0.573
MOD_CK2_1	220	226	PF00069	0.452
MOD_CK2_1	33	39	PF00069	0.544
MOD_CK2_1	585	591	PF00069	0.648
MOD_CK2_1	624	630	PF00069	0.579
MOD_CK2_1	634	640	PF00069	0.589
MOD_CK2_1	84	90	PF00069	0.555
MOD_Cter_Amidation	114	117	PF01082	0.513
MOD_GlcNHglycan	129	133	PF01048	0.703
MOD_GlcNHglycan	134	137	PF01048	0.739
MOD_GlcNHglycan	143	146	PF01048	0.664
MOD_GlcNHglycan	155	158	PF01048	0.774
MOD_GlcNHglycan	163	166	PF01048	0.639
MOD_GlcNHglycan	201	204	PF01048	0.688
MOD_GlcNHglycan	264	267	PF01048	0.693
MOD_GlcNHglycan	281	284	PF01048	0.792
MOD_GlcNHglycan	303	306	PF01048	0.758
MOD_GlcNHglycan	327	331	PF01048	0.697
MOD_GlcNHglycan	358	361	PF01048	0.796
MOD_GlcNHglycan	39	42	PF01048	0.691
MOD_GlcNHglycan	399	402	PF01048	0.736
MOD_GlcNHglycan	45	48	PF01048	0.647
MOD_GlcNHglycan	587	590	PF01048	0.689
MOD_GlcNHglycan	591	595	PF01048	0.702
MOD_GlcNHglycan	603	606	PF01048	0.768
MOD_GlcNHglycan	612	615	PF01048	0.774
MOD_GlcNHglycan	646	649	PF01048	0.664
MOD_GlcNHglycan	657	660	PF01048	0.757
MOD_GlcNHglycan	662	665	PF01048	0.791
MOD_GlcNHglycan	669	672	PF01048	0.665
MOD_GlcNHglycan	673	676	PF01048	0.655
MOD_GlcNHglycan	715	718	PF01048	0.736
MOD_GSK3_1	124	131	PF00069	0.710
MOD_GSK3_1	141	148	PF00069	0.540
MOD_GSK3_1	160	167	PF00069	0.625
MOD_GSK3_1	169	176	PF00069	0.615
MOD_GSK3_1	262	269	PF00069	0.550
MOD_GSK3_1	275	282	PF00069	0.597
MOD_GSK3_1	329	336	PF00069	0.637
MOD_GSK3_1	33	40	PF00069	0.661
MOD_GSK3_1	371	378	PF00069	0.740
MOD_GSK3_1	388	395	PF00069	0.658
MOD_GSK3_1	396	403	PF00069	0.624
MOD_GSK3_1	479	486	PF00069	0.731
MOD_GSK3_1	535	542	PF00069	0.449
MOD_GSK3_1	597	604	PF00069	0.650
MOD_GSK3_1	619	626	PF00069	0.725
MOD_GSK3_1	655	662	PF00069	0.699
MOD_GSK3_1	667	674	PF00069	0.689
MOD_GSK3_1	80	87	PF00069	0.561
MOD_N-GLC_1	388	393	PF02516	0.712
MOD_N-GLC_1	539	544	PF02516	0.406
MOD_N-GLC_1	678	683	PF02516	0.481
MOD_NEK2_1	239	244	PF00069	0.418
MOD_NEK2_1	275	280	PF00069	0.564
MOD_NEK2_1	356	361	PF00069	0.543
MOD_NEK2_1	376	381	PF00069	0.700
MOD_NEK2_1	382	387	PF00069	0.691
MOD_NEK2_1	483	488	PF00069	0.565
MOD_NEK2_1	539	544	PF00069	0.406
MOD_NEK2_1	601	606	PF00069	0.602
MOD_NEK2_1	660	665	PF00069	0.800
MOD_NEK2_1	696	701	PF00069	0.577
MOD_NEK2_1	732	737	PF00069	0.681
MOD_NEK2_1	8	13	PF00069	0.362
MOD_NEK2_2	597	602	PF00069	0.594
MOD_PIKK_1	266	272	PF00454	0.502
MOD_PIKK_1	277	283	PF00454	0.677
MOD_PIKK_1	476	482	PF00454	0.486
MOD_PKA_1	199	205	PF00069	0.704
MOD_PKA_1	713	719	PF00069	0.736
MOD_PKA_2	276	282	PF00069	0.785
MOD_PKA_2	483	489	PF00069	0.544
MOD_PKA_2	601	607	PF00069	0.603
MOD_PKA_2	642	648	PF00069	0.798
MOD_PKA_2	713	719	PF00069	0.715
MOD_PKA_2	735	741	PF00069	0.605
MOD_Plk_1	139	145	PF00069	0.533
MOD_Plk_1	539	545	PF00069	0.398
MOD_Plk_1	563	569	PF00069	0.492
MOD_Plk_1	629	635	PF00069	0.814
MOD_Plk_1	89	95	PF00069	0.648
MOD_Plk_2-3	455	461	PF00069	0.646
MOD_Plk_4	282	288	PF00069	0.537
MOD_Plk_4	378	384	PF00069	0.744
MOD_Plk_4	77	83	PF00069	0.457
MOD_Plk_4	89	95	PF00069	0.425
MOD_ProDKin_1	106	112	PF00069	0.628
MOD_ProDKin_1	193	199	PF00069	0.641
MOD_ProDKin_1	269	275	PF00069	0.781
MOD_ProDKin_1	347	353	PF00069	0.685
MOD_ProDKin_1	422	428	PF00069	0.513
MOD_ProDKin_1	493	499	PF00069	0.682
TRG_DiLeu_BaLyEn_6	228	233	PF01217	0.422
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.650
TRG_DiLeu_BaLyEn_6	290	295	PF01217	0.672
TRG_DiLeu_BaLyEn_6	501	506	PF01217	0.500
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.772
TRG_DiLeu_BaLyEn_6	692	697	PF01217	0.569
TRG_ENDOCYTIC_2	20	23	PF00928	0.513
TRG_ENDOCYTIC_2	555	558	PF00928	0.480
TRG_ENDOCYTIC_2	67	70	PF00928	0.646
TRG_ENDOCYTIC_2	702	705	PF00928	0.611
TRG_ENDOCYTIC_2	79	82	PF00928	0.447
TRG_ENDOCYTIC_2	98	101	PF00928	0.542
TRG_ER_diArg_1	117	120	PF00400	0.649
TRG_ER_diArg_1	177	179	PF00400	0.661
TRG_ER_diArg_1	180	182	PF00400	0.681
TRG_ER_diArg_1	183	185	PF00400	0.681
TRG_ER_diArg_1	251	254	PF00400	0.532
TRG_ER_diArg_1	314	316	PF00400	0.663
TRG_ER_diArg_1	483	485	PF00400	0.502
TRG_ER_diArg_1	545	547	PF00400	0.400
TRG_ER_diArg_1	693	695	PF00400	0.683
TRG_ER_diArg_1	713	715	PF00400	0.388
TRG_NLS_MonoExtC_3	115	120	PF00514	0.508
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.659
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	694	698	PF00026	0.680

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK26	Leptomonas seymouri	41%	89%
A0A3S5H6C2	Leishmania donovani	69%	95%
A4HTU0	Leishmania infantum	69%	95%
E9AMM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	96%
Q4QHZ8	Leishmania major	69%	100%